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Autonomous vehicles and people with disabilities: a scientometric and integrative analysis of the literature
No full textAutonomous vehicles (AVs) promise a new mobility reality for People with Disabilities (PWDs) by offering more possibilities for their inclusion into modern transport systems. When considering AVs’ dissemination for PWDs is related to different types and features of disabilities. Via a scientometric and integrative review, this paper proposes a research agenda on the field of AVs and PWDs. The search and analyses were based on papers indexed on Scopus, having resulted in a total of 294 articles. This database was chosen since it contains a larger number of records when compared to other academic databases, but mainly by yielding more complete metadata to be used on bibliometric analytical software. The articles were collected in a single search. As for the main results, research on AVs and PWDs is concentrated in Europe (mainly in the Netherlands), Asia, and United States. The research agenda provides a guidance for researchers in AVs, human disabilities, and transport inclusion. It was possible to envisage some principles: proper communication with PWDs about transport technologies along with the industry; engagement with users or PWDs consumers with interactive technologies, and adequate regulations of accessibility and safety. The main contributions of this study were: to delineate a landscape of the past research on AVs and PWDs, and to envision a research agenda on this subject. Another important contribution was to observe that some benefits of AVs applicable for PWDs could be also applied to the elderly. Therefore, the elaboration of new technologies on transport must be inclusive and interactive
Physicochemical characteristics and bioactive compounds of three puçá (Mouriri pusa Gardner) varieties, an underexploited fruit from the Brazilian Cerrado
Full text linkPuçá fruits are native to the Cerrado biome yet little explored, presenting different varieties with distinct fruit peel colors. Although puçá fruits have been known to exhibit a good source of bioactive compounds, the phenolic profile of some varieties remains unknown. Based on this context, our research aimed to evaluate the chemical composition and bioactive compounds and characterize for the first time the phenolic profile in yellow puçá, brown puçá, and black puçá by high-performance liquid chromatography coupled with diode array detection (HPLC–DAD). The three puçá varieties contained considerable quantities of important food constituents, such as high concentrations of vitamin C, carotenoids and phenolic compounds. These fruits are mostly composed of phenolic acids, with p-coumaric acid being the major compound in all varieties, while ellagic acid was detected only in the brown puçá. Moreover, (−)-epicatechin was found only in the yellow puçá. This study is the first to report the identification of the phenolic profile in puçá. Moreover, our data indicate that the three fruit varieties present a promising chemical composition, suggesting that they may serve as potential sources of natural antioxidants. In addition, these findings can contribute to the establishment of puçá as a novel ingredient for formulations with functional claims
Proteína quimérica, kit e método para diagnóstico da COVID-19, e usos
No full textA presente tecnologia trata de uma proteína recombinante quimérica, compreendendo epítopos de proteínas do SARS-CoV-2. A tecnologia compreende também um kit para diagnóstico da COVID-19 contendo tal proteína recombinante e um método para diagnóstico baseado na plataforma ELISA
Sondando interações entre complexos de vanádio e alvos em potencial para o tratamento de Alzheimer: parametrização de um novo campo de força amber e aplicações biológicas
No full textAlzheimer's disease (AD) affects a large part of the world population, with social and economic impacts. One of the etiological hypotheses proposes that there is a link between AD and type 2 diabetes mellitus (T2DM), even though the mechanism is yet to be unraveled. Studies show that vanadium complexes, such as the BMOV and VO(metf)2·H2O, are potential agents against this neurodegenerative disorder. Thus, Molecular Dynamics (MD) simulations are advantageous for obtaining information about the structures and interactions of these complexes with the biological targets involved in the process, namely AMPK and PTP1B. However, DMs are dependent on the choice of a good force field. Therefore, the present work aims to develop AMBER force field parameters for BMOV and VO(metf)2·H2O, since the literature lacks such information on metal complexes. From quantum-mechanical calculations, the global minimum energy structures were found, with theory level B3LYP/def2-TZVP plus ECP for the vanadium atom. RESP charges and Hessian matrix calculations were performed using the same functional and basis set. The values of force constants were obtained by diagonalizing the Hessian matrix and the Lennard-Jones parameters were assigned based on GAFF, for all atoms except vanadium. In order to validate the developed force fields, MD simulations in vacuum and room temperature were carried out. After that, MDs were performed in order to acquire information about relevant interactions between vanadium complexes and the proteins associated to AD. The new models developed and reported by this work showed to be efficient to describe the molecules under study, when compared to experimental data and to quantum references. Furthermore, great insights about the behavior of the systems, such as relevant residues that interact with BMOV and VO(metf)2·H2O are reported. It is expected that this work may assist to motivate future work involving vanadium complexes for the treatment AD.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)A doença de Alzheimer (DA) afeta uma grande parte da população mundial, com impactos sociais e econômicos. Uma das hipóteses etiológicas propõe que existe uma ligação entre DA e diabetes mellitus tipo 2 (DMT2), embora o mecanismo ainda não tenha sido desvendado. Estudos mostram que complexos de vanádio, como o BMOV e o VO(metf)2·H2O, são agentes potenciais contra este distúrbio neurodegenerativo. Dessa forma, as simulações de Dinâmica Molecular (DM) são vantajosas para obter informações sobre a estrutura e interação destes complexos com os alvos biológicos envolvidos no processo, nesse caso, AMPK e PTP1B. Entretanto, as DMs dependem da escolha de bons campos de forças. Portanto, o presente trabalho visa desenvolver parâmetros de campo de força AMBER para BMOV e VO(metf)2·H2O, uma vez que a literatura carece de tais informações sobre complexos metálicos. A partir de cálculos quanto-mecânicos, foram encontradas estruturas com mínimos de energia global, empregando o nível de teoria B3LYP/def2-TZVP mais ECP para o átomo de vanádio. As cargas RESP e os cálculos da matriz de Hessiana foram realizados usando os mesmos funcional e função de base. Os valores das constantes de força foram obtidos através da diagonalização da matriz de Hessiana e os parâmetros de Lennard-Jones foram atribuídos com base no GAFF, para todos os átomos, exceto vanádio. A fim de validar os campos de força desenvolvidos, foram realizadas simulações de DM no vácuo e em temperatura ambiente. Depois disso, foram realizados cálculos de DMs a fim de adquirir informações sobre as interações relevantes entre os complexos de vanádio e as proteínas associadas a estas duas condições. Os novos modelos desenvolvidos e relatados por este trabalho se mostraram eficientes para descrever as moléculas sob estudo, quando comparadas aos dados experimentais e as referências quânticas. Além disso, grandes insights sobre o comportamento dos sistemas, tais como resíduos relevantes que interagem com BMOV e VO(metf)2·H2O são relatados. Espera-se que este trabalho possa ajudar a motivar trabalhos futuros envolvendo complexos de vanádio para o tratamento DA
Effect of selenium and soil ph on cadmium phytoextraction by urochloa decumbens grown in oxisol
No full textIt has been speculated that selenium (Se) supply can affect cadmium (Cd) ‘availability’ and increase the Cd tolerance of plants used for phytoextraction, in a pH-dependent process. Thus, we evaluated the interaction Cd-Se and the effects of soil pH in this interaction on plant availability of Cd and phytoextraction efficiency of Urochloa decumbens cv. Basilisk grown in Oxisol. Two soil concentrations of Cd (0.93 and 3.6 mg kg-1) and Se (<0.2 and 1 mg kg-1) and two soil pH (0.01 mol L-1 CaCl2) conditions (4.1 and 5.7) were considered. At both pH, Se supply increased the exchangeable fraction of Cd and decreased the residual Cd fraction. At pH 4.1, the growth of U. decumbens was impaired by Se addition, regardless of Cd exposure. The lower root growth and tillering of U. decumbens exposed to Cd disappeared at pH 5.7 due to uptake of low Se concentrations. Thus, the toxic or beneficial effects of Se on growth of U. decumbens used for Cd phytoextraction depend on the amount of Se assimilated. The Cd phytoextraction efficiency of U. decumbens was not improved by Se supply, regardless of soil pH. Therefore, we cannot recommend the application of Se to increase Cd phytoextraction by this grass
Adubo verde e reguladores de crescimento na produção de biomassa, óleo essencial e capacidade antioxidante de Origanum vulgare L. (Lamiaceae)
No full textArquivo retido, a pedido do autor, até abril de 2024.Oregano (Origanum vulgare L.) is one of the most commercially important species of the Lamiaceae family, as it has been widely used in the agricultural, pharmaceutical and cosmetic industries. Among the practices used to increase biomass and essential oil production in medicinal plants are: green manuring (GM) and foliar application of plant regulators. The present study aimed to: (1) evaluate the effect of green manuring (Crotalaria juncea L.) on biomass production, essential oil chemical composition, accumulation of phenolic compounds and antioxidant activity of O. vulgare and (2) observe the influence of foliar application of plant growth regulators (PGRs) on biomass production, secondary metabolites and enzymatic antioxidant activity of O. vulgare. The green manure experiment consisted of eight treatments: control (soil); 200 g pot-1 (crotalaria root); 150, 300, 450 and 600 g pot-1 sunn hemp aerial part (Sh=leaf+stem) + 200 g pot-1 (crotalaria root); 600 g pot-1 aerial part of crotalaria (Sh); and positive control (cattle manure 300 g pot-1). For PGRs, 3 types were used (Giberellin-GA3, Indolebutyric acid-IBA, Kinetin-KIN) with 3 concentrations (25, 50, 100 mg L-1) + control. Dry weight, photosynthetic pigments, essential oil content and yield and antioxidant activity were evaluated. The GM management provided the highest dry weight averages at doses 300, 450 and 600 g (Sh+R) and 600 g pot-1 (Sh), as well as cattle manure (300 g). Treatment without GM (control) resulted in a 75% lower essential oil production compared to treatment 450 g pot-1 GM (Sh+R) and approximately 71% compared to treatments 300, 600 g GM (Sh + R) and 600 g pot-1 GM (Sh). Regarding the experiment with PGRs, the application of GA3 at a dose of 25 mg L-1 increased the dry weight of the leaf, stem, root, shoot and total dry weight in relation to the control. The highest chlorophyll a content was observed for the KIN25 dose. The gains in oil content with the KIN25 and IBA25 doses were 30.9 and 29.6%, respectively, in relation to the control and the highest average yields were observed at the lowest doses. The lowest average levels of hydrogen peroxide (H2O2) and malondialdehyde (MDA) were observed in the presence of PGRs. PGRs stimulated enzymatic antioxidant activity, signaling protection against oxidative stress. In conclusion, the use of C. juncea as GM is a low-cost resource that has a positive effect on the cultivation of O. vulgare, and its use can reduce the application of chemical fertilizers, making it an ecologically appropriate strategy for the cultivation of medicinal plants. The foliar application of PGRs at low doses may contribute to increase dry matter and chemical constituents in O. vulgare.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)O orégano (Origanum vulgare L.) é uma das espécies mais importantes comercialmente da família Lamiaceae, pois tem sido largamente utilizada nas indústrias agrícolas, farmacêuticas e de cosméticos. Dentre as práticas usadas para aumentar a biomassa e produção de óleo essencial nas plantas medicinais encontram-se: adubação verde (AV) e aplicação foliar de reguladores vegetais. No presente estudo objetivou-se: (1) avaliar o efeito da adubação verde (Crotalaria juncea L.) na produção de biomassa, composição química do óleo essencial, acúmulo de compostos fenólicos e atividade antioxidante de O. vulgare e (2) observar a influência da aplicação foliar de reguladores de crescimento de plantas (RCPs) na produção de biomassa, metabólitos secundários e na atividade antioxidante enzimática de O. vulgare. O experimento de adubação verde foi constituído por oito tratamentos: controle (solo); 200 g vaso-1 (raiz de crotalária); 150, 300, 450 e 600 g vaso-1 parte aérea de crotalaria (PA=folha+caule) + 200 g vaso-1 (raiz de crotalária); 600 g vaso-1 parte aérea de crotalaria (PA); e controle positivo (esterco bovino 300 g vaso-1). Para os RCPs foi utilizado 3 tipos (Giberelina-GA3, Ácido indolbutírico-AIB, Cinetina-KIN) com 3 concentrações (25, 50, 100 mg L-1) + controle. Foram avaliados o peso seco, pigmentos fotossintéticos, teor e rendimento de óleo essencial e atividade antioxidante. O manejo da AV proporcionou as maiores médias de peso seco nas doses 300, 450 e 600 g (PA+R) e 600 g vaso-1 (PA), assim como o esterco bovino (300 g). O tratamento sem AV (controle) resultou em uma produção de óleo essencial 75% menor em comparação ao tratamento 450 g vaso-1 AV (PA+R) e de aproximadamente 71% em relação aos tratamentos 300, 600 g AV (PA + R) e 600 g vaso-1 AV (PA). No que tange ao experimento com RCPs, a aplicação de GA3 na dose de 25 mg L-1 aumentou o peso seco da folha, caule, raiz, parte aérea e peso seco total em relação ao controle. O maior teor de clorofila a foi observado para a dose de KIN25. Os ganhos de teor de óleo com as doses de KIN25 e IBA25 foram de 30,9 e 29,6%, respectivamente, em relação à testemunha e as maiores médias de rendimento foram observadas nas doses mais baixas. Os menores níveis médios de peróxido de hidrogênio (H2O2) e malondialdeído (MDA) foram observados na presença dos RCPs. Os RCPs estimularam a atividade antioxidante enzimática, sinalizando proteção ao estresse oxidativo. Em conclusão, o uso de C. juncea como AV é um recurso de baixo custo que tem efeito positivo no cultivo de O. vulgare, e sua utilização pode reduzir a aplicação de fertilizantes químicos, tornando-se uma estratégia ecologicamente adequada para o cultivo de plantas medicinais. A aplicação foliar de RCPs em baixas doses pode contribuir para aumentar a matéria seca e os constituintes químicos em O. vulgare
SANEG
Full text linkBR 51 2020 000843 7CC10-Solo (mecânica das rochas, mecânicas dos solos, aterro, escavação, talude,
movimento de terra, obra de terra; nivelamento de terra; obra de contenção:
estrutura de arrimo, contenção de encosta); TC01-Telecom (política de telecomunicações, modelo de telecomunicaçõ es)
Processamento de linguagem natural para palavra por imagem
Full text linkEducação ED06-Educação (pedagogia, ensino, sistema educacional, rede de ensino, educação de adulto, educação de base, de massa, etc, política educacional; educa ção ectra-escolar: educação comunitária, recuperadora)
SIGEEI
Full text linkBR 51 2021 000745 0EL01-Ecologia
(biosfera, relação biótica, relação abiótica, ecologia agr ícola, aquática,
florestal, equilíbrio / desequilíbrio ecológico, fenômeno ecológico); EL04-Ec Veg/Anm Ecologia Vegetal/Ecologia
Animal (autoecologia,
sinecologia, habitat, vida selvagem); MA01-Meio Amb (artificial, natural, política do meio ambiente);
MA02-Recurs Nat (natureza: conservação, recursos naturais renováveis, não renov áveis, área
protegida)
Apoyo organizativo a la orientación empresarial: la percepción de los profesionales de los centros de enseñanza preescolar en Brasil
No full textEntrepreneurial Orientation (EO) has become increasingly prominent in the public sector and in educational organizations. A policy for educational management based on EO has dimensions related to innovation, proactiveness, and risk-taking, which are preceded by organizational characteristics such as management support, discretion/autonomy, rewards/recognition, organizational boundaries, and time availability. The objective of this study is to analyze the organizational characteristics that influence EO in Municipal Centers for Early Childhood Education (Centros Municipais de Educação Infantil - CEMEIs) in Brazil. The study was conducted in a town in the state of Minas Gerais and involved 15 CEMEIs, applying questionnaires to education professionals as coordinators, monitors, and teachers, whose data were processed using descriptive statistics and a structural equation model. The results present a construct for validating organizational characteristics that can influence EO in public early childhood education organizations. However, autonomy and management support were the determinants of EO in the organizations studied. Finally, there are implications and considerations for policies and strategies in public educational organizations, indicating EO as a way to deal with contingencies, resource scarcity, the stimulation of (intra)entrepreneurial culture and even potential early childhood education for entrepreneurship