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Dynamics of multispecies biofilm growth at the water-air interface
No full textViševrsni biofilm mikrobna je zajednica koja se sastoji od više različitih mikrobnih vrsta. Na granici voda-zrak mikroorganizmi formiraju biofilm. U istraživanju se prati stvaranje viševrsnog biofilma kvasca Saccharomyces cerevisiae te bakterija Acinetobacter baumannii, Acinetobacter junii, Staphylococcus aureus i Bacillus cereus. Svi organizmi iz istraživanja sudjelovali su u stvaranju biofilma. Stvoreni biofilmovi bili su kod određenih organizama izraženiji i formirani u kraćem vremenskom periodu. Iz formiranog biofilma mikroorganizmi su se kretali duž staklene, nehranjive podloge. Bakterije Acinetobacter junii, Acinetobacter bauamnnii, Bacillus cereus i Staphylococcus aureus duž stakalca su se kretale samostalno ili zajedno s bakterijom druge vrste. Kvasci Saccharomyces cerevisiae duž stakalca se kreću zajedno s drugim bakterijama. Istraživala se ovisnost organizama u pokretljivosti te interakcije prokariota i eukariota unutar viševrsnog biofilma. Kod fosfat-akumulirajućih bakterija pomoću fluorescencijskog mikroskopa proučavala se brojnost polifosfata u stanici te njihov utjecaj na pokretljivost bakterija.A multispecies biofilm is a microbial community consisting of various microbial species. Microorganisms at the water-air interface form biofilms. The research focuses on observing the formation of multispecies biofilm involving yeast Saccharomyces cerevisiae and bacteria Acinetobacter baumannii, Acinetobacter junii, Staphylococcus aureus, Bacillus cereus. All organisms in the study contributed to the biofilm formation. Biofilms created by certain organisms were more present and formed in a shorter time frame. Microorganisms within the formed biofilm moved along the glass, non-nutritive surface. The bacteria Acinetobacter junii, Acinetobacter baumannii, Bacillus cereus and Staphylococcus aureus moved along the glass independently or together with bacteria of another species. Yeast Saccharomyces cerevisiae along the glass moves with other bacteria. The research investigated the dependence of organisms on mobility and the interaction between prokaryotes and eukaryotes within the multispecies biofilm. Using a fluorescence microscope, the study examined the abundance of polyphosphates in the cell and their impact on bacterial mobility in phosphate-accumulating bacteria
Funkcionalna analiza gena povezanih s glikozilacijom imunoglobulina G
No full textImmunoglobulin G (IgG) is a key player in the human immune system. Pletohora of its roles is determined by its alternative N-glycosylation of Fc region, which has a role in defining its pro- or antiinflamatory character. Except Fc region, 20-25% of IgG molecules are glycosylated on the Fab region. Genome-wide association studies (GWAS) showed that IgG glycosylation is regulated by a complex gene network including genes with roles in immune cell development and immune response. However, role of these genes in IgG glycosylation is unknown. Therefore, twenty-three of GWAS hits were selected for functional validation in a model system FreeStyle™ 293-F with VPR-dSaCas9 and KRAB-dSpCas9 stably integrated in the genome. This system was modified for simultaneous analysis of Fab and Fc glycosylation followed by gene manipulation. Ten genes were functionally proven to be relevant for Fab and/or Fc glycosylation: KIF3C, MANBA, TNFRSF13B, EEF1A1, HIVEP2, TBX21, SPPL3, DERL2, RRBP1, and KDELR2.Imunoglobulin G (IgG) jedan je od ključnih igrača u imunom sustavu čovjeka s velikim brojem različih uloga koje su određene altrernativnom N-glikozilacijom njegove Fc regije, uključujući njegovo proupalno ili protuupalno djelovanje. Izuzev regije Fc, 20-25% molekula IgG je glikozilirano na regiji Fab. Cjelogenomske studije povezanosti (engl. genome wide association studies, GWAS) su otkrile da je glikozilacija IgG-a regulirana kompleksnom mrežom gena koja uključuje gene s ulogom u razvoju imunoloških stanica i imunološkim odgovorima, čija uloga u IgG glikozilaciji nije poznata. Dvadesettri gena otkrivenih studijama GWAS odabrano je za funkcionalnu validaciju u staničnom modelu FreeStyle™ 293-F sa stabilno ugrađenim fuzijama VPR-dSaCas9 i KRAB-dSpCas9 za manipulaciju gena, a koji je modificiran u svrhu istovremene analize glikozilacije regija Fab i Fc. Rezultat ovog istraživanja otkriva deset gena (identificiranih studijama GWAS) s ulogom u Fab i/ili Fc glikozilacijskom putu: KIF3C, MANBA, TNFRSF13B, EEF1A1, HIVEP2, TBX21, SPPL3, DERL2, RRBP1 i KDELR2
The expression of IL1B and CXCR4 genes in EGFR-positive non-small cell lung cancer
No full textKarcinom pluća vodeći je uzrok smrtnosti povezane s tumorima u svijetu. Ovisno o molekularnim
karakteristikama, karcinom pluća dijeli se na podtipove, a njihova precizna karakterizacija nužna
je za primjenu ciljane, što efikasnije terapije. Za jedan od podtipova karcinoma pluća nemalih
stanica, adenokarcinom, osobito je važna mutacija gena EGFR. Vodeća mutacija u genu za receptor
epidermnog faktora rasta definira podtip karcinoma pluća, a povezana je i s promjenama u
tumorskom mikrookolišu. Interakcija stanica tumorskog mikrookoliša putem brojnih signalnih
molekula ključna je za imunosni odgovor organizma na tumor, a uključena je i u odgovor na
terapiju. U ovom radu istražena je ekspresija interleukina-1β i kemokina CXCR4 koji su dio
imunosnog odgovora kod pacijenata s karcinomom pluća. Kako bi se utvrdila potencijalna
povezanost između ekspresije gena IL1B, koji kodira proupalni citokin interleukin-1β, i gena
CXCR4, koji kodira kemokinski receptor 4, s mutacijom u genu EGFR, izolirana je RNA iz uzoraka
karcinoma pluća nemalih stanica koji ima mutaciju gena EGFR, provedena je reverzna
transkripcija te je lančanom reakcijom polimerazom u stvarnom vremenu utvrđena razina
ekspresije tih dvaju gena. Dobiveni podaci uspoređeni su s podacima za karcinom pluća nemalih
stanica koji nema mutaciju gena EGFR i pokazano je da je ekspresija gena IL1B i CXCR4 statistički
značajno niža kod tumora s mutacijom.Lung cancer is the leading cause of cancer-related mortality worldwide. There are several subtypes
of lung cancer, depending on molecular characteristics, which must be precisely characterized to
apply targeted, most efficient possible therapy. Adenocarcinoma, one of the subtypes of non-small
cell lung cancer, is often characterized by the mutation of the EGFR gene. This driver mutation in
the epidermal growth factor not only defines a specific subtype of cancer but is also associated with
specific changes in the tumor microenvironment. Cells of the tumor microenvironment
communicate through an intricate net of signaling molecules which is crucial for the body’s
immune response to the tumor and the tumor’s response to therapy. In this thesis, the expression
of interleukin 1β and chemokine CXCR4, both part of the immune response, is investigated. To
determine a potential association between their expression and the EGFR gene mutation, RNA was
isolated from non-small cell lung cancer samples, reversely transcribed into cDNA with which
polymerase chain reaction in real time was performed. Expression levels of these genes were also
compared to the data for non-small cell lung cancer lacking the EGFR mutation. It was shown that
the expression of the IL1B and CXCR4 genes is significantly lower in the tumors with the EGFR
gene mutation
Correlations and dynamics in many-body non-Hermitian systems
No full textOvaj rad istražuje međuigru temeljnih aspekata nehermitske kvantne mehanike i međudjelovanja čestica primjenom Bose-Hubbard modela s asimetričnim amplitudama preskoka i odbojnim interakcijama. U prvom dijelu analiziramo sustav s malim brojem bozona te pomoću računa smetnje i numeričkih metoda istražujemo razlike u odnosu na hermitski i jednočestični nehermitski slučaj. U nastavku proučavamo suprafluid-Mott izolator fazni prijelaz te ispitujemo kako nehermitska priroda sustava utječe na kritičnu vrijednost interakcije potrebnu za taj prijelaz.This thesis investigates the interplay between fundamental aspects of non-Hermitian quantum mechanics and particle interactions through the Bose-Hubbard model with asymmetric hopping and repulsive interaction. In the first part, we analyze a system with a small number of bosons and use perturbation theory and numerical methods to explore the differences compared to the Hermitian and single-particle non-Hermitian case. In the second part, we study the superfluid–Mott insulator phase transition and examine how system's non-Hermicity affects the critical value of interaction required for the transition to happen
Genetic and population characteristics of stone crayfish Austropotamobius torrentium (Schrank, 1803) in Sušik cave
No full textPotočni rak, Austropotamobius torrentium (Schrank, 1803), autohtona je i najmanja vrsta slatkovodn ih
deseteronožnih rak ova u Europi i prioritetna vrsta Europske unije. P odručje sjevernih centralnih
Dinarida , uključujući Hrvatsku , prepoznato je kao centar raznolikosti vrste Cilj rada bio je istražiti
genetske i populacijske značajke neistražene populacije ponora Sušik , jednog od rijetkih nalaza ove
vrste u podzemlju . U razdoblju od srpnja do listopada populacija na početnom dijelu ponora je istražena
metodo m označavanja i ponovnog ulova . Svakoj ulovljenoj jedinki određeni su spol, dužina i težina.
Kod ukupno 30 jedinki uzet je jedan pereopod za potrebe genetskih analiza. Tijekom istraživanja,
ulovljena je 181, a označene 153 jedinke. Veličina populacije procijenjena je na 1,01 jedinki / m 2 .
Populacija je stabilna, s ujednačenim omjerom mužjaka i ženki i stabilnom uzrasnom strukturom u kojoj
su zastupljeni svi veličinski razredi. Zabilježena su odstupanja od godišnjeg ciklusa koja potencijalno
pokazuju prilagodbu populacije na špiljski okoliš. Analizom mitohondrijskog gena COI , utvrđena je
pripadnost populacije postojećim haplotipovima 44 i 45, te potencijalno postojanje dva nova haplotipa.
Analiza osam mikrosatelitnih markera pokazala je izoliranost populacije, nepostojanje protoka gena te
vel iku vrijednost privatnih alela što ukazuje na genetsku jedinstvenost populacije . Rezultati rada temelj
su za buduće usporedbe podzemnih i nadzemnih populacija okolice.The stone crayfish, Austropotamobius torrentium (Schrank, 1803), is the smallest native European freshwater crayfish and a priority species on the European union’s Habitats Directive. Northern central Dinarides are recognized as its biodiversity hotspot. The aim of this study was to determine genetic and population characteristics of the stone crayfish in cave Sušik, one of its rare underground populations. Between July and October of 2023, a total of 181 individuals were caught at the mouth of cave Sušik and their sex, length and weight were measured. Of those, 153 were marked to conduct the mark and recapture method. Pereopods were removed from 30 specimens for further genetic analysis. The population is stable, with an estimated size of 1.01 individuals / m2, and with even distribution of sexes and size classes. A deviation from the usual year cycle was noted, possibly indicating an adaptation to subterranean environment. Analysis of mitochondrial COI gene placed the individuals within two existing haplotypes with the possibility of existence of two new ones. Microsatellite analysis established poor gene flow but high number of private alleles, pinpointing isolation of the studied population. The results of this thesis provide baselines for further comparisons of populations above and below ground
Vimentin expression in nefrotoxic epithelial-mesenchymal transition caused by cysplatine in Wistar rat
No full textCisplatina je jedan od najčešćih kemoterapeutika u liječenju solidnih tumora.Vezanje cisplatine za DNA uzrokuje smrt neoplazmi, dok je nefrotoksičnost glavna negativna strana terapije. U štakorskom modelu nefrotoksičnosti cisplatine dolazi do oštećenja ravnog dijela proksimalnog kanalića (PK). Epitelno-mezenhimalna tranzicija (EMT) se očituje jedinstvenim molekulskim i morfološkim promjenama, pri čemu stanice mijenjaju ekspresiju proteina, gube polarnost, diferenciranost i funkciju epitelne barijere. Prethodno uočene promjene citoskeleta aktina i tubulina u epitelnim stanicama PK uz promjenu ekspresije intermedijarnog proteina vimentina ukazale bi da li se u nefrotoksičnosti cisplatine zbiva EMT. Korišteni su arhivski uzorci modela nefrotoksičnosti nakon jednokratne obrade cisplatinom (i.p. u dozi 5 mg/kg) mužjaka štakora soja Wistar. Najizraženiji učinak toksičnosti javlja se 5. dan nakon tretmana, a pratio se i vremenski tijek u kojem EMT nastaje. Praćenje raspodjele vimentina rađeno je imunofluorescencijski na tkivnim rezovima. Prisutnosti vimentina praćena je u homogenatima tkiva bubrega analizom western blot, dok se promjena u ekspresiji glasničke RNA pratila end- point RT-PCR tehnikom. Pojava ekspresije vimentina uočena je kroz vremenski tijek (3. dan) u tkivnim rezovima te je nađena promjena u prisutnosti proteina u homogenatima tkiva 5. dan. Nefrotoksičnost cisplatine još nije u potpunosti razjašnjena, a naši rezultati pokazuju uključenost EMT koja može objasniti gubitak funkcije bubrega i uputiti na mehanizme obrane od sekundarnih tumora i nefrotoksičnosti kod pacijenata tretiranih cisplatinom.In the treatment of solid tumors, one of the most common chemotherapeutic agents is cisplatin. The binding of cisplatin to DNA causes the death of neoplasms, while nephrotoxicity is the main downside of this therapy. In a rat model of cisplatin nephrotoxicity, damage even part of the proximal tubule (PK) occurs. Epithelial-mesenchymal transition (EMT) manifests itself through unique molecular and morphological changes, wherein cells undergo alterations in protein expression, lose polarity, differentiation, and epithelial barrier function. Previously observed cytoskeletal changes in actin and tubulin in PK epithelial cells, along with a change in the expression of intermediate protein vimentin, would indicate whether EMT occurs in cisplatin nephrotoxicity. Archival nephrotoxicity model samples were used after a single treatment with cisplatin (i.p. at a dose of 5 mg/kg) in male Wistar rats. The most pronounced toxicity effect occurs on the 5th day after treatment, during which the time course of EMT was also monitored. Vimentin distribution was observed through immunofluorescence on tissue sections. The presence of vimentin was monitored in the homogenates of kidney tissue by western blot analysis, while changes in the expression of messenger RNA were monitored using endpoint RT-PCR technique. The appearance of vimentin expression was observed over time (day 3) in tissue sections, and a change in the presence of proteins in tissue homogenates was found on day 5. The nephrotoxicity of cisplatin has not yet been fully elucidated, and our results indicate an involvement of EMT that can explain the loss of kidney function, pointing to defense mechanisms against secondary tumors and nephrotoxicity in patients treated with cisplatin
Expression of Hedgehog GLI signaling pathway members in primary human head and neck tumor cell lines
No full textSignalni put Hedgehog-GLI (HH-GLI) je ključan u embrionalnom razvoju čovjeka i drugih sisavaca, a u odraslom organizmu aktivan je samo u održavanju matičnih stanica i cijeljenju rana. Transkripcijski faktori GLI mogu doprinijeti nenormalnoj funkciji ili regulaciji signalizacije što često dovodi do razvoja karcinoma kao što je karcinom pločastih stanica glave i vrata (HNSCC). On obuhvaća tumore koji nastaju u usnoj šupljini, grkljanu, gornjem, srednjem i donjem dijelu ždrijela i žlijezdama slinovnicama te po zastupljenosti predstavlja 6% svih karcinoma u ljudskoj populaciji s izuzetno visokim postotkom smrtnosti. Ovo istraživanje imalo je za cilj proučavanje tumorskih stanica stvaranjem primarnih staničnih linija. Uspoređivali smo gene signalnog puta HH-GLI u tim staničnim linijama s onima u tumorima iz kojih potječu. Također, testirali smo određene inhibitore signalnog puta HH-GLI kako bi se uvidio njihov utjecaj na ekspresiju gena i proteina. Osim toga, usporedili smo dobivene rezultate s onima dobivenim drugim istraživanjem na komercijalnim staničnim linijama. Utvrđeno je da inhibitori, poput LiCl, GANT61 i ATO, različito utječu na signalni put HH-GLI. Konkretno, primijećeno je da LiCl aktivira fosforilaciju GSK3β u citoplazmi, dok GANT61 i ATO, kada se nalaze u jezgri stanice, djeluju izravno na faktore transkripcije. Razumijevanje i manipuliranje tim molekularnim mehanizmima moglo bi utrti put inovativnim terapijskim pristupima u borbi protiv raka povezanih s deregulacijom HH-GLI.The Hedgehog GLI (HH GLI) signaling pathway plays a crucial role in the embryonic
development of humans and other mammals. In the adult organism, its activation is limited to
the stem cells maintenance and wound healing processes. However, dysregulation of GLI
transcription factors in this pathway can lead to aberrant signaling, often contributing to the
development of cancers, such as head and neck squamous cell carcinoma (HNSCC). HNSCC
encompasses tumors arising in various regions, including the oral cavity, larynx, pharynx
(upper, mi ddle, and lower parts), and s alivary glands. It constitutes approximately 6% of all
cancers and is associated with a particularly high mortality rate. This research aimed to study
tumor cells by creating primary cell lines. We compared the HH GLI pathway genes in these
cell lines with those in the tumors they originated from . We also tested certain inhibitors on a
HH GLI pathway to see how they affected expression of genes and proteins. We also compared
our results with another study on commercial cell line s. The inhibitors, like LiCl, GANT61, and
ATO, were found to impact the HH GLI pathway differently. Specifically, LiCl was observed
to activate GSK3 β phosphorylation in the cytoplasm, while GANT61 and ATO, when located
in the cell nucleus , act directly towards influencing transcription factors . Understanding and
manipulating these molecular mechanisms could pave the way for innovative therapeutic
approaches in fighting cancers associated with HH GLI dysregulation
Determining the minimum of quality of life: Case study of Krapina-Zagorje County
No full textOvaj rad problematizira kvalitetu života u Krapinsko-zagorskoj županiji. Hijerarhijskom klaster analizom naselja Županije grupirana su u šest klastera (tipova) naselja prema broju i dostupnosti usluga od općeg interesa. Kako bi se identificirale potrebe stanovništva, korištena je mješovita metodologija, koja podrazumijeva primjenu kvalitativnih i kvantitativnih metoda, odnosno fokusnih skupina i anketnog istraživanja. Iako minimum kvalitete života predstavlja nešto elementarno i nužno za život, aspekti koji ga čine variraju ovisno o klasteru stanovanja i potrebama stanovništva. Kvalitetom života u Krapinsko-zagorskoj županiji ispitanici su generalno zadovoljni; ona uglavnom koincidira s brojem i dostupnošću usluga od općeg interesa – što je naselje opremljenije uslugama, to je kvaliteta života veća. Ipak, uočena je iznimka u smanjenom zadovoljstvu u onim klasterima koji su opremljeniji uslugama, a u bliskoj prošlostisu zabilježili pad broja usluga od općeg interesa. Usluge od općeg interesa imaju snažan kohezivni učinak – one okupljaju stanovništvo i doprinose zajednici, dok njihovo gašenje utječe na (sve manju) socijalizaciju te gubitak osjećaja mjesta i zajedništva. Najveće prednosti života u Županiji predstavljaju sigurnost naselja, odnosno mogućnost neometanog kretanja javnim prostorom te blizina prirode kao mjesta provođenja slobodnog vremena. S druge strane, kao najveći nedostatak ističe se loša povezanost javnim prijevozom, koji igra važnu ulogu u dostupnosti usluga nužnih za svakodnevno funkcioniranje kod onih koji nemaju pristup osobnom automobilu.This paper examines the quality of life in Krapina-Zagorje County. Using hierarchical cluster analysis, the County’s settlements were grouped into six clusters (types) based on the number and accessibility of services of general interest. In order to identify the population's needs, a mixed-methods approach was applied, combining qualitative and quantitative methods, specifically focus groups and surveys. While the minimum of quality of life represents something fundamental and necessary for living, the aspects that constitute it vary depending on the cluster and the needs of the population. Respondents are generally satisfied with the quality of life in Krapina-Zagorje County, which largely coincides with the number and availability of services of general interest— the better a settlement is equipped with services, the higher the quality of life. However, an exception was observed in clusters that are well-equipped with services but have experienced a decline in the number of services of general interest in recent years, leading to decreased satisfaction. Services of general interest have a strong cohesive effect – they contribute to the community, while their ceasing negatively impacts socialization and leads to a loss of sense of place and belonging. Key advantages of Krapina-Zagorje County include the safety of its settlements, which allows for free movement in public spaces, as well as its proximity to nature, regarded as a recreational space. On the other hand, the most significant drawback is the lack of efficient public transport services, which are crucial for accessing essential services, particularly for those without access to private vehicles
Seismogeological interpretation of a basinal succession of a prograding delta (Pannonian, eastern part of the Drava depression)
No full textU ovom radu su analizirani i interpretirani seizmogeološki podatci iz pet bušotina sa područja istočne Hrvatske, radi boljeg razumijevanja geološke prošlosti i prepoznavanja geoloških resursa. Pri tome je korišten 3D seizmički volumen popraćen geofizičkim podatcima mjerenja u pet bušotina kao i geološki podatci prikupljeni istražnim radovima u bušotini. Od geofizičkih podataka u bušotinama za korelaciju istraživanih naslaga korištene su karotažne krivulje spontanog potencijala, RT otpora i prirodne gama radioaktivnosti. Interpretirano je devet horizonata od kojih je izdvojeno četiri kao relevantnih za istraživanje. Za četiri izdvojena horizonta napravljene su strukturne vremenske karte i karte Root mean square atributa i atributa koherencije. Napravljene karte pokazuju prisutnost kanala i taložnih formi okarakteriziranih kao sediment waves (pješčani valovi). Analizom podataka bušotinskih jezgri i krivulja spontanog potencijala dokazana je prisutnost pretežito lapora i turbidita na području istraživanja. Svi rezultati upućuju na postojanje rezervoarskih stijena koje bi mogle imati dobro zatvaranje.This work focuses on the analysis of seismo-geological data from five wells drilled in eastern Croatia, with the goal of better understanding the geological history and identifying geological resources in the area. The work presented in this thesis integrates 3D seismic data, well data and geological data from well cores. Well data used in the work are wellbore logs of spontaneous potential (SP), resistivity, and gamma ray. From nine horizons interpreted in this work, four were selected as important for the research. Structural time maps, Root Mean Square (RMS) maps, and coherence maps were made for each of the selected horizons. The maps show the existence of channels and sedimentary forms characterized as sediment waves. Core data and SP logs have proven the existence of mostly marls and turbidites in the research area. The results suggest the existence of reservoir rocks that could have a good seal in regard of potential hydrocarbon research
NMR istraživanje kvantne kritičnosti u Ce3Pd20Si6 i m-PhNO2BNO sustavima
No full textThe studied heavy fermion Ce3Pd20Si6 (CPS) and the quantum magnetic m-PhNO2BNO (BoNO) systems feature a rich phase diagram at low temperatures due to competing electronic interactions. This NMR/NQR study reveals the microscopic structure of magnetically ordered phases and characterises the quantum phase transitions (QPTs). Both systems can be driven through quantum critical points (QCPs) using an external magnetic field, with similar effects observed in other systems under hydrostatic pressure or doping. Near the QCP, strong quantum fluctuations lead to the formation of quantum critical matter, hypothesised to have a universal description. With two distinct cerium magnetic moments in CPS, antiferroquadrupolar (TQ = 470 mK) and antiferromagnetic (TN = 250 mK) orders are observed at low temperatures. Neutron scattering research links the magnetic activity to cerium moments at the Ce(8c) position, and CPS shows a Kondo-breakdown QCP, where magnetic order suppression coincides with Fermi surface reconstruction. We investigated CPS using 105Pd NQR and 29Si NMR, determined the quadrupolar coupling parameters νQ and η, and found no conventional magnetic order down to 70 mK. However, temperature-dependent relaxation rates suggest the presence of two Kondoscreening energy scales, with no sign of quantum criticality at low temperatures, implying an unobserved magnetic order between Ce(4a) moments. BoNO, an organic biradical, forms an effective S =1 Haldane state, confirmed by bulk magnetisation and X-band EPR measurements. We investigated its magnetic field-induced long-range ordered (LRO) phase using 1H NMR, determining critical exponents consistent with a 3D-XY antiferromagnetic QPT (ν = 2/3). In the gapless phase, nuclear relaxation rates align with the Tomonaga-Luttinger liquid model. The staggered magnetic moment evolution in the LRO regime matched the mean-field and Quantum Monte Carlo (QMC) predictions, though slight discrepancies suggest magnetostriction effects under an external magnetic field. Finally, we compared BoNO with other field-induced Bose-Einstein condensate systems and used the standard scaling relations to describe quasiparticle behaviour in the quantum critical region.U ovom su radu istraživani spojevi iz klase sustava teških fermiona i kvantnih magneta, Ce3Pd20Si6 (CPS) i m-PhNO2BNO (BoNO). Proučavana je njihova struktura, struktura magnetski uređenih faza, spinska dinamika i priroda uočenih faznih prijelaza. Kvantni fazni prijelazi (KFP) pojavljuju se pri temperaturama od T = 0 K kada zbog suprotstavljenih elektronskih interakcija sustav mijenja svoje osnovno stanje. KFP proučavani u ovom radu mijenjaju osnovno stanje sustava iz magnetski uređenoga (antiferomagnetskog) u neuređeno paramagnetsko i/ili metalno stanje (Fermijeva tekućina). Tehnikom nuklearne magnetske i kvadrupolne rezonancije okarakterizirana su magnetski uređena stanja u ovim sustava, te kvantni fazni prijelaz kada primjenom vanjskog magnetskog polja sustave tjeramo kroz kvantnu kritičnu točku (KKT). U sličnim sustavima kvantni fazni prijelazi su također inducirani primjenom hidrostatičkog tlaka ili kemijskog dopiranja. Univerzalni teorijski opis kvantno kritičnog ponašanja u blizini KKT neovisan je o eksperimentalnoj realizaciji (tj. uzorku) kvantnog magnetskog sustava. Poznato je da takav univerzalni opis ovisi isključivo o dimenzionalnosti sustava i prirodi osnovnih stanja (magnetsko uređenje, orbitalno uređenje) s obje strane KKT