3855 research outputs found
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RNA disruption in response to cellular stress
No full textRNA disruption is a novel cellular phenomenon that occurs under various cellular stress conditions and has a significant impact on cellular function. This critical review essay synthesizes research findings from a range of experiments performed over several years to present a comprehensive summary of the stressors that induce RNA disruption, the impact of RNA disruption on ribosomal proteins, the potential link between RNA disruption and other cellular phenomenon (e.g., apoptosis and autophagy), the molecular mechanism and the implications for disease treatment, specifically chemotherapeutic treatment. The review also identifies the weaknesses and/or limitations of the research performed to date and suggests methods to overcome them. Future research directions are proposed to address gaps in knowledge/understanding, such as utilizing other experimental techniques (e.g., LC-MS) to elucidate the key molecules involved in RNA disruption. By providing an in-depth critical analysis and suggesting options for improvement, this review aims to guide future research and provide a deeper understanding of RNA disruption
Metabolic syndrome as a nexus of diabetes and cardiovascular disease: pathophysiological insights, epidemiological evidence, and therapeutic implications
No full textMetabolic Syndrome (MetS) constitutes a constellation of interrelated abnormalities: central obesity, insulin resistance, dyslipidemia, hypertension, and impaired fasting glucose that collectively heighten the risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). This thesis critically examines the pathophysiological mechanisms, epidemiological trends, and therapeutic strategies associated with MetS, underscoring its role as a pivotal nexus between T2DM and CVD. Key pathogenic drivers include visceral adiposity, chronic low-grade inflammation, and mitochondrial dysfunction, which perpetuate insulin resistance and metabolic imbalance. Epidemiological data emphasizes the global burden of MetS, its strong association with T2DM and CVD, and the necessity of early detection through criteria such as those established by the IDF and NCEP ATP III. Current interventions encompass lifestyle modification, pharmacotherapy (statins, SGLT2 inhibitors, GLP-1 receptor agonists), and nutraceuticals. Emerging precision medicine approaches, including metabolomics and proteomics, promise individualized therapy. Future perspectives should explore genetic susceptibility, epigenetic regulation, and gut microbiome interactions
La question de la pensée critique et des modalités de son développement chez le futur personnel enseignant francophone lors des stages en Education Physique et Santé: points de vue du personnel enseignant associé francophone de l’Ontario
Get PDFCette étude qualitative descriptive explore les perceptions du personnel enseignant associé francophone (PEAF) de l’Ontario relatives à l’utilité et / ou à l’importance de la pensée critique (PC) et les modalités de son développement chez le futur personnel enseignant (FPE) en éducation physique et santé (EPS). Elle s’inscrit dans un contexte éducatif francophone minoritaire où la PC est de plus en plus considérée comme un levier essentiel de professionnalisation. L’enquête s’appuie sur des questionnaires et des entrevues individuelles, et mobilise le paradigme de la « pensée des enseignants » (Clark & Peterson, 1986) ainsi que les modèles de supervision pédagogique réflexive comme théories de référence. Le corpus recueilli a été analysé selon un processus inductif d’analyse de contenu (Fortin et Gagnon, 2016). Les résultats révèlent des perceptions variées de la PC, des stratégies concrètes de son développement, ainsi que des défis contextuels propres aux stages en EPS. L’étude met en lumière le rôle crucial du PEAF dans la formation à la pensée critique du FPE en contexte de stage
Experiences of Anishinaabe kweok (Anishinaabe momen) accessing health care and dreams for the future
No full textThe experiences that Indigenous people have with health are impacted by their cultures and the consequences of colonization. The thesis project aims to communicate the experiences that Northern Anishinaabe kweok (Anishinaabe women) are having accessing health care, what health means to them and their dreams for the future of health. The study took place in Sudbury, Ontario. Through storytelling sessions, seven Northern Anishinaabe kweok shared their experiences. Rooted in an Anishinaabe paradigm, hermeneutic phenomenology and thematic analysis were used to understand the stories shared during the storytelling sessions. Storytellers described their conceptions of health, their experiences accessing health care, and their dreams for the future of health care. Experiences accessing health care were defined by interactions with health care providers, outcomes and the environment in which in the interactions took place. The conceptions of health described by the storytellers were influenced by the examples of health they had around them, such as observing their parents. Health was defined by cultural factors, including holism. The storytellers shared two major ways the health care system can be improved; how health care is approached and more education about culturally safe health care for providers and policy makers, as well as more education about the health and the health care system for Indigenous people and community members. The stories support the need to improve health care access and treatment for not only Anishinaabe kweok, but Indigenous people in general
Northern Lightness: a TEKnological architectural typology to help restore Anisininew health in Northwestern Ontario
No full textThis research addresses the current state of failings of architecture in remote Northern Ontario Indigenous reserves. The architectural ethos implemented in these reserves must be rectified as the poor quality of housing has created a pervasive housing and health crisis. To understand the existing crisis, this study examines the colonial impacts on the homes of Indigenous Peoples in Northern Ontario. Subsequently, Indigenous ways of living, which are rooted in community and ecological knowledge, are ex-amined. Traditional ways of living in combination with techno- logical advancements informs a hybrid approach that improves northern building performance and longevity. A primary focus is on reducing transportation costs and construction inefficiencies. While many materials for architecture are required to come from outside the community, an understanding of place and culture is used to promote culturally sustainable practices. These practices include local labour and material acquisition to improve building relevance, quality, and health
Advanced electromagnetic methods for deep mineral exploration : development of a three-component transmitter system and principal component analysis for target discrimination
No full textThe discovery of mineral deposits at increasing depths presents significant challenges for electromagnetic (EM) exploration methods. Traditional single-component transmitter systems face fundamental limitations in detection depth due to poor coupling with variably oriented conductors and low signal-to-noise ratios. This thesis addresses these challenges through two interconnected studies: the development of a novel three-component transmitter (3CTx) system and the application of principal component analysis (PCA) for differentiating conductor signatures in complex geological settings.
The first study presents the design, construction, and initial field testing of a prototype 3CTx system comprising three orthogonal, co-located transmitter loops operating simultaneously at distinct base frequencies (30, 32.5, and 35 Hz). The system was validated through three field tests, demonstrating that individual transmitter signals can be successfully separated during processing with minimal cross-coupling. Cross-coupled signals were consistently two to three orders of magnitude smaller than primary signals. When compared with data from a conventional ground-loop system over a known conductive target, the 3CTx system produced comparable results, validating the fundamental methodology.
The second study develops a PCA-based processing workflow for extracting localized conductive targets masked by dominant regional conductors. Using synthetic models generated with Maxwell plate-modeling software and a distributed array of three-component transmitters and receivers, the method successfully isolates the spatial signature of regional conductors, residual energy calculations then reveal otherwise masked local targets. Analysis of three distinct geometric configurations with 2% Gaussian noise demonstrates robust suppression of regional signatures and clear delineation of local target location and orientation. Comparison with single-component transmitter data validates that the multiplicity of data from the three-component system is critical for effective regional characterization and local target detection.
Together, these studies establish the feasibility and advantages of three-component transmitter technology for mineral exploration. The 3CTx system provides enhanced coupling to variably oriented targets, while the PCA processing method offers a data-driven approach to isolate targets in conductively complex terrains. These advances represent important steps toward improving detection capabilities for deep mineral deposits and provide a foundation for future development of operational multi-component EM systems.NSERC Discovery grant, MITACS Accelerate Internship co-funded by DIAS Geophysics
Tectonometamorphic evolution, fluid production, and evaluation of gold liberation in the Quetico metasedimentary belt, Canada
No full textThe Quetico subprovince is a prominent 1200 x 100 km tectonometamorphic belt in the north-central Superior Province and represents one of the largest exposures of siliciclastic metasedimentary rock globally. It has historically been a key feature in advancing subductionaccretion geodynamic models for Neoarchean crust, which many recent studies have challenged in favour of plume-sagduction models. Part of the confusion stems from poor constraints on the regional architecture of these belts and the nature and timing of tectonometamorphic events. Recent studies have also suggested that metasedimentary basins may represent sources of goldbearing fluids for nearby orogenic gold deposits through metamorphic devolatilization. Yet, the pressure-temperature-composition (P-T-X) conditions for fluid release and the breakdown of auriferous pyrite in these basins are poorly defined. This thesis demonstrates that the architecture of the Quetico is largely symmetrical: pre-Quetico lithotectonic units have similar composition, age, and distribution on the N and S margins; sediment layers vary from calc-semipelite-rich at the margins to pelite-rich in the interior; stratigraphy is largely outward facing; the sequence, geometry and relative timing of isograds are mirrored; and strain fabrics are consistently subvertical. Quetico sediments are richer in Ca and Na and poorer in K and Al than the typical pelite and mainly derived from a single felsic volcanic source at ~2.7 Ga. The metamorphic sequence of chlorite, biotite, garnet, staurolite + andalusite, cordierite, sillimanite, in situ melt, K-feldspar, and orthopyroxene is consistent with a single protracted clockwise P-T path that is syn-to post-regional deformation, D2. The subsolidus P-T history is characterized by burial to ~6.5 kbar/550 °C, followed by heating and decompression to ~3 kbar/600 °C. The simultaneous breakdown of calcite and muscovite in biotite zone semipelites (470–500°C/~4.5 kbar) produced a major pulse of CO2-rich fluid (XCO2 = ~0.3). Under these conditions, gold was likely liberated in the pyrite to pyrrhotite transition for weakly oxidized bulk compositions (XFe3+ ≈ 0.05–0.08). Under more oxidizing conditions, pyrite breakdown is predicted above 550 °C, and under less oxidizing conditions, pyrite is consumed at T < 350 °C, outside of any significant fluid production window. Only a small amount of H2S is added to the fluid (XH2S < 0.005) during devolatilization, as excess S from pyrite readily reacts with Fe in silicates to form additional pyrrhotite. Garnet Lu-Hf and U-Pb monazite ages constrain prograde metamorphism through the garnet to sillimanite zones from ~2680 to 2660 Ma in the western Quetico. In the eastern Quetico, metamorphism in equivalent zones appears to be ~10 Ma younger, and peak temperatures in the migmatite zones were reached simultaneously with those in the subsolidus zones. These spatiotemporal features indicate a geodynamic setting dominated by near-field sedimentation, subsidence, and advective ductile flow in the middle-upper crust, characteristic of ultra-hot orogens (UHOs). The finding providing new belt-scale insights into the thermal structure and fluid evolution of Archean transpressive UHOs.Metal Earth research initiative, Canada First Research Excellence Fund, Sudbury Integrated Nickel Operations, GoldSpot, SOQUEM, NxGold, SpaceKnow, Noront, Kirkland Lake Gold, Yorbeau Ressources Inc., TMAC Resources Inc., Cobalt Power Group, and IVEX
Exploring if Indigenous cultural programming in prison could influence a decline in the rate of incarceration of Indigenous women in Canada?
No full textThis thesis explores the notion that if principled programming was fittingly available in Canadian prisons, a sense of healing may be gained for incarcerated Indigenous women thus giving rise to esteem in their life. Principled programming is thus defined as instances of learning which echoes opportunities to gain understanding and skill by using of a method which may resonate from inherent knowledge. I investigate if the insight acquired from participation in programming in prison is enough to transcend the impositions from the legal system which prevails over the high rate of incarceration of Indigenous women in Canadian prisons: Hence women finding their voice.
The overall research examines if culturally fitting programming in Canadian prisons has enough promise to influence a decline of the future over-representation for Indigenous women. The primary objective is to identify to what extent the use of programming may contribute to a life of meaning for Indigenous women prisoners. The secondary objective is to identify barriers such as financial and political narratives that may demonstrate that a priority other than a common good for the women is at the forefront, thus contributing to a lower rate of incarceration.
Indigenous storying method and auto-ethnographic inquiry are used to navigate the discourse and personal insights urging an analysis of the barriers that Indigenous women in prison encounter. To summarize, if the methods used within the current framework of criminalization are sufficiently bestowed, there may not be an incentive to change the judiciary’s, or the state’s methods in the incarceration of Indigenous women
Strategies for supporting the mental health of students exposed to simulated learning activities: a systematic and immersive review
No full textThe field of addictions and mental health is growing in Canada due to various factors, including the high prevalence of mental health disorders and addiction, the increasing awareness and recognition of the toxic drug crisis, and the rising demand for mental health services as evidenced by lengthy wait times and shortage of accessible and affordable health care professionals. As such, there is an urgent need to prepare future practitioners with the necessary skills and knowledge to address the imminent challenges and escalating changes within the field of addictions and mental health. This research paper investigates the strategies essential for supporting the mental health of students engaged in simulated learning activities within post-secondary addictions and mental health programs. Given the importance of bridging theoretical knowledge with real-world applications within this particular field of study, simulated learning activities can serve as crucial components of contemporary education. This paper employs a systematic integrative literature review methodology to answer the research question: What strategies are needed to support the mental health of students exposed to simulated learning activities in post secondary addictions and mental health programs? A total of 26 articles were identified and reviewed for this analysis. Nine themes were identified in the literature across three distinct stages of simulation design: development, integration, and facilitation
Developing a modern-day samurai: a Canadian perspective
No full textKarate is an unarmed system of self-defence originating from Okinawa, Japan. While many of the techniques developed and taught can cause significant harm to another human being, the teachings are typically framed in the context of personal growth and development. Many karate schools’ marketing strategies boast that values such as discipline, respect, determination, and perseverance are part of the curriculum. Are these simply buzz-words used to appease the public while students are taught how to maim or kill each other or are these values realistically included in everyday practice? Whether by design or by chance, values are attached to modern day karate training and an integral part of the martial arts experience in Canada. Karate curricula include the process of teaching and learning physical techniques but rarely does a curriculum describe, in any relevant manner, a transfer of knowledge from master to pupil that promotes the development of the values the martial arts and/or sport.
Through this research, I unearthed what values are imbedded in karate practice in Canada, explored how these values are transmitted from teacher to student, and discovered why this is important. I investigated how modern-day martial arts instructors in Canada promote a sense of personal excellence in their students and instill a desire for high performance (by achieving a black belt, a podium finish, or both) in conjunction with a high sense of morality and kindness. I ascertained that in karate training, the transmission of values was primarily done by the example set by the instructors through existing, traditional Japanese protocols. The curriculum itself, when carefully prepared, also serves as a conduit to the transmission of values.
A Taoist philosophy was used to underpin this research. Taoism emphasizes the interconnected nature of all beings and elements. Similarly, collectivist research focuses on collaboration, interdependence, and recognizing that individual actions affect the collective iv whole. Taoism advocates for non-contention rather than asserting dominance or control. This research, then, is based on cooperation and consensus-building rather than asserting individual dominance. The emphasis is on mutual respect and understanding among the participants. In practical terms, I drew on inspiration from Taoist principles to foster collaboration, adaptability, and harmony among the participants. The Taoist approach is significant since the subject of the matter, karate, is collectivist in nature and Taoism harmonizes well with community-based research. In addition, the marriage of Schinke et al.’s (2013) traits for judging community research and Braun and Clarke’s (2006) 15-point thematic analysis checklist proved to be an innovative and thorough method of engaging in community-based research.
To my knowledge, no study of this kind had taken place. Through this initiative I was able to shed some light on the teaching and learning of values in karate in Canada and I hope that any findings will help serve as a roadmap for current and future teachers and coaches (in martial arts and beyond) to discover their own values and infuse them into the very fabric of their teaching and learning. As we look to develop a healthy, well-balanced society through physical education, sport, and the martial arts, my findings can be used as a guide to help shape curriculum development and pedagogical techniques that impart values into the very exercises practiced by the students. The findings could be extrapolated and derived to fit other martial arts disciplines and organizations within the Canadian context and perhaps internationally. These concepts could also be applied to other sporting fields