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Critical analysis of chagas disease treatment in different countries
No full textAs a result of globalization and constant migratory flows, Chagas disease is now present in almost all continents. The management and treatment of the disease is often influenced by the economic and social context of the societies that host patients. In this
manuscript, we aim to provide a comparative review of approaches to patients with Chagas disease in the Americas and Europe
New observations from the intestinal fauna of Kerodon rupestris (Wied, 1820) (Rodentia, Cavidae), Brazil: a checklist spanning 30,000 years of parasitism
No full textEste levantamento de parasitos intestinais de Kerodon rupestris, um roedor endêmico da região semiárida brasileira,
revelou registros de 25 táxons de enteroparasitos compreendendo Cestoda (Anoplocephalidae), Trematoda,
Acanthocephala e Nematoda (Ancylostomidae, Ascarididae, Heterakidae, Oxyuridae, Pharyngodonidae, Trichuridae,
Capillariidae, Trichostrongylidae, and Strongyloididae), e dois táxons de coccídios. Os estudos paleoparasitológicos
e parasitológicos publicados até 2019 foram avaliados no presente trabalho e as informações de localização, local da
infecção, datação da amostra e dados do hospedeiro, foram resumidas a partir de cada referência. Análises de fezes
recentes e coprólitos revelaram a maior riqueza de espécies no estado do Piauí. Os dados cronológicos corroboram
que Trichuris spp. e oxiurídeos fazem parte da fauna parasitária de K. rupestris. Essa é a primeira lista de verificação
de parasitos intestinais de K. rupestris.This checklist of parasites of Kerodon rupestris, an endemic rodent from the Brazilian semiarid region, revealed
records of 25 enteroparasite taxa comprising Cestoda (Anoplocephalidae), Trematoda, Acanthocephala and Nematoda
(Ancylostomidae, Ascarididae, Heterakidae, Oxyuridae, Pharyngodonidae, Trichuridae, Capillariidae, Trichostrongylidae,
and Strongyloididae), and two taxa of coccidian. Paleoparasitological and parasitological studies published until
2019 were assessed in the present study and locality information, site of infection, sample dating, and host data were
summarized from each reference. Analyses of recent feces and coprolites revealed the highest species richness in the
Piauí State. The chronological data corroborated that Trichuris spp. and oxyurids are part of the parasitic fauna of
K. rupestris. This represents the first checklist of intestinal parasites from K. rupestris
Phenotypic characterization of Pseudomonas aeruginosa as a tracking tool for investigation in a pharmaceutical industry
No full textOs autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz
A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa
No full textMúltipla Autoria e Afiliação - Ver em Notas. - Marta Giovanetti - Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.The progression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in Africa has so far been heterogeneous, and the full impact is not
yet well understood. In this study, we describe the genomic epidemiology using a dataset of 8746 genomes from 33 African countries and two overseas territories.
We show that the epidemics in most countries were initiated by importations predominantly from Europe, which diminished after the early introduction of
international travel restrictions. As the pandemic progressed, ongoing transmission in many countries and increasing mobility led to the emergence and spread within
the continent of many variants of concern and interest, such as B.1.351, B.1.525, A.23.1, and C.1.1. Although distorted by low sampling numbers and blind spots,
the findings highlight that Africa must not be left behind in the global pandemic response, otherwise it could become a source for new variants
Differential expression profiles of miRNAs and their putative targets in Schistosoma mansoni during its life cycle
No full textBackground: Schistosomiasis is a disease caused by Schistosoma. Due to its complex life cycle, evolutionary position and sexual dimorphism, schistosomes have several mechanisms of gene regulation. MicroRNAs (miRNAs) are short endogenous RNAs that regulate gene expression at the post-transcriptional level by targeting mRNA transcripts.
Objectives: Here, we tested 12 miRNAs and identified their putative targets using a computational approach.
Methods: We performed the expression profiles of a set of miRNAs and their putative targets during the parasite's life cycle by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).
Findings: Our results showed differential expression patterns of the mature miRNAs sma-miR-250; sma-miR-92a; sma-miR-new_4-3p; sma-miR-new_4-5p; sma-miR-new_5-5p; sma-miR-new_12-5p; sma-miR-new_13-3p and sma-miR-new_13-5p. Interestingly, many of the putative target genes are linked to oxidative phosphorylation and are up-regulated in adult-worms, which led us to suggest that miRNAs might play important roles in the post-transcriptional regulation of genes related to energetic metabolism inversion during parasite development. It is noteworthy that the expression of sma-miR-new_13-3p exhibited a negative correlation on SmNADH:ubiquinone oxidoreductase complex I.
Main conclusions: Our analysis revealed putative miRNA genes related to important biological processes, such as transforming growth factor beta (TGF-β) signaling, proteasome regulation, glucose and lipid metabolism, immune system evasion and transcriptional regulatio
COVID-19 e Amamentação
No full textAté que haja evidência clara que o leite materno é uma fonte de infecção por SARS-CoV-2 e que essa infecção cause algum mal à criança, o comprovado benefício do leite materno a curto e longo prazo deve ser a primeira consideração ao aconselhar os pais.FiocruzMaterial Multimídi
Covid-19 e a produção da ignorância
No full textO primeiro ano da pandemia covid-19 nos ensinou muitas lições no campo da saúde coletiva. Uma das mais importantes, contudo, talvez tenha recebido menos atenção: a questão da ignorância. Assim como o conhecimento, a ignorância é uma construção. Ignorância não é simplesmente falta de conhecimento. Pelo contrário, a ignorância tem sido ativamente construída e produzida socialmente dentro de determinados contextos e processos políticos. Compreender a produção da ignorância é essencial para saber como enfrentá-la com conhecimento e informação
Corpus callosum dysgenesis causes novel patterns of structural and functional brain connectivity
No full textDevelopmental malformations (dysgenesis) of the corpus callosum lead to neurological conditions with a broad range of clinical
presentations. Investigating the altered brain connectivity patterns is crucial to understanding both adaptive and maladaptive neu roplasticity in corpus callosum dysgenesis patients. Here, we acquired structural diffusion-weighted and resting-state functional
MRI data from a cohort of 11 corpus callosum dysgenesis patients (five with agenesis and six with hypoplasia) and compared their
structural and functional connectivity patterns to healthy subjects selected from the Human Connectome Project. We found that
these patients have fewer structural inter- and intra-hemispheric brain connections relative to healthy controls. Interestingly, the
patients with callosal agenesis have a scant number of inter-hemispheric connections but manage to maintain the full integrity of
functional connectivity between the same cortical regions as the healthy subjects. On the other hand, the hypoplasic group pre sented abnormal structural and functional connectivity patterns relative to healthy controls while maintaining the same total
amount of functional connections. These results demonstrate that acallosal patients can compensate for having fewer structural
brain connections and present functional adaptation. However, hypoplasics present atypical structural connections to different
brain regions, leading to entirely new and abnormal functional brain connectivity patterns.202
Complicações em Terapia Intravenosa
No full textÉ fundamental construir e implementar instruções de trabalho para nortear a prática segura da terapia intravenosa em crianças e recém-nascidos.FiocruzMaterial Multimídi
Healthcare Workers’ Knowledge about Chagas Disease: A Systematic Review
No full textCNPq process 400904/2013-6 PROEP.Transmission of Chagas disease (CD) has decreased in recent decades, but the disease remains an important problem in endemic areas. There was an increase in the proportion of nonvector transmission mainly in non-endemic countries. The aim of this study was the gater evidence concerning healthcare professional's knowledge about CD. Searches were performed through Medline/PubMed, Lilacs, Web of Science, databases and Scielo archives, from wich 13/97 articles where selected for a qualitative analysis after full-text reading.2022-05-3