İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Evaluation of management strategies for viral upper respiratory tract infections among pediatricians in Türkiye
No full textBackground: To evaluate how pediatricians manage viral upper respiratory tract infections (URTIs) in children and their tendencies about the viral URTIs approaches. Materials and Methods: This study was conducted among pediatricians who participated in a descriptive cross-sectional survey. The survey included pediatricians who were willing to participate and who completed the survey forms between June 2023 and February 2024. The survey gathered data on the demographic characteristics of the pediatricians, as well as their diagnostic and treatment approaches for viral URTIs. Demographic data included the physicians’ gender, age, academic title, province of duty, institution of practice, and duration of experience in pediatrics. Results: This study involved 203 pediatricians. The diagnosis of viral URTI based on clinical findings had a negative correlation with pediatricians’ work experience (OR: 0.96 per year) and was more common among those working in private settings (OR: 0.38). Use of medications for symptomatic cough treatment was 2.72 times higher among pediatricians in private practice. Herbal supplement use was more common among pediatricians in private practice (p = 0.021) and those with ≥10 years of experience (p = 0.010). Systemic decongestant use was more frequent among pediatricians without an academic title (p = 0.030). Pelargonium sidoides root extract was used more often by pediatricians in private practice (p = 0.003), and they also preferred honey-containing supplements more frequently (p < 0.05). There was a negative correlation between experience in pediatric practice and multivitamins and minerals prescriptions for prevention of viral URTIs (OR: 0.97 for each year). Conclusion: Pediatricians in private settings and with more experience tend not to make a diagnosis of viral URTIs solely based on physical examination. Pediatricians working in private settings focus more on treatments that relieve cough symptoms. A viral URTI diagnostic and treatment algorithm with proven validity will help physicians in clinical diagnosis and treatment
Computational insights into iron coordination disruption in the human transferrin–neisseria meningitidis bacterial protein complex
No full textAmong many metal ions in biological systems, iron plays a fundamental role. Transferrins are iron-binding glycoproteins responsible for transporting Fe3+ in vertebrate blood. Neisse ria meningitidis, a Gram-negative pathogen causing meningitis, relies on iron for survival and acquires it from human transferrin (hTf) using two surface proteins, TbpA and TbpB. These proteins interact with hTf to form a ternary TbpA–TbpB–hTf complex, enabling iron capture from the host. The absence of an experimental crystal structure for this complex has hindered computational studies, a detailed understanding of Fe3+ dissociation, and designing efficient therapeutics. This study presents the first computational model of the ternary complex, its validation, and molecular dynamics simulations. Structural analyses revealed key electrostatic interactions regulating Fe3+ coordination and essential contact regions between proteins. The role of Lys359 from TbpA was investigated via QM/MM calculations by evaluating Fe3+ binding energies of isolated hTf, the ternary complex, and Lys359Ala, Lys359Arg, Lys359Asp mutant models. Results revealed that the proton trans fer from Lys359 leads to disruption of Tyr517–Fe3+ coordination, facilitating iron transfer to the bacterial system. Natural bond orbital analysis confirmed this mechanism. The findings provide new molecular insight into N. meningitidis iron acquisition and identify Lys359 as a potential target for covalent inhibitor design, guiding the development of novel therapeutics against meningococcal infection.This work was supported by the Scientific and Technological Research Council of Türkiye (TÜB˙ITAK), Project no: 118Z353 and Project no: 223Z201.
Bu çalışma, Türkiye Bilim ve Teknolojik Araştırma Konseyi (TÜBİTAK) tarafından 118Z353 ve 223Z201 numaralı projelerle desteklenmiştir
Dijital öğrenme ortamında blackboard ve kütüphane entegrasyonu
No full textDijital öğrenme ortamlarının yükseköğretimdeki önemi her geçen gün artmakta, bu bağlamda öğrenme yönetim sistemleri (LMS) ile kurumsal kaynakların bütünleşik bir yapıda sunulması, öğrenci başarısını ve bilgiye erişimi doğrudan etkilemektedir. Bu çalışma, Blackboard platformu ile üniversite kütüphanesi sisteminin entegrasyon sürecini ele almakta ve bu entegrasyonun öğrenme süreçlerine olan katkılarını değerlendirmektedir. Sunumda, entegrasyonun teknik boyutları, kullanıcı deneyimi üzerindeki etkileri ve akademik başarıya olası katkıları örnek uygulamalar üzerinden tartışılacaktır. Ayrıca, bu entegrasyonun dijital okuryazarlık, bilgi erişim hızı ve kullanıcı memnuniyeti üzerindeki olumlu etkilerine de değinilecektir. Çalışma, dijital kampüs yapısının güçlendirilmesinde kütüphanelerin rolünü vurgularken, sürdürülebilir bir bilgi ekosistemi için iş birliğinin önemine dikkat çekmektedir
Girişimcilik ağı: Çok katmanlı dijital girişimcilik ağı platformu tasarımı ve uygulama modeli
No full textBu çalışmada, dijital girişimcilik alanında çoklu kullanıcı tipine uygun olarak geliştirilen ve sürdürülebilir dijital ağ yapısıyla öne çıkan Girisimagi platformu tanıtılmaktadır. Girisimagi, yalnızca üniversite öğrencilerine değil; bireysel girişimcilere, kurumsal firmalara, yatırımcılara ve mentörlere hitap eden bütünleşik bir sistem olarak yapılandırılmıştır. 2024’te Türkiye girişimcilik ekosistemi 331 yatırım anlaşmasıyla 2,6 milyar USD işlem hacmine ulaşırken, internet penetrasyonu %86,5’e yükselmiş. Bu göstergeler, ölçeklenebilir dijital platformlara duyulan ihtiyacı net biçimde ortaya koymaktadır. Proje, kullanıcıların projelerini tanıtabilecekleri, sponsorluk ve mentörlük desteği alabilecekleri, firmaların ihtiyaç duyduğu girişim fikirleri için çağrıda bulunabilecekleri bir dijital ortam sunmaktadır. Girisimagi.org alan adı altında yapılandırılan ana platform, WHM/cPanel altyapısı üzerine kurulu olup; teknik moderasyon, içerik denetimi, kategoriye ayrılmış içerik yönetimi ve proje-firma eşleşme sistemleri gibi gelişmiş özelliklere sahiptir. Literatürdeki benzer platformlardan farklı olarak bu sistemde kullanıcı türlerine göre özelleştirilmiş iş akışları ve açık inovasyon destekli modüller entegre edilmiştir. Sunulan platform, girişimcilik kültürünü yaygınlaştırmak, üniversite-sanayi iş birliğini güçlendirmek ve projeleri somut çıktılarla desteklemek amacıyla geliştirilmiştir. Bildiride sırasıyla (i) modüler platform mimarisi, (ii) LAMP tabanlı teknik altyapı ve ölçeklenebilirlik çözümleri, (iii) pilot uygulamadan elde edilen kullanıcı deneyimi bulguları ve (iv) sürdürülebilirlik ile gelecek çalışma önerileri ele alınarak okuyucuya net bir yol haritası sunulmaktadır
A high geometric albedo and small size for the haumea cluster member (24835) 1995 SM55 determined from a stellar occultation and photometric observations
No full textContext. Trans-Neptunian objects (TNOs) are thought to be some of the most ancient and primitive bodies in our Solar System. Understanding their basic physical properties is crucial to unraveling their origin and the evolution of the outer Solar System beyond Neptune. Stellar occultations are a highly effective and sensitive method of studying these distant and faint objects, allowing us to gather essential information about their physical characteristics. (24835) 1995 SM55 is one of the few members of the Haumea orbital cluster and, therefore, is an especially relevant body to study within the TNO population. Aims. The main objectives of the present work are to determine the projected size, absolute magnitude, and geometric albedo of 1995 SM55 and to analyze the results compared to Haumea. Methods. We predicted a stellar occultation by this TNO for February, 25, 2024, carried out a specific campaign to observe the occultation, and derived the projected size and shape from the occultation observations using an elliptical fit to the occultation chords. We also analyzed a large set of photometric observations of (24835) 1995 SM55 to obtain the absolute magnitude and the rotational period. Finally, we combined these results to derive the geometric albedo of this TNO. Results. The occultation was successfully detected from seven instruments located at five different sites; 33 other sites reported negative detections. Using an elliptical fit to the occultation chords, we determined the size and shape of the limb of (24835) 1995 SM55 during the occultation: an ellipse with semi-axes (104.3 ± 0.4) × (83.5 ± 0.5) km. The area-equivalent diameter (Deq,A) for this ellipse is 186.7 ± 1.8 km. This is consistent with the upper limit of 250 km estimated from Herschel Observatory thermal data. From our photometric observations, we derived an absolute magnitude (HV ) of 4.55 ± 0.03, a phase slope parameter of 0.04 ± 0.02 mag/deg, and a V − R value of 0.37 ± 0.05. The rotational variability has a maximum peak-to-valley amplitude (∆m) of 0.05 mag, but we could not derive an unambiguous rotational period. Combining the projected size from the occultation with the absolute photometry, we obtained a geometric albedo in the V band (pV ) of 0.80 ± 0.04 for 1995 SM55. This value is remarkably high for a TNO and somewhat higher than that of Haumea, but consistent with the concept that 1995 SM55 is a member of the orbital cluster of Haumea.This work was supported by multiple funding agencies and institutions. It was partly funded by the Spanish projects PID2020-112789GB I00 (AEI) and Proyecto de Excelencia de la Junta de Andalucía PY20-01309. J.L.O., P.S.-S., N.M., A.A.C. and R.D. acknowledge financial support from the Severo Ochoa grant CEX2021-001131-S (MCIN/AEI/10.13039/501100011033). P.S.-S. also acknowledges support from the Spanish I+D+i project PID2022- 139555NB-I00 (TNO-JWST) funded by MCIN/AEI/10.13039/501100011033. AAC acknowledges financial support from the project PID2023-153123NB-I00 funded by MCIN/AEI. Gy.M.Sz. acknowledges the SNN-147362, GINOP-2.3.2- 15-2016-00003, and K-138962 grants of the Hungarian Research, Development and Innovation Office (NKFIH). Z.G. acknowledges the PRODEX Experiment Agreement No. 4000137122 between ELTE Eötvös Loránd University and ESA, the VEGA grant No. 2/0031/22 of the Slovak Academy of Sciences, the Slovak Research and Development Agency contract No. APVV-20-0148, and support from the city of Szombathely. J.I.B.C. acknowledges CNPq grants 305917/2019- 6 and 306691/2022-1, and FAPERJ grant 201.681/2019. F.B.R. acknowledges CNPq grant 316604/2023-2. This study was financed in part by CAPES (Finance Code 001) and the National Institute of Science and Technology of the e-Universe project (INCT do e-Universo, CNPq grant 465376/2014-2). A. Takey and A.M. Abdelaziz acknowledge financial support from the Egyptian Science, Technology & Innovation Funding Authority (STDF) under grant 48102. M.A. acknowledges grants 427700/2018-3, 310683/2017-3, and 473002/2013-2. The work of A.S. and D.A.N. was supported by a grant of the Ministry of Research, Innovation and Digitalization (CCCDI -– UEFISCDI, project PN-IV-P6-6.3-SOL-2024-2-0220, within PNCDI IV). D.I. acknowledges funding provided by the University of Belgrade – Faculty of Mathematics through grant 451-03-136/2025-03/200104 from the Ministry of Science, Technological Development and Innovation of the Republic of Serbia. V.N. acknowledges support from the Bando Ricerca Fondamentale INAF 2023 Data Analysis Grant: “Characterization of transiting exoplanets by exploiting the unique synergy between TASTE and TESS”. Opera tion of the University of Haifa’s H80 telescope at the Wise Observatory is partly supported by ISF grant 3200/20. .IST60 and .IST40 are observational facilities of Istanbul University Observatory, funded by the Istanbul University Scientific Research Projects Coordination Unit (projects BAP-3685 and FBG-2017-23943) and by the Presidency of Strategy and Budget of the Republic of Türkiye (project 2016K12137). This work is partly based on observations collected at the Cen tro Astronómico Hispano en Andalucía (CAHA), Observatorio de Sierra Nevada (IAA-CSIC), and the Liverpool Telescope at the Roque de los Muchachos Obser vatory (IAC). This research has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), pro cessed by the Gaia Data Processing and Analysis Consortium (https://www. cosmos.esa.int/web/gaia/dpac/consortium), with funding provided by institutions participating in the Gaia Multilateral Agreement. The authors thank Peter C. Slansky and M. Krahn for their observational contribution, and grate fully acknowledge all observers who attempted to observe this occultation event but are not explicitly mentioned in Table A.1. They also thank their collabora tors at the University of Athens Observatory for utilizing the robotic Cassegrain reflector (see Gazeas (2016) for details).
Bu çalışma, çeşitli fonlama kuruluşları ve kurumlar tarafından desteklenmiştir. Kısmen İspanyol projeleri PID2020-112789GB I00 (AEI) ve Proyecto de Excelencia de la Junta de Andalucía PY20-01309 tarafından finanse edilmiştir. J.L.O., P.S.-S., N.M., A.A.C. ve R.D., Severo Ochoa bursu CEX2021-001131-S (MCIN/AEI/10.13039/501100011033) tarafından sağlanan mali desteği kabul etmektedirler. P.S.-S. Ayrıca, MCIN/AEI/10.13039/501100011033 tarafından finanse edilen İspanyol I+D+i projesi PID2022- 139555NB-I00 (TNO-JWST)'den aldığı desteği de kabul etmektedir. AAC, MCIN/AEI tarafından finanse edilen PID2023-153123NB-I00 projesinden aldığı mali desteği kabul etmektedir. Gy.M.Sz., Macaristan Araştırma, Geliştirme ve İnovasyon Ofisi'nin (NKFIH) SNN-147362, GINOP-2.3.2- 15-2016-00003 ve K-138962 hibelerini kabul etmektedir. Z.G. PRODEX Deneyi'ni kabul eder. ELTE Eötvös Loránd Üniversitesi ve ESA arasındaki 4000137122 numaralı Anlaşmayı, Slovak Bilimler Akademisi'nin 2/0031/22 numaralı VEGA hibesini, Slovakya Araştırma ve Geliştirme Ajansı'nın APVV-20-0148 numaralı sözleşmesini ve Szombathely şehrinin desteğini kabul eder. J.I.B.C., CNPq'nun 305917/2019-6 ve 306691/2022-1 numaralı hibelerini ve FAPERJ'nin 201.681/2019 numaralı hibesini kabul eder. F.B.R., CNPq'nun 316604/2023-2 numaralı hibesini kabul eder. Bu çalışma kısmen CAPES (Finans Kod 001) ve e-Evren Ulusal Bilim ve Teknoloji Enstitüsü projesi (INCT do e-Universo, CNPq hibe 465376/2014-2) tarafından finanse edilmiştir. A. Takey ve A.M. Abdelaziz, Mısır Bilim, Teknoloji & İnovasyon Fonlama Kurumu'ndan (STDF) 48102 numaralı hibe kapsamında aldıkları mali desteği kabul etmektedirler. M.A., 427700/2018-3, 310683/2017-3 ve 473002/2013-2 numaralı hibeleri kabul etmektedir. A.S. ve D.A.N.'nin çalışmaları. Araştırma, İnovasyon ve Dijitalleşme Bakanlığı'nın (CCCDI - UEFISCDI, proje PN-IV-P6-6.3-SOL-2024-2-0220, PNCDI IV kapsamında) bir hibesiyle desteklenmiştir. D.I., Belgrad Üniversitesi - Matematik Fakültesi tarafından Sırbistan Cumhuriyeti Bilim, Teknolojik Gelişme ve İnovasyon Bakanlığı'ndan alınan 451-03-136/2025-03/200104 numaralı hibe ile sağlanan fonu kabul etmektedir. V.N., Bando Ricerca Fondamentale INAF 2023 Veri Analizi Hibesi'nden aldığı desteği kabul etmektedir: “TASTE ve TESS arasındaki benzersiz sinerjiden yararlanarak geçiş yapan ötegezegenlerin karakterizasyonu”. Haifa Üniversitesi'nin Wise Gözlemevi'ndeki H80 teleskobunun işletimi kısmen ISF 3200/20 numaralı hibe ile desteklenmektedir. .IST60 ve .IST40 gözlem tesisleridir İstanbul Üniversitesi Bilimsel Vakfı tarafından finanse edilen İstanbul Üniversitesi Gözlemevi'nin Araştırma Projeleri Koordinasyon Birimi (BAP-3685 ve FBG-2017-23943 projeleri) ve Türkiye Cumhuriyeti Strateji ve Bütçe Başkanlığı tarafından (proje 2016K12137). Bu çalışma kısmen Cen tro Astronómico Hispano en Andalucía (CAHA), Observatorio de Sierra Nevada'da toplanan gözlemlere dayanmaktadır. (IAA-CSIC) ve Roque de los Muchachos Gözlemevi'ndeki (IAC) Liverpool Teleskobu. Bu araştırma, Avrupa Uzay Ajansı (ESA) Gaia misyonundan (https://www.cosmos.esa.int/gaia) elde edilen ve Gaia Veri İşleme ve Analiz Konsorsiyumu (https://www.cosmos.esa.int/web/gaia/dpac/consortium) tarafından işlenen verilerden yararlanmıştır ve Gaia Çok Taraflı Anlaşmasına katılan kurumlar tarafından finanse edilmiştir. Yazarlar, gözlemsel katkılarından dolayı Peter C. Slansky ve M. Krahn'a teşekkür eder ve bu örtülme olayını gözlemlemeye çalışan ancak Tablo A.1'de açıkça belirtilmeyen tüm gözlemcilere minnettar olduklarını belirtirler. Ayrıca, robotik Cassegrain reflektörünü kullandıkları için Atina Üniversitesi Gözlemevi'ndeki işbirlikçilerine de teşekkür ederler (ayrıntılar için Gazeas (2016)'ya bakınız)
An analytical method for the determination of pentachloroaniline and pentachlorobenzene in ginseng tea samples by gas chromatography–mass spectrometry after liquid phase microextraction
No full textThis study describes a sensitive and accurate analytical method for the determination of pentachloroaniline (PCA) and pentachlorobenzene (PCB) at trace levels in ginseng tea samples. For this purpose, spraying based fine droplet formation liquid phase microextraction (SFDF-LPME) method was implemented to extract/preconcentrate the target analytes before their separation and detection by gas chromatography-mass spectrometry (GC-MS). Herein, a lab-made spraying system was used to distribute the extraction solvent throughout the aqueous sample solution. Limit of detection/quantitation (LOD/LOQ) values for PCA and PCB were found as 0.24/0.80 and 0.26/0.85 μg/kg, respectively. When LOD values of GC-MS and SFDF-LPME-GC-MS methods were compared to each other, enhancement in detection power values for PCA and PCB were 285 and 226.9 folds, respectively. Percent recovery results for PCA and PCB were calculated as 92-124 % and 86-129 %, respectively. Green evaluation and practicability of developed SFDF-LPME-GC-MS method was done by Eco-scale (89), AGREEprep (0.39) and BAGI (62.5) tools
Gender differences in the distribution of IDL, LDL, and HDL lipoprotein subfractions in MODY compared to type 2 diabetes: Data from the MODY-Ist study
No full textBackground: The distribution of intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL) and high density lipoprotein (HDL) subfractions specific to diabetes types and changes under dyslipidemia conditions have been well characterised. Research into the distribution of lipoprotein subfractions in Maturity-Onset Diabetes of the Young (MODY) has hitherto been confined to certain subtypes, with gender-based differences remaining to be elucidated. The objective of this study was to comparatively evaluate the distribution of lipoprotein subfractions according to gender in MODY, T2DM patients, and control groups. Methods: Lipoprotein subfractions in 119 serum samples of the study groups were analyzed using the Lipoprint System. Results: The midbands of IDL (MID-A to C) in female MODY cases, and the HDL-small fraction in male MODY cases, were found to be lower compared to female and male T2DM cases, respectively. In the T2DM group, age was positively correlated with MID-C and MID-B in both genders, while it was negatively correlated with MID-A in female cases. ROC analysis demonstrated that the decrease in the MID-C fraction in female MODY subjects (AUC:0.809, p = 0.0001) and the decrease in the HDL-small fraction in male MODY subjects (AUC:0.818, p = 0.002) were significantly associated with the likelihood of MODY. Conclusion: Given that a considerable proportion of MODY patients are frequently misdiagnosed as T2DM, low levels of MID-C and HDL-small fractions, both of which are triglyceride-rich, may have potential as a diagnostic value for female and male MODY patients, respectively.This study was funded by Istanbul University Scientific Research Project Unit (Project no. TOA-2017-24194).
Bu çalışma İstanbul Üniversitesi Bilimsel Araştırma Projeleri Birimi (Proje no. TOA-2017-24194) tarafından finanse edilmiştir
A pilot investigation on possible interactions between clinical parameters and the psychology of couples undergoing IVF
No full textObjective: To investigate the potential reciprocal influences between in vitro fertiliza tion (IVF) and the psychological states of patients. Materials and Methods: A prospective cohort study involved 180 couples who sought consultation for IVF. To monitor the fluctuations in the emotional states of the cou ples throughout the IVF process, questionnaires were administered on two separate occasions: the first was conducted immediately before the initiation of medication, and the second was administered promptly following the completion of embryo trans fer. The BECK inventories for anxiety and depression were employed for evaluation. Pregnancy outcomes were exclusively analyzed for women who received high-quality blastocysts, with cleavage-stage embryo transfers being excluded from consideration. Results: Pregnancy rates did not significantly differ based on the presence of height ened anxiety and/or depression among couples. Notably, a correlation was identified between severe anxiety in women before IVF and diminished rates of fertilization, as well as lower blastocyst/oocyte and blastocyst/metaphase II (M2) ratios (8.7 ± 5.0 vs. 7.5 ± 6.1, P= 0.029; 0.284 ± 0.199 vs. 0.218 ± 0.209, P= 0.001; and 0.333 ± 0.209 vs. 0.272 ± 0.232, P= 0.016, respectively). In the male cohort, elevated anxiety scores, ei ther pre- or post-IVF treatment, were found to be linked with a reduced mean oocyte count, as well as lower rates of M2, fertilization, blastocyst, and total embryo counts (P< 0.05). Conclusions: Pregnancy rates were not affected by the presence of anxiety and de pression, as they do not exert a significant impact on the implantation success of blas tocysts. However, given that fertilization rates are statistically diminished in instances of severe anxiety, which consequently results in a reduced number of blastocysts and total embryos, a decline in cumulative pregnancy rates may be anticipated
Anatomical evaluation of supraorbital notch and supraorbital foramen morphology and supraorbital nerve distribution: A cadaveric study
No full textBackground: Peripheral nerve compression at trigger points is considered a cause of migraine and primary headaches. These trigger points are most commonly found in the sensory regions. In particular, compression of the supraorbital nerve by fascial bands or at the supraorbital foramen has been reported as a source of headache in the literature. This study aimed to evaluate the structures through which the supraorbital nerve passes to reach the innervation area. Methods: Eleven female and 11 male cadaver heads fixed with formalin were dissected and the formation of the supraorbital nerve emerging the cranium was evaluated. Results: Cadaveric sides were divided into four types based on the presence of a notch or foramen. Sides with only one notch constituted the majority at 45.4% (Type A). Conclusions: In this study, in cases with only supraorbital notch, the distance of the notch to the midsagittal line was found to be 23.51±3.74 mm on the right side and 22.77±3.75 mm on the left side on average. In cases with only supraorbital foramen, the right side average was calculated as 20.50±4.30 mm and the left side average was calculated as 25.60±3.83 mm. These measurements are of considerable importance in procedures such as migraine botox or migraine surgery
Classifying stroke recovery profiles based on living environment: A latent class analysis
No full textBackground and Aims: Post-stroke recovery is influenced by multiple factors including living environment. While skilled nursing homes may offer more comprehensive care, including physiotherapy, dietary support, and psychological counseling, many family caregivers remain concerned that such settings may lead to loneliness and a sense of abandonment in stroke survivors, which may negatively impact their recovery. This study investigates how different living environments influence functional and psychological outcomes. Methods: A total of 278 stroke survivors living either in their homes or nursing homes in Istanbul,Turkey were assessed. Patient outcomes were evaluated using Stroke Impact Scale, Stroke Specific Quality of Life Scale, Tampa Scale for Kinesiophobia, Geriatric Depression Scale, UCLA Loneliness Scale, and Tinetti Gait and Balance Test. Covariates included age, stroke years, education, medical history, treatments received and caregiver support. Results: Latent Class Analysis identified two distinct patient class, as shown in figure. Class 2 demonstrated significantly better outcomes char acterized by greater independence, improved quality of life, lower depres sion and loneliness scores, reduced kinesiophobia, lower fall risk, healthier exercise routines and sleep quality. While the overall sample included more individuals receiving home care, the class which exhibited better functional and psychological outcomes contained a higher proportion of nursing home residents. Results: Of the 382 patients, 78 were analyzed (31 stable/35 unstable plaques/12 acute occlusions). When analyzing early radiological changes, there was no significant difference between the three studied plaque types (p>0.05), while when monitoring early neurological changes (NIHSS), significant decrease in deficit was noted in stable (p=0.012) and unstable (p0.05) Conclusions: No significant association was found between carotid plaque morphology detected on CT and early/late stroke severity in carotid territory. Patients with stable plaques showed milder events and had better overall 3-month outcome