İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
Not a member yet
1249 research outputs found
Sort by
Does platelet-rich fibrin improve the clinical outcomes of intentional replantation in the treatment of periodontally hopeless teeth?
No full textPurpose The purpose of this study was to evaluate the impact of using platelet-rich fibrin (PRF) on clinical parameters in intentional replantation (IR) treatment. Materials and Methods Data were obtained from 32 mandibular anterior teeth with a 15-month follow up, treated with either IR (n=17) or IR+PRF (n=15). Periodontal parameters included probing depth (PD), clinical attachment level (CAL), plaque index (PI), gingival index (GI), and keratinized tissue height (KTH), all of which were assessed retrospectively. Results PD reduction at mesial and midlingual sites was greater in the IR+PRF group at the 15-month follow-up (p=0.043 and p=0.017, respectively), whereas CAL gain in the IR+PRF group was significantly higher at 3, 6, and 15 months (p<0.05). GI scores were similar in both groups, while PI scores were higher in the IR group at 6 and 15 months (p<0.05). Changes in KTH were similar in both groups at all follow-up periods. Conclusion IR can be considered for the treatment of periodontally hopeless mandibular anterior teeth, and combining IR with PRF may improve clinical outcomes. However, its clinical use should be recommended cautiously due to the lack of histological data regarding the effects of PRF on IR healing
Anatomical study of the superficial and deep circumflex iliac arteries: Morphology, variability, and surgical relevance
No full textPurpose The vascular anatomy of the groin region plays an important role in reconstructive surgery and regional anesthesia, yet data on the precise morphology and topography of the superficial and deep circumflex iliac arteries remain limited. Methods 28 lower extremities of fourteen formalin-fixed male cadavers were dissected to examine the superficial and deep circumflex iliac arteries. Their origins, branching patterns, diameters, and spatial relationships to the inguinal ligament and femoral triangle were recorded. Morphometric distances were measured with a digital caliper, and correlations between parameters were analyzed statistically. Results The superficial circumflex iliac artery arose exclusively from the femoral artery in all cases and was consistently located within the femoral triangle. Its mean origin diameter was 1.83±0.46 mm. The deep circumflex iliac artery showed greater variability, originating from the external iliac artery in half of the cases and from the femoral artery in the other half. Its mean origin diameter was 2.25±0.40 mm, and it was located outside the femoral triangle in 71.4% of cases. Multiple significant correlations were identified between vessel diameters, bifurcation points, and their spatial relationships with the inguinal ligament. Conclusion The superficial circumflex iliac artery displays consistent anatomy, whereas the deep circumflex iliac artery demonstrates notable variability in origin and topography, though with stable vessel caliber. These findings provide detailed morphometric insights that may support safer flap design and improve surgical and anesthetic planning in the groin region
Temporal trends and regional variations in hepatocellular carcinoma etiology: A multinational study across Asia
No full textBackground Hepatocellular carcinoma (HCC) remains a major health burden in Asia. Advances in antiviral therapies are reshaping the etiological landscape of HCC. This study evaluated temporal shifts in HCC etiology across Asian countries and their clinical implications. Methods This multinational study analyzed 6,261 newly diagnosed HCC patients registered in the APASL Hepatology/ Oncology Consortium (A-HOC) from 19 centers across seven Asian countries and regions between 2013 and 2023. Data on demographics, tumor characteristics, etiology, and treatment patterns were collected. Etiologies included hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholic liver disease (ALD), metabolic dysfunction-associated fatty liver disease (MAFLD), MAFLD plus excess alcoholic intake (MAFLD +eAL), autoimmune liver disease, cryptogenic, and others. Temporal trends and regional variations were assessed. Results In many countries, HBV remained predominant (43.3%–69.5%) and relatively stable throughout the period, while HCV showed only modest reductions. In Japan, HCV was the leading cause of HCC (33.1%), with a significant decline over time, accompanied by a rise in MAFLD-related HCC. ALD-related HCC increased in South Korea, and MAFLD-related HCC rose in Turkey. Tumor size and stage at diagnosis varied by etiology and region, affecting treatment strategies. Early stage diagnosis was more frequent in Japan and Taiwan, whereas advanced-stage HCC was common in China and Indonesia. Conclusions Distinct regional patterns and temporal changes in HCC etiology across Asia highlight the need for tailored prevention and surveillance measures. The growing burden of MAFLD-related HCC emphasizes its emerging role in liver cancer development, particularly in regions with declining viral hepatitis.Open Access funding provided by The University of Tokyo. This study was supported by the APASL (Grant number: [AHOC20230501]).
Açık Erişim fonlaması Tokyo Üniversitesi tarafından sağlanmıştır. Bu çalışma APASL tarafından desteklenmiştir (Burs numarası: [AHOC20230501])
Thermosonication-enhanced bioaccessibility and functional quality of dill juice: An in vitro digestion approach
No full textThis study, the effects of thermosonication, a non-thermal treatment, on the functional components of dill (Anethum graveolens) juice were investigated and its effect on post-digestion bioaccessibility was evaluated. Control (CDJ), thermally pasteurized (P-DJ), and thermosonicated (TS-DJ) samples were compared in terms of total phenolic content (TPC), β-carotene, total chlorophyll, and ferric reducing antioxidant power (FRAP). The stabilities and recovery rates of volatile aroma compounds and bioactive components throughout the digestion process (oral, gastric, and intestinal stages) were analyzed by an in vitro digestion model. Thermosonication provided higher preservation of bioactive components both initially and during 21 days of storage, and significantly higher post-digestion bioaccessibility values were observed. Process optimization was performed using Response Surface Methodology (RSM) and Equilibrium Optimization algorithms, with models validated with high predictive accuracy. Pearson correlation analysis revealed strong positive correlations between total phenolic content (TPC), β-carotene, and specific volatile compounds such as limonene and carvone, indicating that higher levels of these bioactives were associated with enhanced characteristic aroma profiles of dill juice. These results suggest that thermosonication may be a promising alternative to traditional thermal treatments for improving the functional quality and post-digestion bioaccessibility of dill water. In this context, while further research is needed to assess consumer acceptance and industrial scalability, this study provides valuable insights into the development of improved processing methods for plant-based beverages
Safe or dangerous? Evaluating group a sports supplements in the context of the epithelial barrier hypothesis
No full textThe epithelial barrier hypothesis suggests that the integrity of epithelial barriers in the skin, respiratory tract, and intestinal mucosa contributes to various chronic diseases. Long-term and high-intensity training, dehydration, malnutrition, etc., can cause epithelial barrier sensitivity in elite athletes. Elite athletes commonly consume sports supplements (SS) to enhance performance, support physical appearance, and prevent nutrient deficiencies. Scientific evidence indicates that SS can also affect the integrity of epithelial barriers. This study aims to discuss the potential effects of SS classified as Group A by the Australian Sports Institute (AIS) on epithelial barrier integrity.FCT – Fundação para a Ciência e a Tecnologia, I.P./ Foundation for Science and Technology, I.P., Grant/Award Number UIDB/04748/2020 Life Quality Research Center (Centro de Investigação Qualidade de Vida)
FCT – Bilim ve Teknoloji Vakfı, F.İ.P./ Bilim ve Teknoloji Vakfı, F.İ.P., Hibe/Ödül Numarası UIDB/04748/2020 Yaşam Kalitesi Araştırma Merkez
Early stage effectiveness of the automated insulin delivery system—is artificial intelligence really effective?
No full textObjective: This study aimed to evaluate the effectiveness of the self-learning capabilities of artificial intelligence (AI) algorithms. The hypothesis was that if the success of closed-loop insulin delivery is mainly attributed to AI algorithms, then the improvement in glycemic control would be more signifi cant just after the “learning” phase. Methods: The Medtrum A8 TouchCare® Nano system was used on 15 patients with type 1 diabetes. Daily continuous glucose monitoring (CGM) data pre-automated insulin delivery (AID) was statisti cally compared with the post-AID period. Results: Patients (median age 32 (6-54) years, 40% female) had a median HbA1c of 8.4% (5.3-10.7) before initiation of AID and a median GMI of 6.6% (5.8-8.3) after 2 weeks. The shifts in glycemia and glycemic variability between the 5-day period pre-AID vs. the first day and the 3 5-day periods post-AID were significant (pre-AID vs. 1-5-10-15 days; time in range (TIR, %): 55.9 vs. 76.6-81.7-83.8- 81.5 (P=.001); Q1 (mg/dL): 123 vs. 112-108-106-110 (P=.009); Q3 (mg/dL): 204 vs. 176-173-168-169 (P=.004); inter-quarter range (IQR, mg/dL): 78 vs. 57.2-56.6-53-55 (P=.002)). The biggest shift in TIR was achieved in the first day (10.1%). Comparative analysis of the 5-day intervals post-AID was insig nificant by means of the improvement in glycemia (P > .05). No significant change in glycemic param eters between 15, 30, and 90 days were noted (P > .05). Conclusion: Artificial intelligence-augmented AID becomes effective at the very early stages of initia tion. There is a need for further research into glycemic changes in the early days of AID initiation to better define the principles of initiating AID systems
Under-resourced EFL students’ perceptions about the causes and consequences of unfair AI-mediated education
No full textThe use of Artificial Intelligence (AI) technologies in education imposes various social influences on different stakeholders across diverse contexts. However, the voices of under-resourced second language (L2) learners have remained unheard regarding the fairness of AI adoption. To fill this gap, the present qualitative study examined 33 Chinese English as a foreign language (EFL) students’ perceived causes and consequences of unfair AI-mediated education. Thematic analysis of online interviews indicated four causes and four consequences for unfair AI adoption in under-resourced communities. The causes included biased algorithms and databases, digital divide and unequal access, lack of AI-related training and support, and sociocultural mismatch and inappropriateness of AI tools in poor settings. Regarding consequences, it was found that unfair AI adoption may lead to educational inequality, diminished motivation, academic deskilling, and technophobia among under-resourced EFL students. The findings are discussed, and implications for raising AI literacy and readiness of L2 educators and policymakers are enumerated.The current research was supported by the “Construction of Comprehensive Practice for First-Class English Major in Engineering Universities under the Background of New Liberal Arts” (Grant No. J20230722) under the Shanxi Provincial Higher Education Teaching Reform and Innovation Project, and by the project “Cross-Cultural Studies of International Languages and Literature” (Grant No. 2026-CXTD-10) under the 2026 Philosophy and Social Sciences Innovation Team Construction Program of Colleges and Universities in Henan Province, funded by the Education Department of Henan Province.
Bu araştırma, Shanxi Eyaleti Yüksek Öğretim Öğretim Reformu ve İnovasyon Projesi kapsamında yürütülen “Yeni Beşeri Bilimler Anlayışı Bağlamında Mühendislik Üniversitelerinde Birinci Sınıf İngiliz Dili ve Edebiyatı Bölümü İçin Kapsamlı Uygulama Oluşturma” (Burs No. J20230722) ve Henan Eyaleti Eğitim Bakanlığı tarafından finanse edilen Henan Eyaleti Üniversiteleri Felsefe ve Sosyal Bilimler İnovasyon Ekibi Oluşturma Programı kapsamında yürütülen “Uluslararası Diller ve Edebiyatın Kültürlerarası Çalışmaları” (Burs No. 2026-CXTD-10) projeleriyle desteklenmiştir
Development and validation of an ICF-based new scale—Atılım Kinesiophobia Scale: A methodological study
No full textIt is important to assess kinesiophobia, which increases the risk of disability by limiting physical activity. In this cross-sectional study, we aimed to develop a scale that assesses kinesiophobia with the multidimensional structure of International Classification of Functioning, Disability and Health (ICF). Atılım Kinesiophobia Scale (AKS) was developed in Turkish by an expert panel using questionnaires replied by 367 subjects. Finally, 38 questions based on the sub-domains of the ICF described by World Health Organization. In the scope of this cross-sectional study content validity and reliability were assessed; construct validity (both convergent and divergent validity) was checked against Tampa Kinesiophobia Scale-17 and Visual Analog Scale. AKS demonstrated good internal consistency and convergent validity, with significant correlations observed with the Tampa Scale for Kinesiophobia-17 (r = 0.478, P < .001). Divergent validity was supported by insignificant correlations with the Visual Analog Scale (r = 0.019, P = .855). The Cronbach alpha coefficient of 0.862 indicates a high level of internal consistency for the AKS. Based on these findings, the final version of AKS was refined to include 4 factors and 14 items, demonstrating good internal validity. We developed and validated the AKS to assess kinesophobia in patients with acute and/or chronic musculoskeletal pain. This new ICF-based scale can be used to assess kinesiophobia; however further studies are required to prove its validity and reliability in other languages. Abbreviations: AKS = Atılım Kinesiophobia Scale, CFA = confirmatory factor analysis, CFI = comparative fit index, EFA = exploratory factor analysis, ICF = International Classification of Functioning, Disability and Health, KMO = Kaiser–Meyer–Olkin, RMSEA = root mean square error of approximation, SRMR = standardized root mean square residual, TSK = Tampa Kinesiophobia Scale, VAS = Visual Analog Scale
Editöre mektup yanıtı: “Koroner arter kıvrımlılığı ve koroner ateroskleroz yükü”
No full textTo the Editor, First, we would like to thank the author1 and the editorial team for their attention to and interest in our work. We deeply value your constructive criticism and contributions, which we see as an opportunity for further improvement. Collateral circulation plays a significant role in the prognosis of coronary artery disease.2 We acknowledge the importance of considering the effect of collateral circulation when calculating Gensini scores.3 In our retrospective study, while evaluating cases of chronic coronary syndrome that underwent coronary angiography, the coronary collateral flow assessment (Rentrop) score (3) was 0 in all cases. However, we accept that this detail should have been clarified more explicitly in our article. Our study aimed to minimize confounding factors as much as possible to realistically examine the relationship between coronary artery tortuosity and coronary atherosclerosis. While we acknowledged in the limitations section of our study that this might introduce a potential bias in patient selection,4 we accept that it would have been beneficial to explicitly state that we sought to eliminate the effect of collateral circulation. One of the key strengths of our study is the large patient cohort, along with the meticulous exclusion of other confounding factors. In conclusion, while recognizing the importance of collateral circulation, we believe that our study provides important information about the relationship between coronary artery tortuosity and atherosclerotic plaque burden. We hope this research contributes to a deeper understanding of coronary artery disease and offers a new perspective for future studies
Staphylococcus aureus as a signature species of skin microbiome in actinic keratosis and squamous cell carcinoma: A narrative review
No full textCutaneous squamous cell carcinoma (cSCC) is a common type of skin cancer and the second most common type of nonmelanoma skin cancer. Actinic keratosis (AK) is a premalignant lesion that can progress to cSCC over time. AK and cSCC are associated with microbial dysbiosis and an increased abundance of the bacterium Staphylococcus aureus. Although AK and cSCC are highly colonized with S. aureus, a bacterium of the skin microbiota, it is not yet known whether this bacterium is associated with cancer development. Here, we analyze the studies on the relationship between S. aureus and keratinocytic skin neoplasia, evaluating the contribution of S. aureus to the development and prognosis of cSCC and AK lesions. The overabundance of S. aureus and the compounds secreted by this bacterium can induce cancer‑promoting changes in skin cells. The presence of high amounts of certain S. aureus strains in premalignant skin lesions may constitute a protumorigenic stimulus by inducing oxidative stress and DNA damage and downregulating DNA repair mechanisms. S. aureus associated with AK and cSCC can trigger keratinocytes to produce inflammatory cytokines typically upregulated in cSCC. These circumstances also suggest a potential specific involvement of S. aureus in the progression from AK to cSCC