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Female Representation in Jazz
Full text linkLouis Armstrong, Charlie Parker, Thelonius Monk, Dizzy Gillespie, the list of jazz greats goes on and on. These are the people who developed the culture, style, and rules of jazz we know and love today. The question lingers, where are the women? In most other genres, styles, and even in pop culture, most people can list one or two women who had an impact on the development. However, in jazz, there are seemingly no women who made a lasting impact on the genre. Women were incredibly prevalent in the development of jazz, but they are not remembered by history. Although the jazz industry continues to improve the glass ceiling that exists for female performers, there is still a lot of work to do. Improvement must occur across the whole jazz community, from middle and high school band directors, jazz listeners, and band leaders in many different arenas. Teachers especially can be conscious of gender bias while selecting pieces, encouraging students to choose whatever instruments they feel called to, and supporting students to follow any dream they have. Although jazz greats such as Marian McPartland and Mary Lou Williams began this fight in the early twentieth century, the world still has a lot to do as we make the jazz community as inclusive and accessible as it should be
Costimulatory domains in chimeric antigen receptor T cells alter serial killing efficacy against pediatric rhabdomyosarcomas and osteosarcomas
Full text linkChimeric antigen receptor (CAR) T cell therapy is a new promising therapy for hematopoietic malignancies. However, CAR T cells have yet to be successful in the treatment of solid tumors, including pediatric osteosarcoma and rhabdomyosarcoma. Changing the structure of CAR T cell receptors has been considered as a way to enhance the targeting of solid tumors. One method of changing the structure of CAR T cells is by changing the costimulatory domain. Inclusion of various costimulatory domains may alter many functions of CAR T cells, including serial killing, which is an important function needed to overcome the immunosuppressive microenvironment of solid tumors. We developed a novel CAR (chimeric PD-1, chPD1) that targets the programmed death 1 receptor (PD-1) ligands that are expressed on solid tumors. The aim of this study was to compare the inclusions of costimulatory domains, CD28, 411BB, Dap-10, GITR, and OX40, in the chPD1 receptor to see which were able to successfully induce serial killing of pediatric osteosarcoma and rhabdomyosarcoma cells. Three of the CAR T cell designs, chPD1-411BB, chPD1-Dap10, and chPD1-OX40 were successfully able to serially kill the cancer cells after two rechallenges. However, the other two CAR T cell designs, chPD1-CD28 and chPD1-GITR, showed a significant decrease in serial killing efficacy. In addition, T cells expressing chPD1- CD28 and chPD1-GITR receptors had reduced expression and release of killing proteins perforin, granzyme B, FasL and TRAIL on the third restimulation with tumor cells. Therefore, the differences observed in serial killing ability of chPD1-CD28 and –GITR expressing T cells may be partially due to a reduction in these killing proteins. Based on these results, chPD1-41-BB, chPD1-Dap10, and chPD1-OX40 expressing T cells may be promising treatments for pediatric osteosarcoma and rhabdomyosarcoma
LU-167.045b, Student Building (French) and Colonnade
No full texthttps://digitalcommons.longwood.edu/postcard/1053/thumbnail.jp
LU-167.106a, Main Street looking South
No full texthttps://digitalcommons.longwood.edu/postcard/1084/thumbnail.jp
Recognition or Refusal? Marginalized Identity Development in Passing and The Color Purple
Full text link1967 Sigma Sigma Sigma Composite
No full texthttps://digitalcommons.longwood.edu/trisig_composites/1003/thumbnail.jp