Pacific McGeorge School of Law
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Molecular docking and drug virtual screening of novel small molecule inhibitors of anti-apoptotic proteins for cancer treatment
No full textBcl-2, an anti-apoptotic protein, is involved in cancer development and progression and has been considered as a promising target in cancer therapy. ABT-199, a Bcl-2 inhibitor, has been approved, as a single agent or in combinations, for the treatment of adult patients with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or newly diagnosed acute myeloid leukemia (AML) patients with age of 75 years or older. Although most patients can initially benefit from ABT-199 treatment, patients eventually develop resistance majorly due to BCL2 mutations, such as G101V and D103Y, or overexpression of Bcl-xL. Therefore, inhibitors that can target both wild-type and mutant Bcl-2 as well as Bcl-xL have the potential to overcome the resistance mechanisms to ABT-199. LP-118 is a novel inhibitor targeting wild-type Bcl-2, Bcl-2G101V and Bcl-2D103Y mutants, and has moderate activity against Bcl-xL. In preclinical and clinical studies, LP-118 had excellent anticancer activity in animal models and patients with CLL or SLL. However, there is no co-crystal structure information available to show exactly how LP-118 binds to Bcl-2, Bcl-2G101V, Bcl-2D103Y, or Bcl-xL. Molecular docking is one of the most frequently used methods in drug design and discovery, due to its ability to predict the binding-conformation of small molecule ligands to the appropriate target binding site. Using the molecular docking Software ICM-Pro, we are the first to illustrate how LP-118 binds to Bcl-2, Bcl-2G101V, Bcl-2D103Y, and Bcl-xL proteins in 3D. The molecule LP-118 is tightly tugged in the reception pocket of each protein where the interactions, including hydrogen bonding, electrostatic and p-stacking interactions, slightly vary in each case. These knowledge enables a better understanding of the mechanism of actions of LP-118 and provides a foundation for the rational design of future generations of Bcl-2/Bcl-xL inhibitor that will overcome the Bcl-2 mutation resistance. Based on the docking result, we designed over 1,000 analogues of LP-118 by fine-tuning the backbone and substituents on the molecule, used ICM-Pro/VLS software to virtually screen these analogues against Bcl-2, Bcl-2G101V, Bcl-2D103Y, or Bcl-xL, and successfully identified and prioritized 10 top-ranked analogues for chemical synthesis and anticancer activity testing
Occupational Therapy Training Application
No full textProblem: OT students rely on static case studies and limited lab access for adaptive equipment design practice, limiting hands-on rehearsal and consistent feedback. Background: A 3D interactive app integrating motion capture and quizzes can broaden experiential learning and reinforce biomechanical knowledge. Methods: In Unity, we built a 3D app featuring: 10 Activities of Daily Living across kitchen, bedroom, and office scenarios, Blender-modeled humanoid avatars rigged with Rokoko captures, A quiz module with 12 multiple-choice questions on range-of-motion and muscle function, A React Native/Firebase front end for mobile/web access. Status/Development: Core environments, avatar animations, and quiz functionality are complete. Detailed documentation and user-training materials are in preparation. A usability pilot with 30 students is scheduled for Spring 2025. Implications: This platform is poised to enhance OT curricula by delivering scalable, feedback-driven simulations that complement traditional lab exercises
Protecting Portraits and Painters: How Chapter 258 Could Finally Fix the Right to Publicity in the Age of AI
No full textImmortal Gen Tactics
No full textOur vision is to develop a tactical role-playing game that emphasizes strategic depth, player creativity, and accessibility. Inspired by Final Fantasy Tactics (1997, PlayStation One), the project features a 2.5D presentation—using 2D sprites in a 3D environment—with an isometric perspective.
For those unfamiliar with the genre, gameplay revolves around controlling a squad of units on a grid-based map, where players and opponents take alternating turns. On each turn, units typically perform up to two actions: one for movement and one for an attack or technique. Victory is achieved by defeating all opposing units.
Our motivation is to evolve the genre by introducing a core mechanic that allows players to delegate unit actions both during and outside of their turns. This system, combined with intelligent AI and multiple game modes (single-player and multiplayer), aims to deliver a fresh, strategic, and highly replayable experience for players of all skill levels
Language without Barrier: A Machine Learning Based American Sign Language Analyzer
No full textThis project focuses on developing a real-time system that translates American Sign Language (ASL) into written English. The core of the framework uses Temporal Convolutional Networks (TCNs) to recognize and classify motion-based ASL gestures, those involving hand movements over time, rather than static signs. By accurately interpreting these gestures from video input, the system helps improve communication between the deaf or hard-of-hearing community and the hearing world. This work aims to enhance accessibility and support more inclusive digital interactions
PortfolioGen: Automatic Portfolio Website & QR Code Creator for Job Seekers
No full textIn the contemporary digital employment landscape, traditional paper resumes are rapidly giving way to dynamic online portfolios and QR-coded credentials. Despite this paradigm shift, a significant segment of job seekers lacks the technical proficiency to develop these modern presentation formats. This project addresses this gap by developing a comprehensive web application that automates the creation of professional portfolio websites and corresponding QR codes based on user-submitted information.
The platform leverages cutting-edge web technologies to provide an intuitive interface where users can input their professional credentials, accomplishments, and design preferences. Upon submission, the system algorithmically generates a fully responsive, professionally designed portfolio website along with a unique QR code that directs potential employers to the user\u27s digital presence. The application operates as a self-contained ecosystem, processing submissions and delivering outputs without requiring administrative intervention.
This solution democratizes access to contemporary resume presentation methods, effectively bridging the technical divide that prevents many qualified candidates from showcasing their credentials in formats that align with current industry expectations. By empowering users to generate sophisticated digital portfolios regardless of their technical expertise, this platform enhances their competitive positioning in today\u27s digital-first recruitment environment
Discrete Math for Computer Science - Chapter 6: Proofs by contradiction: Proofs by cases
No full textSee this OER textbook full record by clicking here.https://scholarlycommons.pacific.edu/open-videos/1008/thumbnail.jp
Discrete Math for Computer Science - Chapter 23: Probability of an event
No full textSee this OER textbook full record by clicking here.https://scholarlycommons.pacific.edu/open-videos/1024/thumbnail.jp
Discrete Math for Computer Science - Chapter 15: Mathematical induction
No full textSee this OER textbook full record by clicking here.https://scholarlycommons.pacific.edu/open-videos/1016/thumbnail.jp