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Model of fuzzy inference for energy efficiency evaluation at industrial enterprises
No full textAt the moment, with the developing industrialization of society, as well as the
growing demand and consumption of all types of end products, industry is increasing the use of
energy resources to create capacities corresponding to the current time. The main industrial
source of energy in the 21st century is electricity. In industries and enterprises, electricity is
used in large amount, and that is why the main and urgent task to reduce the cost, increase the
competitive ability of the organization and the growth of its microeconomics is the ability to
reduce electricity consumption, and not by reducing production lines, but due to the correct and
modern technology of its use. To solve this problem, many factors, which are expressed in
quantitative and qualitative data, should be taken into consideration. But it is complicated by
the fact that most often these data groups have incompleteness and uncertainty of the used
information. This may be due to outdated equipment, lack of necessary technological
equipment, or simply a human factor. In this regard, there is a not objective and not quite
correct model and assessment of electricity usage by the enterprise. To get out of this situation
with the benefit of industry, it is possible to use the mathematical apparatus of fuzzy logic. The
results obtained using this method can be considered objective. Based on reasonable estimates
of the impact of various factors on energy consumption and energy efficiency of the enterprise
system, it is possible to develop methods for its improvement, increasing energy efficiency,
reducing waste, which leads to an increase in the competitiveness of the enterprise by reducing
the cost of the final product and reducing the cost for the consumer
Normative Ordnungen und Paradoxien – Beiträge aus dem Kontext der Frankfurter Schule: Doppelbesprechung
No full textDer Band ist in die beiden Teile „Theoriegeschichtliche Perspektiven“ und
„Materiale Studien“ gegliedert. Die Aufsätze zur Theoriegeschichte richten sich
jeweils auf einzelne Autoren, nämlich Tocqueville, Nietzsche, Max Weber, Simmel,
Siegfried Kracauer und Albert O. Hirschman.
Der zweite Teil enthält eine Reihe von Fallstudien. Stephan Voswinkel beschreibt
einige Charakteristika moderner Arbeitsformen (über deren empirische
Verteilung und Verbreitung keine Information geliefert wird), zum Beispiel Arbeitszeitsouveränität
Deciphering mutations in actionable genes by integrating structural and evolutionary epistatic features.
No full textDespite the rapid advancement of sequencing technologies and although the wide diffusion of Whole Genome Sequencing (WGS) and Whole Exome Sequencing (WES) led to an increase in the diagnoses of diseases (A. C. Lionel, et al. 2018; D. J. Stavropoulos, et al. 2016; J. C. Taylor, et al. 2015) most genetic variants remain without a clear interpretation. One of the main difficulty related with the assessment of sequencing results is the abundance of Single Nucleotide Variant (SNV), around 4 million, that each healthy individual carries. Nearly all of these mutations will not produce any phenotype, that is equal to say that they have a benign or neutral effect. Only handful of those variants are potentially pathogenic, namely disease-causing. That is why computational Variant Effect Predictor (VEP) tools are used to
prioritize variants worth investigating for medical consideration. Furthermore, the evidence of computational tools is considered among the different sources for variant effect assessment according to the American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pathology (AMP) guidelines. In addition, those software tools can be recognized as medical devices according to the second article of the Medical Device Regulation (MDR) of the European Union (Regulation (EU) 2017/745). That is why building a computational tool that predicts with high accuracy variant pathogenicity might have a direct impact on the healthcare system. Since 2001 more than 100 VEPs tools have been developed. Yet, their thresholds to classify a variant as pathogenic are often set for high sensitivity, that results in high false positive rate, namely misclassification of benign variants (C. Cubuk, et al. 2021). During my PhD, I developed Deciphering Mutations in Actionable Genes (DeMAG), a supervised classifier for interpreting missense mutations, namely SNVs that alter the protein sequence, in a list of 59 actionable genes as identified by the ACMG Secondary Findings (SF) v2.0 list (S. S. Kalia, et al. 2017). DeMAG is a supervised classifier trained with a Gradient boosting machine (GBM) model that employs only 13 conservation-based and structural features derived from AlphaFold 3D models and manually curated Multiple Sequence Alignment (MSA). DeMAG yields the best performance on clinical data among other popular VEP tools, balancing sensitivity and specificity, reaching the highest Matthews Correlation Coefficient (MCC). The advancement of DeMAG is due to the assembling of a balanced and high-quality training set and to the design of the partners score, a feature that captures epistasis, both in the sequence and in the 3D space of the protein. Here, epistasis refers to residues co-evolution in the sequence and residues spatial proximity in the 3D structure of the protein. The feature is a probabilistic score obtained with a mixture discriminant analysis that predicts pathogenicity based on the phenotypic effect of co-evolving and spatially close residues. The partners score feature is a general framework to study genotype and phenotype interactions. For example, those interactions might be between hetero or homoproteins forming a complex as tertiary structure and genetic variants occurring at interfaces, already known to be disease-causing, might be enriched for the same phenotypic effect. The framework of the partners score might not be limited to protein sequence, for example, interactions in the 3D genome might reveal regions enriched with the same phenotypic effect. DeMAG has been trained only on a small set of genes and yet, without further training, it generalizes well to additional 257 genes that have enough clinical data. Because for those new genes I did not manually curate MSA, I noted that the partners score from protein 3D models seems necessary for reaching high performance, while the contribution of the partners score obtained from long-range interactions, as derived from the co-evolution analysis, does not seem crucial for variant effect predictions. DeMAG is a supervised method especially designed for clinical translation purposes. That is why it focuses on clinically actionable genes and it balances its performance between the accuracy of the pathogenic and the benign class, acknowledging the importance of minimizing both the false negatives and false positives to avoid under and over diagnosis, critical to reduce health costs and patients psychological burden. Unsupervised general VEPs are powerful tools to investigate the functional effect of genetic variants as demonstrated by their higher correlation, over supervised tools, with data from Multiplexed Assay of Variant Effect (MAVE) and Deep Mutational Scanning (DMS) experiments. Nevertheless, for targeted clinical applications, I endorse the development of specialized tools that can leverage the existing wealth of data and knowledge available to minimize predictions errors. In order to make DeMAG readily available, I developed a web application available at https://demag.org/demag_app/ that provides predictions for all amino acids substitutions in the 59 and additional 257 genes together with training and testing datasets. Moreover, the app displays all the features of DeMAG highlighting the specific value annotated for the query mutation in relation to the distribution of the features for the pathogenic and benign mutations in the training set. This provides more insights than the minimalistic prediction label
Infodienst Landwirtschaft / Informations- und Servicestelle Großenhain: Informations- und Servicestelle Großenhain
No full textKonditionalität ...: Informationen über die einzuhaltenden Verpflichtungen bei der Konditionalität
No full textZinon Papakonstantinou, Cursing for Justice. Magic, Disputes, and the Lawcourts in Classical Athens. Stuttgart, Steiner 2021. 167 S., € 42,–.
No full textHow local is the Local Structure Theorem for finite groups with a large p-subgroup?
No full textIn the Introduction of the Local Structure Theorem for finite groups with a large p-subgroup [MSS16] Meierfrankenfeld, Stellmacher and Stroth write: “It is obvious that one cannot get any information about M and its action on YM without discussing in one way or another the embedding of M into G. But a priori, it is not clear at all what type of embedding properties one should study and how they would help to get this information”. Here G is a finite group and M a cleverly chosen subgroup, with YM being a canonically determined elementary abelian, normal p-subgroup of M.
On the one side, an answer to the question contained in the above citation is given by the result proven by Meierfrankenfeld, Stellmacher and Stroth; on the other side, one may ask how much of the group G is necessary for such result and how much is lost or changed by retaining only the plocal information of G, i.e. the information carried by the normalizers of non-trivial p-subgroups.
In some way, which will hopefully become more clear and specific by the end of this Introduction, this dissertation can be seen as attempt to answer such question: we replace the group G with localities, as defined in 2.2.7, our choice of structures encoding precisely the p-local information of G, and look for an analogous of the Local Structure Theorem.
In order to provide enough context to understand the statement and reach of [MSS16] as well as reasons and ideas behind the development of localities, we need a long historical digression and a detailed enough description of the strategy that was successful in proving the Local Structure Theorem. For the readers’ convenience we accordingly split our Introduction
Die Bürger von Zwickau und ihre Kirche: Kirchliche Institutionen und städtische Frömmigkeit im späten Mittelalter
No full textgeringfügig überarbeitete und mit geändertem Titel versehene Version der Dissertation (Universität Leipzig, 2010
