Portail HAL de l’Université Claude Bernard Lyon
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Design of water-soluble lanthanide luminescent probes for the selective detection of HOCl
No full textInternational audienceThe synthesis and photophysical properties of tacn- or pyclen-based macrocyclic complexes featuring extended thioanisole-picolinate antennas are reported. These systems efficiently sensitize Eu(iii) luminescence, whereas Tb(iii) emission is quenched due to back-energy transfer (BET). In all lanthanide-containing complexes (Eu, Tb and Gd), the sulfide donor group was readily oxidized by HOCl to the corresponding sulfoxide or sulfone. Upon oxidation, the Tb(iii) complexes became highly luminescent and act as OFF-ON probes when excited at the isosbestic point (302 nm). Finally, a water/buffer soluble Tb(iii) complex combining ether and sulfide antenna was prepared, exhibiting remarkable sensitivity and selectivity towards HOCl detection
Knee kinesiography in 2026: Current and future applications for digital orthopaedics and personalised total knee arthroplasty: A narrative review
No full textInternational audienceKnee Kinesiography, using the KneeKG system, delivers clinically feasible, weight-bearing (WB) three-dimensional knee kinematics and is shifting total knee arthroplasty (TKA) from static templating to function-focused personalisation. This narrative review synthesises how KneeKG applications changed pre-and postoperative care and how these changes can translate into better patient outcomes. Preoperatively, KneeKG quantifies dynamic alignment, varus thrust, dynamic flexion contracture, pivot pattern, tibiofemoral translation, and tibial rotation during gait, defining a functional profile that relates to symptoms and can inform alignment philosophy, bearing selection, and soft-tissue strategy. When coupled with navigation or robotics, these data allow the anticipation of mid-flexion balance requirements while enabling surgeons to set functional targets more likely to yield natural, stable knee in WB condition. A KneeKG-guided prehabilitation pathway also facilitates the recalibration of expectations before surgery and can improve early patient-reported outcomes. Postoperatively, KneeKG audits whether intraoperative parameters (e.g., achieved gaps, implant components, etc.) translate into the intended dynamic behaviour, verifies bearing-intended pivot during WB tasks, and reveals modifiable residual deficits-such as persistent thrust, stiff-knee gait, valgus collapse, or excessive external tibial rotation-to target with therapy. Function-focused rehabilitation programmes anchored on a KneeKG exam demonstrated acceleration of recovery, increase in outcome scores, satisfaction, and raise of the proportion of patients reaching a patient acceptable symptom state, with benefits maintained beyond one year in subsets. Across the episode of care, KneeKG provides a common functional language that links preoperative planning, intraoperative execution, and postoperative rehabilitation, allowing teams to iterate from plan to performance and to close the loop between digital precision and real-world function. By operationalizing dynamic information at the point of care, this exam supports surgeons towards more
SocialFacts
No full textSocialFacts brings a tool to produce easily multiple indicators commonly used in social sciences : Odds Ratio, with p.value and CI Average Marginal Effects, with CI A cramer's V table, to check correlation between your categorical variables A gt table with Yule's Q value compute against the vars_dep argument. A new tool called Average Attributable Fraction, described by Ferguson and al. here : We use the original graphPAF library, and facilitate it's use to produce a table which resume all of this tools in one plac
Natural variation in Arabidopsis uncouples leaf and flower development and reveals massive transcriptomic heterochrony
No full textInternational audiencePlant development is a sequence of precisely timed and spatially coordinated events that produce organs such as leaves and flowers. In Arabidopsis thaliana, for example, the development of leaves (called bracts in the inflorescence) halts once the first flower forms. Understanding how this transition is regulated is key for decoding how developmental programmes are coordinated during the floral transition. In this study, we investigated a natural phenotypic variation that uncouples bract repression from flower initiation. We discovered that the continued formation of bracts after the floral transition involves complex genetic interactions across at least four loci. Interestingly, none of these loci included known floral identity genes previously linked to bract repression, pointing to novel regulators in the coordination of bract and flower development. Using time-series transcriptomics and curve registration, we found that differences in gene expression levels when bracts persist are mainly driven by a massive desynchronization of gene dynamics. This affects a wide range of biological processes beyond those associated with leaf identity. These findings align with the ‘inverse hourglass’ model, which proposes that transcriptomic divergence at transitional stages contributes to morphological variation. Our results suggest that this model may also explain trait variability within species, highlighting how transcriptome dynamics shape phenotypic robustness during developmental transitions
Depth-Resolved Analysis of Dimensional Stability (DS) in Poly(urethane-isocyanurate) Rigid Foams under Humid and Thermal Stress
No full textInternational audienceThis study examines the dimensional stability (DS) of polyisocyanurate rigid (PIR) foams under high relative humidity (RH = 90%) and elevated temperature (T = 70 °C), representative of the extreme conditions that may be encountered in roofing applications. Lateral expansion is observed in the plane perpendicular to the rise direction, which is strongly depth-dependent (Z-axis) and decreases from 5.3% for the surface layer (0−5 mm) to around 1.2% for the inner layers (Z ≥ 15 mm). This phenomenon is mainly attributed to the lower isocyanurate content near the surface and is amplified by the higher partial pressure of isopentane (+9%) near the surface. In contrast, contraction occurs in the rise direction (also called the thickness direction or TD) and remains nearly constant at −1% for Z ≥ 15 mm. This anisotropic behavior is attributed to the elongated cell morphology in the TD, inevitably leading to a decrease in mechanical strength in the plane perpendicular to the rise direction. Moisture content, quantified using Karl Fischer titration, is estimated at around 2.2 wt % (under humid conditions) and appears to play a dual effect, both plasticizing the polymer matrix and increasing internal gas pressure. Postcuring at T = 140 °C significantly increased crosslinking and improved DS, reducing foam expansion in the machine direction (MD) and cross-machine direction (CMD) from ΔL/L0 ≈ 5% to about 2% for the surface layer (0−5 mm). All these findings point toward the dominant role of moisture level, isocyanurate content, and cell shape factor of the final products on the long-term dimensional stability of PIR foams in humid, thermally stressed environments
Timing pre-saccadic attention : Temporal dynamics of the Size-Eccentricity Effect’s compensation
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Eco-friendly Insulating Materials for Transformers in MVDC and HVDC Power Networks
No full textInternational audienceThis work investigates the viability of natural and synthetic ester liquids as potential alternatives to mineral oil in MVDC and HVDC transformer insulation systems. Finite Element Method simulations (FEM) were performed using the measured dielectric properties of the oils and their impregnated pressboards as input parameters to evaluate their influence on steady state electric field distribution. A comparison on the field distribution under AC and DC condition is performed for the different materials, identifying regions of maximum stress around the corona head and high voltage electrode. The temperature dependence of electrical conductivity values of the materials and their effect on the steady state DC electric field distribution is explored. The higher conductivity of ester liquids when compared to mineral oil provides a more uniform field redistribution between the oil and pressboard, also facilitating the shift of maximum electrical stress from the oil to pressboard. The results support the technical merits of using ester-based insulation material for field stress equalization in HVDC networks
Boosting Linear and Nonlinear Optical Properties of Pt1Ag18 Nanoclusters by Manipulating Ligand-shell Rigidity
No full textInternational audienceLigand-protected metal nanoclusters exhibit novel molecular-like optical properties, yet how surface ligands regulate nonlinear optical behavior remains insufficiently understood. Here, we demonstrate a ligand-engineering strategy to modulate both linear and nonlinear optical responses of Pt1Ag18 nanoclusters through controlled tuning of ligand-shell rigidity and electron-core interactions. we prepared a family of [Pt1Ag18(DPPP)6(SR)xCl8-x] 2+ nanoclusters (SR = 1-adamantanethiol or 2-fluorothiophenol; x = 0-8), enabling progressive substitution of flexible 3D cage 1-adamantanethiol ligands with planar electron-donating 2-fluorothiophenol ligands. Increasing fluorinated thiolate content strengthens ligand-metal coupling and rigidifies the ligand environment, leading to suppressed nonradiative decay and markedly enhanced one-photon absorption, photoluminescence quantum yield, and two-photon absorption/twophoton excited photoluminescence cross-sections. Nonlinear optical measurements (700-1000 nm femtosecond excitation) reveal that resonance effects and ligand rigidity jointly govern multiphoton excitation efficiency. Furthermore, introducing bulky counterions induces additional rigidification, achieving substantial amplification of both one-and two-photon luminescence. Supported by TD-DFT calculations, this work establishes a structure-property relationship linking ligand geometry and charge-transfer character to nonlinear optical performance. These findings outline a generalizable ligandshell design strategy for tuning optical responses in atomically precise metal nanoclusters and offer promising candidates for multiphoton bioimaging and photonic applications. CCDC 2520057, 2520058, 2520059 and 22520444 contain the supplementary crystallographic data for this paper.The data that support the findings of this study are available in the Supporting Information of this article.</div
Neoadjuvant immune checkpoint blockade before chemoradiation for cervical squamous carcinoma (GINECO window-of-opportunity COLIBRI study): a phase II trial
No full textInternational audienceCombining immunotherapy with chemoradiation is effective in locally advanced cervical cancer. However, the impact of induction combination immunotherapy on immune modulation and treatment response is poorly understood. In this phase II trial (NCT04256213), 40 females with locally advanced cervical carcinoma received one cycle of nivolumab-plus-ipilimumab immunotherapy before standard chemoradiation, followed by maintenance nivolumab. We show, using multiplex-immunofluorescence tissue imaging, a significantly increased CD8+/FOXP3+ cell ratio (primary endpoint; increase of 0.87 cells/mm², P = 0.0164) and proliferative CD8+ T-cell density after one cycle of combination immunotherapy. HOT score (27-gene-based signature identifying immunologically active tumors) also increased significantly (exploratory analysis; 0.17, P < 0.0001). Objective response rates (secondary endpoint) were 13% immediately after combination immunotherapy, 98% (65% complete response) after chemoradiation, and 90% at treatment completion. High HOT score at baseline and immune changes induced by combination immunotherapy were associated with complete response at treatment completion. Induction immunotherapy may prime tumors for improved response to standard therapy
Interictal epileptiform discharges are involved in momentary lapses of attention in children with epilepsy
No full textInternational audienceAbstract Objective Attention impairments are common in children with epilepsy and widely impact their quality of life. Interictal epileptiform discharges (IEDs) may induce subtle dysfunctions of various cognitive processes, but data regarding the impact of IEDs on sustained attention remain limited. The objective of the present study was to evaluate the impact of IEDs on continuous undivided attention in children with epilepsy, controlling for the number of treatments, type of epilepsy, frequency of seizures in the past year, age at onset, and comorbid attention disorder. Methods Using a computerized sustained attention test synchronized with the electroencephalogram in 61 children with diverse epilepsy syndromes, reaction time (RT), errors, attention stability over time, and the event‐related potential (ERP) in Pz (related to attentional engagement) were collected. The cumulative impact of IEDs was evaluated using multivariate models controlling for epilepsy‐related factors. The transient impact of IEDs was assessed by comparing responses in trials with and without IEDs. Results IEDs were associated with attention fluctuations independently from other epilepsy‐related factors. In terms of cumulative impact, a higher IED rate was associated with a poorer sustained attention performance over the entire task. In terms of transient impact, trials disrupted by IEDs were characterized by longer RT and a lower amplitude of the ERP extending over a long time window that included attentional processing (P300). Significance These results suggest that IEDs may negatively impact sustained attention, independently of other epilepsy‐related features. These findings support the hypothesis that IEDs could contribute to subtle attentional deficits and serve as potential biomarkers of abnormal brain function