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Antibacterial and antibiofilm activities of Malaysian Trigona honey against Pseudomonas aeruginosa ATCC 10145 and Streptococcus pyogenes ATCC 19615
No full textThis study aimed to investigate the antibacterial and antibiofilm activities of Trigona honey against Pseudomonas
aeruginosa and Streptococcus pyogenes. The antimicrobial and anti-biofilm activities were examined by agar well diffusion
assays, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), time-kill curve, biofilm
formation in 96-well plates and scanning electron microscope (SEM). Larger zones of inhibition were recorded from the
agar well diffusion method. Trigona honey samples showed clear zones of inhibitions against P. aeruginosa and S.
pyogenes, 25.2±0.6mm and 26.7±1.0mm respectively. Trigona honey possessed the lowest MIC value against P. aeruginosa
and S. pyogenes was 20% (w/v) and MBC was 25% (w/v). In addition, MICR
50R was between 10%-12.5% (w/v) and MICR
90R
was between 20%-25% (w/v) concentration of honey for both bacteria. In time-kill curve, Trigona honey inhibited P.
aeruginosa and S. pyogenes in a 3 logR
10R at 18 hours, and total viable counts (TVCs) were killed after 24 hours at honey
concentration of 25%. In biofilm degradation assay, Trigona honey degraded 70% of P. aeruginosa and 68% of S. pyogenes
biofilm. Also in biofilm inhibition assay, Trigona honey inhibited 91% of P. aeruginosa and 89% of Streptococcus pyogenes
biofilms. SEM images of P. aeruginosa and S. pyogenes showed that Trigona honey changed shape, size of cells, destroyed
cell wall integrity and lysed the cells in both bacteria. Scanning electron microscope images for biofilm of P. aeruginosa and
S. pyogenes showed that Trigona honey decreased cell density, and cells appeared curved of P. aeruginosa and rough, holes
and crevices of S. pyogenes. In sum, Trigona honey disrupted and damaged biofilm formation. This study demonstrated that
Trigona honey has high antibacterial and antibiofilm activities against both bacteria in vitro and showed the efficacy of
honey against biofilm in different degrees of potential effect. The study supports previous finding that Trigona honey can be
used as an alternative medicine for various bacterial infections
Comparison of smokers employment status in retention behavior among community in Terengganu
No full textSmoking is one of the behaviors that violates the norms of life because it causes harm to oneself and to the environment.
Smoking problems are no longer an unfamiliar behavior for working and non-working people where they have easy access
to the material. The purpose of this study was to identify comparisons between working smokers and non-smokers in
maintaining smoking behavior. This study uses quantitative techniques for the purpose of obtaining accurate answers
from respondents. The respondents of this study were 437 male respondents living in Terengganu state. The analysis used
in this study was discriminant analysis. This discriminant analysis aims to control for variables that separate between three
or more clusters that are clearly joined. Discriminant Analysis (DA) uses misclassified modes, backward stepwise, and
forward stepwise. Standard mode reported 95.88% gain with 21 variables while backward stepwise and forward stepwise
recorded 95.19% with 10 variables for backward stepwise and 7 variables for stepwise forward. Some of the significant
questions with the number 0.0001 were S1, S2, S4, S6, S9, S13, and S18. The government should play a role in drafting
strategies for law enforcement to combat the growing prevalence of smoking
Metode bimbingan lembaga tabung haji terhadap jemaah haji Malaysia: satu penilaian awal
No full textLembaga Tabung Haji (TH) or Malaysian Hajj Fund Board is an institution that manages the
savings of the Malaysian Muslims as well as the pilgrimage of Malaysian pilgrims from the
homeland to the most relevant of all. One of the most important aspects is the teaching and
guidance towards the pilgrims which considered as the heart of the holy journey. There is a
perception that the approach to pilgrimage and umrah brought by TH is too narrow, rigid,
harsh and unfriendly to the congregation. This perception invokes the credibility of TH's
credibility in conducting Malaysian pilgrims. Therefore, this paper will highlight the TH
guidance method for Malaysian pilgrims and make a brief assessment of it. The study used
document analysis methods and interviews and then analyzed using content analysis and
comparison methods. Studies show that TH has its own approach and manhunt in its guidance
to Malaysian pilgrims. It is regulated by the highest body known as the TH-JAKIM Pilgrim
Expert Committee Member (AJPIH). From the side of the jurisprudent resources methods, the
references used is the authority that reflects the credibility of this TH guidance. The guidance
provided is in line with the al-Shafi‘e scholar's approach, and the panel of authors also has a
relatively flexible approach when discussing specific legal issues. This study can contribute to
the resolution of the scientific and critical issues raised. In conclusion, the pilgrimage and
umrah guidance to the target group should be emphasized and strengthened so that everyone
can get the benefits from it
أدب الأوبئة في التراث النقدي والبلاغي - دراسة في شعر علي الدرويش ونقوال االسطمبولي
No full textIt is customary for literature to co-exist with the current
events that the world is experiencing in influence and influence,
and to resonate. and in will not be in vain. he records in memory
ingenuity literary masterpieces, and relic artistic texts; a relief of
pomp, and an abnormality. And with the aggravation of the virus
(Corona) crisis - which souls from it became tired! The year has
spoken a lot, The so-called literary and monetary arena has
resurfaced By (the term epidemiological literature or
epidemiological literature). And that which the poets had told him
recorded bitter poetic experiences; in which the size of the agony
began, and the cruelty of the scene, The impact of the plague on
the environment and society at the time; and describe the
magnitude of the tragedy, giving rise to the duty of consolation.
From these poet Ali al-Darwish (1796m-1853) and poet Nikola El
estambuly (1763m-1828), they each dealt with the epidemic in its
poetic production, which struck the country in the eighteenth
century ad, In a poetic experience that deserves to be identified and
demonstrated, and to know what it has and what it is; to stand on
the differences and reach the veins to inspect their March, and to
follow their course; a clear manifestation of what has been hidden,
Perhaps it is a finger that contributes to the reference to this kind of
literature; to collect the diaspora, and the signs that it has written
about. Thus, the research came in an introduction, a process, and
four points, with a conclusion, sources and references
In-depth characterization of miRNome in papillary thyroid cancer with BRAF V600E mutation
No full textMicroRNAs (miRNAs) are small non-coding RNAs, which play a critical regulatory role in papillary thyroid
carcinoma (PTC). BRAF V600E is a hotspot mutation occurring in a majority of PTC cases and is proposed to be associated
with poor clinical outcomes. The relationship between BRAF V600E status and miRNA expression in PTC has not been
comprehensively studied. In this study, we aimed to identify the differentially expressed miRNAs in PTCs with and without
BRAF V600E in an unbiased manner. Five fresh frozen thyroid cancer tissues paired with their respective adjacent normal
tissues from PTC patients were subjected to BRAF V600E genotyping using Sanger sequencing and small RNA deep
sequencing (miRNAseq). MiRNAs differentially expressed between BRAF V600E-positive and BRAF V600E-negative
PTC tissues were validated in silico using The Cancer Genome Atlas (TCGA) THCA datasets containing 420 samples.
MiRNA target prediction and pathway enrichment analysis were performed to identify biological pathways altered in this
cancer. We identified 174 differentially expressed miRNAs; 80 were significantly over-expressed, while 94 were underexpressed (adj. p-value < 0.1; log2 fold change ≤ -1 or ≥ 1). Fifteen miRNAs were significantly differentially expressed only
in BRAF V600E-positive PTC, and eight of these were validated in TCGA THCA dataset (hsa-miR-212, -132, -135b-3p/5p,
-200b, -200a-3p/5p, -27a-3p/5p, -29a and -1296). Subsequent analysis revealed significant enrichment of cancer-related
pathways including proteoglycans in cancer, ECM-receptor interaction and MAPK pathways in BRAF V600E-positive PTC.
Using the miRNAseq and in silico validation using TCGA THCA study, we identified eight miRNAs that were differentially
expressed in PTC tissues with BRAF V600E. This study also complemented the existing knowledge about deregulated
miRNAs in PTC development
An assessment of knowledge, attitude and practice (KAP) towards recycling activity in Kuantan Pahang, Malaysia
No full textThis study was conducted among the householders at residential area in kuantan at 6 places in Kuantan. It was involving
308 of respondents from all 6 places in Kuantan (Bukit Rangin, Bukit Istana, Astana View, Jaya Gading, Taman
RasauPerdana and Seri DamaiPerdana). The main purpose of this study was to investigate the level of knowledge,
attitude and practice (KAP) of household recycling towards solid waste management. Besides that, the study also was
conducted to identify which factors among the demographic profiles of gender, ages, household incomes and level of
education could give the significantly different to KAP. Then, this study investigated the significant relationship among
of each KAP variables. Data for this study was obtained in quantitative studies through questionnaires and analysing
them using the SPSS software. This study was using the statistically testing of t-test, One-Way ANOVA and Pearson
correlation. For genders the statistical testing’s using was the independent t-test, and it was found that that males and
females did not significantly different (p > 0.05) towards the KAP of household recycling
[Literature review on drug addiction treatment] Sorotan kajian rawatan ketagihan dadah
No full textDrug addiction is a widespread problem in Malaysia. Various treatments to cure drug addiction
are discussed in this study. Among this treatments are religious approaches, based on the Quran
and al-Sunnah. The research questions are more on the concept of drug addiction and drug
dangers, conventional addiction treatment and alternative treatment of Islam as discussed. The
methodology of this scientific study focuses on qualitative methods. This study focuses on the
analysis of the work and the results of the findings. The results show that the Islamic approach is
more successful than conventional treatment. Therefore, Islamic treatment is given priority in
restoring drug addiction which is important to apply in every institution, rehabilitation center
and the family of addicts themselves
Postoperative morbidity and 3 year mortality in diabetic patients undergoing CABG
No full textBSTRACT
Objective: To determine the impact of diabetes mellitus on 30 day postoperative morbidity and after three year mortality following CABG.
Design: A cross sectional study.
Materials and Methods: A total of 205 patients who underwent CABG from January 2002 until December 2005 at
Cardiothoracic Unit of Hospital Universiti Sains Malaysia (HUSM) was conducted. Patients who underwent emergency CABG,
concomitant valve or other surgery during CABG and redo cases were excluded. Patients who underwent operation in other
hospital were also excluded even though being follow up in HUSM. The data was analyzed by using multiple logistic regression.
Results: Out of 205 patients, 90 of them (43.9%) suffered from Type 2 Diabetes Mellitus. Analysis showed that diabetes mellitus did not give impact towards 30 day mortality after adjustment of potential risk factors (COAD, BMI, ejection fraction, cardiopulmonary bypass time and length of ICU stay) (Adjusted odds ratio 4.15; 95% CI: 0.87, 19.80; P = 0.074). The analysis also
showed that diabetes mellitus did not give impact towards the three year mortality after adjustment of risk factors (Adjusted
odds ratio 1.71; 95% CI: 0.52, 5.66; P = 0.380).
Conclusion: This study could be the pioneer for local population to collect our own database before subsequent studies can
be done especially in improving the management strategies for diabetic patient with coronary artery disease
تصويب النطق بالكلام العربي من خلال القرآن الكريم
No full textحيتاج املتعلم للغة العربية إىل البحث عن املهارات اليت ستساعده على إجادة اللغة
وتطويرها، ألن تعدد األساليب واملهارات من ما يعني الطالب على استيعاب املعلومة،
و تعني املعلم على إيصاهلا، و املتبحر يف هذا اجملال يعرف معاانة املعلمني يف املدارس
واملعاهد واجلامعات اليت هتتم ابللسانيات واللغوايت، ال سيما يف النطق الصحيح
ابلكلمات العربية وهنا تكمن املشكلة، وقد كتبت هذه الصفحات إلبراز أمهية التجويد
يف النطق ابلكالم العريب، ال سيما يف التمييز بني الكلمات واحلروف من حيث املخارج
والصفات وعلوم التجويد األ خرى اليت هلا عالقة ابللغة العربية، وهو أمر يهدف إىل تطوير العلوم اليت تتعلق بعلوم اللغة من حيث دقة النطق ومتييز الكلمات بعضها عن
بعض، وقد ظهر لنا من النتائج: أن كل حرف شارك غريه يف املخرج فإننا منيزه
ابلصفات، وإذا احتدت الصفات يف احلروف املختلفة املخرج فإننا منيزه مبواضع خروج
احلرف، وأن القرآن الكرمي حافظ على اللغة العربية من االنداثر، فالقرآن حاكم للغة
وليست اللغة حاكمة للقرآن الكرمي، وأن أفضل طريقة لتعلم النطق الصحيح أن يبدأ
الطالب أبخذ كل حرف على حدة مث ينتقل للكلمات، تطبيق تعلم التجويد يف املدارس
واجلامعات واملعاهد اليت هتتم ابللغة العربية سيعطيها قفزة نوعية يف مستوى طالهبا، من
حيث االتقان والفصاحة
