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    9700 research outputs found

    Climate, Food, and Humans Predict Communities of Mammals in the United States

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    The assembly of species into communities and ecoregions is the result of interacting factors that affect plant and animal distribution and abundance at biogeographic scales. Here, we empirically derive ecoregions for mammals to test whether human disturbance has become more important than climate and habitat resources in structuring communities

    A Portrait of the Artist, 1525–1825: Prints from the Collection of the Sarah Campbell Blaffer Foundation

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    Consisting of fifty-one prints on loan from the Sarah Campbell Blaffer Foundation, Museum of Fine Arts, Houston, this exhibition examines how artists depicted themselves and their profession from the sixteenth to the nineteenth centuries. The show includes artists such as Rembrandt van Rijn, Salvator Rosa, William Hogarth, Claude Lorrian, and Francisco Goya, among others. Created during a period when the social status of artists was in flux, the prints represent both artists’ lives and work, and the roles that both artists and the arts held in society. Full of allegory and rich in satire, the works include self-portraits, representations of artists at work, and exhibition and academy spaces.https://cupola.gettysburg.edu/artcatalogs/1043/thumbnail.jp

    APPC Minutes – December 11, 2024

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    Minutes of the Academic Policy and Program Committee Meeting, December 11, 2024

    Divalent Cations Promote Huntingtin Fibril Formation on Endoplasmic Reticulum Derived and Model Membranes

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    Huntington\u27s Disease (HD) is caused by an abnormal expansion of the polyglutamine (polyQ) domain within the first exon of the huntingtin protein (htt). This expansion promotes disease-related htt aggregation into amyloid fibrils and the formation of proteinaceous inclusion bodies within neurons. Fibril formation is a complex heterogenous process involving an array of aggregate species such as oligomers, protofibrils, and fibrils. In HD, structural abnormalities of membranes of several organelles develop. In particular, the accumulation of htt fibrils near the endoplasmic reticulum (ER) impinges upon the membrane, resulting in ER damage, altered dynamics, and leakage of Ca2+. Here, the aggregation of htt at a bilayer interface assembled from ER-derived liposomes was investigated, and fibril formation directly on these membranes was enhanced. Based on these observations, simplified model systems were used to investigate mechanisms associated with htt aggregation on ER membranes. As the ER-derived liposome fractions contained residual Ca2+, the role of divalent cations was also investigated. In the absence of lipids, divalent cations had minimal impact on htt structure and aggregation. However, the presence of Ca2+ or Mg2+ played a key role in promoting fibril formation on lipid membranes despite reduced htt insertion into and association with lipid interfaces, suggesting that the ability of divalent cations to promote fibril formation on membranes is mediated by induced changes to the lipid membrane physicochemical properties. With enhanced concentrations of intracellular calcium being a hallmark of HD, the ability of divalent cations to influence htt aggregation at lipid membranes may play a role in aggregation events that lead to organelle abnormalities associated with disease

    Criminal Justice Update - November 2024

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    The Criminal Justice Update is a monthly newsletter created by the Adams County Bar Foundation Fellow providing updates in criminal justice policy coming from Pennsylvania\u27s courts and legislature as well as the US Supreme Court. Contents: Updates from PA Governor\u27s Office (no updates this month) Updates from the PA Legislature Updates from the Courts U.S. Supreme Court: Criminal Law & Procedure PA Supreme Court: Criminal Law & Procedure PA Superior Court: Criminal Law & Procedur

    The Unseen War: Struggles of Andersonville Survivors

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    The American Civil War lasted from 1861-1865, in that period many lives were lost and many more lives were forever transformed. Families had lost loved ones and those who returned home were not themselves anymore. This paper will examine the post-war mental health of Andersonville survivors. Focus will also be placed on the difficulties of survivors trying to return to their post-war lives; along with the difficulties survivors faced in receiving a pension. And how Andersonville in recent American memory has been transformed into a place of remembrance, for all American POWs in all American wars. Different sources will be used to help show different effects Andersonville had on survivors. Primary sources used in this paper include personal narratives from the survivors and newspapers. Scholarly secondary sources helped expand the understanding of Andersonville

    Faculty Meeting Minutes - September 26, 2024

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    Minutes of the Gettysburg College Faculty Meeting, September 26, 2024

    Faculty Meeting Minutes - December 5, 2024

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    Minutes of the Gettysburg College Faculty Meeting, December 5, 2024

    “The Times They Are a-Changin”: A Look into Protest Music’s Evolution Throughout the 1950s-1970s

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    This project was created for the 2024 Digital Humanities Fellowship. It looks at the evolution of protest music from 1950 to 1979 as it was influenced by the events that took place and the people involved to understand more of the protest culture at the time. This project uses TimelineJS, ArcGIS StoryMaps, and WordPress to create the documented website

    Giants and Dwarfs in European Art and Culture, ca. 1350-1750

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    Not since Edward Wood’s Giants and Dwarfs published in 1868 has the subject been the focus of a scholarly study in English. Treating the topic afresh, this volume offers new insights into the vogue for giants and dwarfs that flourished in late-medieval and early modern Europe. From chapters dealing with the real dwarfs and giants in the royal and princely courts, to the imaginary giants and dwarfs that figured in the crafting of nationalistic and ancestral traditions, to giants and dwarfs used as metaphorical expression, scholars discuss their role in art, literature, and ephemeral display. Some essays examine giants and dwarfs as monsters and marvels and collectibles, while others show artists and writers emphasizing contrasts in scale to inspire awe or for comic effect. As these investigations reveal, not all court dwarfs functioned as jesters, and giant figures might equally be used to represent heroes, anti-heroes, and even a saint.https://cupola.gettysburg.edu/books/1191/thumbnail.jp

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