İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Osteoporosis and meat dependence in postmenopausal women
No full textBu araştırma Ocak-Mayıs 2024 tarihleri arasında İstanbul ili Avcılar Murat Kölük Devlet Hastanesi Beslenme ve Diyet bölümüne başvuran 18-65 yaş arasındaki postmenopozal dönemdeki kadınlarda et bağımlılığı ile sonuçlar arasındaki ilişki hakkında bireylerin et bağımlılığının osteoporoz ile ne ölçüde ilişkili olduğunu değerlendirmek amacıyla hekimin osteoporoz tanısı alan veya almayan bireylere davetiyle gerçekleştirilmiştir. Çalışma araştırmaya katılmayı kabul eden gönüllü bireyler üzerinde yürütülmüştür. 138 katılımcının 69‘u kontrol grubu olarak belirlenmiştir. Bu araştırmada veri toplamada anket yöntemi kullanıldı. Anket formu 3 bölümden oluşmuştur. Formun birinci bölümünde katılımcı kişilerin sosyodemografik bilgileri ile 27 soruya, ikinci bölümde besin tüketim sıklığı anketi ile 24 soruya, üçüncü bölümde ise et bağımlılığı anketi ile 16 soru ile hazırlanan ölçeğine yer verilmiştir. Anketler yüz yüze görüşme yöntemiyle yapıldı. Verilerin değerlendirilmesi için "SPSS 25.00" istatistiksel veri analiz programı kullanılmıştır. Sonuç olarak postmenopozal kadınlarda osteoporoz ve et bağımlılığı ilişkisinde EBA ile osteoporoz/osteopeni tanı gruplarında anlamlı ilişki gözlenmezken tanısı olmayan bireylerde ise kırmızı et tüketiminde bağımlılık boyutunda, tavuk tüketiminde ise hazcılık ve ilgi boyutlarında gruplar arasında anlamlı bir fark bulunmuştur (p<.05). Postmenopozal kadınlarda et bağımlılığının tanı almayan gruplarda anlamlı olmasının osteoporoz/osteopeni açısından olumlu ilişkisi olduğu bulunmuştur.This study was conducted between January and May 2024 in postmenopausal women aged 18-65 years who applied to the Nutrition and Diet Department of Avcılar Murat Kölük State Hospital in Istanbul province between January and May 2024, with the invitation of individuals who were diagnosed with osteoporosis or not diagnosed with osteoporosis by a physician in order to evaluate the extent to which meat addiction is associated with osteoporosis. The study was conducted on voluntary individuals who agreed to participate in the research. 69 of 138 participants were selected as the control group. In this study, questionnaire method was used for data collection. The questionnaire form consisted of 3 parts. The first part of the form included sociodemographic information of the participants and 27 questions, the second part included food consumption frequency questionnaire and 24 questions, and the third part included meat addiction questionnaire and 16 questions. The questionnaires were conducted by face-to-face interview method. "SPSS 25.00" statistical data analysis program was used for data evaluation. As a result, in the relationship between osteoporosis and meat addiction in postmenopausal women, no significant relationship was observed between EBA and osteoporosis/osteopenia diagnostic groups, while in individuals without a diagnosis, a significant difference was found between the groups in the addiction dimension in red meat consumption and in the hedonism and interest dimensions in chicken consumption (p<.05). The fact that meat addiction was significant in undiagnosed groups in postmenopausal women was positive in terms of osteoporosis/osteopenia
Achieving strategic excellence: Integrating balanced scorecard and IVHF-DEMATEL for strategic management of a medical device SME
No full textNowadays, strategic planning and the establishment of long-term objectives are pivotal for companies from diverse economies based on geographical location, demographic distribution, financial challenges, and distinct customer portfolios. Defining strategic goals is vital more than ever however requires acceptance, adoption, and execution by the entire workforce. In this sense, this paper presents an integrated methodology that combines the Balanced Scorecard and the Interval-Valued Hesitant Fuzzy DEMATEL approaches to enhance strategic management in a Medical Device SME located in Istanbul-Turkey. The proposed approach aims to provide a holistic perspective on organizational performance and facilitate decision-making processes for sustainable growth and competitive advantage
Vesicular drug delivery systems: Promising approaches in ocular drug delivery
No full textOcular drug delivery poses unique challenges due to the complex anatomical and physiological barriers of the eye. Conventional dosage forms often fail to achieve optimal therapeutic outcomes due to poor bioavailability, short retention time, and off-target effects. In recent years, vesicular drug delivery systems have emerged as promising solutions to address these challenges. Vesicular systems, such as liposome, niosome, ethosome, transfersome, and others (bilosome, transethosome, cubosome, proniosome, chitosome, terpesome, phytosome, discome, and spanlastics), offer several advantages for ocular drug delivery. These include improved drug bioavailability, prolonged retention time on the ocular surface, reduced systemic side effects, and protection of drugs from enzymatic degradation and dilution by tears. Moreover, vesicular formulations can be engineered for targeted delivery to specific ocular tissues or cells, enhancing therapeutic efficacy while minimizing off-target effects. They also enable the encapsulation of a wide range of drug molecules, including hydrophilic, hydrophobic, and macromolecular drugs, and the possibility of combination therapy by facilitating the co-delivery of multiple drugs. This review examines vesicular drug delivery systems, their advantages over conventional drug delivery systems, production techniques, and their applications in management of ocular diseases
A sustainable and system-oriented toothpaste packaging design
No full textGiderek artan atıkların yarattığı çevre problemlerine çözüm bulmak için yeni yaklaşımlara ihtiyaç duyulmaktadır. Bu sorunların giderilebilmesi için sadece ürün bazlı değil sistemi bütünüyle ele alan tasarım yaklaşımları da gerekmektedir. Tüm insanların kullanması gereken diş macunlarının klasik tüplerindeki dış karton ambalajı da atık konusunda öne çıkan ürünlerdendir. Bu probleme çözüm bulmak amacıyla bütüncül bir yaklaşım sergilenerek sistem odaklı tasarım uygulanmıştır. Öncelikle literatür taranarak piyasadaki ürünlerin kullanımı ve gerektirdiği davranışları incelenmiştir. Daha sonra zihin haritaları, teknik analizler ve altı şapkalı düşünme yöntemi uygulanmıştır. Planlama, analiz, tasarım uygulama ve değerlendirme başlıkları altında bir diş macunu ambalajı tasarımı yapılmıştır. Böylece çevreye verilen zararı en aza indirgenerek hem sistem içinde hem de ürün bazlı değişikliklere gidilmiştir. Kullanıcı-ürün etkileşimi arasında kullanımı kolaylaştıran bir fark yaratılmıştır. Bu sayede diş macunu ambalajlarının kullanımında alışılmışın dışında bir sistem geliştirilerek fonksiyonel bir tasarım elde edilmiştir. Sistemin verimliliğinin üst düzeyde tutulabilmesi için ürünün kullanım esnasındaki bağlamsal ilişkisi de tasarlanmıştır. Böylece ortaya konan tasarım çözümleri sürdürülebilir bir yaklaşımı desteklemektedir.New approaches are needed to find solutions to the environmental problems caused by increasing waste. In order to solve these problems, design approaches that are not only product-based but also address the system as a whole are required. The outer cardboard packaging of the classic tubes of toothpaste that all people should use is also one of the products that stand out in terms of waste. In order to find a solution to this problem, a holistic approach was taken and system-oriented design was applied. First of all, the use of the products in the market and their required behavior were examined by scanning the literature. Then, mind maps, technical analysis, process analysis and the six thinking hats method were applied. A toothpaste package was designed under the headings of planning, analysis, design application and evaluation. Thus, the damage to the environment was minimized and changes were made both within the system and on a product basis. A difference has been created between userproduct interaction that makes it easier to use. In this way, an unusual system was developed in the use of toothpaste packaging and a design that facilitates the functionality. In order to keep the efficiency of the system at a high level, its contextual relationship, has been designed. Thus, the design solutions presented support a sustainable approach
CoSn(OH)6 nanocubes as a solid sorbent for the effective preconcentration of copper ions in cinnamon (Cinnamomum zeylanicum) extract
No full textThis study was aimed at developing a simple and efficient CoSn(OH)6 nanocubes-based preconcentration method for the preconcentration of copper ions from cinnamon extracts for determination by flame atomic absorption spectrometry. The cube-shaped sorbent was synthesized using the simple stoichiometric co-precipitation method under ambient conditions. Experimental factors of the method were evaluated with a comprehensive optimization approach to maximize the extraction efficiency for the analyte. Under the optimal conditions, the limit of detection (LOD), limit of quantitation (LOQ), and linear dynamic range were recorded as 0.98 µg/L, 3.28 µg/L, and 4.0-75 µg/L, respectively. The enhancement factor was calculated as 101.6-fold by comparing the LODs of the optimized and direct analysis systems. Percent recoveries were found to be within an acceptable range (77.6-115 %), with high repeatability using matrix matching calibration strategy. Results validated the proposed method as a highly efficient extraction approach for the monitoring of copper ions in herbal cinnamon extracts
Bazı 4-klorometil substitüe kumarin bileşiklerinin DPPH antioksidan deneyleri, moleküler kenetlenme çalışmaları ve ADMET tahminleri
No full textCoumarins and their derivatives, which are secondary metobalites of many plants, are heterocyclic bioactive compounds with various biological properties. Due to these properties, the synthesis of various derivatives and the investigation of their properties are of great interest. 4- (chloromethyl)-7-hydroxy-5-methyl coumarin (1), 4-(chloromethyl)-7-hydroxy-8-methyl coumarin (2), and 4-(chloromethyl)-7-hydroxy coumarin (3) synthesized by Pechmann condensation reaction and characterized by FT-IR, NMR spectral data and elemental analysis data. The antioxidant capacities of the compounds were investigated by difhenyl-2- picrylhydrazyl (DPPH) radical scavenger assay using the UV-Vis spectrophotometric method. The interactions of the compounds with ROS-producing cytochrome P-450, xanthine oxidase, lipooxygenase, monoamine oxidase, and nicotinamide adenine dinucleotide phosphate oxidase enzymes were investigated by molecular docking. All compounds interacted well in the active binding site of most of the enzymes (about 6-8 kcal/mol). The pharmacokinetic and toxicokinetic properties of the compounds, indicating their potential as drug candidates, were analyzed by ADMET predictions. All the results obtained showed that the compounds have properties that could be drug candidates.Birçok bitkinin ikincil metobalitleri olan kumarinler ve türevleri, çeşitli biyolojik özelliklere sahip heterosiklik biyoaktif bileşiklerdir. Bu özelliklerinden dolayı çeşitli türevlerinin sentezi ve özelliklerinin araştırılması oldukça ilgi çekicidir. 4-(klorometil)-7-hidroksi-5-metil kumarin (1), 4-(klorometil)-7-histoksi-8-metil kumarin (2) ve 4-(klorometil)-7-hidroksi kumarin (3) Pechmann kondenzasyon reaksiyonu ile sentezlenmiş ve FT-IR, NMR spektrumları ve elementel analiz ile karakterize edilmiştir. Bileşiklerin antioksidant kapasiteleri UV-Vis spektrofotometrik yöntemi kullanılarak difenil-2-pikrilhidrazil (DPPH) radikal süpürme deneyleri ile araştırılmıştır. Moleküler yerleştirme ile bileşiklerin, ROS üreten enzimler sitokrom P-450, ksantin oksidaz, lipooksijenaz, monoamin oksidaz ve nikotinamid adenin dinükleotit fosfat oksidaz enzimleri ile etkileşimleri incelenmiştir. Tüm bileşikler enzimlerin aktif bölgeleriyle iyi etkileşim göstermiştir (about 6-8 kcal/mol). Bileşiklerin farmakokinetik ve toksikokinetik özellikleri, ilaç adayı olabilme potansiyelleri ADMET tahminleri yapılarak incelenmiştir. Tüm sonuçlar bileşiklerin, ilaç adayı olma potansiyellerine sahip özelliklere sahip bileşikler olduklarını göstermiştir
Dynamic planning and workflow management for competitive advantage in businesses
No full textBu çalışma, günümüz iş dünyasında dinamik planlama ve iş akışı yönetiminin önemini vurgulamakta ve bu stratejilerin şirketler için sağladığı avantajları açıklamaktadır. Dinamik planlamanın, iş ortamlarındaki hızlı değişimlere hızlı adaptasyon yeteneği, rekabet avantajı elde etme açısından kritik bir faktördür. Literatür taraması, iş akışı yönetiminin süreç analizi ve otomasyon entegrasyonuyla şirketlerin süreç verimliliğini artırma potansiyelini göstermektedir. İş akışı yönetimi, süreçlerin detaylı analizi ve otomasyon araçlarıyla entegrasyonu sayesinde, iş süreçlerini daha hızlı ve etkili hale getirerek kaynakların daha verimli kullanılmasına olanak tanımaktadır. Sonuç olarak, dinamik planlama ve iş akışı yönetimi, gelişmiş teknolojik altyapı, eğitim ve değişim yönetimi gibi stratejik unsurlarla desteklendiğinde, şirketlere rekabet avantajı kazandırarak başarılı bir iş stratejisi oluşturmanın temelini oluşturmaktadır. Dinamik planlama ve iş akış yönetimi konusundaki literatür taramasında, en fazla çalışmanın bilişim ve inşaat sektöründe olduğu görülmektedir.This study emphasizes the importance of dynamic planning and workflow management in today's business world and explains the advantages of these strategies for companies. The ability of dynamic planning to adapt quickly to rapid changes in business environments is a critical factor in gaining competitive advantage. The literature review shows the potential of workflow management to improve process efficiency of companies through process analysis and automation integration. Through detailed analysis of processes and integration with automation tools, workflow management makes business processes faster and more effective, enabling more efficient use of resources. As a result, dynamic planning and workflow management, when supported by strategic elements such as advanced technological infrastructure, training and change management, form the basis of a successful business strategy, giving companies a competitive advantage. In the literature review on dynamic planning and workflow management, it is seen that most studies are in the IT and construction sectors
Does facial growth pattern affect the perception of lower facial asymmetry?
No full textObjectives To investigate the influence of vertical facial type on esthetic perception of lower facial asymmetry as evaluated by orthodontists, dentists, and laypeople. Materials and Methods Three adult females were selected with normal growth patterns (NGP), vertical growth patterns (VGP), and horizontal growth patterns (HGP). Frontal photographs were made symmetric and digitally altered, rotating the lower facial third clockwise, ranging from 0° to 6° in 1° increments. A web-based survey was designed with 24 images (eight images for each model) in random order. Each image was rated using a scale ranging from 0 (unattractive) to 10 (the most attractive) by 75 orthodontists, 73 dentists, and 78 laypeople. Kruskal-Wallis test was used to determine whether differences among groups were significant. Pairwise comparisons were made with Mann-Whitney U test. The significance level was set at P = .05. Results In NGP, orthodontists and dentists could recognize slighter deviations (2°), while deviations in VGP and HGP under 3° were not recognized by all groups. Severe deviations (≥4°) were distinguished better in HGP by orthodontists and laypeople. In VGP and NGP, there was no significant difference over 4°. Conclusions Growth pattern has a significant influence on perception of lower facial asymmetry. Less severe asymmetry can be detected better in NGP. In severe degrees, increments of asymmetry can be perceived more in HGP by orthodontists and laypeople
The Homeostasis-Enrichment-Plasticity (HEP®) approach for premature infants with developmental risks: A pre-post feasibility study
No full textBackground: The environmental enrichment (EE) framework has inspired several early intervention (EI) approaches. This study evaluated the feasibility, safety, caregiver acceptance, and satisfaction of implementing the HEP Approach intervention, a novel EI model based on the EE paradigm. Outcome measures for motor development, individual functional goals, sensory functions, caregiver-provided environmental affordances, and motivation for movement were examined. Methods: A pre-post-study design examined 18 premature infants (<33 weeks six days gestation) with a corrected age of 4–10 months. A 21-item Likert scale survey assessed the feasibility, safety, acceptability, and satisfaction of implementing the HEP Approach intervention. The Peabody Developmental Motor Scales-2, Test of Sensory Functions in Infants, Affordances in the Home Environment for Motor Development, and Infant Movement Motivation Questionnaire were used for outcomes. The goal attainment scale measured progress toward parent goals. The HEP Approach consisted of 12 one-hour sessions implemented over three months. Results: Most participating parents found the HEP Approach intervention feasible, safe, acceptable, and satisfactory. GAS scores demonstrated significant gains with a mean t-score of 67.75 (SD = 2.00). Results found significant improvement (p ≤ 0.05) in all outcome measures. Conclusions: Results suggest that the HEP Approach intervention is safe, feasible, and acceptable to implement. Outcome measures were meaningful and sensitive in identifying improved motor development, individualized parental goals, sensory functions, caregivers’ use of environmental opportunities, and movement motivation in premature at-risk infants. Results suggest further studies on the HEP Approach are feasible, and highlight the potential of this intervention to inspire and guide future research in this field
Trends of publications on transformational leadership in nursing: a bibliometric analysis
No full textPurpose This study aims to analyze the structure of publications on transformational leadership in nursing and determine its evolution process through a bibliometric analysis. Design/methodology/approach It is a descriptive bibliometric study. Data were collected on October 24, 2022, from the Web of Science and analyzed using Excel, VOSviewer, HistCite and Bibliometrix R programs. Findings A total of 348 studies conducted by 962 authors and published between 1990 and 2021 were included. It was found that 84.5% of these publications were original articles and 97.7% were published in English. The studies are from 82 different journals and were carried out by researchers from 43 countries. The most productive country was the USA (n = 151). Research limitations/implications Only one database was used to search for studies. The searches were limited to the nursing category, and only studies published up to 2021 were included. Another important point is that, although there were no language limitations for the field literature search, English keywords were used; thus, the search can be considered semi-limited. It is believed that more comprehensive search strategies may generate different findings. Originality/value Two main themes were identified as the studies carried out in the field of transformational leadership in nursing, generally, directly or indirectly addressed the effects of this style of leadership either on nurses’ performance/job satisfaction or on quality care/patient safety; however, a gap was observed in the literature in the area of nursing education. Researchers can be inspired by the results of the present study, by learning about the focus of published research on transformational leadership, which will encourage them to plan new studies to improve nursing education, nursing care, nursing management and working conditions of nurses. Through the results of this study, it is also possible to learn about countries and researchers for possible collaborations in future studies