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Senescence-associated lineage-aberrant plasticity evokes T-cell-mediated tumor control
No full textInternational audienceAbstract Cellular senescence is a stress-inducible state switch relevant in aging, tumorigenesis and cancer therapy. Beyond a lasting arrest, senescent cells are characterized by profound chromatin remodeling and transcriptional reprogramming. We show here myeloid-skewed aberrant lineage plasticity and its immunological ramifications in therapy-induced senescence (TIS) of primary human and murine B-cell lymphoma. We find myeloid transcription factor (TF) networks, specifically AP-1-, C/EBPβ- and PU.1-governed transcriptional programs, enriched in TIS but not in equally chemotherapy-exposed senescence-incapable cancer cells. Dependent on these master TF, TIS lymphoma cells adopt a lineage-promiscuous state with properties of monocytic-dendritic cell (DC) differentiation. TIS lymphoma cells are preferentially lysed by T-cells in vitro, and mice harboring DC-skewed Eμ- myc lymphoma experience significantly longer tumor-free survival. Consistently, superior long-term outcome is also achieved in diffuse large B-cell lymphoma patients with high expression of a TIS-related DC signature. In essence, these data demonstrate a therapeutically exploitable, prognostically favorable immunogenic role of senescence-dependent aberrant myeloid plasticity in B-cell lymphoma
Advanced treatment of micropollutants in wastewater: from adsorption to advanced oxidation processes including the emerging disinfectant performic acid
No full textInternational audienc
Ion induced formation of complex organic nitrogen molecules in solid-phase adenine
No full textInternational audienceComplex organic molecules have been found in many space environments like meteorites and comets. There, they are subjected to various forms of radiation (photons, electrons, ions), opening the question of their behavior and chemical evolution, which may have played a crucial role in chemical processes of astrobiological interest. In this study, we investigate the irradiation of adenine (CHN) with oxygen and neon ions. The free parameters of the experiments include varying energies (30-70 keV), temperatures (150, 300 K), sample thicknesses (138-554 nm), and ion fluences (0.69-5 10 ions cm). In situ IR spectroscopy reveals the appearance of CN and N=C=N bands indicating the formation of new species. Ex situ ultra-high-resolution mass spectrometry shows the formation of new complex organic molecules that far exceed the molecular mass of adenine. These macromolecules show great chemical diversity and can be expressed as (HCN)R families, where z can reach 14 and R can be C, H, N, NH, CH or CN. In total, nearly 100 individual families have been identified, 28 of which can be found in every irradiated sample. Their aromaticity equivalent is higher than that in other N-rich samples such as Titan tholins and HCN-polymers, corresponding to polycyclic aromatic nitrogen-bearing hydrocarbons. The high amount of nitrogen in these molecules indicates a very efficient incorporation of nitrogen in the solid phase during the irradiation of adenine. The ease with which complex organic matter forms through irradiation highlights the relevance of these species in space environments
Etude des accumulations sédimentaires en basse et moyenne vallée de la Seine : vers la quantification des apports latéraux à partir de l'identification des processus et des sources d'apports sédimentaires. Exemple du méandre d'Anneville-Ambourville (Seine-Maritime)
No full textInternational audienc
ATMO-ACCESS D8.2 A strategic access plan for access provision to atmospheric RIs
No full textDeliverable 8.2 presents a strategic access plan that builds upon the outcomes of the ATMO-ACCESS project while extending its scope to incorporate insights from two additional Horizon 2020 pilot projects - ORP and NFFA. These projects, operating in distinct scientific domains, provide complementary perspectives on access provision to distributed Research Infrastructures (RIs). The aim of D8.2 is to formulate recommendations that are not only grounded in the atmospheric sciences but also applicable across a broader spectrum of RI communities, thereby contributing to a more inclusive and sustainable European access framework
ATMO-ACCESS D3.4 International access modalities recommendations for 2030 in ATMO-ACCESS RIs based on test cases
No full textThe aim of this deliverable is to summarize and analyze the challenges of international access provision based on the work done in the ATMO-ACCESS project and particularly based on a test case from the Italian infrastructure project “ITINERIS” (Integrated Environmental Research Infrastructures System) [1]. A major part of the ITINERIS activities aim at promoting and supporting access to services provided by the Italian RIs to European Users and for Italian users to services provided by ACTRIS facilities. Based on the work done in ATMO-ACCESS and the test case, we provide recommendations to further develop the international access framework and modalities for atmospheric RIs
Improved Inverse Identification of Anisotropic Polymer Properties via FEMU and VFM With Sensitivity Analysis
No full textInternational audienc
Pore scale microbial biogeography across different soil types
No full textInternational audienceMicrobial activity in soils is influenced by the structural heterogeneity of the pore network, which governs the distribution of microbial communities, their interactions with organic matter and the characteristics of the immediate environment of microorganisms. This study investigates whether microbial activity exhibits consistent patterns across pore size classes in six soil types with diverse physical and chemical properties. Using a matric potential-based approach, we targeted small (3-10 μm) and large (30-100 μm) pores with 13 C-labelled pyruvate to assess microbial respiration and substrate mineralisation. The results revealed that the mineralisation of the added organic substrate was faster in the larger pores of four of the six studied soils, but that the microbial carbon use efficiency was lower compared to smaller pores, where a more efficient carbon use was observed. The exceptions were a forest soil with an abundant fungal community and a long term bare fallow soil with depleted soil organic C content and microbial biomass. Despite differences in soil properties, such as texture, organic matter content and pH, the observed patterns were consistent across most soil types, highlighting universal controls on microbial activity at the pore scale. This work underscores the critical role of soil microstructure in shaping microbial activity and carbon cycling. The findings advance our understanding of microbial biogeography and provide insights for improving soil carbon models to better predict ecosystem responses to environmental change
Estimating the properties of bone phantom cylinders through the inversion of axially transmitted low-frequency ultrasonic guided waves
No full textInternational audienceEarly detection of osteoporosis has increasingly focused on ultrasonic methods, particularly guided waves in axial transmission to assess cortical bone properties. This study demonstrates the potential of low-frequency measurements (500 kHz) for accurately inferring cortical mechanical and geometrical properties. A custom ultrasonic transducer centered at 350 kHz was used to acquire data, processed via a 2D fast Fourier transform to obtain dispersion curves. These were compared with simulations generated using the semi-analytical iso-geometric analysis (SAIGA) method, modeling a quasi-cylindrical bone geometry in void or immersed in olive oil. By incorporating an excitability parameter into the inversion algorithm, the proposed method achieved a less than 5% discrepancy between bone phantom properties determined via SAIGA inversion and bulk wave pulse-echo measurements, demonstrating its accuracy and potential for in vivo applications. Results also showed that high-wavenumber modes predominantly reflect material properties, whereas low-wavenumber modes below 100 kHz are sensitive to the overall bone geometry, highlighting the importance of low frequencies for a global bone characterization
An Instrumented Hammer to Detect the Bone Transitions During an High Tibial Osteotomy: An Animal Study
No full textInternational audienceAbstract High tibial osteotomy is a common procedure for knee osteoarthritis during which the surgeon partially opens the tibia and must stop impacting when cortical bone is reached by the osteotome. Surgeons rely on their proprioception and fluoroscopy to conduct the surgery. Our group has developed an instrumented hammer to assess the mechanical properties of the material surrounding the osteotome tip. The aim of this ex vivo study is to determine whether this hammer can be used to detect the transition from cortical to trabecular bone and vice versa. Osteotomies were performed until rupture in pig tibia using the instrumented hammer. An algorithm was developed to detect both transitions based on the relative variation of an indicator derived from the time variation of the force. The detection by the algorithm of both transitions was compared with the position of the osteotome measured with a video camera and with surgeon proprioception. The difference between the detection of the video and the algorithm (respectively, the video and the surgeon; the surgeon and the algorithm) is 1.0±1.5 impacts (respectively, 0.5±0.6 impacts; 1.4±1.8 impacts), for the detection of the transition from the cortical to trabecular bone. For the transition from the trabecular to cortical bone, the difference is 3.6±2.6 impacts (respectively, 3.9±2.4 impacts; 0.8±0.9 impacts), and the detection by the algorithm was always done before the sample rupture. This ex vivo study demonstrates that this method could prevent impacts leading to hinge rupture