Ouachita Baptist University

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    Reducing Barriers to Education Around the World: A Systematic Framework Using the Community School Model

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    Proposing a systematic framework for reducing barriers to education around the world is necessary to effectifely address the multifaceted needs of global communities. The Community School Model provides one such framework which can provide evidence-based strategies for school improvement in diverse areas

    Three Inches from Death

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    Each year, the village\u27s seventeen-year-olds are sent into the wilderness in trios of two boys and one girl for The Test, a battle to the death to determine which boy will live and marry the girl. When Sydney James, Tarrin Hanson, and Jonas Aberforth are grouped together, they begin trying to solve a logic problem where no one can truly be the winner and everyone is in danger if either Tarrin or Jonas dies

    Dr. Ryan Fogg in a Guest Artist REcital

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    This is the poster for the guest artist recital of pianist Dr. Ryan Fogg. The recital took place on February 1, 2024, in the McBeth Recital Hall

    Refining the Synthesis of a Monomer Towards a Novel Wound Dressing and Designing a Clot-Testing Device

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    For centuries, gauze has been central to wound care and healing. As early as the 1980s, hemostatic dressings have helped stabilize wounds in treating traumatic injuries. However, gauze is a foreign substance to the human body and must be removed over time, which is not ideal for all types of wound healing. Some gauze-based hemostatic systems can also cause secondary burn wounds due to excess chitosan, a required substance for its efficacy. In our study, we designed a novel wound dressing that should improve on current methods. This dressing mimics the human extracellular matrix which helps cell regeneration and will degrade in the body, eliminating the need to change or remove the dressing following application. The amount of chitosan utilized in our dressing is also reduced, lowering the chances of burns within wounds. A carboxylic acid-modified polycaprolactone (PCL) was produced and subsequently modified via amide coupling reactions to produce a biomimetic PCL (bPCL). bPCL was electrospun with chitosan to produce fiber mats ready for testing and analysis as a wound dressing. The other part of the project focused on the design and construction of a device that would simulate an “open wound” environment using 3-D printing and polydimethylsiloxane (PDMS). Such a device allows the clotting properties of the dressing to be tested. Specifically, the device would allow the Hamilton lab to perform flow tests to analyze the clotting capabilities of fiber mats. In order to analyze the hemostatic properties of the bPCL/chitosan fiber mats, samples of platelets were pumped through the device with the fiber mat placed inside. It is anticipated that these novel materials will be utilized in a variety of biomedical applications

    Developing a Novel Succinct Synthetic Approach to the Modification of Alginate for Use in Biomedical Applications

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    Alginate, a natural polymer, can also be electrospun to produce materials for wound healing. The innate groups in alginate lend themselves towards modification to produce a biomimetic and degradable polymer that can be electrospun. Using a new concerted synthesis for the modification of alginate allows for the attachment of four functional groups via amide coupling and can be facilely conducted in an undergraduate research laboratory. This product can be oxidized to enhance alginate degradability. The modified alginate was co-spun with PVA to create nanofibrous scaffolding. The physical properties of these materials were characterized through scanning electron microscopy (SEM), infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy. Cellular responses to these alginate-based fiber mats were examined including cell viability and proliferation. Ongoing nuclear magnetic resonance spectroscopy analysis will compare the efficiency of functional group attachments of this synthetic approach as compared to a traditional stepwise modification of this polymer. Future studies include analyzing antimicrobial properties and in vivo assays

    David Glaze Music Competition to be held at Ouachita on March 14

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    The Division of Music in Ouachita Baptist University’s School of Performing Arts will host the Third Annual David Glaze Music Competition on Thursday, March 14, at 7:30 p.m. in McBeth Recital Hall. This event is free and open to the public. The competition will showcase performances from five student musicians who made it past the preliminary rounds of video entries. All participants must be Ouachita students taking private lessons and pay a $30 entry fee to qualify. This year’s finalists, chosen from 18 entrants, are Katie McManus, a senior instrumental music education major from Buford, Ga.; Amaya Hardin, a junior musical theatre major from Little Rock, Ark.; Annslee Clay, a senior musical theatre major from Bryant, Ark.; Brandon Holloway, a junior vocal performance major from Little Rock, Ark.; and Andrew Pierce, a junior biology and music double major from Benton, Ark

    Equipped, called and capable (Thoughts on the worship studies program)

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    Ouachita’s worship studies degree has been, to me, a beautifully answered prayer. I first answered a call to ministry at my home church, Summit Church of Little Rock. Although we don’t know each other personally, Bill Elliff – the founding pastor of that church – served as one of my biggest motivators for ministry. Seeing his authentic reverence and passion for God helped spark that same fire in myself. At the time I decided on ministry, I didn’t know it was something you could go to college for. I had already dropped out of college once; my chances of returning were incredibly slim. The timing of the creation of the worship studies degree and God’s substantial provision to get me to Ouachita could not have been more perfectly laid out. This was my first indicator there is something of great value here, because I’ve seen God do miraculous things to make a way for people to be a part of it. I didn’t know yet what that would look like, since the degree had just been put into place

    Patient Compliance Through Education for Type 2 Diabetics on New Medications: SGLT-2 Inhibitors and GLP-1 Analogues

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    Objective: Type 2 diabetics have a higher prevalence of cardiovascular disease complications (Glovaci et al., 2019). Cardiovascular disease was the cause of death in 9.9% of Type II Diabetics which represents 50.3% of all deaths related to Type II Diabetes Mellitus (Einarson et al., 2017). Across the world, cardiovascular disease affects approximately 32.2% of all people with Type II Diabetes Mellitus (Einarson et al., 2017). This begs the question: in individuals with type 2 diabetes, does medication education on Sodium-Glucose Co-Transporter 2 inhibitors, or SGLT-2 inhibitors, and Glucagon-Like Peptide-1 Agonists, or GLP-1 agonists, increase patient compliance with medication by medication education? Methods: A literature review was conducted using the Boolean strategy, including the words “AND”, “OR”, and “BUT” in Google Scholar and PubMed search engines. The following filters included: “5 years ago,” “nursing interventions,” “evidence-based research,” and “peer-reviewed.” Results: Four articles were selected for review and they included two meta-analyses of randomized control groups, a cross-sectional study, and a literature review. Three articles showed that SLGT-2 inhibitors had some preventative effects on cardiovascular events, but no significant benefits were found in protecting people with type II diabetes from cardiovascular complications (Nelinson et al., 2021, Palmer et al., 2021, Sayour et al., 2024). The literature review stated that patients educated on medications are more likely to adhere to them, (Nelinson et al., 2021). Discussion: Therefore, there was not enough research to show that adherence to these antidiabetic medications decreased the risk of cardiovascular disease complications in type 2 diabetics. However, research does show that medication education improves medication adherence. Therefore, this evidence should be utilized in nursing because medication education leads to increased compliance with client medication regimens. Nurses should educate the clients on the medications they are giving and the provider’s orders at discharge. If this is implemented, there will likely be a higher success rate in clients complying with and finishing their medications. Adherence to these medications may not drastically reduce cardiovascular disease complications, but it will decrease risk in Type 2 Diabetics who comply with their medications

    The Development of a New Water-Soluble Zinc Porphyrin, ZnTPP-2MP, as a Photodynamic Therapy Agent

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    Photodynamic therapy is a new technique used in cancer treatment involving the use of a photosensitizer and light exposure to kill malignant cells. This research tested the use of ZnTPP-2MP as a photosensitizer using white light as a source of possible treatment of the A549 cancer cell line, with preliminary testing on MYC-22 and other G- quadruplex DNA samples. ZnTPP-2MP was synthesized by the reaction of the porphyrin, ZnTPPC, with 2-amino-2- methyl-1-propanol. Following synthesis, the new porphyrin was purified by column chromatography using Sephadex LH-20 and G-50. To confirm the identity and structure of the product, ZnTPP-2MP was analyzed through nuclear magnetic resonance (NMR), infrared (IR), ultraviolet-visible (UV-vis) and fluorescence spectroscopies. Purity of the final compound was determined using HPLC. Additionally, ROS (reactive oxygen species) production using the novel porphyrin, is currently being tested

    Synthesis of ZnTPP-IL as a Potential Photodynamic Therapy Agent

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    Photodynamic Therapy is a new technique used in cancer treatment involving the use of a photosensitizer—a porphyrin—and light exposure to kill malignant cells. In this research, ZnTPP-IL was used as a photosensitizer with white light as a possible source of treatment of NIH 3T3 fibroblast and A549 lung cancer cell lines, with preliminary DNA testing on MYC-22 and G-quadruplex samples. ZnTPP-IL was synthesized by the reaction of the porphyrin ZnTPPC with isoleucinol. The new porphyrin was then purified by column chromatography using Sephadex LH-20 and G-50. ZnTPP-IL was characterized through NMR, IR, UV-vis, and fluorescence spectroscopies. The purity of the compound was then determined using HPLC. Additionally, ROS production using ZnTPP-IL was determined. The cytotoxicity of ZnTPP-IL was then examined by analyzing MTT assay with A549 lung cancer cell lines when paired with white and red light

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