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Light-driven antimicrobial therapy of palladium porphyrins and their chitosan immobilization derivatives and their photophysical-chemical properties
Get PDFThe emergence of antimicrobial resistance has made the development of photodynamic therapy (PDT) related applications essential, since microorganisms can not form resistance to this method. Porphyrins are well-known photosensitizers for PDT related applications. Thus, the present study outlines the synthesis, characterization and evaluation of the utility of palladium porphyrins and their chitosan inclusion complexes as photosensitizer dye in photodynamic antimicrobial therapy (PACT). Before in vitro cell studies, the photophysical-chemical studies of all obtained structures were performed in solution. It was observed that the immobilization of the porphyrins into the chitosan influenced the photophysical-chemical and PACT activity properties. The determined fluorescence quantum yield was very low, in the range of 0.007–0.028 for all samples indicating the efficient triplet state population to cause high singlet oxygen quantum yield (ΦΔ). The measured ΦΔ values were in the range of 0.51–0.61 for the porphyrins and 0.53–0.66 for porphyrin chitosan immobilization complexes. Our results demonstrate that the PACT activity of cationic porphyrin (P3) and its chitosan immobilization form (P3-Ct) were more efficient in decreasing the number of viable cells up to 100% in vitro
Integrated photocatalyst adsorbents based on porphyrin anchored to activated carbon granules for water treatment
Get PDFIntegration of adsorption and photocatalysis processes can lead to several benefits in water treatment. Integrating well-known adsorbents with photocatalysts ensures that all the interesting components are preserved and helps to overcome the serious downsides of each material and technique when operated independently. In this work, we introduce a new concept of combining both absorption and photodegradation mechanisms using organic photocatalytic adsorbents for water purification. This was achieved by formulating photosensitizing hybrids based on a newly synthesized chloroindium (III) 5,10,15,20-tetrakis(4-acetamidophenyl) porphyrin (InTAAP) compound, anchored on oxygen functionalized coconut shell-based activated carbon granules supports. The fashioned integrated photocatalyst adsorbent hybrid (InTAAP(ACO)) was then studied for their adsorption and photodegradation efficiency using methylene blue dye, where InTAAP(ACO) showed excellent photocatalytic activity compared to ACO and unfunctionalized activated carbon granules (AC), with appreciably high and adsorption properties as AC and ACO
Electrochemical detection of human epidermal growth factor receptor 2 using an aptamer on cobalt phthalocyanines–Cerium oxide nanoparticle conjugate
Get PDFThe role of the biointerface design towards the development of an impedimetric biosensor for the electrochemical detection of human epidermal growth factor receptor 2 (HER2) is investigated. Two novel cobalt phthalocyanines: cobalt tetraphenyl acetic acid phthalocyanine and cobalt tetraphenyl propionic acid phthalocyanine are compared as signal amplifiers and immobilization platforms of the HB5 aptamer towards the electrochemical detection of HER2. In addition, the phthalocyanines are coupled with the metal based cerium oxide nanoparticles. The efficiency of each electrode modification step and the performance of the constructed aptasensors were assessed by impedance spectroscopy. The aptasensors showed very low limit of detection values (all less than 0.2 ng/mL) with high sensitivity and stability. Furthermore, the aptasensors showed very good performance even in human serum samples. Considering these results, the aptasensors demonstrate great potential for improved monitoring of human epidermal growth factor receptor 2 levels for the management of breast cancers
The future of the property valuation profession in South Africa towards 2040
Get PDFValuers within the property valuation profession are ageing while the scope and demand for their work is increasing. The main objective of this study was to explore current challenges and forecast the probable futures of the property valuation profession in South Africa towards 2040. In so doing, it sought to address the deficiency in research regarding the property valuation profession in the country. The study employed a futures methodology framework, namely the Future Studies Approach, as its core research tool that incorporates The Futures Triangle. The Causal Layered Analysis was applied as a secondary approach to guide the theoretical framework. Semi-structured interviews were conducted with a conveniently selected sample of seven qualified professional valuers. The results are diagnostic of the current challenges within the profession and contribute to the development of a set of ‘preferred futures’. The professional valuers were expected to identify a preferred path from the current reality as a departure point. The findings suggested that there were structural and systematic issues, as well as inherent organisational issues confronting the professionals and the profession. Valuers were hopeful about the future of the profession and considered their knowledge and expertise as invaluable in the country. The main challenges identified are linked to the lack of professional legitimacy and authority, stagnant diversity, poor finances, uncoordinated education and the lack of mentorship and accreditation of valuers. Contrary to expectations, the findings showed some optimism in the sustainability of the profession despite varying views by the participants. The deduced possible futures weighed in favour of a marked shortage of experienced professionals due to the lack of interest by younger professionals and a constrained transfer of skills. Probable futures are largely characterised by gloom that is linked to the attrition of skills and loss of prestige, and which will threaten the economic viability of the profession. Preferred futures entail a diverse demographic composition and sound skills base within professional ranks. The study recommends actions to be taken in order to create alternative futures in the present, as an antidote to the gloomy future of the valuation profession in South Africa towards 2040.Thesis (MA) -- Faculty of Business and Economic science, 202
The Impact of Institutional Quality on the Effectiveness of Fiscal Policy in Stimulating Economic Growth: Evidence from sub-Saharan Africa
Get PDFOver the last few decades since the independence of most African countries, which coincided with that of Asia, the economic growth between the two continents has not been the same. As an example, in the year 1965, exports and incomes per capita were much higher in Ghana compared to Korea and it was anticipated that this trend would continue into the future. But these projections were shown to be way off the mark as Koreas’ exports per capita overtook Ghana’s in 1972, and its income level surpassed Ghana’s four years later. Between 1965 and 1995 Korea’s exports increased by 400 times in current dollars. Meanwhile, Ghana’s increased only by 4 times, and real earnings per capita fell to a fraction of their earlier value (World Bank, 2000). This raises questions regarding the tools available for use in the pursuit of economic growth. This study then attempts to examine the role of institutional quality in moderating the impacts of fiscal policy on economic growth in sub-Saharan African economies. Objectives of the study firstly included the investigation of the effect of fiscal policy on economic growth, it then explored the effect of institutional quality on economic growth which was then followed by the analysis of whether the impact of fiscal policy on economic growth is dependent on institutional quality. This dissertation employs the Generalised Method of Moments to analyse the effect of fiscal policy on economic growth given institutional quality for sub-Saharan African countries for the period from 1996 to 2018. The findings show that the conduct of fiscal policy under improved institutional quality positively and significantly improve sub-Saharan African countries output. SSA countries should strengthen independent institutional bodies that prosecute economic crimes through employing participatory and transparent decision-making processes. Citizens should have freedom of association, expression and a free media. Also, African countries should support African agendas that are aligning with global development agenda. Sub-Saharan African countries should strengthen institutions that widen democratic space, civil liberty and the participation of citizen in the development agenda of a country.Thesis (MA) -- Faculty of Business and Economic sciences, 202
Investigating the first level pass-through effects of the SACU Region monetary transmission mechanism
Get PDFThe purpose of this thesis is to investigate the first-level pass-through effects of monetary policy transmission in SACU using the wavelet analysis methodology. The thesis comprises four empirical themes. 1. Investigating the time-frequency relationship in the Fisher’s effect for SACU countries. 2. Investigating the time-frequency relationship in the Purchasing Power Parity (PPP) for SACU countries. 3. Investigating the time-frequency relationship between the exchange rate and the stock returns for SACU countries. 4. Investigating the time-frequency relationship between interest rates, exchange rates, and stock returns for SACU countries. Whilst there exists a considerable amount of empirical works which have studied the four themes in SACU countries that are covered in this study, there is a need for more empirical investigation for several reasons. Firstly, a majority of the studies have focused on South Africa with very little empirical literature existing for Botswana and Lesotho. Secondly, the previous SACU based studies present contradicting findings. Thirdly, Most of these studies did not cover the themes comprehensively, as is the case in this study. Finally, to the best of my knowledge, this methodology has not been employed in any SACU related literature until now. Altogether, the thesis bridges the inconsistencies found in previous SACU-related literature and offers fresh implications for policymakers and market participants. From an empirical perspective, the wavelet coherence analysis proves to be a powerful tool in reconciling previous contradicting empirical evidence on the existence of the Fisher effect in SACU countries. From a policy perspective, more fined tuned implications are derived from the findings of the study as wavelets are able to depict a more accurate description of the different first-level monetary transmission relationships.Thesis (PhD) -- Faculty of business and economic sciences, 202
Crochet cardigan
No full textMade by Mrs Bam Snr, evoked feelings oj joy and warmth. 1978 Mama visited Dr BAM in Switserland and was surprised by the cold weather and told Dr Bam to buy wool in order for her to remain warm. Dr Bam never wore it after her return as it made her miss her mom greatly. Mama Snr sowed Dr BAM'S first coat that she wore at school and she hated wearing it as other kids did not have clothes but little blankets hence she hid it at home in the garden instead of wearing it. She wanted to be like other children. Mama sowed everyting and Dr Bam rarely bought anything from shops.Donated/gifted to Nelson Mandela University ArchivesForms part of: Brigalia Bam collectio
The influence of ethical leadership in the municipal administration: a case of Nelson Mandela Bay Municipality
Get PDFThe South Africa local government is confronted by ethical leadership challenges due to unethical practices by public functionaries and elected representatives in municipalities. The elected representatives are entrusted by legislation to take decisions and municipal officials are expected to implement the decisions taken by the municipal councilin an ethical manner, without fear, favour or prejudice on behalf of their communities. The study adopted a mixed-methods approach to gain a deeper understanding of the phenomenon being studied. Data was collected using a structured Likert Scale interview questionnaire with both closed and open-ended questions. The theories of virtue, deontology and utilitarianism were selected in this study to try to understand the concept of ethics and its relevance to answering the research questions developed for this research.. Among the key findings were that the research has shown that unethical behaviour in municipalities has a direct influence on service delivery and the functioning of municipal administration. It also showed that, despite the plethora of legislation that governs the behaviour of municipal leaders, the municipalities continue to face unethical challenges of corruption, fraud and maladministration. The findings also pointed to a failure by those who are supposed to implement the code of conduct and hold the perpetrators of unethical deeds accountable. Poor consequence management has been seen, inter alia, to be at the heart of the problem. The research reveals a need for the Nelson Mandela Bay Municipality to explore the ways to enforce ethical leadership in the municipality. While the study is limited to the Nelson Mandela Metropolitan Municipality, the following are recommended to mitigate the scourge: provide ethics training for municipal officials and councillors; set minimum qualifications for councillors; and cautiously, extend the application of the findings and recommendations of this research to other municipalities in South Africa as the problem, whilst researched in the Nelson Mandela Metropolitan Municipality, is spread across all municipalities in South Africa.Thesis (PhD) -- Faculty of Management and Commerce, 202
A social history of midwifery practices in colonial Ibadan, Nigeria, 1893 - 1960
Get PDFThis thesis examines the introduction and development of western medical practices in colonial spaces with particular reference to midwifery practices in colonial Ibadan, Nigeria, from 1893 to 1960. This has become necessary because of the importance placed on childbirth and maternal healthcare in the twentieth century. The trends and changes in midwifery and midwifery practices in colonial Ibadan are seen as reflections of other transformations in British African colonies at large. The study begins with a detailed historical analysis of the major metropolitan and local factors that informed the introduction and development of Western obstetrics in colonial Ibadan, Nigeria. It proceeds to examine the development of Western midwifery practices in colonial Ibadan; highlighting the contributions of the Ibadan people to the development of Western midwifery practices and emphasizing policies affecting development, and implementation of Western obstetrics. The thesis goes further to reveal the prejudiced nature of colonial medical policies, and the ways it shaped various responses especially from rural folks who were particularly marginalized since the 1920s when maternal healthcare policies was implemented in the urban areas till the 1950s when a reformed policy for rural medical service scheme was introduced to the rural folks. Thus, influencing the ways they imagined and appropriated ideas of western obstetrics alongside African traditional midwifery practices. The idea is to demonstrate in this thesis the extent to which the precincts in colonial medical policies, most especially the establishment of maternity hospitals, clinics and dispensaries, and the institutionalization of western obstetrics, inspired critical and ingenious responses from colonial doctors, colonial officials, the missionaries, patients, African trained midwives, traditional medical practitioners and the African population in general. Placing all of these historical events within a wider context, this thesis borrows insights from the social history of medicine in an attempt to reconstruct the colonial medical practices in Ibadan, Nigeria, through the sites of midwifery practices and maternal welfare services from 1893 to 1960. This is in addition to its dependence on a comparatively rich, but skewed historical evidence, including a plethora of annual medical reports, official reports of the department of medical and sanitary services, official correspondences within the colonial government in Ibadan and Nigeria, and between the colonial government and the colonial office in the United Kingdom. Details of African responses to medical policies were garnered from oral testimonies, newspaper publications and correspondences between the African public and the colonial government in Ibadan. In exploring this historical evidence, the thesis reveals very interesting details of colonial perceptions about African health and their underlining motives for introducing western medical ideas, the various medical schemes and policies used in driving colonial interest and the ways Africans imagined, re-imagined, and appropriated Western medical practices.Thesis (PhD) -- Faculty of Humanities, History, 202
Developing a socio- ecological framework for the restoration of estuaries using the Swartkops Estuary as a case study
Get PDFThe aim of this study was to develop and test a socio-ecological systems framework for the restoration of estuaries in South Africa using the Swartkops Estuary as a case study. This necessitated a review of existing SES frameworks that have been developed for use in other disciplines. As part of the newly developed framework, the Swartkops estuary condition was assessed using the Estuary Health Index to understand the present ecological state (PES) of the estuary following from the last assessment done in 2013/2014. The Estuary Health Index is a nationally accepted method of measuring the health of South African estuaries. The state of the societal system was assessed through field observations, engagements with estuary users on-site, insights provided by the Zwartkops Conservancy, and from recent literature. The potential for restoration of habitats for the purpose of carbon storage was also assessed as part of this study. The suitability of disturbed habitats for stimulating future salt marsh growth was investigated since an important incentive for restoration is blue carbon storage. This is important as blue carbon ecosystems offer great potential as a climate change mitigation measure through their ability to sequester carbon. This was done by evaluating plant cover and sediment characteristics at sites along the length of the estuary representing disturbed and undisturbed areas. The estuarine health score for the Swartkops Estuary was found to be 47 out of 100 translating to a PES Category D (largely modified estuary). The main problem in the estuary is water quality along with habitat loss and resource exploitation. The three Wastewater Treatment Works (WWTWs) located upstream of the estuary are the main drivers behind the decline in estuary health in addition to other threats to the water quality which are stormwater run-off inputs from the Motherwell canal and Markman canal. This study showed that the health of the estuary is on a negative trajectory towards a largely degraded estuary. Fishing, bait collection and the use of spiritual sites are the dominant vii ecosystem services used at the estuary. Through the assessment of the state of the societal system, the estuary was highlighted to be a major food source for many people living close to the estuary through subsistence fishing and bait collection for selling to recreational fishers. The estuary is also a health hazard to the very same people that depend on it for survival because of the poor water quality particularly high metal inputs from past and present nearby industrial activities. Restoration plans need to be developed in consideration of the estuary status quo that includes the societal system and the ecosystem services provided by the estuary.Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 202