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Original data to accompany Evans et al: "<b>QuickDraw: Detecting HIV in Whole Blood using an Integrated Paper-based Consumable that Enables Direct Amplification of Purified RNA from Paper</b>", 2025
No full textThis folder contains all original data to accompany the manuscript "QuickDraw: Detecting HIV in WHole Blood using an Integrated Paper-based Consumable that Enables Direct Amplification of Purified RNA from Paper" Evans, A. L.; Sogn, A. K.; Mora, A. C.; Arthur, M. N.; Leach, J.; Bosch, S.; Araselvan, S.; Beard, J. W.; Dewhurst, S.; Mace, C. R.; Miller, B. L.Abstract:A definitive diagnosis of HIV typically requires a positive nucleic acid test. Limited access to these tests means that initiation of anti-HIV therapy is delayed or does not occur in a significant part of the world. While rapid antigen tests are more broadly available, these are insufficient for diagnosis on their own. To address the challenge of improving access to HIV testing, we have developed a passive, paper-based microfluidic sample preparation device we term the QuickDraw. We demonstrate that QuickDraw efficiently processes HIV-containing finger stick-quantities of whole blood to yield purified viral RNA. The output of the QuickDraw is then used as input for a colorimetric reverse transcriptase - loop-mediated isothermal amplification (RT-LAMP) assay. Coupled with sample preparation conducted with the QuickDraw, the assay demonstrated a limit of detection of 1,000 copies/mL, with a PPV of 93% and an NPV of 87%. QuickDraw simplifies viral nucleic acid sample preparation and detection by dramatically reducing the amount of equipment needed, suggesting it could be suitable for deployment in clinical and low-resource settings. By decentralizing nucleic acid testing, the QuickDraw platform has the potential to expand access to nucleic acid diagnostics in low-middle income countries (LMICs), while also supporting the UNAIDS goals for HIV detection, leading to wider access to treatment and reduced community transmission. It is also a significant step towards the goal of a simple-to-use nucleic acid-based HIV self test.</p
Journal of Undergraduate Research (jur), Volume 11, Issue 2, Spring 2013
No full text(JUR) is an organization dedicated to providing the University of Rochester student body with intellectual perspectives from various academic disciplines. JUR serves as a forum for the presentation of original research, thereby encouraging the pursuit of significant scholarly endeavors.For more information, please visit the Journal of Undergraduate Research homepage.</p
The Modular μSiM: Perm_EECMBMEC_MM_20220131 uSiM iPSC BMEC 6 days Permeability.xlsx
No full textRaw data for EECM-BMEC permeability using sampling method at UR and UniBe labs for Fig. 6 in The Modular µSiM: A Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro</p
Working Papers in the Language Sciences (WPLS), Volume 4, Number 1, Winter 2008
No full textWorking Papers in the Language Sciences at the University of Rochester (WPLS: UR) is an online publication of working papers from the University's interdisciplinary language sciences community.Any student or faculty member from the University of Rochester can submit their working papers for consideration.For more information, please visit the Working Papers in the Language Sciences homepage.Table of Contents;Measurement of vowel nasalization by multi-dimensional acoustic analysisby Michael A. Berger</p
Working Papers in the Language Sciences (WPLS), Volume 1, Number 1, Spring/Summer 2000
No full textWorking Papers in the Language Sciences at the University of Rochester (WPLS: UR) is an online publication of working papers from the University's interdisciplinary language sciences community.Any student or faculty member from the University of Rochester can submit their working papers for consideration.For more information, please visit the Working Papers in the Language Sciences homepage.Table of ContentsEditors: Katherine Crosswhite and Joyce McDonoughAllowable variability: A preliminary investigation of word recognition in Navajoby Joyce McDonough and Mary Ann Willie, pp. 1-23Comparison of intonation patterns in Mandarin and English for a particular speakerby Katrina Schack, pp. 24-55Simple recurrent networks and competition effects in spoken word recognitionby James S. Magnuson, Michael K. Tanenhaus, and Richard N. Aslin, pp. 56-71Connectionist modeling for... er... linguistsby Bob McMurray, pp. 72-96"Mismatches" of form and interpretationby Greg Carlson, pp. 97-106Vowel reduction in Russian: A unified account of standard, dialectal, and "dissimilative" patternsby Katherine Margaret Crosswhite</p
GAIL 2025: Chasing Fairies: Audio/Visual Literacy in the Age of AI
No full textThe proliferation of generative AI (GenAI) has dominated the news cycle for the last two years. Most of this attention has been focused on large language models (LLMs) such as ChatGPT. However, the role of GenAI tools in generating images, music, and video has been overshadowed by LLMs despite their considerable disruptive potential. Audio and visual literacy instruction are necessary to combat the proliferation of GenAI media in the information ecosystem.This hands-on workshop will briefly explain how GenAI media tools work, give examples of their real-world impact, and discuss the ethical issues inherent in their use. Then participants will be given practical, low-barrier strategies and techniques to identify GenAI media. A curated set of media will be provided to give participants a chance to put these lessons into practice. The session will then conclude with a reflection on the activity, a question and answer segment, and a discussion on strategies for keeping up with a rapidly-evolving medium.By the end of the session, attendees will leave with a foundational understanding of GenAI audio/visual media. Attendees will feel more confident in discussing GenAI media tools, identifying their output, and leading their own sessions.</p
Lineshifts at atomic pressures dataset
No full textAt atmospheric pressures the atom is typically considered immutable with known energy levels for electrons, however in the deep interiors of stars where atoms exist at and beyond the atomic unit of pressure, i.e. hundreds of millions to billions of atmospheres pressure, the atom is fundamentally changed. At such conditions, unbound electrons are squeezed interior to core orbitals of the atom, screening the nuclear charge and dramatically shifting the quantum energy levels for electrons. The plasma becomes integral to the structure and properties of the atom, a regime that is challenging for today’s theoretical tools and where benchmark data are needed. We present the first such data: time resolved measurements of the inner most electron bound-bound transitions, for highly–ionized chromium with pressures up to 10 billion atmospheres (1 petapascal) and temperatures ≈ 400 eV. These results reveal a shortcoming in ab-initio density functional theory modeling of atomic structure and radiative transitions at these extreme conditions. Moreover, a measured 20-eV shift in the x-ray absorption lines together with a simple atomic physics model provides the first constraints for screening effects on atomic orbitals at and beyond atomic pressures. This shift is consistent with a charge of 0.17e (0.005e) penetrating the 2p (1s) orbit for Cr.The data in this archive include lineouts and the full time-energy streak. Data are restricted to (0 to 2.8ns) and photon energy (5380 to 5950eV) to match the data regions plotted in Figs. 2 and 3.Lineouts from Fig. 3 and the raw data are converted to physical units as described in the Supplemental Material. In each, the source emission rate is in units of photons/s/sr/Hz, photon energy is in eV, and time is in nanoseconds.</p
Characterization of Human Glial Progenitor Cell Age on Engraftment, and Spike-In Tumorigenicity
No full textLeukodystrophies are a group of rare genetic diseases affecting the white matter in the central nervous system. Human glial progenitor cells (hGPCs) when differentiated from embryonic stem cells (ESCs) in culture have been shown capable of engrafting and myelinating the dysmyelinated shiverer mouse brain. To optimize the efficiency of the hGPCs ability to engraft and produce myelin, different days in vitro (DIV) were tested. Using these different DIVs, there are trends in the data that show differences in the number of the human cells differentiating as oligodendrocytes. ESCs that have not undergone a specification protocol have potential to become any cell fate and produce tumors after transplantation. When differentiating the cells into GPCs there is potential for a few undifferentiated cells to remain. Different ratios of undifferentiated cells were spiked-in with GPCs to investigate the incidence of tumorigenicity. This study is to look at the safety of the cell injections if ESCs remain.</p
Testing Hands-On Photonics Education (HOPE) Datacom Chips to Measure Loss, Interference, and Quantum Efficiency
No full textPhotonics is a field that utilizes the wave and particle-like properties of light with applications in sensing, telecommunications, and imaging. However, the industry’s needs are unmet with an insufficient number of workers with the knowledge and experience required to advance the field. AIM Photonics has developed the Hands-on Photonic Education (HOPE) kits to teach the fundamentals of photonics to community college instructors, employees in the field, and students through workshops. For my research, I tested Chip 1: Loss measurements, Chip 2: On-chip light manipulation with directional couplers and Mach-Zehnder Interferometers, and Chip 4: Germanium photodetectors. In Chip 1, the total coupling loss is -5.8 ± 1.8 dB, and the slope is -3.1 ± 0.5 dB/cm for the TE mode. For Chip 2, we find that the thru port the total fiber-to-chip loss is -5.5 ± 0.7 dB and the coupling length for max coupling is 62.8 ± 1.5 um, while the total fiber-to-chip loss for the drop port is -6.3 ± 0.2 dB and the coupling length for max coupling is 62.0 ± 2.1 um. For Chip 4, we tested different photodetector lengths to find the quantum efficiency and dark current. We plan to continue testing these chips and hold more workshops to eventually distribute the kits.</p
Codebook and Dataset for the Flourishing in Emerging Adult Transition Study
No full textThis is the Codebook and Dataset for the Wave 1 Flourishing in Emerging Adult Transition Study (FEATS), created by Dr. Nestor Tulagan and his Flourishing, Achievement Motivation, and Identity (FAM&I) Lab at the Department of Psychology. FEATS is an educational and developmental psychology survey study examining ethnoracially minoritized students' science motivation, racial-ethnic identity, and gender identity beliefs. It also examines students' retrospective reports of their science support (academic discussions, homework help, and provision of materials), racial-ethnic socialization (cultural socialization and preparation for bias), and gender socialization (gender egalitarian messages and positive messages about LGBTQIA+ communities).To open the .sav file, you will need SPSS or a third party viewer like AddMaple.</p