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WDR77 Controls Cell Growth Proliferation Through e2f Transcription Factors
No full textWD repeat domain 77 protein (WDR77) is required for cellular proliferation of lung and prostate epithelial cells during earlier stages of development and is reactivated during prostate and lung tumorigenesis. WDR77 also plays an essential role in prostate tumorigenesis mediated by growth regulatory factors. Here, we identified E2F1 and E2F3 mRNAs as translational targets of WDR77. We demonstrated that WDR77 regulated the translation of E2F1 and E2F3 mRNAs through the 5? untranslated regions (UTRs) of E2F1 and E2F3 (E2F1/3) mRNAs. WDR77 physically interacted with programmed cell death 4 (PDCD4) that suppresses the translation of mRNAs containing structured 5? UTRs by interacting with eukaryotic translation initiation factor 4A (eIF4A) and inhibiting its helicase activity. Further, we demonstrated that the interaction between WDR77 and PDCD4 prevented the binding of PDCD4 to eIF4A and relieved PDCD4?s inhibitory effect on eIF4A1. Overall, our work reveals for the first time that WDR77 is directly involved in the translational regulation of E2F1/3 mRNAs through their structured 5? UTRs, PDCD4, and eIF4A1 and provides novel insight into the cell growth controlled by WDR77
Correspondence from Jacob C. Kellem to Andrea D. Lentz, October 23, 1973
No full textThe letter, dated October 23, 1973, addresses Ms. Andrea D. Lentz regarding the Paul Laurence Dunbar and Alice Dunbar Nelson papers. It highlights that the agreement signed by Miss Young was modified from a gift to a loan, allowing single-copy reproductions but not the sale of entire microfilm sets. Miss Young believes she is entitled to half the earnings from the microfilm sales, and the matter is recommended to be submitted to the Society's Director for consideration
Correspondence from Daniel R. Porter to Jacob C. Kellem, December 24, 1973
No full textOn December 24, 1973, the Ohio Historical Society informed Jacob C. Kellem that their Board of Trustees had reviewed Pauline A. Young's request regarding the Paul L. Dunbar and Alice Dunbar Nelson papers. The Board decided to refer the matter to legal counsel and the Director for further action. Enclosed was the legal counsel's opinion, which led to the Society's inability to fulfill Ms. Young's request
15th Atlanta Annual Art Exhibition Register, 1956
No full textA list of participating artists and medium categories for the Atlanta University Annual Exhibition of Paintings, Sculpture, and Prints by Negro Artists held at the Art Gallery at Trevor Arnett Library. Also listed are prize winners and honorable mentions
Proper Planning Promotes Proper Processes. Proper Processes Produce Pleased People: A Case Study of the Quality of Academic Advising for Undergraduate Business Majors at a Private Historically
No full textThe purpose of this mixed methods study was to examine how academic advising is perceived by students and what academic advisors (faculty and staff) need to do to be of better service to the students at a private historically Black university. The samples of this study consisted of 121 students within the researched institution's School of Business and six full-time academic advisors. The results from students and academic advisors were compared, specifically concerning the developmental advising style, to explore students' perceptions and acceptance of the style and the academic advisors' comfortability and ability to advise developmentally. The major findings of the study revealed students prefer to be advised developmentally and academic advisors prefer to advise developmentally as well but lack the support and training to consistently provide developmental advising. Each of the academic advisors reported the absence of training and support needed to provide developmental advising. Thus, there is a significant need to establish a formal training program for academic advisors to reinforce the developmental academic advising style, policies, procedures, and best practices in the field so that they can become more effective advisors and deliver an academic advising program of quality
Persistence to Medical School Acceptance and Matriculation Through the Lens and Lived Experiences of U.S.-Born Black Males at a Historically Black Medical School
No full textIn 2015 through 2017, the lack of Black males in medical school and the woefully low number of Black male physicians were brought into the sharpest of focus, seemingly causing the nation to sit up and take notice of this crisis. Conferences were held, articles were written, and networks did segments on the issue. The numbers have increased slightly. For example, the 813 Black males accepted into and are matriculating in medical school for the 2021-2022 academic year is the highest number in history. However, there is still a great deal more work to be done to address the projected physician shortage and accompanying healthcare needs of the nation in the 2030s and beyond. This qualitative research (phenomenological approach) was conducted by interviewing 14 medical students and master's students in the medical education pipeline program at a historically Black medical school. Data was collected by interviewing and following up to gain an in-depth understanding of Black male students' motivation for medicine, obstacles encountered during the pursuit of a medical education, coping and overcoming strategies, and why they continued to persist to medical school acceptance and enrollment. The research found that the myriad of challenges and obstacles encountered were many and varied. However, the strategies employed to overcome those challenges and continue to persist to medical school serve as both a guide, beacon of hope, and example of resilience, perseverance, and grit. The findings of this study are yet another clarion call to action for policy, prevention, and intervention initiatives to remove some of the obstacles faced by young Black males in their pursuit of a medical education as the health of the U.S. depends on it