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Exercise‐induced airflow changes in horses with asthma measured by electrical impedance tomography
Get PDFBackground
Equine asthma (EA) causes airflow impairment, which increases in severity with exercise. Electrical impedance tomography (EIT) is an imaging technique that can detect airflow changes in standing healthy horses during a histamine provocation test.
Objectives
To explore EIT-calculated flow variables before and after exercise in healthy horses and horses with mild-to-moderate (MEA) and severe equine asthma (SEA).
Animals
Nine healthy horses 9 horses diagnosed with MEA and 5 with SEA were prospectively included.
Methods
Recordings were performed before and after 15 minutes of lunging. Absolute values from global and regional peak inspiratory (PIF, positive value) and expiratory (PEF, negative value) flows were calculated. Data were analyzed using a mixed model analysis followed by Bonferroni's multiple comparisons test to evaluate the impact of exercise and diagnosis on flow indices.
Results
Control horses after exercise had significantly lower global PEF and PIF compared to horses with SEA (mean difference [95% confidence interval, CI]: 0.0859 arbitrary units [AU; 0.0339-0.1379], P < .001 and 0.0726 AU [0.0264-0.1188], P = .001, respectively) and horses with MEA (0.0561 AU [0.0129-0.0994], P = .007 and 0.0587 AU [0.0202-0.0973], P = .002, respectively). No other significant differences were detected.
Conclusions and Clinical Importance
Electrical impedance tomography derived PIF and PEF differed significantly between healthy horses and horses with SEA or MEA after exercise, but not before exercise. Differences between MEA and SEA were not observed, but the study population was small
Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019
Get PDFBackground
Sustainable Development Goal 3.2 has targeted elimination of preventable child mortality, reduction of neonatal death to less than 12 per 1000 livebirths, and reduction of death of children younger than 5 years to less than 25 per 1000 livebirths, for each country by 2030. To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 findings for all-cause mortality and cause-specific mortality in children younger than 5 years of age, with multiple scenarios for child mortality in 2030 that include the consideration of potential effects of COVID-19, and a novel framework for quantifying optimal child survival.
Methods
We completed all-cause mortality and cause-specific mortality analyses from 204 countries and territories for detailed age groups separately, with aggregated mortality probabilities per 1000 livebirths computed for neonatal mortality rate (NMR) and under-5 mortality rate (U5MR). Scenarios for 2030 represent different potential trajectories, notably including potential effects of the COVID-19 pandemic and the potential impact of improvements preferentially targeting neonatal survival. Optimal child survival metrics were developed by age, sex, and cause of death across all GBD location-years. The first metric is a global optimum and is based on the lowest observed mortality, and the second is a survival potential frontier that is based on stochastic frontier analysis of observed mortality and Healthcare Access and Quality Index.
Findings
Global U5MR decreased from 71·2 deaths per 1000 livebirths (95% uncertainty interval [UI] 68·3–74·0) in 2000 to 37·1 (33·2–41·7) in 2019 while global NMR correspondingly declined more slowly from 28·0 deaths per 1000 live births (26·8–29·5) in 2000 to 17·9 (16·3–19·8) in 2019. In 2019, 136 (67%) of 204 countries had a U5MR at or below the SDG 3.2 threshold and 133 (65%) had an NMR at or below the SDG 3.2 threshold, and the reference scenario suggests that by 2030, 154 (75%) of all countries could meet the U5MR targets, and 139 (68%) could meet the NMR targets. Deaths of children younger than 5 years totalled 9·65 million (95% UI 9·05–10·30) in 2000 and 5·05 million (4·27–6·02) in 2019, with the neonatal fraction of these deaths increasing from 39% (3·76 million [95% UI 3·53–4·02]) in 2000 to 48% (2·42 million; 2·06–2·86) in 2019. NMR and U5MR were generally higher in males than in females, although there was no statistically significant difference at the global level. Neonatal disorders remained the leading cause of death in children younger than 5 years in 2019, followed by lower respiratory infections, diarrhoeal diseases, congenital birth defects, and malaria. The global optimum analysis suggests NMR could be reduced to as low as 0·80 (95% UI 0·71–0·86) deaths per 1000 livebirths and U5MR to 1·44 (95% UI 1·27–1·58) deaths per 1000 livebirths, and in 2019, there were as many as 1·87 million (95% UI 1·35–2·58; 37% [95% UI 32–43]) of 5·05 million more deaths of children younger than 5 years than the survival potential frontier.
Interpretation
Global child mortality declined by almost half between 2000 and 2019, but progress remains slower in neonates and 65 (32%) of 204 countries, mostly in sub-Saharan Africa and south Asia, are not on track to meet either SDG 3.2 target by 2030. Focused improvements in perinatal and newborn care, continued and expanded delivery of essential interventions such as vaccination and infection prevention, an enhanced focus on equity, continued focus on poverty reduction and education, and investment in strengthening health systems across the development spectrum have the potential to substantially improve U5MR. Given the widespread effects of COVID-19, considerable effort will be required to maintain and accelerate progress.
Funding
Bill & Melinda Gates Foundation
Impacts of nano-emulsified vegetable oil on growth, hemato-biochemical markers, oxidative stress, and gut microbiota of New Zealand white and V-line rabbits
No full textThe present study aimed to examine the impact of magic oil® (a nano-emulsified vegetable oil) (NEVO) on growth and carcass traits, serum metabolites, and intestinal microbiota of New Zealand White (NZW) and V-line rabbits. A total of 450 rabbits of both breeds (male, five weeks old) with a 700 ± 19 g average live body weight was uniformly distributed into six groups (75 rabbits per each). Each group was subdivided into five replicates, each of 15 rabbits. Animals randomly allocated into a two × three completely factorial design (two breeds: NZW and V-line, and three treatments of NEVO: control (0.0), 0.5, and 1.0 ml of NEVO per liter of water, respectively). The findings of the present study revealed that V- line rabbits recorded a significant increase in the final body weight, final body weight gain, and total feed conversion ratio, along with carcass traits when compared to New Zealand White (NZW). Comapred with the control group, the final body weight, final body weight gain, and carcass traits of rabbits, orally supplemented with NEVO were significantly improved. At the same time, feed intake was not significantly improved. The effect of the NEVO supplement and its association with the breed (p < 0.001) have improved significantly the final body weight, final body weight gain, feed conversion ratio and carcass characteristics. A significant improvement in serum and tissue metabolites was observed with increasing NEVO levels. A remarkable increase in the serum total protein and globulin associated with a significant reduction (p < 0.001) in the serum total lipids and total cholesterol levels were also noticed with increasing NEVO levels. Total bacterial count, and the population of Escherichia coli and lactobacilli in the jejunum and colon were significantly (p < 0.001) lower in both rabbit breeds supplemented with NEVO than that of the control group. Based on these findings, supplementation of NEVO enhanced growth, antioxidant status and minimized pathogenic bacteria in rabbits
A consortium of Rhizosphere-Competent actinobacteria exhibiting multiple plant Growth-Promoting traits improves the growth of Avicennia marina in the United Arab Emirates
Get PDFGray mangrove (Avicennia marina) is the dominant vegetation distributed along the coast of the United Arab Emirates (UAE). Despite its performance as natural coastal guardians, very little is known about the reforestation projects to increase mangrove cover over the years in the UAE and in the Arabian Gulf. Plant growth-promoting actinobacteria (PGPA) were isolated from the mangrove rhizosphere sediments found in the UAE and were evaluated for their potential to produce plant growth regulators (PGRs) and to enhance mangrove growth under seawater irrigation conditions. In vitro screening identified nine rhizosphere-competent actinobacterial isolates, in a naturally competitive environment, of which Streptomyces coelicoflavus (Sc) showed a high phosphorus solubilizing activity. Moreover, Streptomyces polychromogenes (Sp), Streptomyces bacillaris (Sb), and Streptomyces ferrugineus (Sf) produced auxins, polyamines (PAs), and 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase, respectively. Although sediment inoculation with single isolates significantly improved the dry biomass of mangrove shoots (43.2–74.0%) and roots (40.8–75.9%), the consortium of isolates (Sc/Sp/Sb/Sf) caused a greater increase in the dry weight of shoots (82.1%) and roots (81.6%) compared with seawater-irrigated plants (control). In our greenhouse experiments, the levels of photosynthetic pigments, in planta auxins, and PAs significantly increased in plant tissues inoculated with Sc/Sp/Sb/Sf; whereas ACC contents were reduced. This was also evident as the maximum velocity of rubisco carboxylation (Vcmax) increased four-fold in plants treated with the mixture of isolates over control. To the best of our knowledge, this is the first study reporting culturable halotolerant, rhizosphere-competent PGPA inhabiting salty and arid ecosystems applied individually or in combination to promote mangrove growth under harsh conditions such as those found in the Arabian coastal areas
Continuous practice of conservation agriculture for 3–5 years in intensive rice-based cropping patterns reduces soil weed seedbank
Get PDFWhen farmers first shift from conventional tillage (CT) to conservation agriculture (CA) practices, the control of weeds may be more difficult, due to the absence of tillage. However, continuous CA, over several years, may alter the weed seedbank. The nature of the weed seedbank changes over time, in intensively cropped rice-based rotations that are typical of the Eastern Gangetic Plain, are not well understood. Two on-farm CA experiments were sampled (in Beluapara after 3 years and Digram after 5 years) in Bangladesh for the effects of strip planting (SP) and bed planting (BP) at both the sites, plus no-tillage (NT) in Beluapara, and increased retention of the residue of previous crops (20% vs. 50%). The conventional tillage (CT) and 20% residue was the control treatment. The weed seedbank in 0–15 cm soil was quantified by assessing the emergence of weeds from soils collected from the field after irrigation, (Boro) rice in Digram and wheat in Beluapara, and they were allowed to emerge in trays in a shade-house experiment. The year-round count of emerged weeds at both the locations revealed the fewest number of weed species (especially broadleaf weeds), and the lowest weed density and biomass in SP, followed by CT, BP, and NT, with 50% crop residue mulch. Relative to CT, the SP, BP, and NT produced relatively more perennials weeds, as follows: Alternanthera denticulata ((R.) Brown.), Cyperus rotundus (L.), Dentella repens (L.), Jussia deccurence (Walt.), Leersia hexandra (L.), and Solanum torvum (Sw.), which was the opposite of CT that was enriched with the following annual weeds: Cyperus iria (L.), Digitaria sanguinalis (L.), Euphorbia parviflora (L.), Fimbristylis miliacea (L.), Lindernia antipoda (L.), L. hyssopifolia (L.), and Monochoria hastata (L.). The soil weed seed bank reduced by 13% in SP, while it increased by 19% and 76% in BP and NT, respectively, compared with CT. The species diversity reduced in SP and NT, by 24% and 11%, respectively, but increased by 2% in BP. In 50% residue, the soil weed seed bank and species diversity reduced by 16% and 14%, respectively, relative to that of 20% residue. The continuous practice of CA, for 3 or more years, in two rice-based crop rotations, decreased the size of the weed seedbank, but increased the relative proliferation of specific perennial weeds
Complete genome sequence of community-associated methicillin-resistant Staphylococcus aureus Sequence type 1, SCC mec IV[2B], isolated in the 1990s from northern Western Australia
Get PDFSequence type 1 (ST1) methicillin-resistant Staphylococcus aureus (MRSA) SCCmec IV[2B] has become one of the most common community-associated MRSA clones in Australia. We report the complete genome sequence of one of the earliest isolated Australian S. aureus ST1-MRSA-IV strains, WBG8287, isolated from an Indigenous Australian patient living in the remote Kimberley region of Western Australia
Appropriate modelling of school compositional effects: A response to Malatinszky and Armor, and Marks
No full textWe respond to Malatinszky and Armor’s, and Marks’ comments on our article recently published in this journal. We agree with Marks in the use of prior achievement to control for spurious effects in school effects research. Marks makes an incorrect statement about our article, refers to dated critiques, and presents an empirical demonstration with some problems. We agree with Malatinszky and Armor that school composition may have sufficient within-student variation to detect a potential effect on achievement growth in fixed-effects models. We argue that fixed-effects models exclude most of the variation in socioeconomic composition, are incapable of measuring the commonly defined conceptualisation of school composition and can mischaracterise the relative importance of socioeconomic composition
The development of aboriginal brain injury coordinator positions: A culturally secure rehabilitation service initiative as part of a clinical trial
Get PDFBrain injury, resulting from stroke and traumatic brain injury, is a common occurrence in Australia, with Aboriginal people affected at a significant rate and impact felt by individuals, families and communities. Access to brain injury rehabilitation services for Aboriginal people is reported to be often limited, with very little support outside the hospital environment. Our research involving Aboriginal brain injury survivors and their families to date has revealed that people often manage ‘on their own’ following such events. Following recommendations from survivors and their families, the Healing Right Way clinical trial, currently underway in Western Australia, has created the role of Aboriginal Brain Injury Coordinator (ABIC) to assist in navigating information and services, particularly after discharge from hospital. Eight positions for this role have been instigated across metropolitan and rural regions in the state. Healing Right Way’s aim is to enhance rehabilitation services and improve quality of life for Aboriginal Australians after brain injury. The ABIC’s role is to provide education, support, liaison and advocacy services to participants and their families over a six-month period, commencing soon after the participant’s stroke or injury has occurred. This paper outlines the development of this role, the partnerships involved, experiences to date and identifies some facilitators and barriers encountered that may impact the role’s ongoing sustainability. Details of components of the planned full Process Evaluation of Healing Right Way related to the ABIC role and the partnerships surrounding it are also provided. In combination with the trial’s ultimate results, this detail will assist in future service planning and provide a model of culturally secure care for stroke and brain injury services that can also inform other sub-acute and primary care models
