Repositorio Universidad Europea del Atlántico
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Prevalence and genetic diversity of rotavirus in Bangladesh during pre-vaccination period, 1973-2023: a meta-analysis
Get PDFIntroduction: Rotavirus infection is a major cause of mortality among children under 5 years in Bangladesh. There is lack of integrated studies on rotavirus prevalence and genetic diversity during 1973 to 2023 in Bangladesh.
Methods: This meta-analysis was conducted to determine the prevalence, genotypic diversity and seasonal distribution of rotavirus during pre-vaccination period in Bangladesh. This study included published articles on rotavirus A, rotavirus B and rotavirus C. We used Medline, Scopus and Google Scholar for published articles. Selected literatures were published between 1973 to 2023.
Results: This study detected 12431 research articles published on rotavirus. Based on the inclusion criteria, 29 of 75 (30.2%) studies were selected. Molecular epidemiological data was taken from 29 articles, prevalence data from 29 articles, and clinical symptoms from 19 articles. The pooled prevalence of rotavirus was 30.1% (95% CI: 22%-45%, p = 0.005). Rotavirus G1 (27.1%, 2228 of 8219) was the most prevalent followed by G2 (21.09%, 1733 of 8219), G4 (11.58%, 952 of 8219), G9 (9.37%, 770 of 8219), G12 (8.48%, 697 of 8219), and G3 (2.79%, 229 of 8219), respectively. Genotype P[8] (40.6%, 2548 of 6274) was the most prevalent followed by P[4] (12.4%, 777 of 6274) and P[6] (6.4%, 400 of 6274), respectively. Rotavirus G1P[8] (19%) was the most frequent followed by G2P [4] (9.4%), G12P[8] (7.2%), and G9P[8], respectively. Rotavirus infection had higher odds of occurrence during December and February (aOR: 2.86, 95% CI: 2.43-3.6, p = 0.001).
Discussion: This is the first meta-analysis including all the studies on prevalence, molecular epidemiology, and genetic diversity of rotavirus from 1973 to 2023, pre-vaccination period in Bangladesh. This study will provide overall scenario of rotavirus genetic diversity and seasonality during pre-vaccination period and aids in policy making for rotavirus vaccination program in Bangladesh. This work will add valuable knowledge for vaccination against rotavirus and compare the data after starting vaccination in Bangladesh
Edge of Things Inspired Robust Intrusion Detection Framework for Scalable and Decentralized Applications
No full textUbiquitous data monitoring and processing with minimal latency is one of the crucial challenges in real-time and scalable applications. Internet of Things (IoT), fog computing, edge computing, cloud computing, and the edge of things are the spine of all real-time and scalable applications. Conspicuously, this study proposed a novel framework for a real-time and scalable application that changes dynamically with time. In this study, IoT deployment is recommended for data acquisition. The Pre-Processing of data with local edge and fog nodes is implemented in this study. The threshold-oriented data classification method is deployed to improve the intrusion detection mechanism’s performance. The employment of machine learning-empowered intelligent algorithms in a distributed manner is implemented to enhance the overall response rate of the layered framework. The placement of respondent nodes near the framework’s IoT layer minimizes the network’s latency. For economic evaluation of the proposed framework with minimal efforts, EdgeCloudSim and FogNetSim++ simulation environments are deployed in this study. The experimental results confirm the robustness of the proposed system by its improvised threshold-oriented data classification and intrusion detection approach, improved response rate, and prediction mechanism. Moreover, the proposed layered framework provides a robust solution for real-time and scalable applications that changes dynamically with time
Propuesta preventiva sobre el esguince de tobillo en jugadoras de 2ªRFEF Futsal
Get PDFEl objetivo de este estudio fue analizar la eficacia del programa preventivo a través del entrenamiento pliométrico y control motor sobre la estabilidad del tobillo en jugadoras de fútbol sala de Segunda división nacional. Se diseñó un estudio cuasiexperimental de intervención con una evaluación de pre-post test, durante la temporada 2021-2022, con una duración de 4 semanas, más dos de evaluación. Los test utilizados para ello fueron, el CMJ, THT y el YBT. 8 jugadoras (féminas) de fútbol sala de edad (25.78 ± 6.44 años) y altura (165.0 ± 7.07 cm) de nivel semiprofesional, que compite actualmente en Segunda División Nacional, llevaron a cabo el programa preventivo, compuesto por un circuito de 7 postas de trabajo específico. Los resultados obtenidos tras la intervención no obtuvieron mejoras significativas en las siguientes pruebas, CMJ y THT (p>0,060 y p>0.507) respectivamente, aun así, en el test CMJ la altura del salto vertical aumentó 2 cm con respecto al pre test y la media de la pierna izquierda en el THT obtuvo una mejora de (p<0.085). Por otro lado, el rendimiento del CS en el YBT sí mejoró significativamente, tras un periodo de intervención de 4 semanas, (p<0.045, TE = 1.12; y p<0.007, TE=1.9), aumentando un 14% en el CS. El programa preventivo llevado a cabo durante la intervención, demostró que no se obtuvieron mejoras significativas en líneas generales, a excepción del YBT, el cual mostró mejoras en la dorsiflexión del tobillo para ambos pie
In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain
Get PDFThere is growing evidence that Alzheimer’s disease (AD) can be prevented by reducing risk factors involved in its pathophysiology. Food-derived bioactive molecules can help in the prevention and reduction of the progression of AD. Honey, a good source of antioxidants and bioactive molecules, has been tied to many health benefits, including those from neurological origin. Monofloral avocado honey (AH) has recently been characterized but its biomedical properties are still unknown. The aim of this study is to further its characterization, focusing on the phenolic profile. Moreover, its antioxidant capacity was assayed both in vitro and in vivo. Finally, a deep analysis on the pathophysiological features of AD such as oxidative stress, amyloid-β aggregation, and protein-tau-induced neurotoxicity were evaluated by using the experimental model C. elegans. AH exerted a high antioxidant capacity in vitro and in vivo. No toxicity was found in C. elegans at the dosages used. AH prevented ROS accumulation under AAPH-induced oxidative stress. Additionally, AH exerted a great anti-amyloidogenic capacity, which is relevant from the point of view of AD prevention. AH exacerbated the locomotive impairment in a C. elegans model of tauopathy, although the real contribution of AH remains unclear. The mechanisms under the observed effects might be attributed to an upregulation of daf-16 as well as to a strong ROS scavenging activity. These results increase the interest to study the biomedical applications of AH; however, more research is needed to deepen the mechanisms under the observed effect
Effects of extremely low-frequency magnetic fields on human MDA-MB-231 breast cancer cells: proteomic characterization
Get PDFExtremely low-frequency electromagnetic fields (ELF-MF) can modify the cell viability and regulatory processes of some cell types, including breast cancer cells. Breast cancer is a multifactorial disease where a role for ELF-MF cannot be excluded. ELF-MF may influence the biological properties of breast cells through molecular mechanisms and signaling pathways that are still unclear. This study analyzed the changes in the cell viability, cellular morphology, oxidative stress response and alteration of proteomic profile in breast cancer cells (MDA-MB-231) exposed to ELF-MF (50 Hz, 1 mT for 4 h). Non-tumorigenic human breast cells (MCF-10A) were used as control cells. Exposed MDA-MB-231 breast cancer cells increased their viability and live cell number and showed a higher density and length of filopodia compared with the unexposed cells. In addition, ELF-MF induced an increase of the mitochondrial ROS levels and an alteration of mitochondrial morphology. Proteomic data analysis showed that ELF-MF altered the expression of 328 proteins in MDA-MB-231 cells and of 242 proteins in MCF-10A cells. Gene Ontology term enrichment analysis demonstrated that in both cell lines ELF-MF exposure up-regulated the genes enriched in “focal adhesion” and “mitochondrion”. The ELF-MF exposure decreased the adhesive properties of MDA-MB-231 cells and increased the migration and invasion cell abilities. At the same time, proteomic analysis, confirmed by Real Time PCR, revealed that transcription factors associated with cellular reprogramming were upregulated in MDA-MB-231 cells and downregulated in MCF-10A cells after ELF-MF exposure. MDA-MB-231 breast cancer cells exposed to 1 mT 50 Hz ELF-MF showed modifications in proteomic profile together with changes in cell viability, cellular morphology, oxidative stress response, adhesion, migration and invasion cell abilities. The main signaling pathways involved were relative to focal adhesion, mitochondrion and cellular reprogramming
An Optimized Privacy Information Exchange Schema for Explainable AI Empowered WiMAX-based IoT networks
No full textThe Internet of Things (IoT) has recently surpassed wired communication. WiMAX is a wireless transmission technology that allows for faster internet access. Wireless network innovations, like some other communication networks, are not safe and secure. Security and authorization models are intended to prevent unauthorized use of network services. Numerous authorization and encrypted communication mechanisms have been introduced for WiMAX privacy, but the communication systems are still insecure and vulnerable to attacks such as zero-day attacks, rouge base station attacks, Man in the Middle (MITM) attacks, and Denial of Service (DoS) attacks. Wireless technologies have come a long way in the last few decades. Because most wireless transmission systems rely on radio signals, the system channel is essentially vulnerable to interception. As a result, data security is always critical in the presentation of a system. Because WiMAX is a wireless communication technology, it is particularly vulnerable to interception, so security is a top priority. Individuals must be protected from security breaches that occur across network interfaces, networking devices, and everything in between. Robust security management is required to protect WiMAX from attacks and vulnerabilities, despite the fact that emerging Artificial Intelligence (AI) technologies necessitate different security governance than existing technologies. We proposed an Optimized Privacy Information Exchange Schema for Explainable AI Empowered WiMAX-based IoT that addresses vulnerabilities and threats during the identification and authorization phases to improve the functionality and performance characteristics of the traditional system. The Scyther tool was used to validate the proposed privacy scheme, which is safer and more secure than existing systems
The use of authentic materials in an English for Specific Purposes university class
Get PDFThe present article shows a didactic application based on the use of authentic materials and English for Specific Purposes (ESP) in a university class. The designed proposal was applied throughout a period of fifteen weeks in an English as a foreign language subject, equivalent to a B1.2 level according to the Common European Framework of Reference for Languages (CEFR). This lesson plan was applied in a group class of forty students belonging to two different bachelor’s degrees: Psychology, and Sports Science and Physical Activit
Modulatory effect of Andean blackberry polyphenols on genes related to antioxidant and inflammatory responses, the NLRP3 inflammasome, and autophagy
No full textBACKGROUND: The Andean blackberry (Rubus glaucus Benth) is one of Ecuador’s most iconic Andean berries for which a high anthocyanin content has been described. OBJECTIVE: The aim of the present study was to determine the chemical composition and anti-inflammatory potential of the Andean blackberry from Ecuador, with an emphasis on its effects on NLRP3 inflammasome activation and autophagy processes. RESULTS: Andean blackberry extracts were rich in hydroxycinnamates (coumaric acid and derivates), in addition to quercetin and kaempferol as principal flavonols. Cyanidin and its glycosides were identified as the main anthocyanins present. Andean blackberry extracts efficiently reduced oxidative stress markers in the lipopolysaccharide-stimulated RAW 264.7 cells. The extracts also caused a moderate decrease in the expression of the pro-inflammatory and antioxidant genes NFκB1, TNF, IL-1β, IL-6, and NOS2 expression, while they significantly increased the mRNA levels of both SOD1 and NFE2L2 genes. Andean blackberry extracts significantly decreased the activation of the NLRP3 inflammasome complex, as well as p62 levels, and the LC3I/LC3II ratio increased, suggesting a direct action of Andean blackberry compounds on the inflammatory response and restoration of the autophagy process. CONCLUSIONS:These results suggest that Andean blackberries potentially have an anti-inflammatory effect through their ability to regulate genes related to the inflammatory and antioxidant response, as well as modulate the activation of the NLRP3 inflammasome complex and autophagy processes
Emotional Management in Journalism and Communication Studies
No full textCommunication professionals are experiencing a growing level of exposure to traumatic events as a result of their involvement in the coverage of various tragedies, including accidents, climatic disasters, rights violations, and acts of terrorism. However, it is worth noting that journalism and communication university courses often lack comprehensive instruction on effectively managing emotional challenges, anxiety, trauma, self-care, and the prevention of vicarious trauma. The objective of this study is to assess the inclusion of emotional management within the curricula of Journalism and Communication programmes offered by two universities in Catalonia, namely the University of Barcelona and the Autonomous University of Barcelona. In order to accomplish this objective, a series of semi-structured interviews were carried out with a total of twelve (12) professors who specialise in the fields of Journalism and Communication. Additionally, a thorough analysis was conducted on a set of 97 study plan guides. The results indicate that none of the participants in the interviews possess knowledge regarding any existing training programmes focused on emotional management. Furthermore, they unanimously agree on the importance of implementing such courses. The study plans did not include any subjects that were specifically dedicated to the topic of emotional management. This study presents a set of strategies aimed at creating a cross-disciplinary teaching-learning model that offers a comprehensive educational experience for students. This entails integrating precise subject matter on the previously mentioned topics, fostering critical contemplation and discourse regarding emotions within the educational setting, and advocating for ethical and sound professional behaviours
Diagnosing Training Needs in European Tourism SMEs: The TC-NAV Project for Managing and Overcoming Virulent Crises
Get PDFThis research aims to gather opinions from experts in the European tourism sector regarding training needs to address severe crises, such as Covid, in Small and Medium-Sized Enterprises (SMEs) across five countries: Spain, Iceland, Ireland, Scotland, and Germany. This study was conducted within the scope of the European TC-NAV project, which is funded by the European Union. The ultimate goal of this project is to develop training solutions for European SMEs Most existing literature on tourism crises primarily examines the impact on destinations as a whole rather than on individual tourism enterprises. Thus, this research is both relevant and timely The methodology employed was qualitative, and data being collected using a 9-question interview guide. This guide underwent validation by experts, achieving a Cronbach's Alpha value of 0.7. In total, 30 individuals were interviewed: 5 civil servants, 9 company directors, 5 university professors, 6 researchers, and 5 entrepreneurs. Some notable findings include the importance of innovation for change, promoting sustainable tourism, fostering informal partnerships among regional companies, the essential role of government support, the benefits of flexible planning and service digitisation, and the ongoing need for training and upskilling