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When Surviving Jim Crow is a Preexisting Condition : The Impact of COVID-19 on African Americans in Late Adulthood and Their Perceptions of the Medical Field
Get PDFShift in Conformational Equilibrium Underlies the Oscillatory Phosphoryl Transfer Reaction in the Circadian Clock
Get PDFOscillatory phosphorylation/dephosphorylation can be commonly found in a biological system as a means of signal transduction though its pivotal presence in the workings of circadian clocks has drawn significant interest: for example in a significant portion of the physiology of Synechococcus elongatus PCC 7942. The biological oscillatory reaction in the cyanobacterial circadian clock can be visualized through its reconstitution in a test tube by mixing three proteins—KaiA, KaiB and KaiC—with adenosine triphosphate and magnesium ions. Surprisingly, the oscillatory phosphorylation/dephosphorylation of the hexameric KaiC takes place spontaneously and almost indefinitely in a test tube as long as ATP is present. This autonomous post-translational modification is tightly regulated by the conformational change of the C-terminal peptide of KaiC called the “A-loop” between the exposed and the buried states, a process induced by the time-course binding events of KaiA and KaiB to KaiC. There are three putative hydrogen-bond forming residues of the A-loop that are important for stabilizing its buried conformation. Substituting the residues with alanine enabled us to observe KaiB’s role in dephosphorylating hyperphosphorylated KaiC, independent of KaiA’s effect. We found a novel role of KaiB that its binding to KaiC induces the A-loop toward its buried conformation, which in turn activates the autodephosphorylation of KaiC. In addition to its traditional role of sequestering KaiA, KaiB’s binding contributes to the robustness of cyclic KaiC phosphorylation by inhibiting it during the dephosphorylation phase, effectively shifting the equilibrium toward the correct phase of the clock
The Greenbook, Faculty Handbook, 2021-2022
Get PDFThis book has been published for the faculty of Marshall University for the specified period of time. This book was created by Academic Affairs and is for the period of 2021-2022
The Interaction of Open Educational Resources (OER) Use and Course Difficulty on Student Course Grades in a Community College
No full textStudents report that not being able to afford course materials has adverse academic consequences. It is possible that this would be more problematic in relatively more difficult courses. Open Educational Resources (OER) are teaching and learning materials that are openly licensed and often available at low or no cost to students. This study examined the interaction between OER use through a campus zero textbook cost (ZTC) initiative and course difficulty on student course grades from 35 different courses at a community college while controlling for student gender, previous grade point average, and Pell grant eligibility status. Although the main effect of increasing course difficulty is decreasing individual students’ grades, there was a significant interaction between OER use and course difficulty. Student grades in sections using OER declined at a lower rate compared to the decline in student grades in sections without OER use. The findings indicate that one particular context, course difficulty, may be important for understanding the efficacy of OER adoption
Baldwin-Felts detectives killed in the Matewan Massacre, May 19, 1920
No full textBaldwin-Felts detectives killed in the Matewan Massacre, May 19, 1920 Lee captioned this picture as: Baldwin-Felts mine guards killed in Matewan Massacre: Top row, l to r: C. T. Higgins, Albert Felts and Lee Felts Bottom row, l to r: C. B. Cunningham, A.J. Boorher, E. C. Powell, and J. W. Ferguson (he appears to have misspelled two of the names: Boorher should be Booher and E. C. Powell should be E. O. Powell) An original of this collage is in the Eastern Regional Coal Archives at Bluefield, W.Va., with a page stating that copies were prepared and given to the families of these seven victims.Published in Bloodletting in Appalachia, by Howard B. Lee, p.56https://mds.marshall.edu/howard_lee_papers/1011/thumbnail.jp
The Relationship Between Health Issue and Overtime-Working in Japan
No full textThe purpose of this presentation is to discuss overtime-working and how it affects the health of Japanese office workers. Higher price of land is threatening the sustainability of many companies, which harms workers. More workers are working more hours for less money, which leads to poor health and suicide
Yokai in the Modern Era
No full textIn the 1980s, while the US was having a ‘Satanic Panic’, attacking any form of media that featured remotely ‘dark’ imagery such as Dungeons and Dragons, in Japan there was a ‘Yokai Boom’. These ‘ghostly’ or ‘dark’ creatures became increasingly popular in 80s media as more yokai were being invented as translations of fears of urban life; such as Inmenken, (the human-faced dog) and Toire-no-Hanako-san (Hanako of the Toilet). While American-Christian views tend towards being ‘black and white’ due to its monotheistic nature, Japan’s Shinto religion often employs a more nuanced approach to their entities due to its polytheistic nature. By further contrasting their between the two cultures, delving into yokais’ historical significance, their role in the modern world and their international influence we can understand the integral place these creatures have in Japanese culture. This is important because yokai are not just a thing of the past, they are currently being reinvented in the modern era. In understanding this we then can understand Japan more deeply
Enough to Condemn: A Look at Surrealism and Mental Health Through Breton’s Nadja
No full textIn this project, we see the relation between Surrealism and the field of mental health, and how André Breton (1896-1966) was influential in both movements. Breton is perhaps one of the most notable, and certainly one of the first proponents of the Surrealist movement, and he had a terrific impact on the direction it took. Breton was greatly influenced by Freud and other mental health experts of the time. I argue that his novel Nadja (1928) illustrates how Surrealism took many of its ideas from Freud and other practitioners of psychology and psychiatry. The two are clearly and closely related, and the importance is seen in how Nadja is treated in the novel, as well as how Breton reacts to it
The Venus Figurines: What Were They, and Who Were They Intended For?
No full textThe Venus figurines have been fascinating archaeologists for many years, ever since the first was discovered in 1864 in France. What were they? How were they made? This paper hopes the answer that. They are typically depicted with exaggerate secondary sexual characteristics, with large bellies, breasts, thighs, and buttocks, and have no arms or feet. They date back to the Upper Paleolithic, with most being made in the Gravettian period approximately 27,000 years ago. Prehistoric art falls into two different categories – parietal and mobiliary. Parietal encompasses all forms of cave drawings, while mobiliary is anything that can be transportable. There are several working theories for what the Venus figurines were for, including a representation of the female Supreme Creator, a woman’s view of her own body, a sexual or fertility symbol, and a symbol of the ideal woman’s body shape during this time. Some limitations of this study include time. In conclusion, the Venus figurines were a symbol of survival and hope for the future. They directly correlated in size to the rise and fall of the glaciers during the Ice Age, with the most heavyset ones being made when the glaciers were advancing, and the relatively smaller ones being made when they were retreating
Joseph Cox & Isabelle Cox family, Raleigh County, WVa
No full textJoseph Cox & Isabelle Cox family, Raleigh County, WVa, b&w Back reads: Top left: Wilbur Daniel Cox top middle: Erna Lillian Cox Top right: Lundie Cox Father: Joseph Loden Lafyette Cox Mother: Isabelle Tennessee Holbreck Hanshaw Cox Bottom Middle: Thornton Devore Cox Baby: Winnie Belle Coxhttps://mds.marshall.edu/harlow_warren_papers/1034/thumbnail.jp