Repositorio Universidad Europea del Atlántico
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Clinical phenotypes and short-term outcomes based on prehospital point-of-care testing and on-scene vital signs
No full textEmergency medical services (EMSs) face critical situations that require patient risk classification based on analytical and vital signs. We aimed to establish clustering-derived phenotypes based on prehospital analytical and vital signs that allow risk stratification. This was a prospective, multicenter, EMS-delivered, ambulance-based cohort study considering six advanced life support units, 38 basic life support units, and four tertiary hospitals in Spain. Adults with unselected acute diseases managed by the EMS and evacuated with discharge priority to emergency departments were considered between January 1, 2020, and June 30, 2023. Prehospital point-of-care testing and on-scene vital signs were used for the unsupervised machine learning method (clustering) to determine the phenotypes. Then phenotypes were compared with the primary outcome (cumulative mortality (all-cause) at 2, 7, and 30 days). A total of 7909 patients were included. The median (IQR) age was 64 (51–80) years, 41% were women, and 26% were living in rural areas. Three clusters were identified: alpha 16.2% (1281 patients), beta 28.8% (2279), and gamma 55% (4349). The mortality rates for alpha, beta and gamma at 2 days were 18.6%, 4.1%, and 0.8%, respectively; at 7 days, were 24.7%, 6.2%, and 1.7%; and at 30 days, were 33%, 10.2%, and 3.2%, respectively. Based on standard vital signs and blood test biomarkers in the prehospital scenario, three clusters were identified: alpha (high-risk), beta and gamma (medium- and low-risk, respectively). This permits the EMS system to quickly identify patients who are potentially compromised and to proactively implement the necessary interventions
Novel model to authenticate role-based medical users for blockchain-based IoMT devices
No full textThe IoT (Internet of Things) has played a promising role in e-healthcare applications during the last decade. Medical sensors record a variety of data and transmit them over the IoT network to facilitate remote patient monitoring. When a patient visits a hospital he may need to connect or disconnect medical devices from the medical healthcare system frequently. Also, multiple entities (e.g., doctors, medical staff, etc.) need access to patient data and require distinct sets of patient data. As a result of the dynamic nature of medical devices, medical users require frequent access to data, which raises complex security concerns. Granting access to a whole set of data creates privacy issues. Also, each of these medical user need to grant access rights to a specific set of medical data, which is quite a tedious task. In order to provide role-based access to medical users, this study proposes a blockchain-based framework for authenticating multiple entities based on the trust domain to reduce the administrative burden. This study is further validated by simulation on the infura blockchain using solidity and Python. The results demonstrate that role-based authorization and multi-entities authentication have been implemented and the owner of medical data can control access rights at any time and grant medical users easy access to a set of data in a healthcare system. The system has minimal latency compared to existing blockchain systems that lack multi-entity authentication and role-based authorization
Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action
No full textCardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota
Schoolchildren’s Thinking on the Subject and Teachers of Physical Education According to Gender and Educational Grade
No full textThe objective of this study was to understand the perceptions of Primary (PrE) and Secondary Education (SE) students in Cantabria about the subject of physical education (PE) and their teachers. A descriptive, comparative relational analytical cross-sectional design was used. A total of 1164 students (387 from PrE and 777 from SE) answered an ad hoc questionnaire on their satisfaction with their PE classes (eight items) and teachers (nine items). The results indicate that the PrE students were more satisfied than the SE students regarding the following statements about PE: more hours per week (p < 0.001); classes and subjects that I like the most (p < 0.001); I enjoy and have fun (p < 0.001); interesting and motivating (p < 0.001); and useful for life (p < 0.001) and easy (p = 0.006). The boys’ responses reflected higher values than the girls’ on all the previous items (p < 0.005). Regarding their thinking about their PE teachers, statistically significant differences were found in the PrE students’ responses compared with those of the SE students for the following: explains well and is easily understood (p = 0.006); stimulates and encourages participation (p = 0.050); cares and is interested in the students (p = 0.031); treat boys and girls the same (p < 0.001); and I prefer a woman because she understands me better (p = 0.021). Therefore, the male and primary-stage students showed more positive attitudes towards PE. In general, there was a favorable disposition towards PE and towards teachers, which must be taken into account to achieve SDG 4
Diseño de una propuesta para atender los problemas conductuales relacionados con la adicción a las pantallas en jóvenes con edades comprendidas entre los 12 y 15 años de edad matriculados en el IES Vega del Táder de Molina de Segura (Murcia, España).
No full textEste proyecto establece la existencia de un problema real y presente en el IES Vega del Táder, basado en la existencia de problemas de conducta como consecuencia de la adicción a las pantallas, abordado a través del diseño y la puesta en práctica de una propuesta; constituyéndose como un trabajo con enfoque profesionalizador, basado en el diseño de un proyecto
Mediterranean Diet and Sleep Features: A Systematic Review of Current Evidence
No full textThe prevalence of sleep disorders, characterized by issues with quality, timing, and sleep duration is increasing globally. Among modifiable risk factors, diet quality has been suggested to influence sleep features. The Mediterranean diet is considered a landmark dietary pattern in terms of quality and effects on human health. However, dietary habits characterized by this cultural heritage should also be considered in the context of overall lifestyle behaviors, including sleep habits. This study aimed to systematically revise the literature relating to adherence to the Mediterranean diet and sleep features in observational studies. The systematic review comprised 23 reports describing the relation between adherence to the Mediterranean diet and different sleep features, including sleep quality, sleep duration, daytime sleepiness, and insomnia symptoms. The majority of the included studies were conducted in the Mediterranean basin and reported a significant association between a higher adherence to the Mediterranean diet and a lower likelihood of having poor sleep quality, inadequate sleep duration, excessive daytime sleepiness or symptoms of insomnia. Interestingly, additional studies conducted outside the Mediterranean basin showed a relationship between the adoption of a Mediterranean-type diet and sleep quality, suggesting that biological mechanisms sustaining such an association may exist. In conclusion, current evidence suggests a relationship between adhering to the Mediterranean diet and overall sleep quality and different sleep parameters. The plausible bidirectional association should be further investigated to understand whether the promotion of a healthy diet could be used as a tool to improve sleep quality
Characterization of Phenolic Compounds in Extra Virgin Olive Oil from Granada (Spain) and Evaluation of Its Neuroprotective Action
No full textThe olive oil sector is a fundamental food in the Mediterranean diet. It has been demonstrated that the consumption of extra virgin olive oil (EVOO) with a high content of phenolic compounds is beneficial in the prevention and/or treatment of many diseases. The main objective of this work was to study the relationship between the content of phenolic compounds and the in vitro neuroprotective and anti-inflammatory activity of EVOOs from two PDOs in the province of Granada. To this purpose, the amounts of phenolic compounds were determined by liquid chromatography coupled to mass spectrometry (HPLC–MS) and the inhibitory activity of acetylcholinesterase (AChE) and cyclooxygenase-2 (COX-2) enzymes by spectrophotometric and fluorimetric assays. The main families identified were phenolic alcohols, secoiridoids, lignans, flavonoids, and phenolic acids. The EVOO samples with the highest total concentration of compounds and the highest inhibitory activity belonged to the Picual and Manzanillo varieties. Statistical analysis showed a positive correlation between identified compounds and AChE and COX-2 inhibitory activity, except for lignans. These results confirm EVOO’s compounds possess neuroprotective potential
Manual de Procedimientos para la revista Prisma Tecnológico de la Universidad Tecnológica de Panamá
No full textLa Revista Prisma Tecnológica requiere continuar con su proceso de indexación internacional. Para lograr esta meta es condición sine qua non una serie de procedimientos editoriales establecidos, documentados, revisados y aprobados bajo los requisitos de la norma ISO 9001 vigente, en lugar de un conjunto buenas prácticas de la Dirección del Comité editorial de esta revista. El objetivo de este trabajo de fin de máster es un manual de procedimientos para la gestión editorial de la revista Prisma Tecnológico de acuerdo con los requerimientos de la norma ISO 9001 en la Universidad Tecnológica de Panamá. La metodología utilizada corresponde a los procedimientos, guía e instructivos del sistema de gestión de la calidad institucional. Los resultados corresponden al desarrollo de 4 procedimientos: procedimiento de control antiplagio para la revista Prisma Tecnológico, propuesta de procedimiento para la selección, actualización de biografías científicas, propuesta de procedimiento para sección de juegos, adivinan-zas, acertijos científicos y propuesta de procedimiento para selección y elaboración de las entrevistas a personalidades del mundo de la ciencia, tecnología y cultura. Los resultados incluyen un análisis esta-dístico de medidas de tendencia central y variación de los artículos publicados. Adicionalmente se presenta un plan general de implementación de estos procedimientos que abarca aspectos como cronograma propuesto, detalla de las actividades de la fase de implementación, plan de la calidad, plan de la gestión de riesgos, plan de comunicaciones y plan de divulgación
LAM Test: A New Cognitive Marker for Early Detection in Preclinical Alzheimer’s Disease
No full textBackground:With the arrival of disease-modifying treatments, it is mandatory to find new cognitive markers that are sensitive to Alzheimer’s disease (AD) pathology in preclinical stages. Objective:To determine the utility of a newly developed Learning and Associative Memory face test: LAM test. This study examined the relationship between AD cerebrospinal fluid (CSF) biomarkers and performance on LAM test, and assessed its potential clinical applicability to detect subtle changes in cognitively healthy subjects at risk for AD. Methods:We studied eighty cognitively healthy volunteers from the Valdecilla cohort. 61% were women and the mean age was 67.34 years (±6.416). All participants underwent a lumbar puncture for determination of CSF biomarkers and an extensive neuropsychological assessment, including performance on learning and associative memory indices of the LAM-test after 30 min and after 1 week, and two classic word lists to assess verbal episodic memory: the Rey Auditory Verbal Learning Test (RAVLT) and the Free and Cued Selective Reminding Test (FCSRT). We analyzed cognitive performance according to amyloid status (A+ versus A–) and to ATN model (A–T–N–; A+T–N–; A+T+N–/A+T+N+). Results:Performance on the LAM-test was significantly correlated with CSF Aβ ratio. A+ participants performed worse on both learning (mean difference = 2.19, p = 0.002) and memory LAM measures than A– (mean difference = 2.19, p = 0.004). A decline in performance was observed along the Alzheimer’s continuum, with significant differences between ATN groups. Conclusions:Our findings suggest that LAM test could be a useful tool for the early detection of subjects within the AD continuum, outperforming classical memory tests
Assessment Of Lower Limb Asymmetries In Soccer Players According To The Stage Of The Season
No full textPURPOSE: Muscle asymmetries can be associated with increased risk of injury. Using countermovement jump (CMJ) to analyze muscular asymmetries in the lower limbs of soccer players, according to the stage of the season