İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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In vivo reflectance confocal microscopy for detecting cutaneous metastasis in breast cancer
No full textA 45-year-old female with a history of invasive ductal breast carcinoma (IDBC) presented with an asymptomatic erythematous nodule on the right mastectomy scar. Dermos copy revealed erythematous peripheral border, polymor phous and atypical vessels, focal scaling, and multiple white structureless areas appearing as white clods and strands. Reflectance confocal microscopy (RCM) revealed a normal epidermis with a preserved honeycombed pattern, with der mal tumoral clusters of varying sizes consisting of highly polymorphous hyporeflective cells with different sizes and shapes
Özel gereksinimli çocuğu olan ebeveynlerin anne- baba stresi, aile psikolojik sağlamlık ve umut düzeyleri arasındaki ilişkinin incelenmesi
No full textBu makale “Özel Gereksinimli Çocuğu Olan Ebeveynlerin Anne- Baba Stresi, Aile Psikolojik Sağlamlık ve Umut Düzeyleri Arasındaki İlişkinin İncelenmesi”adlı yüksek lisans tezinden üretilmiştir.Bu araştırmanın amacı özel gereksinimli çocuğu olan ebeveynlerin anne-baba stresi, aile psikolojik sağlamlık ve umut düzeyleri arasındaki ilişkinin incelenmesidir. Nicel araştırma yöntemi ve ilişkisel tarama modeli kullanılan bu araştırmada küme örnekleme metodu kullanılmış ve araştırmanın örneklemini 2024-2025 eğitim öğretim yılında İstanbul ili Sultangazi ve Gaziosmanpaşa ilçesinde bulunan Millî Eğitim Bakanlığına bağlı özel eğitim ve rehabilitasyon merkezine devam eden özel gereksinimli çocukların anne ve babaları oluşturmaktadır. Araştırmaya 332 anne ve baba katılmıştır; bunların 223’ü kadın, 109’u erkektir. Veri toplama aracı olarak; Anne- Baba Stres Ölçeği, Aile Psikolojik Sağlamlık Ölçeği Kısa Formu, Sürekli Umut Ölçeği ve Demografik Bilgi Formu kullanılmıştır. Verilerin 76 analiz süreci, SPSS 25.0 istatistik yazılım programı aracılığıyla yürütülmüştür. Araştırmada, normallik değerlendirilmesi çarpıklık ve basıklık katsayıları üzerinden yapılmış; betimsel istatistiklerin yanı sıra Bağımsız Örneklemler T-Testi, Tek Yönlü Varyans Analizi (Anova), LSD testi ve Pearson korelasyon analizi gibi çeşitli parametrik testlerden yararlanılmıştır. Çalışmada elde edilen bulgular, anne ve babaların demografik değişkenlere göre farklılıklar olduğunu göstermektedir. Kadın katılımcılar, erkeklere göre daha yüksek düzeyde aile psikolojik sağlamlık ve umut düzeyine sahipken, aynı zamanda daha yüksek stres yaşadıkları saptanmıştır. 0–6 yaş arası çocuğu olan ebeveynler daha yüksek umut ve psikolojik sağlamlık düzeyine sahipken daha düşük stres yaşadıkları saptanmıştır. Korelasyon ve regresyon analizleri; umut ve psikolojik sağlamlık arasında pozitif, stres düzeyi ile her iki değişken arasında ise negatif yönde anlamlı ilişkiler olduğunu saptanmıştır. Umut ve stres düzeyleri psikolojik sağlamlığın; aile psikolojik sağlamlığı ve stres düzeyleri ise umudun anlamlı olduğu belirtilmiştir. Araştırma bulguları, psikolojik sağlamlık düzeyinin ebeveyn stresini azaltmada önemli bir rol oynadığını göstermektedir. Bu durum, psikolojik sağlamlığın önleyici ve koruyucu ruh sağlığı hizmetlerinde öncelikli olarak ele alınması gereken bir değişken olduğunu ortaya koymaktadır. Ayrıca, ebeveynlerin umut düzeylerini artırmaya yönelik geliştirilecek müdahale ve programların, stresle baş etme becerilerini destekleyebileceği düşünülmektedir. Bu bağlamda, ailelere yönelik hazırlanacak psikoeğitim programlarının hem psikolojik sağlamlığı hem de umut duygusunu güçlendirecek şekilde planlanması, ebeveynlerin psikolojik iyi oluşlarını desteklemede etkili bir yaklaşım sunabilir.The aim of this study is to examine the relationship between parental stress, family resilience, and levels of hope among parents of children with special needs. This research, conducted using a quantitative research method and a relational survey design, employed a cluster sampling method. The sample consisted of mothers and fathers of children with special needs who attended special education and rehabilitation centers affiliated with the Ministry of National Education in the Sultangazi and Gaziosmanpaşa districts of Istanbul during the 2024–2025 academic year. A total of 332 parents participated in the study, of whom 223 were women and 109 were men. 77 As data collection tools, the Parental Stress Scale, the Family Resilience Scale Short Form, the Dispositional Hope Scale, and a Demographic Information Form were utilized. The data analysis process was carried out using the SPSS 25.0 statistical software. Normality was assessed through skewness and kurtosis coefficients; in addition to descriptive statistics, several parametric tests such as the Independent Samples T-Test, One-Way Analysis of Variance (ANOVA), LSD test, and Pearson correlation analysis were conducted. The findings revealed differences in parental outcomes based on demographic variables. Female participants reported higher levels of family resilience and hope compared to males, while also experiencing higher levels of stress. Parents of children aged 0–6 were found to have higher levels of hope and resilience but reported lower stress levels. Correlation and regression analyses indicated significant positive relationships between hope and resilience, while stress levels were found to be significantly and negatively related to both variables. Moreover, hope and stress levels significantly predicted resilience, whereas family resilience and stress levels significantly predicted hope. The findings suggest that resilience plays a key role in reducing parental stress. This highlights the importance of prioritizing resilience in preventive and protective mental health services. Furthermore, interventions and programs aimed at enhancing parental hope may contribute to strengthening coping skills against stress. In this context, psychoeducational programs designed for families that aim to reinforce both resilience and hope could provide an effective approach to supporting parents’ psychological well-being
Design, use, and contemporary technological approaches of mouthguards in pediatric athletes
No full textOrofacial trauma is a common concern among pediatric athletes, particularly those participating in contact and high impact sports. Due to their developing dentofacial structures, children are more vulnerable to injuries. Mouthguards are intraoral devices designed to absorb and disperse impact forces, playing a critical role in injury prevention. This review outlines the classification of mouthguards, fabrication techniques, and the process of personalized design. It also examines usage trends in children and highlights how awareness among parents and coaches influences adherence. Recent advancements in digital dentistry—especially CAD/CAM systems and 3D printing technologies—have enabled the production of custom-made mouthguards that provide superior fit, comfort, and protection. Studies suggest that individualized mouthguards improve compliance among pediatric athletes and significantly reduce the risk of orofacial trauma. Therefore, technological innovations, combined with increased stakeholder awareness, are believed to enhance the adoption and clinical success of effective protective mouthguards in pediatric sports dentistry
Pharmacovigilance analysis of immune checkpoint inhibitor-related reproductive adverse effects based on the FDA adverse event reporting system
No full textThis study aims to investigate the adverse effects of immune checkpoint inhibitors (ICIs) on the female and male reproductive systems. In the FDA Adverse Event Reporting System (FAERS) database, adverse reactions under the "Reproductive system and breast disorders" category in the System Organ Classes were included, covering a period from January 1, 2015, to June 30, 2023. We identified 133,512 patients treated with ICIs. Immune checkpoint inhibitor-related reproductive adverse effects (irRAEs) were reported in 568 (0.43%) patients. Spermatogenesis abnormality (ROR025 = 7.91) had the highest signal strength associated with ICI use in males. Genital tract fistula was the only significant irRAE (ROR025 = 2.72) in females. PD-1 inhibitors pose greater risk than CTLA-4 inhibitors (OR = 1.65 [1.05-2.79], p = 0.045). Gynecologic cancers in females (OR = 3.77 [2.82-4.99], p < 0.0001) and urogenital cancers in males (OR = 1.56 [1.17-2.06], p = 0.0018) carried the highest risk compared to other cancers. Additional targeted drugs (OR = 2.32 [1.76-3.02], p < 0.0001), particularly lenvatinib (OR = 3.50 [2.48-4.94], p < 0.0001) and cabozantinib (OR = 3.71 [1.96-7.03], p < 0.0001) significantly increased the risk for females. Additional use of chemotherapy drugs was associated with a significant reduction in the risk for males (OR = 0.65 [0.42-0.96], p = 0.042) except for doxorubicin (OR = 2.58 [1.22-5.47], p = 0.013) and cyclophosphamide (OR = 2.36 [1.05-5.29], p = 0.038). This study demonstrates that ICIs could potentially lead to a wide range of adverse effects in the reproductive system in both males and females
Smart thermoresponsive sol–gel formulation of polyhexanide for rapid and painless burn and wound management
No full textTraditional wound and burn treatments often fall short in balancing antimicrobial efficacy, patient comfort, and ease of application. This study introduces a novel, transparent, ther moresponsive sol–gel formulation incorporating polyhexamethylene biguanide (PHMB) for advanced topical therapy. Utilizing Poloxamer 407 as a biocompatible carrier, the formulation remains a sprayable liquid at room temperature and instantly gels upon contact with body temperature, enabling painless, pressure-free application on sensitive, injured skin. Comprehensive in vitro and in vivo evaluations confirmed the formulation’s broad-spectrum antimicrobial efficacy (≥5 log10 reduction in 30 s), high biocompatibility (viability > 70% in fibroblasts), non-irritancy (OECD 425-compliant), and physical stabil ity across three months. Importantly, the formulation maintained fibroblast migration capacity—crucial for wound regeneration—while exhibiting rapid sol-to-gel transition at ~34 ◦C. These findings highlight the system’s potential as a next-generation wound dressing with enhanced user compliance, transparent monitoring capability, and rapid healing support, particularly in disaster or emergency scenarios
Comparative effects of propolis and polyphenolic cocktail (PFK5120) on EGFR signaling in MCF-7 hormone positive breast cancer cell line
No full textComparative effects of propolis and polyphenolic cocktail (PFK5120) on EGFR signaling in MCF-7 hormone positive breast cancer cell line
İyon destekli sıvı fazlı ekfoliasyon yöntemiyle hidroksi fonksiyonlu hekzagonal bor nitrür nanotabakaların etkin ve kolay sentezi
No full textHexagonal boron nitride (h-BN) nanosheets have attracted significant attention due to their unique mechanical, thermal, and electronic properties. Their biocompatibility, thermal conductivity, chemical stability, and versatility make them indispensable in cutting-edge technologies. Hydroxy-functionalized h-BN nanosheets (h-BNNS-OH) exhibit immense potential in various applications, including electrochemical energy storage, drug delivery systems, and heat spreaders in thermal management systems. This study focuses on the hydrothermally ion-assisted liquid-phase exfoliation of h-BN powder to produce few-layer h BNNS-OH. The exfoliation process involves hydrothermal treatment of bulk h-BN in the presence of concentrated aqueous solution of KOH and NaOH at 180 °C, followed by sonication for dispersion of h-BNNS-OH in water. Characterization of h-BNNSs was performed using powder X-ray diffraction (XRD), Raman spectroscopy, Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). The resulting exfoliated h-BNNSs are hydroxyl-functionalized on their surface. This study demonstrates the effectiveness of the successive execution of the hydrothermal treatment in the presence of excess alkali metal hydroxides and probe sonication as a facile and efficient exfoliation process, resulting in dispersions of h-BNNS-OH in water with remarkably high stability (beyond 9 weeks) and high product yield (17 %) at only one exfoliation cycle.Hekzagonal bor nitrür (h-BN) nanotabakalar, sahip oldukları sıra dışı mekanik, termal ve elektronik özellikler sayesinde son yıllarda önemli bir araştırma konusu haline gelmiştir. Biyouyumlulukları, yüksek ısıl iletkenlikleri, üstün kimyasal kararlılıkları ve çok yönlü yapıları, bu malzemeleri ileri teknoloji uygulamalarında vazgeçilmez kılmaktadır. Hidroksi grupları ile fonksiyonlandırılmış h-BN nanotabakalar (h-BNNS-OH’lar), elektrokimyasal enerji depolama, ilaç taşıma sistemleri ve termal yönetim uygulamalarında ısı yayıcı olarak kullanılma potansiyeli açısından dikkat çekmektedir. Bu çalışmada, h-BN tozunun hidrotermal olarak iyon destekli sıvı faz eksfoliasyonu yöntemiyle birkaç katmanlı h-BNNS OH’ların sentezi amaçlanmıştır. Eksfoliasyon sürecinde, hacimli h-BN, konsantre sulu KOH ve NaOH çözeltisi varlığında 180 °C’de hidrotermal işleme tabi tutulmuş, ardından elde edilen ürün, sulu dispersiyon formunda h-BNNS-OH elde edilmesi amacıyla sonikasyona maruz bırakılmıştır. Üretilen h-BNNS’lerin karakterizasyonu; Fourier dönüşümlü kızılötesi spektroskopisi (FTIR), Raman spektroskopisi, taramalı elektron mikroskobu (SEM), enerji dağılımlı X-ışını spektroskopisi (EDS), X-ışını kırınımı (XRD) ve geçirimli elektron mikroskobu (TEM) teknikleri kullanılarak gerçekleştirilmiştir. Elde edilen h-BNNS’lerin yüzeylerinin hidroksil grupları ile fonksiyonlandırıldığı belirlenmiştir. Bu çalışma, fazla miktarda alkali metal hidroksit varlığında gerçekleştirilen ardışık hidrotermal işlem ve problu sonikasyonun, yalnızca bir eksfoliasyon çevrimi ile yüksek stabiliteye (9 haftadan daha uzun süre) ve yüksek ürün verimine (%17) sahip sulu h-BNNS-OH dispersiyonlarının elde edilmesi için etkili ve uygulanabilir bir eksfoliasyon yöntemi olduğunu ortaya koymaktadır
Numerical investigation of a savonius wind turbine with different blade overlap distances
No full textThis study examines the aerodynamic efficiency of a Savonius-type vertical-axis wind turbine with various blade gap configurations at different wind speeds through numerical methods. Blade gaps of 10 mm and 20 mm were examined at constant inlet wind velocities of 3, 7, and 11 m/s using two-dimensional transient Computational Fluid Dynamics (CFD) models. The numerical studies utilised the standard k–ε turbulence model to minimise computational expenses, employing a time step of 0.002 seconds across a total simulation period of 15 seconds. The findings indicate that the 10 mm blade gap consistently surpasses the 20 mm arrangement across all wind speed conditions. The findings demonstrate that a diminished blade gap markedly enhances flow organisation, torque stability, and energy conversion efficiency, underscoring the promise of optimised Savonius rotor geometries for small-scale and low-wind renewable energy applications
Eco-friendly nano-additives: Energy, exergy, and environmental impacts in motor vehicle emission control
No full textThis study investigates the performance and emission behavior of borax decahydrate nanoparticles when blended with biodiesel and commercial diesel fuels in diesel engines. Experimental tests were conducted at five different engine power levels: 1 kW, 2 kW, 3 kW, 4 kW, and 5 kW-to evaluate the impacts of these fuel blends on engine performance, emissions, energy efficiency, exergy, and exergoenvironmental parameters. The data collected demonstrated a general trend where higher engine power output led to increased heat generation. Among the tested blends, the D40W50P1 fuel achieved efficiencies of 15.236%, 15.466%, 18.290%, 25.606%, and 24.258% at the respective power levels, highlighting the positive effect of borax nanoparticle addition on engine performance. The inclusion of borax nanoparticles particularly improved the performance of diesel/waste cooking oil blends. The results also revealed that the D50W50 fuel blend performed optimally at 2 kW, whereas the D40W50P3 blend showed a notable improvement, achieving an efficiency increase of 12.10%. Furthermore, sustainability index values were consistently above 1, indicating a favorable environmental and energetic balance for all tested fuel blends. The lowest recorded sustainability index was 1.123, observed for the D50W50 blend. In terms of exergoenvironmental analysis, the D40W50P2 fuel blend demonstrated carbon dioxide (CO2) emissions of 311.69 kg/month at 1 kW and 786.34 kg/month at 5 kW. These results highlight the potential of borax nanoparticle additives to not only improve fuel efficiency and engine performance but also contribute to reducing environmental emissions. The results indicate that boron additives can enhance engine performance and energy efficiency while reducing CO2 emissions. Additionally, the improvement in the sustainability index reveals the potential of boron-based fuels from both environmental and economic perspectives. These findings serve as an important reference for future research and industrial applications related to alternative fuel additives
Performance and emission characteristics of a single-cylinder diesel engine fueled with a 10% olive pomace oil– diesel blend
No full textThis study investigates the effects of using a 10% olive pomace oil–diesel blend on the performance and emission characteristics of a single-cylinder diesel engine under varying load conditions. The blend was prepared by volumetrically mixing 10% olive pomace oil with standard diesel fuel. The engine was tested under four different load conditions: 25%, 50%, 75%, and 100% of full load capacity.The experimental results revealed that the engine power output decreased by a maximum of only 0.1 kW across all load conditions when compared to standard diesel. This minor reduction indicates that the blend maintains comparable engine performance. Fuel consumption increased by a maximum of 16 ml/h, which is a relatively small difference and within acceptable limits for alternative fuel use. In terms of emissions, carbon monoxide (CO) levels decreased slightly—by approximately 0.01%—across all load conditions, suggesting improved combustion efficiency. However, the reduction in CO was minimal. On the other hand, nitrogen oxides (NOₓ) emissions showed an increase, particularly at higher loads. A maximum increase of 160 ppm was recorded at 75% load, while other conditions showed moderate increases ranging from 55 to 65 ppm. Despite the slight rise in NOₓ emissions, the findings suggest that blending olive pomace oil with diesel at a 10% volumetric ratio can be a viable and sustainable alternative fuel option for diesel engines, with minimal impact on performance and moderate changes in emissions