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Enquête sur les motivations et freins des propriétaires à la vaccination de leur chat en 2025
No full textLe chat est le deuxième animal de compagnie le plus présent dans les foyers français, et sa population ne fait qu’augmenter depuis plus de 20 ans. Les propriétaires, qui aiment sa présence dans leur quotidien et son impact positif sur leur bien-être, sont de plus en plus attentifs à sa qualité de vie, sa santé et plus exigeants concernant sa prise en charge vétérinaire. La médecine féline est en plein essor dans la profession vétérinaire, dont la médecine préventive qui permet de protéger le chat et son propriétaire contre les risques infectieux et parasitaires, et de dépister les maladies et signes d’inconfort le plus précocement possible. La vaccination reste un des aspects fondamentaux de la médecine préventive chez le chat contre certaines maladies auxquelles il peut être exposé : le syndrome coryza, la panleucopénie, la leucose féline et la rage. Notre enquête réalisée auprès de la clientèle du CHUV de VetAgroBio Oniris permet d’étudier les motivations des propriétaires à faire vacciner leur chat, leur compréhension des situations dans lesquelles leur compagnon est le plus exposé aux risques infectieux et leur avis par rapport aux informations qu’ils détiennent sur la vaccination. Bien que ces motivations soient surtout basées sur la protection de la population féline, elles sont aussi liées à d’autres facteurs qui n’engagent pas toujours une compréhension complète de l’exposition du chat par les propriétaires. Ces manques de clarté peuvent être améliorés par une meilleure communication de la part du vétérinaire. Une manipulation plus attentive et bienveillante du chat peut également limiter certains freins à la vaccination identifiés au cours de cette enquête
Corrigendum to “Cutaneous and subcutaneous nodular scedosporiosis in a cat” [J Mycol Med (2026) 101609]
No full textInternational audienc
Reducing packaging waste in care units: a national survey
No full textInternational audienceObjectives: Ecological transition has become an increasing concern among healthcare professionals, prompting interest in pro-environmental practices. This study aimed to provide evidence-based recommendations to guide healthcare professionals in selecting between single- and double-packaged sterile medical devices (SMD) based on their perceptions and practices.Methods: A survey was co-constructed by the French Pharmaceutical Society of Medical Devices (SPFDM), the French Society for Sterilisation Sciences (SF2S), the French Society for Hospital Hygiene (SF2H), and the National Association of State-Certified Operating Room Nurses (UNAIBODE). The questionnaire was distributed electronically to healthcare professionals working in operating theatres across France.Results: A total of 130 respondents completed the survey, including 72 operating room and registered nurses (55.5%), 30 pharmacists (23%), 20 managers (15.5%) and eight others (6%). Most participants worked in public health establishments (80.8%) with established waste sorting systems (83.1%), mainly for paper/cardboard, metal and plastic. Daily use of single-pack SMD was reported by 61.5% of respondents, although only 11.3% applied this to implantable MD. Packaging was considered an environmental criterion by 71.5% of participants, mainly based on the number of packages. Safety concerns were prevalent, with 66.9% indicating that single packaging alone was insufficient for SMD. A majority (70.8%) supported transitioning to single-pack MD where appropriate, whereas the trend reversed for implantable SMD, with 60.0% opposing single packaging. Most respondents (75.4%) favoured wider availability of dematerialised records, and 97% supported a pictogram indicating recyclability of SMD packaging.Conclusion: This national survey provides valuable insights into SMD packaging practices in French operating theatres. While safety remains the primary concern-particularly for implantable SMD-there is strong environmental awareness and willingness to adapt practices when clinical safety is not compromised. Based on these findings, professional societies plan to develop recommendations promoting single-pack SMD where clinically appropriate, while maintaining double packaging for high-risk implantable SMD
Intracellular Membrane Repair Dysregulation and Accumulation of Mature Myostatin Protein are Novel Markers of Muscle Pathophysiology in Pompe Disease
No full textInternational audiencePompe disease is an autosomal recessive metabolic disorder caused by acid alphaglucosidase deficiency, characterized by progressive skeletal muscle weakness and respiratory insufficiency. Affected muscles exhibit glycogen-filled lysosomes, autophagic build-up, and mitochondrial abnormalities. Despite global myofibrillar disorganization, satellite cells (SCs) fail to activate, due to mechanisms that remain unclear. This study sought to comprehensively characterize the phenotypic features of affected muscles in Pompe disease, focusing in particular on membrane repair processes, as membrane damage is a primary trigger for SC activation. Longitudinal transcriptomic analysis of muscle from a Pompe disease mouse model, combined with immunohistochemical and biochemical analyses, showed early and sustained overexpression of dysferlin (DYSF), annexin A2 (ANXA2), and AHNAK2, proteins involved in membrane repair. Abnormal localization of these proteins was observed throughout the disease course, as evidenced by sarcoplasmic accumulation at lysosomes, autophagosomes, and T-tubules, respectively. These alterations suggest a compensatory mechanism to preserve the integrity of intracellular structures. Analysis of muscle biopsies from patients with lateonset Pompe disease (LOPD) suggested sarcoplasmic localization of DYSF, ANXA2 and AHNAK2 that correlated with the severity of the histological phenotype. Moreover, in the mouse model, we observed persistent post-transcriptional accumulation of mature myostatin, a key negative regulator of muscle growth, which may contribute to impaired SC activation and the absence of muscle regeneration despite extensive tissue damage. In conclusion, our findings identified differential expression of proteins associated with intracellular membrane repair and dysregulation of myostatin as key markers in the course of Pompe disease. These insights provide new perspectives on the underlying pathophysiology and point to novel therapeutic avenues for limiting disease-associated damage
Impact of the physico-chemical properties of commercial pea proteins concentrate and isolate on the quality of meat analogs
No full textInternational audiencePlant proteins extracted from soys and peas, have been identified as potential functional ingredients for plantbased meat analogs producted by high moisture extrusion cooking (HMEC). However, the extraction process (dry for concentrate and wet for isolate) can have an impact on the primary structure of the proteins, affecting their technical and functional properties. This study aims to compare the impact of two fractionation process on pea proteins (structure, fractions, flowing index) and their ability to create a network, which can mimic the fiber structure found in meat, within moisture extrusion. Pea protein concentrates (PPC) obtained by dry fractionation, and pea protein isolate (PPI) by isoelectric precipitation were characterized in terms of functional and flow properties. Results showed that PPI have a higher aggregation, lower solubility and water-holding capacity than PPC, and no thermal event was highlighted by differential scanning calorimetry, indicating proteins denaturation of PPI. Denaturation of proteins before the heating step in extruder barrel contrasts with the current model described in the literature. However, treating with HMEC, PPC is less suitable than PPI where better results in term of flow properties (respectively with flowability indexes of 27.33 and 56.17) and anisotropic structure. In that way, it appears that proteins concentration (55 % and 70 % respectively for PPC and PPI) is the most important parameter for creating a meat like texture in the conditions of the experiment
Effects of composition and process on the performance of thermopressed materials prepared from model and real-life biomass
No full textInternational audienceThere is growing interest in turning the by-products of agricultural processes into biobased and biodegradable materials. The complexity of composition and structure of biomass makes it difficult to understand the mechanisms involved in its transformation into materials, requiring model systems. In this study, solid materials were obtained from model cellulosic fibers (modulus of 5.5-5.8 GPa) and biomass from brewery co-products (modulus of 2.2-2.6 GPa) using uniaxial compression. Their properties were comparable to or exceeded those reported for conventional binderless cellulosic materials processed at higher temperatures (~200 • C), thus highlighting the efficiency of our low-temperature process. The effect of the fiber size and composition, of the processing temperature on the resulting samples mechanical properties was assessed. We show that longer initial fibers, with higher aspect ratio, led to improved flexural modulus and strength due to a higher degree of fiber entanglement, which translated into better performance for the less transformed biomass. While purely cellulosic samples displayed better mechanical properties than those prepared from biomass at a pressing temperature of 100 • C, the increase to 140 • C closed the gap between the two biomasses particularly in terms of water resistance due to a reduced porosity. Finally, model cellulosic polymers improved the water resistance of the cellulosic samples due to the formation of water tight matrix. This low temperature, binder-free method is promising for the green transformation of biomass coproducts
Population pharmacokinetic modelling of oxytetracycline in rainbow trout (Oncorhynchus mykiss): Effects of route of administration, temperature and ploidy
No full textInternational audienceThe aim of this study was to perform a pharmacokinetic (PK) study of oxytetracycline (OTC) in rainbow trout using different routes of administration and different doses, and to investigate the influence of the bodyweight, the ploidy status (diploid versus triploid) and the water temperature (10 °C versus 16 °C).A cross-over design was used with 361 trout (median bodyweight: 389 g), each fish receiving OTC intravenously (8–30 mg/kg) and orally (50–150 mg/kg), by gavage or by spontaneous intake via a coating of OTC on the feed to mimic farming practice. Each fish, for each modality, was sampled 3–4 times over a period of 11 days, to establish its individual PK profile. Coated feed and plasma samples were assayed using a sensitive HPLC-MS/MS method. A population PK modelling approach was used to analyse plasma data and estimate key PK parameters and their variability.A bi-compartmental PK model best described the plasma data. The absolute oral bioavailability appeared to be very low (around 3 %) and the elimination of OTC was slow and strongly influenced by temperature (elimination half-life approximately 79 h at 16 °C versus 113 h at 10 °C). A comparison of spontaneous intake and gavage showed a significant loss of antibiotic due to leaching (about 30 %). Bodyweight and water temperature were the most influential covariates affecting the PK of OTC compared to the effect of ploidy. Pharmacodynamic (PD) studies with OTC against the major trout pathogens are now required to allow a more robust assessment of the expected efficacy thanks to a PK/PD approach
Development of Dating Motivations During High School: Contributions of Romantic Experiences
No full textInternational audienceABSTRACT Objective Adolescent dating motivations are often considered a key issue in understanding dating and sexual behaviors. Despite their initial identification, the development of these motivations and their correlates remains understudied. The present study aimed to investigate the development of dating motivations over a 3‐year period using a longitudinal design, and to explore the moderating roles of romantic experiences and current dating status. Method French late adolescents ( N = 493; 61% girls) completed a questionnaire six times over 3 years. Rooted in self‐determination theory, the questionnaire assessed their amotivation for dating, intrinsic motivation (intimacy and companionship), identified regulation (pleasure and dating timetable), and external motivation (peer pressure), as well as their romantic experiences and current dating status. Results As expected, growth models revealed an increase in identified regulation and intrinsic motivation, and a decrease in amotivation, and external motivation between the beginning and end of high school. Gender differences emerged in the developmental trajectories of these motivations: girls showed a more rapid decline in amotivation and a steeper increase in identified regulation than boys. Furthermore, the gender gap in intrinsic motivation increased across the six waves. Conclusions Overall, the findings support the view that adolescents progressively shift toward more self‐determined motivations with age—a process that appears to occur earlier in girls than in boys. Romantic experiences and current dating status hindered the decrease in amotivation and made only a small contribution to the development of other forms of regulation. Practical implications of the development of dating motivation and gender differences are discussed
Free-range versus conventional: A comparison of microbial composition and Campylobacter contamination in broiler carcasses after chilling
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Flash Profile method, is it suitable for complex multi-layered products? Application to strawberry-filled biscuits: a “SWEET project”
No full textInternational audienceComposite foods are consumed daily, but understanding their sensory properties is a major challenge. This study aims to evaluate the efficiency of Flash Profile (FP) method to characterize strawberry-filled biscuits properties, in a context of sugar reduction. Investigations were carried out on fillings (with/without added sugar, with/ without strawberry aroma), then biscuits (with sugar or maltitol or sorbitol, with/without vanilla aroma) and finally on the complex fruit-filled biscuits, corresponding to a progressive matrix complexification strategy.FP allowed a discrimination of the products for the 3 matrices according to their formulation and flavouring. Fruit fillings and biscuits were described with both flavour and texture attributes, whereas fruit-filled biscuits were mainly described with texture attributes. This texture predominance could result from complex changes of texture perceived during chewing. Panellists may also have focused on the first perceived characteristics or on the product's most distinguishing features to ease the task.FP was efficient to discriminate samples in each set of samples according to formulation. The characteristics allowing differentiation between samples varied depending on the matrix. Flavour attributes were mainly used for fluid matrices while texture was dominant for solid matrices. In our study, all panellists evaluated the 3 sets of products in the same order which could have influence their evaluation of complex products during the last session. Further investigations about the evaluation of complex solid products with FP may determine if texture is always dominant, even with a lower number of products.</p