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Image of unidentified man
No full textImage of unidentified man, col. (This could be an ambrotype, it was difficult to identify).https://mds.marshall.edu/floyd_stark_pitt_stark_collection/1004/thumbnail.jp
Thornburg Apartments, Huntington, W.Va.
No full textThornburg Apartments, Huntington, W.Va., b&w. Sidney Day was a well-known architect, and designed several buildings in the Huntington area. In a folder with other folders dated 1955.https://mds.marshall.edu/robert_sidney_day_collection/1045/thumbnail.jp
The Prevalence of Musculoskeletal Injuries within the Center for Wellness in the Arts at Marshall University
Get PDFBackground: The demands on successful performing artists are two-fold. First, they have to perform at a high skill level for their specific art, such as theater, marching band, dance, and color guard. Second, they need to achieve the aesthetic demands of their discipline. Musculoskeletal (MSK) injuries can impact either or both of these elements and affect their overall performance. If MSK injuries are not addressed early in a performer’s career, they can develop into chronic problems that take performers out of rehearsals, practices, and performances.
Purpose: This epidemiological study aimed to investigate the prevalence of MSK injuries within the Center for Wellness in the Arts at Marshall University (CWA) and then compare the prevalence of MSK injuries in the published literature. The hypothesis was that the CWA would result in a lower prevalence of MSK injuries due to the collegiate age of the performers.
Methods: Investigators sorted through the published literature and found 24 studies or reviews that established a baseline prevalence of MSK injury outside of Marshall University’s performing arts community. Investigators implemented a retrospective evaluation of data collected within the CWA to compare the prevalence of injuries within the performing arts at Marshall University to the published literature.
Results: The CWA reported less than expected injuries to the knee (χ2 = 21.969, p \u3c 0.001), ankle (χ2 = 12.931, p = 0.003), calf (χ2 = 11.253, p = 0.007), foot (χ2 = 22.039, p \u3c 0.001), lumbar spine (χ2 = 30.613, p \u3c 0.001), shoulder (χ2 = 42.726, p \u3c 0.001), thoracic spine (χ2 = 5.045, p = 0.024), hand/wrist/and finger (χ2 = 55.181, p \u3c 0.001), upper arm/elbow/and forearm (χ2 = 47.292, p \u3c 0.001), head and neck (χ2 = 35.011, p \u3c 0.001), lower extremity (χ2 = 181.967, p \u3c 0.001), and illnesses or ailments categorized as “other” (χ2 = 7.506, p \u3c 0.001). Data analysis, with a p-value greater than 0.05, resulted in no statistical difference between injury prevalence of the CWA data compared to the published literature. The CWA reported a greater prevalence of injuries to the hip (χ2 = 2.274, p = 0.131), thigh (χ2 = 0.257, p = 0.611), and upper extremities (χ2 = 0.043, p = 0.835) compared to the reported literature.
Conclusions and Practical Relevance: The CWA showed a lower prevalence of MSK injuries than the published literature in the epidemiological review. Implementing preventative medicine interventions earlier in a performing artist’s career can reduce the detrimental impact of overuse injuries. This can result in prolonging the careers of performing artists and improving their health
Fatigue-related jump landing knee injuries in dancers
Get PDFNon-contact knee injuries are prevalent in dancers and have great financial and social costs. These injuries may be prevented with training that modifies jump landing movement patterns and improves lower body strength and cardiorespiratory fitness. Identifying the movement-based risk factors that are most strongly related to injury mechanisms allows healthcare providers to create effective training interventions. The purpose of this study was to determine the relationship between multivariate risk factors and injurious knee forces as a dancer lands from a jump. Twenty female dance students with at least eight years of experience were recruited. These dancers were injury-free and actively rehearsing, volunteered to participate, and signed informed consent. Participants took part in two testing sessions. On day one participants completed a dance history questionnaire, had their height and weight measured, tested their knee flexion/extension muscular endurance using an isokinetic dynamometer, and their cardiorespiratory fitness using a submaximal, graded step test. On a second day, participants completed switch leap jump landings before and after performing a Dance Aerobic Fitness Test at an increasing tempo. Threedimensional lower extremity kinematics of their landings were measured using a retro-reflective motion analysis system. Landing forces were measured using two force plates. Joint angles during the leap and at landing, and knee joint anterior shear force and external valgus moment at landing were calculated from the biomechanical data. Stepwise multiple regressions showed that when landing while fatigued, increased knee anterior shear force was predicted by a combination of greater knee valgus angle at landing and greater knee flexion angle at landing. Increased external knee valgus moment was predicted by a combination of decreased knee valgus angle at landing and decreased knee flexion angle at landing. These results indicate that a more extended landing position is possible when a dancer is fatigued, and this position can generate a greater knee valgus moment, which stresses the MCL. These results also indicate that a knee flexed and valgus landing position in combination with lower fitness levels may generate high knee anterior shear force, which stresses the ACL. A statistically significant interaction term was identified for the regression analyses, indicating that fitness level may function as a moderator of the relationships between knee angles at landing and knee joint anterior shear force, as well as knee angles at landing and external knee valgus moment. These findings can be used to direct training interventions to improve jump landing movement patterns and help to guide future research for a better understanding of fitness and its impact on fatigued landings
Structure-based design and synthesis of transient receptor potential melastatin 8 (TRPM8) ion channel ligands
No full textTRP channels are the major temperature sensing receptors in the body. TRPM8 is the primary cold thermoreceptor for both innocuous cold and cold pain, and has been linked to a variety of diseases, including chemotherapy (oxaliplatin)-induced cold allodynia and chronic neuropathic pain. Antagonists of TRPM8 have been proposed as a viable therapeutic option for those disease states. Current data from our lab shows that the TRPM8 antagonist VBJ-103 is 100-fold selective for TRPM8 vs. related thermoTRP channels TRPV1 (vanilloid 1) and TRPA1 (ankyrin 1). Analogs of VBJ-103 using a structure-based drug design approach may result in changes to selectivity and antagonist potency for TRPM8. The hypothesis is that selectivity could improve by targeting a basic Arg842 residue with acidic functional groups. A nine-step synthesis was undertaken to prepare acidic analogs of VBJ-103. This work demonstrates the completed synthetic route optimization and scale-up of the initial four steps that resulted in generation of 3.7 g of a critical amine intermediate (4) consisting of cis and trans isomers, verified by 2D NMR experiments. It was determined that the racemic mixture of 5 had an IC50 of 13.68 ± 0.2 µM. Finally, two chimeric analogs of the well-known TRPM8 antagonist AMTB and our scaffolds were designed and synthesized for biological evaluation. VBJ103-AMTB chimera (vbj_2_070) has an IC50 of 0.94 ± 0.2 µM, and VBJ104TB-AMTB chimera (vbj_2_071) has an IC50 of 0.5 ± 0.1
Girl Scouts, group photo
No full textGirl Scouts during Girl Scout Badge College, Saturday, November 13, 2021, on the Marshall University, Huntington campus.https://mds.marshall.edu/bd_girl_scout_badge_college_2021/1010/thumbnail.jp