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"There isn’t one or two influencing factors that lead to crime and substance use”, A qualitative interview study on the experienced impact of the social growth environment on juvenile delinquency
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Mobile health interventions on vaccination coverage among children under 5 years of age in Low and Middle-Income countries; a scoping review
No full textObjectives: Increased mobile phone use in Low- and Middle-Income countries (LMIC) has led to suggestions that health interventions using mobile phones can help solve some health problems. Vaccination has been shown to be an effective means of improving health outcomes. However, vaccination coverage in many LMIC has been generally low. The aim of this study was to synthesize evidence concerning the context, mechanisms, and outcome elements of mobile health interventions in improving vaccination coverage among children under 5 years of age in LMIC.
Methods: A search conducted using PubMed, Web of Science, ScienceDirect, CINAHL, Embase, and the Cochrane library led to 27 studies included in the final analysis out of 357 identified articles.
Results: Twenty-one studies were from Africa, four from Asia and two studies were from Latin America and the Caribbean. Short Message Service (SMS) intervention was used exclusively in 21 studies while six studies used a combination of SMS and phone calls, and one intervention was based only on phone calls.
Conclusion: The results from most studies suggest an improved uptake of vaccination with mobile health interventions. However, there is a need for further research to quantify the impact of these interventions and determine the most effective strategies
Circular RNA circ_0061183 regulates microglial polarization induced by airborne ultrafine particles in HMC3 cells via sponging miR-98-5p
No full textAirborne ultrafine particulate matter (PM0.1) can enter the brain, induce microglia activation, and promote the development of Alzheimer’s disease (AD). Circular RNAs (circRNAs) are also involved in AD pathogenesis. However, the role of AD-related circRNAs in PM0.1-induced microglia activation remains unclear. Therefore, we explore cytotoxicity, microglia activation, and AD-associated circRNA expression in human microglial HMC3 cells treated with PM0.1, and further examined circRNA expression in mice and cognitively impaired individuals. The results revealed that PM0.1 exposure decreased cell viability, increased lactate dehydrogenase activity, caused microglia activation, elevated microglial M1 maker expression, downregulated microglial M2 maker expression, and reduced AD-related circ_0061183 expression in vitro. Functionally, circ_0061183 silencing enhanced microglia activation and microglial M1 polarization, but inhibited microglial M2 polarization. Mechanistically, circ_0061183 can bind to miR‐98‐5p to co-regulate M2 microglial-related IL10 expression, which may affect transforming growth factor-β signaling to regulate PM0.1-inhibited microglial M2 polarization. Moreover, circ_0061183 downregulation was observed in the brain of PM2.5-exposed mice and AD mice and in the blood of cognitively impaired individuals. Furthermore, circ_0061183 was positively related to mini–mental state examination scores and amyloid-β42 peptide expression in elderly individuals. Overall, the current work offers epigenetic insights into the regulatory mechanisms of circRNAs on microglial activation caused by environmental pollutants
