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Chronic Myeloid Leukemia with Variant Chromosomal Translocations: Results of Treatment with Imatinib Mesylate.
No full textObjective: To evaluate the efficacy of imatinib in chronic myeloid leukemia patients with variant translocations. Methods: Forty eight chronic myeloid leukemia patients carrying variant translocations and treated with imatinib at our institute were considered for the study. Survival and response rates were evaluated. Results: The median follow up was 48 months(m). Forty three (89.58%) patients achieved complete hematologic response. Thirty one (64.58%) patients achieved complete cytogenetic response and 19(39.58%) achieved major molecular response anytime during their follow up period. Only 18.75% of the patients achieved complete cytogenetic response and major molecular response within the stipulated time frames.The estimated overall survival at 48 m median follow up was 81.2%.The progression free survival was also 81.2% and the event free survival was 79.1%.There was no significant survival difference between low vs intermediate and high risk sokal group. Conclusion: We report suboptimal responses to imatinib in chronic myeloid leukemia with variant translocations. Further studies with imatinib and the newer more active drugs dasatinib and nilotinib are justified
Cellular-Automata and Innovation within Indonesian Traditional Weaving Crafts
No full textThe paper reports the possibility of Indonesian traditional artisans of weaving designs and crafts to explore the cellular automata, a dynamical model in computation that may yield similar patterns. The reviews of the cellular automata due to the perspective of weaving process reveals that the latter would focus on macro-properties, i.e.: the strength of structural construction beside the aesthetic patterns and designs. The meeting of traditional weaving practice and the computational model is delivered and open the door for interesting discourse of computer-aided designs for the traditional artists and designers to come
Tuberculosis Notification: Issues and Challenges.
No full textTuberculosis (TB) is a major public health problem. An emerging menace in India is drug resistant forms of TB. In order to ensure proper TB diagnosis and case management, reduce TB transmission and address the problems of emergence of spread of Drug Resistant-TB, it is essential to have complete information of all TB cases. Therefore, Govt. of India declared Tuberculosis a notifiable disease on 7th May 2012. This paper highlights the fact that notification of TB in the absence of regulation of diagnostic practices, rational use of anti-TB medicines and availability of diagnostic and treatment facilities for drug-resistant TB will pose more problems rather than provide solutions to this problem
Attitude and Myths Towards Rape among Medical Students in Rajkot, India
No full textBackground: Violence against women takes many forms – physical, sexual, psychological and economic. Violence against women harms families and communities across generations and reinforces other violence prevalent in society. Rape myths encompass a set of (false) beliefs about rape that places the blame on the victim and not the perpetrator. Objective: to assess the prevailing attitudes on rape myths among the medical students. Methods: The study was conducted after taking informed consent among 346 undergraduate medical students of P D U Government Medical College, Rajkot, India from January to June, 2013 by using previously validated questionnaire using updated Illinois Rape Myth Acceptance Scale. Results: The age range of 346 medical students was 17 to 23 years with 172 male and 174 female students. Total 24.4% male and 23% female students had very good positive attitude. One fourth of male and one fifth of female students had a more negative attitude. No relation was observed for rape myth acceptance among medical students for residential or socio-economic status. Conclusion: The present study provides insight to the prevalence of attitude and rape myths towards rape among medical students. Introduction of education on gender violence with introduction of courses on ‘sexual violence’ in medical curriculum may help to decrease rape incidence and for better management of victims
Variant Musculo-tendinous Slip between Teres major and Triceps brachii
No full textA variation of the muscles of the scapular region is a very rare finding. During the routine dissection for the undergraduates, a variant short musculo-tendinous slip in between the teres major and the long head of triceps brachii muscles was seen. This slip could cause compression of the underlying brachial vessels and the cords of brachial plexus. Therefore this type of variation is worthy of being noted by the surgeons
Insular Carcinoma of Thyroid Presenting as a Giant Skull Lesion: A Dilemma in Treatment.
No full textThyroid surgeons are becoming increasingly more aware of a histologically distinct subset of thyroid carcinoma whose classification falls between well-differentiated and anaplastic carcinomas with respect to both cell differentiation and clinical behavior. This subtype of tumors has been categorized as poorly differentiated or insular carcinoma, based on its characteristic cell groupings. Although the differentiation of insular carcinoma from other thyroid carcinomas has important prognostic and therapeutic significance, relatively little about insular carcinoma has been published in the otolaryngology literature. In this article, we discuss a case of insular carcinoma of thyroid presenting with concurrent distant metastasis to skull, lung, ribs, and inguinal region with review of the literature. We conclude that insular thyroid carcinoma warrants aggressive management with total thyroidectomy and excision of accessible giant lesion followed by radioactive iodine ablation of any remaining thyroid tissue
Perspectives on problem solving in educational assessment: analytical, interactive, and collaborative problem solving
No full textProblem solving has received broad public interest as an important competency in modern societies. In educational large-scale assessments paper-pencil based analytical problem solving was included first (e.g., Programme for International Student Assessment, PISA 2003). With growing interest in more complex situations, the focus has shifted to interactive problem solving (e.g., PISA 2012) requiring identification and control of complex systems. In the future, collaborative problem solving represents the next step in assessing problem solving ability (e.g., PISA 2015). This paper describes these different approaches to assessing problem solving ability in large-scale assessments considering theoretical questions as well as assessment issues. For each of the three types of problem solving, the definition and understanding of the construct is explained, items examples are shown together with some empirical results, and limitations of the respective approach are discussed. A final discussion centers on the connection of cognitive and differential psychology within educational research and assessment
The GIST of Concepts
No full textA unified general theory of human concept learning based on the idea that humans detect invariance patterns in categorical stimuli as a necessary precursor to concept formation is proposed and tested. In GIST (generalized invariance structure theory) invariants are detected via a perturbation mechanism of dimension suppression referred to as dimensional binding. Structural information acquired by this process is stored as a compound memory trace termed an ideotype. Ideotypes inform the subsystems that are responsible for learnability judgments, rule formation, and other types of concept representations. We show that GIST is more general (e.g., it works on continuous, semi-continuous, and binary stimuli) and makes much more accurate predictions than the leading models of concept learning difficulty,such as those based on a complexity reduction principle (e.g., number of mental models,structural invariance, algebraic complexity, and minimal description length) and those based on selective attention and similarity (GCM, ALCOVE, and SUSTAIN). GIST unifies these two key aspects of concept learning and categorization. Empirical evidence from three\ud
experiments corroborates the predictions made by the theory and its core model which we propose as a candidate law of human conceptual behavior
Healthcare Can Change from Within: Sustained Improvement in the Healthcare Response to Intimate Partner Violence
No full textThere is a great need to demonstrate sustained improvement in healthcare-based inquiry, intervention, and prevention provided to patients exposed to intimate partner violence (IPV). We evaluated implementation of the Healthcare Can Change from Within model (HCCW) in three primary care clinics and an emergency department within a large healthcare system, using two other primary care clinics for a usual-care comparison on selected variables. Outcome measures included individual-level variables (staff knowledge and attitudes) and system characteristics (clinic policies, procedures, patient education materials, and IPV documentation in patient records). Doctors and nurses reported increased self-efficacy, understanding of referral resources, and understanding of legal issues; IPV knowledge was unchanged. Intervention clinics implemented new policies and procedures, increased patient education, and increased documentation of IPV screening, an improvement which was sustained at 2-year follow-up. Results suggest HCCW is a promising practice for improving the healthcare response to IPV
Isolated Amoebic Abscess of Spleen
No full textAmoebic liver abscess is the most common extraintestinal manifestation of amoebiasis. Extrahepatic amoebic abscesses have occasionally been described in the lung, brain, and skin and presumably result from hematogenous spread. Isolated amoebic abscess of spleen has been reported scarcely in literature. We report here a case of isolated amoebic abscess of spleen