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Synthesis of the phenylboronic and cinnamic acid conjugate : diploma thesis
No full textFenilborna kiselina je spoj s izraženim terapeutskim potencijalom, posebno u kontekstu borbe protiv raka. Analizirana literatura ističe njezine pozitivne karakteristike te naglašava njezinu moguću primjenu kao farmaceutskog agensa u terapiji raka. Jedan od ključnih izazova u terapiji raka jest minimiziranje njenih štetnih utjecaja na zdrave stanice i organe. U tom kontekstu, u fokusu ovog rada je istraživanje sinteze konjugata fenilborne i cimetne kiseline, biološki aktivne prirodne organske kiseline. Sinteza je provedena korištenjem protokola uobičajenog za dobivanje amidne veze, koji koristi aktivaciju karboksilne kiseline N,N-dialkilkarbodiimidom uz nekoliko modifikacija reakcijskih uvjeta (sastav reakcijskog medija, korišteni karbodiimid, temperature, itd), u potrazi za najefikasnijim sintetskim postupkom za dobivanje derivata aminofenil borne kiseline. Iako nakon provedenih sinteza nije bilo moguće izolirati čisti željeni konjugat, u ovom je radu dan iscrpan pregled korištenih metoda sinteze i pročišćavanja sirovih produkata. Naposljetku, pokazano je da već i smjesa anhidrida cimetne kiseline i njezinogkonjugata s aminofenilbornom kiselinom pokazuje izrazitu citotoksičnost, a time i izniman potencijal za daljnji razvoj ovog tipa antitumorskih lijekova. Stoga će ovaj rad zasigurno predstavljati temelj za razvoj novih sintetskih pristupa dobivanju konjugata feniborne i prirodnih biološki aktivnih organskih kiselina.Phenylboronic acid is a compound with significant therapeutic potential, particularly in the context of cancer treatment. The analyzed literature highlights its positive characteristics and potential application as a pharmaceutical agent in cancer therapy. One of the key challenges in cancer therapy is minimizing its harmful effects on healthy cells and organs. In this context, the focus of this work is the investigation of the synthesis of conjugates of phenylboronic and cinnamic acid, a biologically active natural organic acid. The synthesis was conducted using a protocol common for the formation of amide bonds, which involves the activation of a carboxylic acid with N,N-dialkylcarbodiimide, with several modifications to the reaction conditions (reaction medium composition, carbodiimide used, temperature, etc.) in search of the most efficient synthetic procedure for obtaining derivatives of aminophenylboronic acid. Although it was not possible to isolate the pure desired conjugate after the syntheses, this paper provides a comprehensive review of the synthesis methods and purification of the raw products used. Ultimately, it was shown that even a mixture of cinnamic acid anhydride and its conjugate with aminophenylboronic acid exhibits significant cytotoxicity, and thus exceptional potential for further development of this type of antitumor drugs. Therefore, this work will undoubtedly serve as a foundation for the development of new synthetic approaches to obtaining conjugates of phenylboronic acid and naturally biologically active organic acids
THE INFLUENCE OF SWEET WORMWOOD EXTRACT (Artemisia annua L.) ON THE FORMATION OF AN OXIDE FILM OF ALLOYS IN ARTIFICIAL SEAWATER IN THE PRESENCE OF THE BACTERIUM Pseudomonas aeruginosa : doctoral thesis
No full textRazličitim elektrokemijskim, spektroskopskim i površinskim tehnikama istražen je utjecaj vodenog ekstrakta slatkog pelina, Artemisia annua L. (AAE) na stvaranje oksidnog filma tri vrste čelika (A36, 304 i 316L) i aluminijeve legure (5083) u umjetnoj morskoj vodi (ASW) u prisutnosti bakterije Pseudomonas aeruginosa. Provedena istraživanja usmjerena su na studij strukturnih svojstava meĎufaznih granica, električnih i dielektričnih svojstava površinskih filmova, te elektrokemijskih reakcija na meĎufaznoj granici elektroda/ASW pri čemu su korištene elektrokemijske tehnike elektrokemijske impedancijske spektroskopije, potenciodinamičke polarizacije i cikličke voltametrije. Morfologija površine istraživanih materijala ispitana je beskontaktnom optičkom profilometrijom i pretražnom elektronskom mikroskopijom (SEM), a kemijska analiza je provedena energijski razlučujućom rendgenskom spektrometrijom (EDS), fotoelektronskom spektroskopijom X-zrakama (XPS) i infracrvenom spektroskopijom s Fourierovom transformacijom uz prigušenu totalnu refleksiju (ATR-FTIR). Stabilnost oksidnog filma dodatno je istražena optičkom emisijskom spektrometrijom s induktivno spregnutom plazmom (ICP-OES). AAE je karakteriziran pomoću tekućinske kromatografije visoke djelotvornosti (HPLC) i ATR-FTIR spektroskopije. Kombinacijom elektrokemijskih i površinskih metoda usporeĎena su elekrokemijska svojstva površinskih filmova s njihovim strukturnim karakteristikama, na osnovu čega je predložen mehanizam nastanka oksidnog filma na površini ispitivanih elektroda u prisutnosti bakterije, te mehanizam inhibitornog djelovanja AAE prema mikrobiološki izazvanoj koroziji. Oksidni film formiran u prisutnosti AAE pokazuje poboljšana zaštitna svojstva te inhibira Faradayske procese oksidacije elektrode i prijenosa naboja izmeĎu elektrode i ASW uzrokovanih djelovanjem biofilma i klorida na površinski film. Navedeno je pripisano stvaranju tanjeg oksidnog filma, boljih dielektričnih svojstava te adsorpciji fenolnih kiselina, koje su za metalne ione vezane elektrostatskim interakcijama (ΔG ≈ –16,30 ± 0,80 kJ mol –1 ) i inhibiraju mikrobiološku aktivnost.Various electrochemical, spectroscopic, and surface techniques were utilized to examine the influence of the aqueous extract of sweet wormwood, Artemisia annua L. (AAE) on the formation of an oxide film of three types of steel (A36, 304 and 316L) and aluminum alloy (5083) in artificial seawater (ASW) in the presence of bacterium Pseudomonas aeruginosa. The research is focused on studying the structural properties of interface boundaries, electrical and dielectric properties of surface films, and electrochemical reactions at the electrodes/ASW interface boundary using electrochemical techniques of electrochemical impedance spectroscopy, potentiodynamic polarization, and cyclic voltammetry. The surface morphology of the investigated materials was examined by non-contact optical profilometry and scanning electron microscopy (SEM), while chemical analysis was performed using energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS) and Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR- FTIR). The stability of the oxide film was further investigated by inductively coupled plasma optical emission spectrometry (ICP-OES). AAE was characterized using high-performance liquid chromatography (HPLC) and ATR- FTIR spectroscopy. The combination of electrochemical and surface techniques enabled the comparison of the electrochemical properties of the surface films with their structural characteristics. Based on experimental evidence the mechanism of the formation of the oxide film on alloys in the presence of bacteria was proposed, along with the mechanism of the inhibitory effect of AAE on microbiological corrosion. The oxide film formed in the presence of AAE showed improved protective properties and inhibited the Faraday processes of electrode oxidation and charge transfer between the electrode and ASW caused by the action of biofilm and chlorides on the surface film. This was attributed to the formation of a thinner oxide film, with better dielectric properties and the adsorption of phenolic acids on the charged metal surfaces through electrostatic interactions (ΔG ≈ –16.30 ± 0.80 kJ mol –1 ) that prevented microbiological activity
THERMAL PROCESSES OF SEAWATER DESALINATION : bachelor thesis
No full textPitka voda je neophodna za sav život na Zemlji. Svakodnevnom upotrebom, porastom industrije te samim porastom standarda, potreba za vodom je sve veća. Posebno je potrebna na područjima koja ne obiluju prirodnim izvorima pitke vode. Jedno od rješenja za taj problem je izgradnja te unaprijeđivanje desalinizacijskih postrojenja kojih je sve više kako u svijetu tako i u Europi. Glavni zadatak desalinizacije je pretvaranje slane morske vode u pitku vodu. U ovom radu prikazane su države i geografska područja koja imaju najveći broj desalinizacijskih postrojenja. Naglasak u ovom radu je na toplinskim procesima desalinizacije. Najčešće se koriste u zemljama s dostupnim izvorima energije poput Bliskog Istoka. Razvojem tehnologije se nastoji postići što veća učinkovitost uz smanjenje troškova jer su desalinizacijski procesi s energetskog gledišta skupi. Toplinski procesi se temelje na procesima destilacije, odnosno fizičkoj promjeni faza vode. Prikazane su različite metode destilacije te su navedene njihove prednosti i nedostatci. Toplinskim desalinizacijskim postrojenjima cilj je iz različitih izvora neupotrebljive vode proizvesti vodu u korisnom obliku, čistu pitku vodu.Drinking water is essential for all life on Earth. With daily use, the growth of industry and rising standards, the demand for water is increasing. This is especially true in areas where there are no abundant natural sources of drinking water. One of the solutions to this problem is the construction and improvement of desalination plants, of which there are more and more both in the world and in Europe. The main purpose of desalination is to turn salty seawater into drinking water. This paper presents the countries and geographical areas with the largest number of desalination plants. The focus is on thermal desalination processes. They are most commonly used in countries with available energy sources such as the Middle East. The development of the technology aims to achieve the highest possible efficiency while reducing costs at the same time, as desalination processes are expensive from an energy point of view. Thermal processes are based on distillation processes, i.e. the physical change of water phases. Various distillation processes are presented and their advantages and disadvantages are listed. The aim of thermal desalination plants is to recover water in a usable form, namely clean drinking water, from various sources of unusable water
Preparation and characterization of polymeric inclusion membranes : bachelor thesis
No full textCilj ovog rada je istražiti polimerne inkluzivne membrane (PIM), s posebnim naglaskom na njihov sastav, prijenos tvari i fizikalno-kemijska svojstva. Razmatraju se prednosti PIM-a u industrijskim primjenama, pri čemu se posebna pažnja posvećuje utjecaju dodatka staklenih vlakana (GF) u sastava membrane, kako bi se ispitao utjecaj udjela staklenih vlakana na mehanička svojstva membrana te njihovu sposobnost prijenosa analita od interesa.This work investigates polymer inclusion membranes (PIMs), focusing on their composition, mass transport, and physicochemical characteristics. It considers the advantages of PIMs in industrial applications, with specific attention given to the effect of adding glass fibers (GF) to the membrane composition to examine how the percentage of GF influences membrane mechanical properties and mass transport
Optimization process parameters of catalytic gasoline reforming process : diploma thesis
No full textProces katalitičkog reformiranja jedan je od najvažnijih procesa u naftnoj industriji. On omogućuje proizvodnju motornog benzina u većim količinama s obzirom na velike zahtjeve tržišta. U Rafineriji nafte Rijeka 1984. godine izvršena je modifikacija postrojenja Platforming 2, čime je omogućen rad pri znatno nižem tlaku (do 17 bara u visokotlačnom separatoru). Niži tlak za posljedicu ima veće iscrpke vodika i reformata, ali i pojačano koksiranje katalizatora. U laboratorijima Rafinerije nafte Rijeka provedene su eksperimentalne analize za niskooktanski benzin i reformat benzin. Te analize uključuju: određivanje gustoće, destilacijskih krivulja, određivanje količine ukupnog sumpora, dušika, vode, parafina, olefina, naftena, aromata, olova i žive. Drugi dio rada zahtijevao je praćenje procesnih parametara kao što su: tlak u visokotlačnoj sekciji, temperaturu pojne smjese na ulazu u reaktore, omjer vodika i ugljikovodika (H 2 /CH) i dr. Optimizacijom procesnih parametara utvrđeno je da tlak u visokotlačnoj sekciji ne utječe na vrijednost istraživačkog oktanskog broja (IOB-a), već da vrijednost IOB-a ovisi o temperaturi pojne smjese na ulazu u reaktor kao i o kapacitetu postrojenja. Viši tlak u visokotlačnoj sekciji znači veću čistoću vodika koja omogućuje da se pri istom omjeru H 2 /CH smanji stvaranje koksa i zadrže vrijednosti iscrpka vodika i reformata.Catalytic reforming represents one of the most significant processes in the oil industry. It enables the production of gasoline in quantities high enough to satisfy the market demands. At the Rijeka Oil Refinery, a modification of the Platforming 2 complex had been carried out in 1984, which enabled production at considerably lower working pressure (up to 17 bar in the high-pressure separator). Lower working pressure leads to higher hydrogen and reformate yield, but also to increased coking of the catalyst. Experimental analyses of the low-octane gasoline and reformate gasoline were performed at the Rijeka Oil Refinery laboratories. The analyses included: measurement of density, distillation curves, total sulphur, nitrogen, water, paraffin, olefin, naphthene, aromatic, lead and mercury content. The second part of the thesis required the monitoring of process parameters, such as: pressure in high-pressure section, reactor entrance temperature, hydrogen/hxdrocarbons ratio (H2/CH) quotient, etc. Through the optimization of process parameters, it was determined that the pressure in high-pressure section does not influence the value of research octane number (RON). Instead, RON was dependant on the reactor entrance temperature, as well as the capacity of the complex. Higher pressure in the high-pressure section signifies increased hydrogen purity, which in turn leads to lower coke formation, while the H2/CH ratio remains the same, along with the hydrogen and reformate yiel
Aplication of the hybrid process of electrocoagulation and natural zeolite for treatment of compost leachate : bachelor thesis
No full textU ovom radu provedena su ispitivanja hibridnog procesa elektrokoagulacije i prirodnog zeolita za obradu kompostne procjedne vode. Ispitivan je utjecaj početne koncentracije kompostne procjedne vode na efikasnost uklanjanja štetnih tvari praćenih preko kemijske potrošnje kisika (KPK) i mutnoće. Eksperimenti su provedeni u elektrokemijskoj ćeliji, uz korištenje aluminijevih elektroda, pri konstantnoj udaljenosti elektroda od 3 cm i brzine vrtnje miješala od 70 okr/min. Tijekom eksperimenta praćena je promjena pH vrijednosti, temperature i električne vodljivosti, a na početku i kraju eksperimenta određivani su mutnoća, ukupni isparni ostatak, kemijska potrošnja kisika. Nakon provedenog eksperimenta hibridnog procesa elektrokoagulacije s prirodnim zeolitom ispitan je test taloživosti. Rezultati pokazuju da je kod veće početne koncentracije KPK u početnoj kompostnoj procjednoj vodi veća količina uklonjene štetne tvari te se postiže veća brzina taloženja. Ispitani su utrošci aluminijevih elektroda tijekom hibridnog procesa elektrokoagulacije i prirodnog zeolita te su izračunati operativni troškovi.In this paper, the integrated process of electrocoagulation and natural zeolite was applied for compost leachate treatment. The influence of the initial chemical oxygen demand (COD) concentration of compost leachate on the removal efficiency of harmful substances monitored through COD and turbidity was investigated. The experiments were performed in an electrochemical cell, using aluminum electrodes, at a constant electrode distance of 3 cm and at stirring speed of 70 rpm. During the experiment, the change in pH, temperature and electrical conductivity was measured, and at the beginning and end of the experiment, turbidity, total solids, and COD were determined. After conducting an experiment of integrated electrocoagulation with natural zeolite, a settling test was examined. The results show that higher initial concentration of COD in the compost leachate induce higher amount of removed harmful substances and higher settling rate. The consumption of aluminum electrodes during the hybrid process of electrocoagulation and natural zeolite was analyzed, and operation costs were calculated
Equilibrium adsorption of copper ions from copper (II) chloride on humus : master thesis
No full textIspitana je adsorpcija bakrovih iona na prosijanom humusu u ovisnosti o različitim početnim koncentracijama otopina bakrovih iona (2,664 mmol dm-3, 4,244 mmol dm-3, 6,203 mmol dm-3, 8,013 mmol dm-3 i 9,949 mmol dm-3). Eksperiment je proveden pri stalnoj temperaturi od 308 K i brzini okretaja od 200 okr min-1, u trajanju od 96 h te veličini čestica < 500 μm. Početne i ravnotežne koncentracije bakrovih iona u otopini bakrovog(II) klorida, c0 i ce, izmjerene su mjerenjem na UV/VIS spektrofotometru pri valnoj duljini od 815 nm. Na temelju dobivenih rezultata može se zaključiti kako se količina adsorbiranih bakrovih iona (qe) neznatno mijenja s porastom početne koncentracije bakrovih iona u otopini (c0), a svoju maksimalnu vrijednost dostiže pri početnoj koncentraciji od 8,013 mmol dm-3 te iznosi qe = 0,495 mmol g-1 za uvjete pri kojima je eksperiment proveden. Najviši učinak adsorpcije bakrovih iona postignut je pri najnižoj odabranoj početnoj koncentraciji otopine bakrovog(II) klorida (c0=2,664 mmol dm-3) i iznosi 57,375% te nakon toga opada s porastom početne koncentracije bakrovih iona u otopini. Najbolje slaganje eksperimentalnih podataka s modelima izotermi pokazuje Langmuirov adsorpcijski model.The adsorption of copper ions on sieved humus was studied depending on the different initial concentrations of copper ion solutions (2.664 mmol dm-3, 4.244 mmol dm-3, 6.203 mmol dm-3, 8.013 mmol dm-3 i 9.949 mmol dm-3). The experiment was carried out at a constant temperature of 308 K, stirring speed of 200 rpm, and a particle size of < 500 μm for 96 h. The initial and equilibrium concentrations of copper ions in the copper(II) chloride solution, c0 and ce, were measured by measuring on a UV/VIS spectrophotometer at a wavelength of 815 nm. Based on the results obtained, it can be concluded that the amount of copper ions adsorbed (qe) changes slightly with the increase of initial concentration of copper ions in solution (c0), reaching its maximum value at an initial concentration of 8.013 mmol dm-3 with the value of qe = 0.495 mmol g-1 for the conditions under which the experiment was conducted. The copper ions adsorption efficiency reaches its maximum value for the lowest selected initial concentration of 2.664 mmol dm-3 with the value of 57.375% and then decreases with the increase of initial concentration of copper ions in solution. The best agreement of the experimental data with the isotherm models is shown by the Langmuir adsorption model
Determination of fatty acids by GC-FID technique : diploma thesis
No full textMasne kiseline sastoje se od ravnih lanaca s parnim brojem ugljikovih atoma s karboksilnom skupinom. Grade lipide, ključna su komponenta u membranama stanica te sudjeluju u prijenosu tvari i signala u stanicama živih bića. Masne kiseline mogu se podijeliti s obzirom na zasićenost. Zasićene masne kiseline sadržavaju isključivo jednostruke veze između ugljikovih atoma, dok nezasićene masne kiseline imaju jednu ili više dvostrukih veza. Višestruko nezasićene masne kiseline koje ljudski organizam ne može sam sintetizirati nazivaju se esencijalnim masnim kiselinama. To su linolna, linolenska i arahidonska masna kiselina te ih je potrebno unositi hranom. Od esencijalnih masnih kiselina se u organizmu stvaraju nizovi omega masnih kiselina koje su od iznimne važnosti za normalno funkcioniranje organizma. Masne kiseline određuju se u obliku njihovih metilnih estera te je u tu svrhu korištena smjesa 37 metilnih estera masnih kiselina kao standard. Metoda za odjeljivanje te kvalitativno i kvantitativno određivanje razvijena je korištenjem plinske kromatografije uz plamenoionizacijski detektor (GC-FID). Metoda preporučena od strane proizvođača kolone modificirana je i optimizirana promjenom temperaturnog programa kako bi se uspješno odijelilo 37 estera masnih kiselina. Ispitivani parametri vrednovanja metode (raspon, linearnost, granica dokazivanja i određivanja, točnost, ponovljivost, srednja preciznost te prikladnost sustava) pokazali su se zadovoljavajućima. Metoda je primijenjena i na uzorke jestivih ulja te standarde masnih kiselina. Rezultati realnih uzoraka ukazali su na važan korak pripreme uzorka te je uočeno da je nužno poboljšati korak esterifikacije masnih kiselina u uljima.Fatty acids consist of straight chains with an even number of carbon atoms with a carboxyl group. They build lipids, are a key component in cell membranes and participate in the transmission of substances and signals in the cells of living beings. Fatty acids can be divided according to saturation. Saturated fatty acids contain only single bonds between carbon atoms, while unsaturated fatty acids have one or more double bonds. Polyunsaturated fatty acids that the human body cannot synthesize on its own are called essential fatty acids. These are linoleic, linolenic and arachidonic fatty acids and must be consumed with food. From essential fatty acids, series of omega fatty acids are created in the body, which are extremely important for the normal functioning of the body. Fatty acids are determined in the form of their methyl esters, and for this purpose a mixture of 37 methyl esters of fatty acids was used as a standard. The method for separation and qualitative and quantitative determination was developed using gas chromatography with a flame ionization detector (GC-FID). The method recommended by the column manufacturer was modified and optimized by changing the temperature program to successfully separate 37 fatty acid esters. The examined parameters of the evaluation of the method (range, linearity, limit of proof and determination, accuracy, repeatability, mean precision and suitability of the system) proved to be satisfactory. The method was also applied to edible oil samples and fatty acid standards. The results of real samples indicated an important step of sample preparation and it was observed that it is necessary to improve the step of esterification of fatty acids in oils
DETERMINATION OF FUNCTIONAL COMPOUNDS IN COFFE AND ITS BY-PRODUCTS : bachelor thesis
No full textPrženje kave, jednog od najpopularnijih napitaka na svijetu, stvara značajne nusproizvode, poput ljuski, čija upotreba ima potencijal smanjenja negativnih utjecaja na okoliš. U ovom istraživanju analiziran je sastav masnih kiselina i aminokiselina u nusproizvodima (BP), te u sirovoj (BR), svijetlo prženoj (LR) i tamno prženoj (DR) kavi. Dominantne masne kiseline u tim uzorcima uključuju C18:2, C16:0, C18:1 i C18:0. U LR i DR uzorcima, nezasićene masne kiseline, osobito C18:2 i C18:1, činile su 52,11-53,95% ukupnih masnih kiselina, dok su u BP uzorcima bile prisutne u manjoj mjeri, oko 35%. BR kava sadržavala je pretežno zasićene masne kiseline, s C16:0 kao najdominantnijom (66,84%). Dodatno, masne kiseline kao što su C20:0, C21:1, C20:4 i C22:0 bile su uglavnom prisutne u BP uzorcima, s visokim udjelom C22:0 od 17,01%. Analiza aminokiselina pokazala je manje razlike između BR, pržene kave i BP, pri čemu su glutamin (15,81-20,16%) i glicin (12,71-14,88%) bili najzastupljeniji. BR kava imala je nešto više arginina, treonina (10,59%) i lizina (2,98%). Iako su profili aminokiselina slični, koncentracija u BP bila je 2,5 do 3 puta niža. Nusproizvodi kave pokazuju potencijal kao jeftin izvor masti i aminokiselina te bi mogli biti korisni kao funkcionalni sastojak hrane.Roasting coffee, one of the most popular beverages in the world, creates significant by-products, such as husks, the use of which has the potential to reduce negative environmental impacts. In this research, the composition of fatty acids and amino acids in by-products (BP), and in raw (BR), light roasted (LR) and dark roasted (DR) coffee was analyzed. The dominant fatty acids in these samples include C18:2, C16:0, C18:1, and C18:0. In LR and DR samples, unsaturated fatty acids, especially C18:2 and C18:1, accounted for 52.11-53.95% of total fatty acids, while in BP samples they were present to a lesser extent, around 35%. BR coffee contained mostly saturated fatty acids, with C16:0 as the most dominant (66.84%). Additionally, fatty acids such as C20:0, C21:1, C20:4 and C22:0 were mostly present in BP samples, with a high proportion of C22:0 at 17.01%. Amino acid analysis showed smaller differences between BR, roasted coffee and BP, with glutamine (15.81-20.16%) and glycine (12.71-14.88%) being the most abundant. BR coffee had slightly more arginine, threonine (10.59%) and lysine (2.98%). Although the amino acid profiles were similar, the concentration in BP was 2.5 to 3 times lower. Coffee by-products show potential as a cheap source of fats and amino acids and could be useful as a functional food ingredient
Formation of volatile compounds during the production of Dalmatinska pečenica : bachelor thesis
No full textDalmatinska pečenica je tradicionalni dimljeni suhomesnati proizvod od svinjskog mesa koji ima značajnu ulogu u kulturnoj baštini i gastronomiji Hrvatske. Tehnološki proces proizvodnje uključuje niz operacija među kojima se ističu soljenje, dimljenje te sušenje i zrenje, tijekom kojih nastaje specifična i prepoznatljiva aroma. Cilj ovog rada bio je pratiti formiranje aromatičnog profila kroz određivanje hlapljivih spojeva u pojedinoj fazi tehnološkog procesa proizvodnje. Izolacija hlapljivih spojeva iz uzoraka provedena je metodom mikroekstrakcije vršnih para na krutoj fazi (HS-SPME) a identifikacija istih primjenom plinske kromatografije-spektrometrije masa. U svježem i soljenom uzorku najzastupljenija skupina hlapljivih spojeva su bili aldehidi. Među njima je najdominantniji heksanal koji je nastao oksidacijom linolne kiseline. U uzorku dimljene i sušene pečenice očekivano najzastupljenija skupina su bili fenoli, porijeklom iz dima. Među njima najviši udio je imao 2-metoksi fenol. Dobiveni rezultati ukazuju na kompleksnost kemijskih reakcija kojima nastaju hlapljivi spojevi koji doprinose specifičnom aromatičnom profilu Dalmatinske pečenice te održavaju njenu kvalitetu i prepoznatljivost.Dalmatinska pečenica is a traditional smoked, dry-cured pork meat product that plays a significant role in Croatia's cultural heritage and gastronomy. The technological process involvesseveral operations, including salting, smoking, drying and ripening which create a specific and recognizable aroma. The aim of this study was to investigate the formation of the aromatic profile through the determination of volatile compounds in a particular phase of the technological production process. The volatile compounds were isolated from samples by solid phase microextraction (HS-SPME) and their identification using the gas chromatography-mass spectrometry system (GC-MS). In the fresh and salted sample, aldehydes were the most abundant group of volatile compounds. Among them, hexanal formed by the oxidation of linoleic acid was the predominant. In smoked sample, phenols, originating from smoke, were expectedly the most represented group of volatiles. Among them, 2-methoxyphenol had the highest proportion. The results obtained indicate the complexity of chemical reactions that produce volatile compounds that contribute to the specific aromatic profile of Dalmatinska pečenica and maintain its quality and recognizability