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[Book Review] <i>Doing doctoral research at a distance: flourishing in off-campus, hybrid and remote pathways</i>
No full textPreimplantation genetic testing for aneuploidy ‘rescues’ poor-quality blastocysts and increases embryo availability for transfer: a 9-year single centre analysis
No full textResearch Question: Does preimplantation genetic testing for aneuploidy (PGT-A) and the transfer of euploid poor-quality blastocysts (PQBs) reduce the number of transfers needed to achieve live births in comparison to the transfer of their untested counterparts?
Design: Single-centre retrospective cohort study included 7,332 PGT-A blastocysts obtained from 2,258 cycles across 1,344 patients between 2015 and 2024. Transfer outcomes were analysed for a subset of 74 cycles involving tested PQBs from 69 patients and compared with 192 cycles involving untested PQBs from 180 patients during the same period.
Results: High-quality blastocysts (HQBs; AA, AB, BA, and BB) were most likely to be euploid, while poor-quality blastocysts (PQBs; CC, DC, CD, and DD) were more likely to be aneuploid. Embryos that reached the blastocyst stage by day 5 had a higher likelihood of being euploid. Among transferred PQBs, PGT-A did not significantly impact the pregnancy rate (33.3% vs. 23.4%); however, the miscarriage rate was significantly lower in the PGT-A-tested group (13.6% vs 51.2%). The number of live births was higher in the PGT-A group (26.4 % vs 11.1%) and with the transfer of day 5 frozen blastocysts. Notably, live births were also observed from blastocysts with the poorest expansion and morphology scores. Analysis of live births revealed no significant differences in gestational age or birthweight between the PGT-A and untested groups.
Conclusions: A clinically relevant proportion of PQBs are euploid, PQBs can result in live births and euploid transfer is associated with lower miscarriage rates. In combination, this suggests that PQBs should not be routinely discarded, particularly if they are prior-tested using PGT-A
The collective use of the discipline of noticing to inform pedagogic actions
No full textProfessional development depends on enriching and expanding the range of professional actions that become available to be enacted either during preparation, or in-the-moment in a session. The Discipline of Noticing was articulated to support this process. Noticing involves both attention and awareness. The Discipline of Noticing provides a method for exploring, researching, or exploiting not only what one is currently sensitised to attend to, but also the nature and form of that attention, together with associated awarenesses which provide access to actions. In this paper, we provide examples of how professionals, in this case mathematics education researchers who are also mathematics teacher educators, located changes in what they were sensitised to notice, and how that became part of their professional repertoire by the process that Gattegno called “educating awareness”. These changes arose and were noticed through joint reciprocal reflections, and the subsequent planning and teaching of future professional development sessions. Among the aspects that contributed to the researchers’ / teacher educators’ development and engagement in the Discipline of Noticing, we emphasise communication with oneself and with others in group discussions
Characterizing resistance in prostate cancer at a single cell level with hormonal treatment and epigenetic inhibitors
No full textBackground: Late-stage prostate cancer is treated with hormonal therapy. While initially effective, development of drug resistance is common. Hypoxia, a local-environmental occurrence in tumours, is known to trigger hormone-independence and concurrent drug resistance in cancer cells.
Methods: Here we analyse single-cell transcriptomes of LNCaP cells throughout drug treatment. These cells were exposed to chronic hypoxia and treated with Enzalutamide, a hormonal drug which inhibits the androgen receptor, both with and without Tazemetostat, an epigenetic drug that inhibits EZH2 catalytic activity, which renders Enzalutamide-resistant clones partially sensitive to hormonal therapies. We identify genes characterizing the resistant clone and assess clinical relevance.
Results: We characterize a resistant cluster present with Enzalutamide treatment but not with combination therapy. The top 10 upregulated genes in this cluster included genes previously linked to resistance: DDIT3, MDM2, and CDKN1A, and one previously proposed as a pan-cancer hallmark (HSP90B1). Analysis of clinical databases showed expression of CDKN1A, POLH, and GADD54 to be significantly upregulated in association with neuroendocrine prostate cancer.
Conclusion: This work characterizes at a single-cell level the Enzalutamide resistant clone and the impact of epigenetic inhibitors on resistance development. This characterization may enable the identification of resistant and non-resistant cells by their gene expression profile
How well supported are employees with terminal illness in the workplace? A snapshot of evidence from the Higher Education sector
No full textWhy Read Beauvoir today?
No full textIn this accessible, personal yet rigorous study, Cristina Chimisso examines Simone de Beauvoir’s philosophy across her oeuvre and locates it within the context of current concerns. Her key ideas are discussed, notably freedom and self-creation, with special attention to their constraints and limitations. Her mature view of other people as freedoms necessary to one’s existence is brought into focus, along with solidarity and communal action. The most important aspects of her feminist philosophy are debated, from the existential consequences of typically female roles, such as wife and mother, to ways in which women misleadingly attempt to make their lives meaningful by depending on other people, or by attending to their own self-image. Chimisso argues that Beauvoir’s analysis of narcissism has acquired renewed importance with the creation of social media, and so has her discussion of women’s complicity with their oppressor now that some women hold positions of power. Her attention to the body is shown to be philosophically rich and capable of stimulating any number of debates, from her rather controversial view of female biology to her phenomenology of old, sick, and dying bodies
ArcticNet for Semantic Segmentation of Meltpond Regions in the Arctic Sea Ice
No full textAs climate change drives global temperatures upward, seasonal sea ice in the Arctic is rapidly diminishing, leading to the formation of meltponds. Meltponds absorb more solar radiation compared to snow due to lower reflectivity (albedo), accelerating the melting of the ice underneath. The manual assessment of the complex boundaries of meltponds is a demanding and time-consuming endeavor. To streamline this process, we introduce a novel method for detecting and segmenting meltponds based on the UNet architecture, named ArcticNet. Our framework combines two UNets that incorporate recurrent, residual and attention operations. The first UNet extracts intermediate features that are further refined by the second UNet improving overall performance by learning hierarchical representations. The proposed architecture possesses the ability to enhance the boundaries of meltponds while accurately capturing their precise locations. The inclusion of residual and recurrent operations gives an expanded field of view for segmentation. Combining this with an attention gate, which concentrates primarily on target regions of diverse shapes and sizes, has been demonstrated to enhance the overall performance and robustness of the network by boosting model sensitivity and improving predictions. The performance of our model was assessed using 3–channel (RGB), high–resolution aerial images from Healy–Oden Trans Arctic Expedition (HOTRAX) and NASA's Operation IceBridge. The ArcticNet architecture categorized the HOTRAX and Operation IceBridge images into three and two classes respectively. HOTRAX include meltponds, open water, and snow, whereas Operation IceBridge includes only meltponds and snow. The new algorithm showed superior performance in segmenting meltponds when compared to other state-of-the-art approaches
On mixture relationships between central and non-central chi-squared difference distributions
No full textGaunt (2026) introduced and studied the non-central chi-squared difference distribution. One version of this arose as the distribution of the product of the two marginal random variables of the general (non-degenerate) bivariate normal distribution. Initially, I provide an alternative basic argument as to why this is so. The main focus of the article, however, is to extend a number of known mixing relationships between (non-central) chi-squared distributions to the (non-central) chi-squared difference distribution case. In certain circumstances, just a single mixing random variable remains required rather than the two independent ones that are trivially applicable in general
Social Work History
No full textThere is a longstanding debate about the purpose of the study of history and oft-repeated suggestions that, unless we know about the past, we are unable to understand the future, a sentiment with which I agree. This chapter focuses on social work history. In doing so, I am combining my two great passions, my social work identity and my interest in history, including that of social work. Understanding things that happen in a person’s life that make them what they are – their history – is a fundamental element of the practice of social work. In this chapter, therefore, I argue that understanding the history of social work is crucial for it as a profession; it allows us to acknowledge the things that have happened in the life of social work and to understand what makes it what it is. Moreover, it enables us to celebrate its achievements and its value