Portail HAL de l’Université Claude Bernard Lyon
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Health-related quality of life after second-line axi-cel in transplant-ineligible patients with large B-cell lymphoma
No full textInternational audienceThe phase 2 ALYCANTE trial aimed to evaluate the investigator-assessed complete metabolic response at 3 months from the axicabtagene ciloleucel (axi-cel) infusion as a primary end point in patients with high-risk relapsed/refractory large B-cell lymphoma who are ineligible for autologous stem cell transplantation (ASCT). This study showed a significant improvement in complete metabolic response rate at 3 months based on historical controls. This study reports the health-related quality of life (HRQoL) results as a secondary end point. HRQoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) cancer-specific questionnaire, the Quality of Life Questionnaire high-grade non-Hodgkin lymphoma 29 (QLQ-NHL-HG29) , and the EuroQol Quality of Life Scale-5 dimensions-5 levels of severity (EQ-5D-5L) generic questionnaire at baseline and 1, 3, 6, and 12 months after axi-cel infusion. Among the 62 patients included, 60 (97%) completed a baseline and at least 1 postbaseline HRQoL assessment. At 1 month infusion, adjusted mean change in HRQoL scores from baseline showed a clinically significant deterioration (greater than the clinical threshold) in physical, role, social functioning, and fatigue. However, all HRQoL dimensions recovered by 3 months after infusion and remained stable or continued to improve by 12 months. In an exploratory analysis, adjusted mean change in HRQoL score from baseline in ALYCANTE was similar to or better than in ASCT-eligible patients who received axi-cel in the phase 3 ZUMA-7 trial. Finally, the global health status and fatigue scores of the ALYCANTE population improved to levels comparable to the general French population of similar age by 3 months after infusion. These findings indicate that axi-cel improves HRQoL regardless of transplant eligibility, supporting its use across a broad patient population. This trial was registered at www.clinicaltrials.gov as #NCT04531046
RISK MITIGATION ACCOUNTING: A NEW PORTFOLIO-BASED MODEL UNDER CONSULTATION CONCEPT AND ARCHITECTURE OF THE RMA MODEL
No full textInternational audienceIn late 2025, the IASB published an Exposure Draft proposing a new Risk Mitigation Accounting (RMA) model aimed at better reflecting how financial institutions manage interest rate repricing risk on a portfolio basis. The model seeks to reduce accounting volatility arising from measurement asymmetries between derivatives measured at fair value and instruments measured at amortised cost. It introduces a portfolio-based framework built around net repricing risk exposure and the recognition of a risk mitigation adjustment in the balance sheet. The article explains the architecture of the model and discusses its potential implications for insurers, particularly in the context of IFRS 17.L’IASB a publié fin 2025 un projet de norme introduisant un modèle optionnel de Risk Mitigation Accounting (RMA) visant à mieux refléter, dans les états financiers, la gestion du risque de repricing des taux d’intérêt au niveau portefeuille. Le modèle cherche à réduire la volatilité comptable liée aux asymétries de valorisation entre dérivés et instruments mesurés au coût amorti. Il repose sur une approche fondée sur l’exposition nette au risque de repricing et sur la reconnaissance d’un ajustement de mitigation du risque au bilan. L’article présente l’architecture du modèle et discute ses implications potentielles pour les assureurs, notamment dans le contexte d’IFRS 17
Locally -categorical theories and locally Roelcke precompact groups
No full textInternational audienceIt is well-known that Polish Roelcke precompact groups are the groups that can be represented as automorphism groups of -categorical structures in continuous logic and that there is a precise correspondence between properties of the group and properties of the structure. The goal of this paper is to extend this correspondence to the classes of locally Roelcke precompact groups and locally -categorical structures, the latter of which we define here. We characterise locally Roelcke precompact groups in terms of their isometric actions. We define locally -categorical theories and structures, prove an appropriate version of the Ryll-Nardzewski theorem, and identify the Polish locally Roelcke precompact groups as the automorphism groups of such structures. In all locally -categorical structures, there is a definable metric, which we call localising, and which captures the coarse geometric structure of the corresponding automorphism group. We show that two locally -categorical structures are bi-interpretable if and only if their automorphism groups are isomorphic. Finally, we show that (the unit ball of) a Banach space is -categorical if and only if the corresponding affine space is locally -categorical (as a metric space)
Impact of systematic ultrasonography on lateral ankle sprain management
No full textInternational audienceBackground: Lateral ankle sprain (LAS) is the most common traumatic injury, yet its diagnosis and management remain suboptimal. This contributes to a high prevalence of residual symptoms, negatively impacting patient quality of life and increasing healthcare costs. We hypothesized that routine ultrasonography (US) following LAS could significantly modify the treatment strategy established by a specialist. Additionally, we hypothesized that US is an efficient tool for identifying osseous injuries and associated ligamentous injuries.Methods: Fifty-one ankles with lateral instability diagnosed in the emergency department (ED) were retrospectively included. A second evaluation by an orthopedic surgeon was conducted within the first ten days to establish the "initial treatment". All patients underwent US and MRI within the first three weeks after the initial ED assessment and were reevaluated to establish the "post-US treatment". We determined concordance between initial and post-US treatment. Additionally, we assessed the diagnostic accuracy of US for identifying osseous and associated ligament injuries, including the anteroinferior talofibular ligament (AITFL), deltoid ligament, spring ligament, calcaneocuboid ligament (CCL), dorsal talonavicular ligament (DTNL), and bifurcate ligament, MRI serving as the reference standard for assessing ligamentous and osseous injuries.Results: Treatment for LAS was modified for 16 ankles (31.3 %) following US examination (W=97, p < 0.05). US demonstrated excellent sensitivity (0.73) and specificity (0.95) for identifying osseous injuries. Additionally, US detected injuries to the AITFL in 6 ankles (11.8 %), deltoid ligament in 16 (31.3 %), spring ligament in 1 (2 %), CCL in 1 (2 %), DTNL in 1 (2 %), and bifurcate ligament in 2 (3.9 %).Conclusion: US examination following LAS was significantly associated with treatment modifications. It also proved high accuracy for detecting osseous injuries missed by plain X-rays and diagnosing associated ligament injuries. Given these findings, it appears relevant to update the current diagnostic algorithm for LAS, including US
Optical sensor characterization for rapid detection of nitrogen phosphorus and potassium concentrations in soil
No full textInternational audienceAccurate and timely monitoring of soil nutrient concentrations, particularlynitrogen (N), phosphorus (P), and potassium (K), is crucial for optimizing agriculturalproductivity and minimizing environmental impact. In this study, we present thecharacterization of an optical sensor designed for the rapid and non-destructiveassessment of N, P, and K levels in soil samples. The sensor employs Visible-NearInfrared (VIS–NIR) spectroscopy to analyse the spectral signatures of soil samplesand extract quantitative information regarding nutrient concentrations. A total of30 experimental samples classified into six distinct categories, comprising varioussoil-fertilizer mixtures, were prepared to calibrate the sensor's performance. Thesesamples were made from four primary constituents: black soil (sourced from a farmin the Auvergne-Rhone-Alpes region of France), NPK (6:3:12) fertilizer, ammoniumnitrate, and urea. The six categories were grouped into two sets: sample type 1consisted of pure samples, while sample types 2 through 6 were mixtures of soiland fertilizer. The mixed samples were prepared with nutrient concentrations higherthan those typically found in agricultural soils to enable controlled calibration ofsensor performance. The pure sample, specifically Sample10, consisting of humussoil without fertilizer amendment, was included as a reference to approximatereal-soil conditions. Laboratory experiments involved illuminating the sampleswith specific wavelengths of light and measuring the intensity of reflected lightwithin a controlled environment. Calibration curves and equations specific to eachmacronutrient were developed through regression analysis using data collected fromthe experiments. Performance evaluation metrics, including Root Mean Square Error(RMSE), Coefficient of Determination (R2), Predicted Residual Error Sum of Squares(PRESS), and Standard Error (s), were employed to assess model accuracy. Resultsdemonstrated satisfactory performance across all sample types, with average R2,RMSE, PRESS, and s values of 0.7835 V, 0.0097 V, 0.0003 V, and 0.0003 V, respectively.Statistical analyses further validated the sensor, indicating average standard errorsof 0.003 V for repeatability and 0.001 V for reproducibility, along with a sensitivity of7% and a linearity of R2 = 0.8. These findings validate the effectiveness of the opticalsensor in accurately quantifying soil macronutrient concentrations
A comprehensive review on autonomous and plan-based QoS-aware service composition approaches in service community
No full textInternational audienceIn the evolving landscape of the Internet of Things (IoT), many smart devices provide basic functionalities as services that often fail to meet users’ requirements. To address this gap, fine-grained services are combined to create coarse-grained services, giving rise to the QoS-aware service composition challenge. The growing number of IoT devices has resulted in numerous fine-grained services with similar functional properties (inputs and outputs) but different non-functional properties, typically related to quality of service (QoS). The QoS-aware service composition approaches can be categorized into two main classes: plan-based approaches and autonomous ones. Existing surveys in this domain primarily focus on either a single class or technical aspects, such as composition representation and utility functions. In contrast, this study offers a comprehensive and systematic review of both classes, emphasizing resolution and validation methodologies. The contributions of this paper are fourfold: 1) introduce a novel taxonomy that classifies QoS-aware service composition approaches from the past decade based on their reliance on preexisting abstract composition plans, 2) provide a detailed comparative analysis of these approaches using the most relevant criteria in the service composition field, 3) investigate their resolution and validation methodologies along with the quality and appropriateness of the datasets used in the reviewed approaches, and 4) discuss future directions for advancing the field. This review not only bridges the knowledge gap in understanding these approaches but also serves as a foundation for researchers to develop more robust and efficient QoS-aware service composition methods
Photothermal Reshaping and Cavity Formation in Silica-Coated Gold Nanorods Using Nanosecond Pulsed Lasers
No full textInternational audienceThe aspect ratio of Au nanorods can be precisely engineered using near-infrared nanosecond-pulsed laser irradiation, which enables ultrafast, confined energy deposition inaccessible under continuous-wave irradiation. In this study, we demonstrate a novel method for reshaping Au nanorods encapsulated within thin (<10 nm) silica shells. By leveraging the silica shell as a rigid nanocrucible, nanosecond laser irradiation induces rapid, end-selective shortening of the Au nanorod core, creating terminal cavities of a controllable size. Transmission electron microscopy confirms that while hexadecyltrimethylammonium bromide-coated Au nanorods convert into spherical and ϕ-shaped nanoparticles, the silica shell constrains the laser induced reshaping process, preserving the rod-like morphology while systematically reducing the aspect ratio. Consequently, the distinct longitudinal and transverse plasmon resonances are retained post-irradiation. The reshaping can be precisely controlled by adjusting laser fluence, resulting in a fine-tuned aspect ratio and a significantly narrowed longitudinal resonance, an outcome typically associated with femtosecond laser systems. 4D Scanning transmission electron microscopy reveals that the Au nanorods transform from single crystal to polycrystalline structures upon irradiation, providing direct evidence that nanosecond pulsed irradiation induces complete Au core melting and rapid recrystallization within the shell – with multiple nucleation sites. Despite the polycrystalline structure the resonance peak was narrower than that of the starting nanorod. This method for fabricating Au nanorods with integrated cavities within the offers significant potential for applications in triggered drug delivery, biosensing, and photoacoustic imaging
Which theories have a measurement problem?
No full textInternational audienceIt is shown that any theory that has certain properties has a measurement problem, in the sense that it makes predictions that are incompatible with measurement outcomes being absolute (that is, unique and non-relational). These properties are Bell Nonlocality, Information Preservation, and Local Dynamics. The result is extended by deriving Local Dynamics from No Superluminal Influences, Separable Dynamics, and Consistent Embeddings. These results are achieved using a framework of \textit{perspectival theories} that generalizes the notion of a Heisenberg cut beyond quantum theory. As well as explaining why the existing Wigner's-friend-inspired no-go theorems hold for quantum theory, the results also shed light on whether a future theory of physics might overcome the measurement problem. In particular, they suggest the possibility of a theory in which absoluteness is maintained, but without rejecting relativity theory (as in Bohm theory) or embracing objective collapses (as in GRW theory)
Predictors of brain death after hanging-induced cardiac arrest
No full textInternational audienceBrain death after hanging-induced cardiac arrest is a fatal complication about which few data are available. We aimed at identifying the early predictors of progression to brain death in patients with hanging-induced cardiac arrest
Patient-Reported Symptoms and Quality of Life With Sacituzumab Govitecan Versus Docetaxel in Metastatic NSCLC: The Phase 3, Randomized EVOKE-01 Trial
No full textInternational audienceIn the phase 3 EVOKE-01 trial (NCT05089734), sacituzumab govitecan (SG) exhibited a numerical improvement in overall survival and tolerability compared with docetaxel in patients with metastatic NSCLC previously treated with platinum-based chemotherapy and programmed cell death protein (ligand) 1 inhibitors, although results were not statistically significant. This analysis evaluated health-related quality of life (HRQoL) data from EVOKE-01