Portail HAL de l’Université Claude Bernard Lyon
Not a member yet
165895 research outputs found
Sort by
Inefficacy of Intraoperative Renal Replacement Therapy in Mitigating Early Allograft Dysfunction Among Liver Transplant Recipients: A Propensity Score Matched Study
No full textInternational audienceIntraoperative continuous renal replacement therapy (IoCRRT) represents a viable approach for managing the hemodynamic and metabolic challenges encountered during liver transplantation (LT), particularly in high-acuity patients. Our objective was to evaluate the impact of IoCRRT in comparison with conservative treatment on liver graft function during the immediate post-transplant period
Influence of strangeness on the anisotropic flow of prompt D mesons in PbPb collisions at = 5.02 TeV
No full textInternational audienceThe azimuthal anisotropy of prompt D mesons produced in lead-lead (PbPb) collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV is measured using data obtained with the CMS detector. The dataset corresponds to an integrated luminosity of 0.58 nb. The azimuthal anisotropy of heavy charmed mesons provides a key constraint on the interactions of charm quarks with the quark-gluon plasma (QGP) medium. These interactions include coalescence mechanisms and parton energy loss in the QGP. The anisotropy is quantified by the second- () and third-order () Fourier coefficients of the azimuthal distribution of the D mesons. The coefficient is determined in the transverse momentum range 4 40 GeV for three event centrality classes, while the coefficient is measured in the range 4 20 GeV for a single event centrality class. The results for the D mesons are compared to those previously measured for D mesons. The azimuthal anisotropy coefficients for D and D mesons are found to be consistent within the precision of this measurement, suggesting that the strangeness content of the D meson does not significantly alter its azimuthal distribution within the measured range
Data Management Plan of project "Multi-scale APproach for a microscopicunderStanding of thermal transport in nanocomposites" ANR-20-CE05-0046
No full textJe code : les bonnes pratiques en éco-conception de service numérique à destination des développeurs de logiciels
No full textSuite aux plaquettes sur les bonnes pratiques en matière de développement logiciel qui ont été réalisées par le GT-Patri du réseau DevLOG (en lien avec la DRE CNRS), le GDRS EcoInfo a établi une plaquette sur les bonnes pratiques en éco-conception de service numérique à destination des développeurs de logiciels.Cette plaquette est un complément aux 3 plaquettes de bonnes pratiques liées au développement logiciel proposées par leréseau des acteurs du DEVeloppement LOGiciel au sein de l'Enseignement Supérieur et de la Recherche : DevLOG.Ce volet est dédié aux bonnes pratiques en termes d'écoconception de service numérique qui permettent d'appréhender,de comprendre et de réduire l’impact environnemental du numérique.Après avoir explicité le contexte général dans une première fiche, une seconde fiche ("Mais pourquoi ?") met en évidencela nécessité d’intégrer une dimension environnementale dans nos conceptions de service numérique, et par conséquentdans nos développements de logiciels. La troisième fiche ("Quand ?") rappelle les étapes du cycle de vie d'un servicenumérique pour introduire les fiches de bonnes pratiques qui correspondent aux différentes étapes : "Avant", "Pendant" et"Après", en gardant à l’esprit que le développement est souvent itératif, et les frontières entre les différentes étapes sontperméables.Vous trouverez à la fin de la plaquette une fiche spécifique sur les bonnes pratiques d’écoconception pour le calculscientifique, ainsi que des fiches concernant le développement web, l’IA générative, ou les systèmes embarqués
Condensin loop extrusion properties, roadblocks, and role in homology search in S. cerevisiae
No full textThe in vivo mechanism, cis-acting roadblocks, and biological functions of loop extrusion by eukaryotic SMC complexes are incompletely defined. Here, we identify condensin-dependent Hi-C contact stripes at the Recombination Enhancer (RE) and the rDNA in S. cerevisiae. The RE is an autonomous condensin loading site only active in MATa cells from which oriented, unidirectional loop extrusion proceeds with an estimated processivity ~150-250 kb and a density ~0.04-0.18 that varies across the cell cycle. Centromeres, replication forks and highly-transcribed RNA PolII-dependent genes are roadblocks for condensin. Cohesin is not an obstacle for condensin while Top2 promotes its loop extrusion activity. A DNA double-strand break at MAT blocks loop extrusion, resulting in the establishment of a ~170 kb-long RE-MAT loop. The RE and the DSB are required and sufficient to form this site-specific loop, which promotes RE-proximal homology identification in the early stages of recombinational DNA break repair. We propose that the juxtaposition of the broken MATa site and its target HMLalpha donor is the relevant structure by which condensin promotes MATa-to-alpha switching
Neonatal hypothyroidism in male mice is associated to developmental delay and metabolic dysregulations in the adult
No full textThe postnatal period of mouse development is critical for the maturation of many organs and fine tuning of hormonal feedback loops. These developmental transformations are necessary to allow the transition from a suckling pup to an independent life but they also determine the metabolic features of the adult. Thyroid hormones are key hormones that control these postnatal events. However, the impact of a short-term exposure to maternal hypothyroidism during the perinatal period on the metabolic outcome of the descendants was not clearly established. We used a new protocol to obtain animals exposed to maternal hypothyroidism only during gestation or only during their two first postnatal weeks. The developmental and the long-term consequences of these two short perinatal periods of hypothyroidism were assessed. Animals born from hypothyroid mothers did not show developmental delays. As adults they were undisguisable from the controls and could adequately face metabolic stresses such as exposure to a high fat diet or cold temperature. In contrast pups exposed to maternal hypothyroidism during lactation presented delayed growth and remained leaner than the controls. The expression of genes involved in different metabolic pathways in liver or brown adipose tissues were affected both during development and in adults. The adults were also more sensitive to diet induced obesity and to cold exposure. In conclusion in mice severe hypothyroidism in the pregnant dam is not detrimental for postnatal development or metabolic programing of the pups. In contrast postnatal hypothyroidism leads to developmental delays and long-lasting metabolic dysregulation in otherwise euthyroid animals
Improving the identification of pesticide transformation products and assessing their ecotoxicity for aquatic organisms
No full textPlant protection products used in agriculture contain molecules specifically designed to be toxic to target organisms. However, their use can also have unintended effects, posing potential risks to ecosystems and non-target organisms, including humans. Research has deepened our understanding of the links between exposure to these substances and the effects observed in the environment. In particular, studies have highlighted how even low levels of exposure can cause chronic effects on non-target organisms and disrupt ecosystems. These findings underscore the importance of quantifying and characterising these exposures in order to better assess their potential impacts on human health and the environment.International audienceThe TAPIOCA project investigated pesticide transformation products (TPs) in the environment and their ecotoxicity on a selection of aquatic organisms. The project enabled to (i) develop non-targeted analytical methods and apply them to the identification of TPs in various environmental matrices, (ii) improve knowledge of the ecotoxic effects of a selection of pesticides and TPs under controlled laboratory conditions, and (iii) test the benefits of tools for predicting the environmental fate and ecotoxicological effects of TPs relative to their parent substance, in order to provide an initial assessment of the environmental risks arising from the formation of TPs
An original approach combining biogeochemical signatures and a mixing model to discriminate spatial runoff-generating sources in a peri-urban catchment
No full textInternational audienceAbstract. Hydrograph separation using biogeochemical data is a commonly used method for the vertical decomposition of flow into surface, subsurface and groundwater contributions. However, its application to the spatial decomposition of flow remains limited, despite its potential to identify contributions linked to geological, pedological, and land use characteristics, as well as anthropogenic contaminant sources. In this study, a Bayesian mixing model was applied to the Ratier peri-urban sub-catchment of the OTHU Yzeron observatory. Eight runoff-generating sources were identified and sampled, including different land uses (e.g. forest, grassland, agricultural areas), a colluvium aquifer, and urban point discharges (e.g. sewer system, urban and road surface runoff). A wide range of biogeochemical parameters were analysed including classical (i.e., major chemical compounds, dissolved metals) and innovative tracers (i.e., characteristics of dissolved organic matter, microbial indicators). Streamwater samples collected under contrasting hydro-meteorological conditions revealed distinct source signatures and highly variable contributions, with wastewater dominating under dry weather and rapid surface runoff during summer storms. Using these results, we improved a previously designed perceptual hydrological model of the Ratier and Mercier catchments, at the hillslope scale, which highlighted the potential of spatial tracer-based decomposition in addition to classical vertical hydrological separation. More broadly, this study demonstrates the potential of such mixing model, using classical but also more innovative tracers, to provide insights for validating distributed hydrological models and to anticipate the influence of land use, urbanisation, and climate changes on runoff generation
BrGDGT-based palaeothermometer in drylands: the necessity to constrain aridity and salinity as confounding factors to ensure the robustness of calibrations
No full textInternational audiencePast temperature reconstructions offer valuable insights into the impact of climate change on the global climate-human-vegetation system. Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are recognized as effective temperature proxies, particularly in lakes and peatlands, where they are well preserved. However, their reliability as palaeothermometers can be compromised by factors beyond air temperature, especially in drylands. This study investigates the recently compiled Arid Central Asian (ACA) brGDGT surface Data Base, a regional dataset consisting of 753 surface samples from the drylands of ACA. The distribution of brGDGTs in relation to climate and environmental variables was analysed to explore their potential as reliable temperature proxies, mainly focusing on brGDGTs methylation (MBT), cyclisation (CBT), and isomer (IR) indices. The brGDGT-based palaeothermometer is a promising tool for understanding past climates, but our comparison between an ACA-centred database and a worldwide continental surface sample database reveals several challenges. Drylands exhibit extreme climate and soil/lacustrine properties, amplifying the impact of confounding factors on brGDGT-based relationships with mean annual air temperature. Salinity emerges as the dominant factor influencing brGDGT variance, followed by sample type, pH, and aridity, all of which contribute significantly. These factors interact in complex ways, with the salinity effect varying between soil and lacustrine deposits. For sample physicochemical conditions, the IR6+7Me′ index is best for salinity, and IR6Me is most suitable for pH reconstruction. Thus, the MBT5Me′-temperature relationship is limited in ACA, particularly for lacustrine samples, and MBT6Me′ does not offer a better solution under hyper- to semi-arid conditions. Sub-calibrating models for specific environmental conditions such as salinity and aridity improves the accuracy of temperature reconstructions. Furthermore, the difference between MBT5Me′ and MBT6Me′ provides a promising proxy to assess aridity. Although the brGDGT signal in drylands is influenced by multiple controlling factors, it remains a valuable tool for understanding past climate and environmental conditions, especially when accounting for the complex interactions between these factors based on each study's unique physicochemical and bioclimatic context. Further research, incorporating a broader range of surface samples alongside comprehensive soil and climate data, holds the potential to enhance the accuracy of brGDGT-based climate reconstructions
Py_justiceadmin
No full textCe projet s'appuie sur le site de l'opendata des décisions de la justice administration avec pour objectif de réimplémenter le comportement du moteur de recherche avec une interface en python. Il est ainsi possible de récupérer les décisions de la justice administrative en open source avec quelques arguments