Repositório Institucional da Universidade Estadual da Paraíba
Not a member yet
17921 research outputs found
Sort by
Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders
No full textWe characterized the genetic architecture of the attention-deficit hyperactivity disorder-substance use disorder(ADHD-SUD) relationship by investigating genetic correlation, causality, pleiotropy, and common polygenic risk.Summary statistics from genome-wide association studies (GWAS) were used to investigate ADHD (Neff =51,568), cannabis use disorder (CanUD, Neff = 161,053), opioid use disorder (OUD, Neff = 57,120), problematicalcohol use (PAU, Neff = 502,272), and problematic tobacco use (PTU, Neff = 97,836). ADHD, CanUD, and OUDGWAS meta-analyses included cohorts with case definitions based on different diagnostic criteria. PAU GWAScombined information related to alcohol use disorder, alcohol dependence, and the items related to alcohol problematic consequences assessed by the alcohol use disorders identification test. PTU GWAS was generated amulti-trait analysis including information regarding Fagerstr¨om Test for Nicotine Dependence and cigarettes perday. Linkage disequilibrium score regression analyses indicated positive genetic correlation with CanUD, OUD,PAU, and PTU. Genomic structural equation modeling showed that these genetic correlations were related to twolatent factors: one including ADHD, CanUD, and PTU and the other with OUD and PAU. The evidence of a causaleffect of PAU and PTU on ADHD was stronger than the reverse in the two-sample Mendelian randomizationanalysis. Conversely, similar strength of evidence was found between ADHD and CanUD. CADM2 rs62250713was a pleiotropic SNP between ADHD and all SUDs. We found seven, one, and twenty-eight pleiotropic variantsbetween ADHD and CanUD, PAU, and PTU, respectively. Finally, OUD, CanUD, and PAU PRS were associatedwith increased odds of ADHD. Our findings demonstrated the contribution of multiple pleiotropic mechanisms tothe comorbidity between ADHD and SUDs
The (re)rise of the far right in the franco-german axis: a case study of the ideological and electoral evolution of Alternative for Germany and Rassemblement National and their impacts on european integration (2024-2025)
No full textThe European Union, historically driven by the Franco-German axis as the engine of regional integration and interdependence, faces structural challenges in the 21st century. Successive economic and migration crises have provided the ideal backdrop for the proliferation of the 'fourth wave' of the far right, characterized by the intersection of nativism, authoritarianism, and populism. In this context, the objective of this monograph is to analyze the performance of the AfD and RN parties and the resulting weakening of regional integration within the European Union in 2024 and 2025. The central hypothesis asserts that the political strength gained by the far-right parties AfD and RN in the 2024 and 2025 legislative elections weakened support for EU regional integration. To test this premise, the research adopts an explanatory qualitative-quantitative approach. In the qualitative dimension, it is structured as a comparative case study, utilizing a literature review to trace the evolution of regionalism theories, the history of European treaties, and the strategic shifts of the AfD and RN. In the quantitative dimension, it employs graphs using the Chapel Hill Expert Survey (CHES) database for 2014, 2019, and 2024. Data processing was performed using R software, culminating in the formulation of a Multiple Linear Regression (OLS) model designed to test the impact of independent variables - such as ideological extremism, nationalism, GALTAN, and anti-elite salience - on party support for integration. The results statistically demonstrate that the consolidation of the far right on the axis has transformed traditional skepticism into an agenda of 'integral sovereignty,' emerging as a vector of instability that reshapes governance and strains the supranational model of integration in the face of the resilience of European institutions.A União Europeia, historicamente impulsionada pelo eixo franco-alemão como motor de funcionamento e interdependência regional, enfrenta desafios estruturais no século XXI. As sucessivas crises econômica e migratória proporcionaram o cenário ideal para a proliferação da "quarta onda" da ultradireita, caracterizada pela intersecção entre nativismo, autoritarismo e populismo. Neste contexto, o objetivo desta monografia é analisar a atuação dos partidos AfD e RN e o consequente enfraquecimento da integração regional no âmbito da União Europeia no ano de 2024 e 2025. A hipótese central afirma que a força política adquirida pelos partidos ultradireitistas AfD e RN, nas eleições legislativas 2024 e 2025, enfraqueceu o apoio à integração regional da União Europeia. Para testar essa premissa, a pesquisa adota uma abordagem qualitativa-quantitativa de caráter explicativo. Na dimensão qualitativa, configura-se como um estudo de caso comparado, valendo-se de revisão bibliográfica para traçar a evolução das teorias de regionalismo, o histórico dos tratados europeus e as mudanças estratégicas do AfD e do RN. Na dimensão quantitativa, emprega gráficos utilizando o banco de dados da Chapel Hill Expert Survey (CHES) para os anos de 2014, 2019 e 2024. O processamento dos dados foi realizado no software R, culminando na formulação de um modelo de Regressão Linear Múltipla (OLS) destinado a testar o impacto de variáveis independentes - como extremismo ideológico, nacionalismo, GALTAN e saliência anti-elite - sobre o apoio partidário à integração. Os resultados demonstram estatisticamente que a consolidação da ultradireita no eixo converteu o ceticismo tradicional em uma agenda de "soberanismo integral", configurando-se como um vetor de desequilíbrio que reconfigura a governabilidade e tensiona o modelo supranacional de integração frente à resiliência das instituições europeias
Complex and transdisciplinary teaching: resistance to the homeschooling standardization project in Brazil
No full textO presente trabalho visa apresentar a Didática Complexa e Transdisciplinar como transgressão à proposta de formalização do homeschooling no Brasil. A partir de pesquisas e de estudos acerca das origens e das implicações do ensino domiciliar, com foco especial em seu desenvolvimento no Brasil diante das recentes mudanças políticas, e acerca da Teoria da Complexidade (Morin, 2011; 2015) e do princípio da Transdisciplinaridade (Nicolescu; 1999; Nicolescu, Morin e Freitas, 1994; Suanno, 2015; Santos, 2008), observou-se que o projeto controverso e obscurantista do homeschooling prejudica o processo de ensino-aprendizagem e o desenvolvimento dos sujeitos envolvidos nele. Dessa forma, este trabalho propõe uma reflexão crítica sobre a relação entre o ensino domiciliar e a Didática Complexa e Transdisciplinar, argumentando que, embora o ensino domiciliar possa oferecer flexibilidade, carece das qualidades democráticas, críticas e humanizadoras essenciais para a formação da cidadania, fatores que são defendidos pelas didáticas críticas emergentes. Logo, trata-se de um trabalho que luta por um processo educativo que integre os diferentes conhecimentos e as experiências diversas dos sujeitos e, por isso, considera a Didática Complexa e Transdisciplinar como uma contraposição necessária à natureza unilateral do homeschooling no Brasil
Reflexiones de la práctica educativa de maestros de matemáticas panameños en ejercicio
No full textThe purpose of this document is to analyze the results of previous research where the components with the low or null presence of the Didactical Suitability Criteria (DSC) in developed tasks (didactic sequences) for a training course in the teaching of Mathematics are reviewed. Individual semi-structured interviews were conducted with five teachers who participated in the previous research to gather information on why these results were obtained. The interview consisted of eight questions on the component's connections, didactical innovation, representativeness of complexity, errors, social-professional practicality, and autonomy. The analysis was conducted through a qualitative study of the semantic units of meaning (descriptive analysis). These were extracted from the transcripts of the interviews guided. The results revealed that most interviewees indicated that components, such as autonomy and social-professional practicality, generate positive emotions in their students. It is concluded that the teachers' reflection on their mathematics classes up to that time was considered a non-priority for the components whose score was low. However, the interviewees considered the importance of modifying their educational practices by employing other components of the DSCs to have quality teaching and learning processes
Los álbumes de dibujos de la Máscara Real en honor de la infanta María Antonia Fernanda de Borbón (Barcelona, 1750)
No full text[cat] El treball estudia els àlbums de dibuixos realitzats per Francesc Tramulles amb motiu de l'estada de l'infanta Antonia Fernanda de Borbó, el 1750, amb motiu del seu casament amb el princep de Saboya. L'article resegueix el trajecte, així com les festes i celebracions que es van fer en aquesta ocasió. També incideix en el paper del Marquès de la Mina en aquests esdeveniments.[esp] En 1750, la ciudad de Barcelona obsequió a la infanta María Antonia Fernanda de Borbón tres álbumes con los diseños de las “cuadrillas de naciones”, realizados por el pintor Francesc Tramulles, que amenizaron los actos de entretenimiento que se le ofreció a su paso por la ciudad con motivo de su matrimonio con Vittorio Amedeo de Saboya. Desconocidos hasta la fecha, los autores profundizan en su singularidad gracias a la localización y estudio de dos de ellos.
El presente artículo recoge los actos festivos dedicados a la real comitiva, estudia los dibujos en relación a la irrupción del gusto rococó en el país, analiza las diferencias existentes entre ellos y pone de manifiesto el papel que desempeñó el Marqués de la Mina como promotor de los fastos realizados en Cataluña.[eng] In 1750, the city of Barcelona bestowed the Infanta María Antonia Fernanda de Borbón three albums with the designs performed by the “cuadrillas de naciones”, made by the painter Francesc Tramulles, which enlivened the entertainment acts that were rendered to her when she visited the city on the occasion of her marriage to Vittorio Amedeo of Savoy. So far unknown, researchers can now delve within their uniqueness due to the discovery and study of two of these works.
The following article lists the festivities dedicated to the royal party, studying the drawings in relation to the emergence of the Rococo style in the country, additionally, the existing differences between them are analyzed, highlighting the role played by Marqués de la Mina as the promoter of the pomp performed in Catalonia
Characterization of the gene family encoding acetoacetyl-CoA thiolase in Arabidopsis
No full textThiolases are ubiquitous enzymes involved in many essential biochemical processes. Biosynthetic thiolases, also known as acetoacetyl-CoA thiolases (AACT), catalyse a reversible Claisen-type condensation of two acetyl-CoA molecules to form acetoacetyl-CoA. Here, we report the characterisation of two genes from Arabidopsis thaliana L., ACT1 and ACT2, which encode two closely related AACT isoforms (AACT1 and AACT2, respectively). Transient expression of constructs encoding AACT1 and AACT2 fused to GFP revealed that the two proteins show a different subcellular localisation. While AACT1 is found in peroxisomes, AACT2 localises in the cytosol and the nucleus. The peroxisomal localisation of AACT1 depends on the presence of a C-terminal peroxisomal targeting sequence (PTS1) motif (Ser-Ala-Leu) not previously found in other organisms. ACT1 and ACT2 genes are also differentially expressed. Whereas ACT2 is expressed at relatively high level in all plant tissues, the expression of ACT1 is restricted to roots and inflorescences and its transcript is present at very low levels. The obtained results are in agreement with the involvement of AACT2 in catalysing the first step of the mevalonate pathway. The metabolic function of AACT1 is not clear at present, although its particular peroxisomal localisation might exclude a role in isoprenoid biosynthesis
Advancing Viscoelastic Material Characterization ThroughComputer Vision and Robotics: MIRANDA and RELAPP
No full textThis study introduces MIRANDA, a computer vision system, and RELAPP, a complementary force measurement system, developed for characterizing viscoelastic materials. Our aim was to evaluate their combined ability to predict key rheological parameters and demonstrate their utility in material analysis, offering an alternative to traditional methods. We analyzed five distinct flour dough samples, correlating MIRANDA and RELAPP variables with established rheological reference values. Support Vector Machine (SVM) regression models were trained using MIRANDA’s stable TR and elasticity data to predict industrially relevant parameters: baking strength (W), tenacity (P), extensibility (L), and final viscosity (RVU) from Chopin alveograph and viscosimeter. The predictive models showed promising results, with R2 values of 0.594 (p = 0) forW, 0.575 (p = 0) for P, and 0.612 (p = 0.03763) for viscosity, all statistically significant. While these findings are promising, it is important to note that the small sample size may limit the generalizability of these models. The synergy between the systems was evident, exemplified by strong positive correlations, such as between MIRANDA’s Elasticity and RELAPP’s c_exp (parameter ‘c’ of its mathematical model m1, r = 0.858) and final resistive force (r = 0.839). Despite the limited sample size, these findings highlight MIRANDA’s versatility and speed for efficient material characterization. MIRANDA and RELAPP offer significant industrial implications for viscoelastic materials, including accelerating development cycles and enhancing continuous quality control. This approach has strong potential to reduce reliance on slower, traditional methods, warranting further validation with larger datasets
Rational and more than rational sciences in the Umayyad Caliphate: dialogue, debate, and confrontation
No full textThe time of the Umayyad caliphate of Cordoba (early fourth/tenth century to early fifth/eleventh century) represents a crucial phase in the creation of the scientific and philosophical culture of al-Andalus. At the beginning of the fourth/tenth century, the economic and political situation of the Umayyad regime was weak and the rulers were largely unable to sponsor the arts and sciences. Due to the general instability of the time, the rulers needed the support of the religious scholars, and so the disciplines that most of these scholars rejected (namely astrology, philosophy, and rational theology) were banned from the court. The ascent of ʿAbd alRah.ma¯n III (r. 300-50/912-61), who proclaimed the caliphate in 316/929, signified a new beginning for scientific and intellectual activity, which flourished until the end of the period, most particularly during the caliphate of al-H. akam II (350-66/961-76). There was intense activity in disciplines that appeared particularly controversial in the eyes of religious scholars, like astrology, magic, and alchemy. These and other disciplines made their mark in learned society and at the court. This article explores the political and intellectual considerations underlying this process and analyzes the extent of the practice of controversial disciplines in the context of the period, paying particular attention to the role played by Maslama b. Qa¯sim and Maslama al-Majrı¯t.ı¯
Attuning doped ZnO-based composites for an effective light-driven mineralization of pharmaceuticals via PMS activation
No full textWater treatment technologies need to go beyond the current control of organic contaminants and ensure access to potable water. However, existing methods are still costly and often inadequate. In this context, novel catalysts that improve the mineralization degree of a wider range of pharmaceuticals through more benign and less consuming methodologies are highly sought after. ZnO, especially when doped, is a well-known semiconductor that also excels in the photocatalytic removal of persistent organic pollutants. In this study, we investigated the effect of doping ZnO nanoparticles with either copper, gallium or indium on the structure, morphology, photophysical properties and photocatalytic mineralization of pharmaceuticals. Their architecture was further improved through the fabrication of composites, pairing the best performing doped ZnO with either BaFe12O19 or nickel nanoparticles. Their suitability was tested on a complex 60-ppm multi-pollutant solution (tetracycline, levofloxacin and lansoprazole). The activation strategy combined photocatalysis with peroxymonosulfate (PMS) as an environmentally friendly source of highly oxidative sulfate radicals. The alliance of doped ZnO and BaFe12O19 was particularly successful, resulting in magnetic microcroquette-shaped composites with excellent inter-component synergy. In fact, indium outperformed the other proposed metal dopants, exceeding 97% mineralization after 1 h and achieving complete elimination after 3 h. All composites excelled in terms of reusability, with no catalytic loss after 10 consecutive cycles and minimal leakage of metal ions, highlighting their applicability in water remediation