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Spelman Messenger February 1939 vol. 55 no. 2
Get PDFThe Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the Council on Library and Information Resources (CLIR) in supporting the processing and digitization of a number of historic collections as part of the projectOur Story: Digitizing Publications and Photographs of the Historically Black Atlanta University Center Institutions
The Atlanta University Bulletin (newsletter), s. II no. 16: Commencement Number, July 1914
No full textThe Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the Council on Library and Information Resources (CLIR) in supporting the processing and digitization of a number of historic collections as part of the project: Our Story: Digitizing Publications and Photographs of the Historically Black Atlanta University Center Institutions.</em
A descriptive study of self-esteem and anxiety: key issues in an HIV support group for African American males, 1995
Get PDFThis descriptive study examined the effects support groups have on the self-esteem and anxiety levels of HIV positive African American males. A total of thirty African American males in a local support group in Atlanta, Georgia were asked to participate in this study. Simple descriptive statistics were used to analyze the data. The findings revealed that there is no significant differences in self esteem and anxiety levels of HIV positive African American males in a support group
ID4 acts as a tumor suppressor via P53: mechanistic insight, 2016
Get PDFOverexpression of tumor-derived mutant p53 is a common event in tumorigenesis, suggesting an advantageous selective pressure in cancer initiation and progression. Given that p53 is found to be mutated in 50% of all human cancers, restoration of mutant p53 to its wild type biological function has been a widely sought after avenue for cancer therapy. Most research efforts have largely focused on restoration of mutant p53 by artificial means given that p53 has some degree of conformational flexibility allowing for introduction of short peptides and artificial compounds. Recently, theoretical modeling and studies focused on restoration of mutant p53 by physiological means has raised the question of whether there are effective therapies worth exploring that focus on global physiological mechanisms of restoration of p53. Herein, we provide computational analysis of the thermodynamic stabilities of both wild-type and mutant p53 core domains by studying their respective minimum potential energies. Also, it is widely accepted that wild type p53 is modulated by various acetyl transferases as well as deactylases, but whether this mechanism of p53 modulation can be exploited for physiological restoration of mutant p53 remains under intense investigation. Using prostate cancer cell lines representative of varying stages of aggressiveness as a model, we show that ID4 dependent acetylation promotes mutant p53 DNA-binding capabilities to its wild type consensus sequence, thus regulating p53-dependent target genes leading to subsequent cell cycle arrest and apoptosis. Specifically, we identify that ID4 promotes acetylation of K373 and to a lesser extent K320, in turn regulating p53-dependent biological activities. Together, our data provides computational analysis of the core domain of certain mutant forms of p53 and a molecular understanding of ID4 dependent acetylation that suggests a strategy of enhancing p53 acetylation at sites K373 and K320, critical sites of post translational modification of p53, that may serve as a viable mechanism of physiological restoration of mutant p53 to its wild type biological function. KEY TERMS: ID4, p53, tumor suppressor, bhlh, prostate cancer, molecular dynamics, acetylation, Biology, Biophysics, Cancer Biology, Cell Biology, Life Sciences, Molecular Biolog
Spelman Messenger May 1974 vol. 90 no. 3
Get PDFThe Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the Council on Library and Information Resources (CLIR) in supporting the processing and digitization of a number of historic collections as part of the projectOur Story: Digitizing Publications and Photographs of the Historically Black Atlanta University Center Institutions
Atlanta University Center Faculty Publications: A Selected Bibliography, March 21, 2011
Get PDFOn February 28, 2006, the Robert W. Woodruff Library and the Library Advisory Council hosted an exhibit and reception celebrating the published works of Atlanta University Center faculty. As a complement to that event, the Robert W. Woodruff Library presents this publication, Atlanta University Center Faculty Publications: A Brief Bibliography, which highlights selected scholarly and research contributions of the Atlanta University Center faculty. The celebration has become an annual event and the bibliography illustrates the richness of faculty contributions within each institution and across the Atlanta University Center community. It should be viewed as a fluid document to be updated as new contributions emerge and will be preserved on the Librarys website for future reference and use
The National Conference of Black Mayors, Inc., (NCBM) in an environment of increasing conservatism, 1982
Get PDFThe main purpose of this degree paper is to assess the impact of Reaganomics on the National Conference of Black Mayors (NCBM). In the context of this effort, the follow ing categories of NCBM programs and activities will be analyzed: educational and research; economic development;community development; municipal management; program coordination; and legislative and policy advocacy. By use of the case study approach, the writer conducts a detailed assessment of the impact of Reaganomics on a minority organization which to a large extent relies on Federal funding. The dismantling of certain programs and departments, coupled with a reduction in spending, tax cuts and the shifting of both the tax burden and public services from Washington to state and local government is seen by the NCBM as an attempt to reduce the gains made by minorities since the Reconstruction. The NCBN, like many other non-profit organizations endeavors to find alternative sources of funding to enable it to continue to operate and eventually become selfsustaining. The writer views various measures which are being pursued to ameliorate the negative impact of Reaganomics. The main source of information for this descriptive study was obtained as a result of the writers participative observation while assigned to the NCBM as an intern. Primary information was elicited from NCBM staff members as well as black mayors. A wider variety of information was derived from secondary sources such as textbooks, magazines, newsletters and NCBM file data
