İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
Not a member yet
1249 research outputs found
Sort by
The role of hexagonal boron nitride (h-BN) in enhancing electrolytes for safer and efficient lithium-based batteries
No full textHexagonal boron nitride (h-BN), with its unique structural and thermal properties, has emerged as a versatile material capable of addressing challenges such as thermal instability, dendrite formation, and limited ionic conductivity across liquid, gel polymer, and solid-state electrolytes (SSEs) for high-performing lithium ion and lithium metal batteries (LMBs). In liquid electrolytes, h-BN improves ionic mobility and suppresses side reactions, while in gel polymer electrolytes (GPEs), it enhances mechanical flexibility and thermal stability. SSEs benefit from h-BN's ability to suppress dendrites, reinforce mechanical strength, and optimize interfacial compatibility, making it a key enabler for next-generation battery technologies. Despite its promise, challenges such as dispersion uniformity, cost, and interfacial complexity must be addressed. Future directions, including the development of multifunctional architectures, dynamic electrolytes, and sustainable synthesis methods, are discussed to guide the integration of h-BN in emerging energy storage systems. This perspective article explores the multifunctional roles of h-BN, highlighting its contributions to enhancing ionic transport, thermal management, and interfacial stability. By presenting a comprehensive overview of h-BN's role in electrolytes, this work aims to inspire further research into its potential to revolutionize energy storage technologies
A little-known vaginitis-like picture: Cytolytic vaginosis
No full textBackground: Cytolytic vaginosis (CV) is a condition characterized by an increase in lactobacilli in the vaginal flora, causing complaints of discharge, itching, dyspareunia, and dysuria. Since there are no antimicrobials in the treatment protocols of CV, the diagnostic and therapeutic criteria of which were first defined by Cibley, differential diagnosis of CV from other vaginitis agents will prevent unnecessary use of antimicrobials and recurrent com-plaints. In our study, we aimed to determine the frequency of CV in patients presenting with vaginitis complaints and the diagnostic accuracy of the diagnostic criteria. Methods: In total, 140 women, 103 with vaginitis complaints and 37 without vaginitis complaints, were examined for bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), Trichomonas vaginalis (Tv), and CV. For the diagnosis of CV, vaginal pH ≤ 4.5, the presence of a large number of lactobacilli in Gram staining, the presence of false clue cells, cytolysis in vaginal epithelial cells, leukocyte deficiency or absence, absence of Tv, BV, or VVC were used. Results: Out of 103 patients, 30 (29.1%) had BV, 20 (19.4%) had VVC, 20 (19.4%) had CV, 5 (4.9%) had BV and VVC, and 4 (3.9%) had Tv. The sensitivity and specificity of the diagnostic criteria were 80% and 99% for epithelial cytolysis, 70% and 99% for false clue cells, 100% and 86% for pH ≤ 4.5, and 100% and 56% for numerous lactobacilli, respectively. Conclusions: In Turkey and worldwide, CV is not considered in vaginitis cases. In our study, the high rate of 19.4% in vaginitis cases shows the need for comprehensive research on this subject
Kafeinin epigenetik etkileri
No full textPurpose: Caffeine is one of the most widely consumed bioactive compounds worldwide, naturally found in coffee and cocoa beans, tea leaves, guarana berries, and kola nuts. In recent years, the effects of caffeine consumption on chronic diseases, neurological disorders, and pregnancy outcomes have attracted attention, particularly in relation to epigenetic mechanisms. The aim of this study is to evaluate the epigenetic effects of caffeine and their potential health implications.Amaç: Kafein, kahve ve kakao çekirdeklerinde, çay yapraklarında, guarana meyvelerinde ve kola fıstığında bulunan, dünya genelinde en yaygın tüketilen biyoaktif bileşenlerden biridir. Son yıllarda kafein tüketiminin epigenetik mekanizmalarla ilişkili olarak kronik hastalıklar, nörolojik bozukluklar ve gebelik sonuçları üzerindeki etkileri dikkat çekmektedir. Bu çalışmanın amacı, kafeinin epigenetik düzeydeki etkilerini ve bu etkilerin olası sağlık sonuçlarını değerlendirmektir
Process parameter optimization of laser beam machining for AISI -P20 mold steel using ANFIS method
No full textAISI P20 mold steel is commonly used for injection molds to produce plastic materials, car accessories, and electronic equipment molds. This study employed a fiber laser beam for precise machining of AISI P20 mold steel. The experimental design, based on the Taguchi 27 model, was carried out using Minitab software to optimize machining parameters, including cutting speed, gas pressure, and laser power. Surface roughness (Ra) and kerf width were the response parameters investigated. The ANFIS model, developed and analyzed using MATLAB, successfully predicted response parameters and was experimentally validated, showing improved predictions over actual measurements. The Brute Force algorithm identified the minimum combination for an optimal parameter set. The Taguchi method determined the best process parameters, indicating that cutting speed had the most significant impact. The optimum Ra was achieved with 1 m/min cutting speed, 2 bar gas pressure, and 1.8 kW laser power, while the lowest kerf width was obtained with 2 bar gas pressure, 1 m/min cutting speed, and 1.9 kW laser power. Based on the Brute Force algorithm, the minimum combination resulted in a kerf width of 0.84 mm and a surface roughness of 4.48175 μm. Microstructural analysis was performed on samples with high and low surface roughness to assess the machining surface quality
Kas hastalıklarının tanısı ve fonksiyonel yakın kızılötesi spektroskopisinin (fNIRS) kullanımı
No full textMuscle diseases are a class of illnesses that share several pathologies and can be brought on by auto immune, metabolic, inflammatory, toxic, or hereditary factors. Investigating the pathophysiological properties of diseases and developing appropriate diagnostic methods are essential for implementing appropriate therapeutic approaches and evaluating treatment effectiveness. Although anamnesis and clinical examination findings are still the most effective way to diagnose muscle diseases in routine practice, methods such as muscle electrophysiology, laboratory tests, and neuroimaging are important, especially for the differential diagnosis of complex muscle diseases. In recent years, another neuroim aging method, functional near-infrared spectroscopy (fNIRS), has begun to assess muscle oxygenation during exercise or rest in healthy and pathological conditions. fNIRS is an optical-based, noninvasive imaging method used to assess oxygenation in many tissues, such as the brain and muscle, since the 1980s. It provides information about the metabolic activity of the tissue through tissue oxygenation. The device sends light in the near-infrared range through the source optode to the tissue to evaluate ox ygenation change. Oxygen-carrying chromophores (hemoglobin and myoglobin, respectively) found in blood and skeletal muscle absorb near-infrared light sent to the tissue. Detector optodes collect the rays reflected back from the tissue, and the concentration change of oxygenated and deoxygenated chromophores in the tissue is determined according to the absorption amount. In recent years, its use in various physiological and pathophysiological conditions has become widespread. It is a promising approach, particularly for diagnosing muscle disorders, comprehending their etiology, and developing effective treatment plans.Kas hastalıkları genetik, otoimmun, inflamatuar, toksisite, metabolik kaynaklı nedenlerle oluşabilecek, farklı patolojileri paylaşan hastalıkların dahil olduğu bir hastalık grubunu ifade etmektedir. Hastalık ların patofizyolojik doğasının araştırılması ve uygun tanı yöntemlerinin geliştirilmesi, uygun tedavi yaklaşımlarının uygulanması ve tedavi etkinliklerinin değerlendirilmesi açısından oldukça önemlidir. Rutinde kas hastalıklarının tanısı ile ilgili hala en etkili yol anamnez ve klinik muayene bulguları olsa da özellikle karmaşık kas hastalıklarının ayırıcı tanısı için kas elektrofizyolojisi, laboratuvar testleri, nörogörüntüleme yöntemleri gibi yöntemler önem arz etmektedir. Son yıllarda bir başka nörogörüntü leme yöntemi olan fonksiyonel yakın kızılötesi spektroskopisi (fNIRS) sağlıklı ve patolojik koşullarda, egzersiz veya dinlenim durumunda kas oksijenizasyonunu değerlendirmek için kullanılmaya başlan mıştır. fNIRS, 1980lerden beri beyin ve kas gibi pek çok dokuda, oksijenasyonu değerlendirmek ama cıyla kullanılan optik temelli, girişimsel olmayan bir görüntüleme yöntemidir. Doku oksijenizasyonu yoluyla dokunun metabolik aktivitesiyle ilgili bilgi sağlar. Cihaz oksijenizasyon değişimini değerlen dirmek üzere dokuya kaynak optodu yoluyla, yakın kızılötesi aralıkta (700-900 nm dalga boyunda) ışık gönderir. Kanda ve iskelet kasında bulunan oksijen taşıyıcı kromoforlar (Hemoglobin ve myoglobin, sırasıyla), dokuya gönderilen yakın kızılötesi ışığı absorbe ederler. Dedektör optodları dokudan geri yansıyan ışınları topar ve absorbsiyon miktarına göre dokudaki kromoforların konsantrasyon deği şikliği belirlenir. Son yıllarda çeşitli fizyolojik ve patofizyolojik durumda kullanımı oldukça yaygın laşmıştır. Özellikle kas hastalıkların doğasının anlaşılabilmesi, hastalara teşhis konulabilmesi, uygun tedavinin planlanabilmesi için kullanılabilecek umut vaadeden bir yöntemdir
Çeşitli ülkelerde depremlerin ruh sağlığı üzerindeki sonuçları
No full textEarthquakes are among the most devastating natural disasters, causing significant loss of life, widespread destruction of infrastructure, and long-term psychological and physical impacts on survivors. These events, which often occur without warning, pose a global public health concern due to their suddenness, uncontrollability, and large-scale effects. Unlike other events, earthquakes represent an ongoing series of impacts, with their effects continuing long after the immediate danger has passed, sometimes lasting for years. The psychological consequences, in particular, can persist for months and may even outlast physical injuries caused by the disaster. This chapter explores the mental health consequences of major earthquakes with high fatality rates in various countries, with a particular focus on post-traumatic stress disorder, depression, and anxiety symptoms. The mental health effects of earthquakes on populations in China, Haiti, Iran, Japan, Nepal, Pakistan, Syria, and Turkey are specif- ically analyzed. Earthquakes are handled differently in various countries, depending on the resources available and the interventions that can be made. In developing countries, earthquakes are especially challenging because health systems are often overwhelmed by the large number of people needing help for trauma. This chapter explores how earthquakes affect mental health and what factors can help protect and support people during recovery, with a focus on different countries. Overall, the need for global cooperation in addressing the mental health impacts of natural disasters, particularly in less-developed regions, where resources and infrastructure are limited are emphasized
Stribling, J. C. (Ed.). (2020). Klinik tıp kütüphanecisinin el kitabı. Rowman & Littlefield
No full text"The Clinical Medical Librarian's Handbook" adlı eser, klinik tıp kütüphaneciliğinin tarihsel gelişimi, uygulamaları ve mesleki katkılarını ele alan kapsamlı bir çalışmadır. Kitapta, klinik tıp kütüphaneciliğinin doğuşu ve gelişimi, klinisyenlerle kurulan güçlü iş birliklerinin önemi, sağlık okuryazarlığına katkıları, onkoloji alanındaki bilgi terapisi uygulamaları ve halk sağlığı kütüphaneciliği gibi konular ele alınmaktadır. Ayrıca, kütüphanecilerin eğitimdeki rolleri, staj programlarının önemi ve klinik kütüphane hizmetlerinin dönüşümü için stratejik yaklaşımlar da kitapta yer almaktadır. Eser, klinik tıp kütüphaneciliğinin çeşitli yönlerini özetleyerek bu alanda çalışan profesyonellere rehberlik etmeyi amaçlamaktadır
Feeding the mind: Preliminary insights into the effects of anthocyanin-rich extract from black carrots on brain activity and gut microbiota in patients with cognitive impairments
No full textAnthocyanins, known for their antioxidant and anti-inflammatory properties, have been associated with cognitive benefits, potentially mediated by gut-brain axis interactions. This study investigates the effects of a 12-week Anthocyanin-Rich Extract (ARE) intervention on brain activity and gut microbiota composition in older adults with neurocognitive impairments. In this study, 50 participants underwent electroencephalography (EEG) recordings and gut microbiota analyses before and after the intervention. EEG data were analyzed using connectivity and entropy metrics across multiple frequency bands. Gut microbiota composition was assessed via 16S rRNA sequencing to evaluate taxonomic shifts. Results revealed increased EEG connectivity, particularly in alpha, beta, and gamma frequency bands, suggesting improved neural communication and complexity following ARE consumption. Significant changes in nonlinear EEG metrics were observed, consistent with previous findings in the literature. Microbiota analysis indicated non-significant alterations in overall diversity but revealed increases in Alistipes, Streptococcus thermophilus, and Flavonifractor, alongside a decrease in Hungatella, potentially implicating SCFA metabolism and inflammatory regulation. These findings suggest ARE may enhance cognitive health by modulating neural activity and gut microbiota composition. While these results provide preliminary evidence of neuroprotective effects, further research with larger, disorder-specific cohorts and placebo-controlled designs is necessary to validate outcomes and explore gut-brain axis mechanisms in cognitive decline
Exploring cervical vestibular evoked myogenic potential responses to different stimuli at different frequencies
No full textObjetive: This study aimed to compare cervical vestibular evoked myogenic potentials (cVEMP) elicited by Tone Burst (TB) and Narrow Band Level-Specific Chirp (NB LS-CE Chirp) stimuli at 500, 1000, 2000, and 4000 Hz in healthy individuals. Methods: Thirty-two healthy participants (15 females, 17 males; mean age: 24.59 ± 1.93 years) underwent otoscopic examination, pure-tone audiometry, and cVEMP testing at 95 dB nHL using TB and NB LS-CE Chirp stimuli. P1 latency, N1 latency, and P1N1 amplitude were recorded. Results: At 500 Hz, both stimuli elicited responses in all subjects. Significant differences in P1 latency, N1 latency, and P1N1 amplitude were found between the stimuli at 500 and 1000 Hz (p 0.05). Conclusion: NB LS-CE Chirp stimuli generate larger and earlier cVEMP responses than TB stimuli, particularly at lower frequencies, suggesting higher effectiveness for saccular assessment
Regenerative dentistry: Applications of bioactive materials in dentin-pulp complex
No full textTissue engineering in dentistry is revolutionizing the regeneration of dental pulp. The dental pulp is a specialized connective tissue that plays an important role in maintaining tooth health and supporting healing processes. However, exposure of the pulp to harmful factors, such as infections or trauma, can negatively impact its function, leading to inflammation, tissue necrosis, and ultimately pulp loss. As a solution to these challenges, tissue-engineered vital pulp therapies (VPTs) are emerging as an alternative to conventional root canal treatments. These therapies aim to preserve the vitality of the pulp, stimulate natural healing processes, and restore the dentin-pulp structure. Regenerative dentistry is also exploring tissue repair through innovations such as three-dimensional (3D) bioprinting, exosome-based therapies, and novel scaffold structures.This chapter explores the potential of tissue engineering in dental pulp regeneration, focusing on the role of stem cells, growth factors, scaffolds, and bioactive materials. In particular, stem cells derived from dental pulp are critical to this process due to their ability to differentiate into odontoblast-like cells and promote dentin production. The combination of these stem cells with bioactive scaffolds that release growth factors can significantly enhance the healing of pulp tissue. Furthermore, innovative materials, such as calcium silicate-based materials and bioactive glasses, have shown promising results in pulp regeneration and restorative dentin formation. While the future of these therapies is promising, challenges such as clinical application, long-term efficacy, and cost-effectiveness remain. As research advances, the importance of interdisciplinary collaboration and clinical trials will grow in overcoming these barriers