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Cancer Lett
Get PDFBackground:Cisplatin-based chemotherapy is currently part of the standard of care for bladder cancer (BC). Unfortunately, some patients respond poorly to chemotherapy and have acquired or developed resistance. The molecular mechanisms underlying this resistance remain unclear. Here, we introduce a multidimensional proteomic analysis of a cisplatin-resistant BC model that provides different levels of protein information, including that of the global proteome and phosphoproteome.Methods:To characterize the global proteome and phosphoproteome in cisplatin-resistant BC cells, liquid chromatography-mass spectrometry/mass spectrometry experiments combined with comprehensive bioinformatics analysis were performed. Perturbed expression and phosphorylation levels of key kinases associated with cisplatin resistance were further studied using various cell biology assays, including western blot analysis.Results:Analyses of protein expression and phosphorylation identified significantly altered proteins, which were also EGF-dependent and independent. This suggests that protein phosphorylation plays a significant role in cisplatin-resistant BC. Additional network analysis of significantly altered proteins revealed CDK2, CHEK1, and ERBB2 as central regulators mediating cisplatin resistance. In addition to this, we identified the CDK2 network, which consists of CDK2 and its 5 substrates, as being significantly associated with poor survival after cisplatin chemotherapy.Conclusions:Collectively, these findings potentially provide a novel way of classifying higher-risk patients and may guide future research in developing therapeutic targets.U01DP006079/ACL HHS/United StatesUL1 TR000124/TR/NCATS NIH HHS/United StatesU24 DK097154/DK/NIDDK NIH HHS/United StatesU01 DP006079/DP/NCCDPHP CDC HHS/United StatesR01 DK100974/DK/NIDDK NIH HHS/United StatesU01 DK103260/DK/NIDDK NIH HHS/United States2019-11-28T00:00:00Z30145203PMC6181132693
Rabies specimen submission guidelines
Get PDFThe Rabies Laboratory at the CDC\u2019s Pox and Rabies Branch (PRB) performs a variety of diagnostic techniques for the detection of rabies virus. Below is a list of tests that can be ordered. Click the links to find the right test for your needs. Each link has details about contact information, specimen requirements, test turnaround time, and other test-specific information you may need.Publication date from document properties.specimen-submission-guideline-508.pdf201
Water-related environmental public health
Get PDFEnvironmental conditions greatly influence the relation between water and human health. Challenges to the healthfulness of U.S. water include (1) pathogens resistant to standard water treatment methods, (2) chemical and biological contaminants, (3) aging or inadequate water system infrastructure, and (4) emergency- or disaster-related events. During 1999\u20132000, 25 states reported 39 drinking water-related outbreaks that caused 2,068 cases of illnesses and 2 deaths. Of the 22 outbreaks for which a cause was identified, 20 were associated with pathogens (parasites, bacteria, or viruses) and 2 were associated with chemical poisonings (nitrate and sodium hydroxide) (MMWR November 22, 2002;51[SS08]:1\u201328). There are concerns that some substances in water, such as disinfection byproducts and toxins released by marine algae, are associated with health effects.factsheet.pd
Preventing an opioid overdose
Get PDFKnow the signs. Save a life.Prescription opioids (like hydrocodone, oxycodone, and morphine) and illicit opioids (like heroin and illegally made fentanyl) are powerful drugs that have a risk of a potentially fatal overdose.Publication date from document properties.Preventing-an-Opioid-Overdose-Tip-Card-a.pdf20171124
National Lead Poisoning Prevention Week : October 21-27, 2018 [Spanish]
No full textNational Lead Poisoning Prevention Week : October 21-27, 2018 [Spanish]Publication date from document properties.Comprenda los datosHaga examinar su casaHaga examinar a sus nin\u303osPublication date from document properties.201
2018-2019 Influenza Season Week 1 ending January 5, 2019 [Spanish]
No full text2018-2019 Influenza Season Week 1 ending January 5, 2019 [Spanish]Hay una visi\uf3n general del sistema de vigilancia de la influenza de los CDC, incluida su metodolog\ueda y descripciones detalladas de cada componente, disponible en: http://www.cdc.gov/flu/weekly/overview.htm.Sinopsis: Influenza activity increased in the United States. Los virus de influenza A(H1N1)pdm09, influenza A(H3N2) e influenza B siguen circulando de manera simult\ue1nea. A continuaci\uf3n hay un resumen de los indicadores clave de la influenza para la semana que finaliz\uf3 el 19 de enero del 2019:\u2022 Vigilancia viral :The percentage of respiratory specimens testing positive for influenza viruses in clinical laboratories increased. Los virus de influenza A fueron predominantes en los Estados Unidos desde principios de octubre. Los virus de la influenza A(H1N1)pdm09 han predominado en la mayor\ueda de las \ue1reas del pa\ueds; no obstante, los virus de la influenza A(H3) han predominado en el sudeste de Estados Unidos (regi\uf3n del HHS 4).o Caracterizaci\uf3n del virus: la mayor\ueda de los virus de influenza caracterizados antig\ue9nica y gen\ue9ticamente son similares a los virus de referencia cultivados en c\ue9lulas que representan los virus de influenza presentes en la vacuna 2018-2019 del hemisferio norte.o Antiviral Resistance:The vast majority of influenza viruses tested (>99%) show susceptibility to oseltamivir and peramivir. All influenza viruses tested showed susceptibility to zanamivir.\u2022 Vigilancia de Enfermedades Similares a la Influenza:La proporci\uf3n de consultas de pacientes ambulatorios por una enfermedad similar a la influenza (ILI) fue del 3.3%, lo que se encuentra por encima del nivel de referencia nacional del 2.2% . Las 10 regiones reportaron que las ILI se encuentran dentro del nivel de referencia espec\uedfico de la regi\uf3n.o ILI State Activity Indictor Map: New York City and 18 states experienced high ILI activity; 10 states experienced moderate ILI activity; the District of Columbia and eight states experienced low ILI activity; 14 states experienced minimal ILI activity; and Puerto Rico had insufficient data.\u2022 Propagaci\uf3n geogr\ue1fica de la influenza: The geographic spread of influenza in 36 states was reported as widespread; Puerto Rico and 11 states reported regional activity; three states reported local activity; the District of Columbia and the U.S. Virgin Islands reported sporadic activity; and Guam did not report.\u2022 Hospitalizaciones asociadas a la influenza Se report\uf3 una tasa acumulativa de 14.8 hospitalizaciones asociadas al virus de la influenza confirmadas por laboratorio cada 100 000 habitantes. La tasa m\ue1s alta de hospitalizaciones se encuentra entre los adultos de 65 a\uf1os de edad en adelante (38.3 hospitalizaciones por cada 100 000 habitantes).\u2022 Mortalidad por neumon\ueda e influenza: la proporci\uf3n de muertes atribuidas a la neumon\ueda y la influenza (N e I) est\ue1 por encima del nivel de epidemia espec\uedfico de cada sistema en el Sistema de vigilancia de mortalidad del Centro Nacional de Estad\uedsticas de Salud (NCHS, por sus siglas en ingl\ue9s).\u2022 Muertes pedi\ue1tricas asociadas a la infuenza: Se reportaron a los CDC tres muertes pedi\ue1tricas asociadas a la influenza durante la semana 3.2019713
Do you have diabetes? [Spanish]
No full textDo you have diabetes? [Spanish]Tiene muchas cosas que atender.\ua1Pero no se olvide de su salud!Pida ver a un m\ue9dico o a una enfermera que le puedan ayudar con su diabetes.Publication date from document properties.diabetes_flyer_spanish.pdf201
Children may not say how they are feeling during a disaster
Get PDFTalk to them. Answer questions.Make sure they feel lovedCall SAMHSA\u2019s Disaster Counseling Helpline at 1-800-985-5990 Text \u201cTalkWithUs\u201d for English or \u201cHablanos\u201d for Spanish to 66746CS296646CFlorence_MentalHlth_4x6PstCrd.pdf201
500 Cities Project : local data for better health, 2016 : Centennial, CO
No full textThe 500 Cities Project \u2013 Better Health Through Local Data \u2013 is a collaboration between the Robert Wood Johnson Foundation, the CDC Foundation, and the Centers for Disease Control and Prevention (CDC). The purpose of the project is to provide high quality small area estimates for behavioral risk factors that influence health status; for health outcomes; and the use of clinical preventive services. These estimates can be used to identify emerging health problems and to inform development and implementation of effective, targeted public health prevention activities.The CDC Behavioral Risk Factor Surveillance System 2015, 2016 data. The Census Bureau 2010 census population data, American Community Survey 2011-2015 and 2012-2016 estimates. Esri ArcGIS Online basemaps.20181174