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Electronic patient-reported outcome-based symptom management, a new era in surgical patient management
Full text linkWe comment on Dr. Dai et al.’s well-designed study in
Journal of Clinical Oncology (1). This article reports the
results of a randomized clinical trial comparing standard
postoperative care with electronic patient-reported
outcomes (ePROs), where patients reported their symptoms
immediately across five key domains, and these reports were
transmitted directly to the surgical team. The focus of the
study was on long-term outcomes (1 year), following an
earlier publication from the same group detailing data from
the first mont
Fibrilación auricular subclínica en los marcapasos doble cámara seguidos por monitorización remota. Incidencia, factores clínicos y pronóstico
Full text link328 p.Los marcapasos (MP) actuales son capaces de detectar y almacenar todos los episodios de fibrilación auricular (FA), incluso antes de su manifestación clínica, en una población de pacientes cada vez más numerosa por el envejecimiento de la población. Los objetivos de esta tesis que es un estudio observacional y retrospectivo son: 1) Determinar la incidencia de FA de nuevo diagnóstico en una muestra (265 pacientes) de portadores de MP doble cámara en seguimiento por monitorización domiciliaria, 2) Valorar los factores clínicos asociados a la detección de la arritmia y 3) Describir los eventos adversos y la mortalidad en el seguimiento de estos pacientes. Los pacientes de la muestra eran de avanzada edad (media 71 años), con cardiopatía hipertensiva o isquémica (2/3) y con un alto riesgo embólico y hemorrágico. La incidencia de FA subclínica durante el seguimiento medio de 6 años fue elevada (41%). Los predictores independientes para la detección de FA fueron la edad, la dilatación de la aurícula izquierda (AI) y el antecedente de broncopatía crónica. La incidencia de eventos clínicos mayores también fue elevada, destacando la insuficiencia cardiaca (IC) descompensada. La detección de FA subclínica como variable dicotómica no se comportó como factor independiente para la aparición de ictus, hemorragia grave, IC o mortalidad de cualquier causa. Es posible que la FA subclínica sea un marcador de riesgo aumentado de eventos adversos, más que la causa última de los mismos, al menos en sus formas iniciales y de menor duración.Estos hallazgos pueden poner de manifiesto la necesidad de abandonar la clásica concepción binaria de la FA como presente o ausente en favor de una evaluación clínica individual de los pacientes basada en sus factores de riesgo y una carga arrítmica cuantitativa que tenga en cuenta su duración y su variabilidad temporal
Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review
Full text linkMyotonic dystrophy type 1 (DM1) is an inherited neuromuscular disorder often considered a model of accelerated aging due to the early appearance of certain age-related clinical manifestations and cellular and molecular aging markers. Frailty, a state of vulnerability related to aging, has been recently studied in neurological conditions but has received considerably less attention in neuromuscular disorders. This narrative review aims to describe 1) the common characteristics between Fried’s frailty phenotype criteria (muscular weakness, slow gait speed, weight loss, exhaustion/fatigue, and low physical activity) and DM1, and 2) the psychological and social factors potentially contributing to frailty in DM1. This review gathered evidence suggesting that DM1 patients meet four of the five frailty phenotype criteria. Additionally, longitudinal studies report the deterioration of these criteria over time in DM1. Patients also exhibit psychological/cognitive and social factors that might contribute to frailty. Monitoring frailty criteria in the DM1 population could help to implement timely preventions and interventions to reduce the disease burden and severity of frailty symptoms.This work was supported by Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (Ref: 609), from the Institute of Health Carlos III cofounded by the European Union [PI22/01118 to Andone Sistiaga]; Basque Government [2022111031 to Andone Sistiaga; IT1732-22 to Joana Garmendia, Garazi Labayru, Andone Sistiaga and Adolfo López de Munain]; University of the Basque Country [PIF 20/238 to Joana Garmendia].This work was performed in the context of the IHU HealthAge, which was benefited from funding by the Agence Nationale de la Recherche under the France 2030 program [ANR-23-IAHU-0011 to Philipe de Souto Barreto]
A reuse proposal on a former air-raid shelter in Turin: Via Giordano Bruno 159
Full text linkThis thesis proposes a practicable reuse for an abandoned air-raid shelter which built
in 1930s. The aims are to renovate the damaged underground constructions, to insert new functional volumes, to revitalize the desolate neighborhood with the idea of transferring the site to a museum to show the 20 century heritage and the history, story, and culture in the 1930s war time. After studying the air-raid shelter architecture and the development plan of the city Torino, a careful design project is proposed to show the images of the floor plan, section, facade, panorama, and so on. The master dissertation follows principles of protecting 20th century architectural and urban heritage and contribute to the idea for the repair and reuse in Via Giordano Bruno 159
Media Narratives of Human-Wildlife Conflict: Iberian Orcas and Boats in the Spanish Press
Full text linkThe killer whale (Orcinus orca) is a crucial predator in marine ecosystems, affecting prey populations and overall ecosystem health. Since May 2020, Iberian killer whales in the Strait of Gibraltar have interacted unusually with pleasure boats, posing significant maritime safety challenges. Recognized as critically endangered by the IUCN, a conservation plan for these whales has been approved in Spain. This study analyzes media coverage of these interactions, as media can shape public opinion and influence policies regarding human–wildlife conflicts. A total of 107 news articles published between June 2022 and September 2024 in Spanish media were examined, focusing on the interactions between Iberian killer whales and boats. The research included six variables from prior studies to enhance understanding of media representation and its effects on conservation management. Findings suggest that media coverage often limits comprehension of orca behavior and their vulnerable status.This research was funded by University of the Basque Country, grant number PES17/39 and GIU21/029
Structural concepts for metallic LH2 tank designs life enhancement
Full text linkHydrogen is positioning itself as a key solution to decarbonise aviation, offering a clean and sustainable alternative to reduce pollutant emissions in a sector that significantly contributes to climate change. This thesis presents a fatigue analysis of preliminary designs for liquid hydrogen (LH2) storage tanks manufactured from AA2219-T87 aluminium alloy with friction stir welding (FSW). A global finite element method (FEM) model has been developed to capture stress distributions under cryogenic conditions, supported by a refined submodel for precise crack propagation analysis. Two approaches have been examined: classical fatigue life estimation based on crack initiation using S–N data, and damage tolerance assessment through fracture mechanics of crack growth at cryogenic temperatures. The results indicate an overestimation of fatigue life during initiation, mainly due to assumptions and limited experimental evidence, while crack propagation is significantly faster and strongly influenced by environmental conditions and the reduced thickness of the tank walls. These findings highlight the importance of complementing structural-scale analyses with localised fracture assessments. Future work will focus on experimental validation and advanced monitoring techniques to improve the safety and reliability of liquid hydrogen tanks.El hidrógeno se está posicionando como una solución clave para descarbonizar la aviación, ofreciendo una alternativa limpia y sostenible para reducir las emisiones contaminantes en un sector que contribuye significativamente al cambio climático. Esta tesis presenta un análisis de fatiga de diseños preliminares para tanques de almacenamiento de hidrógeno líquido (LH2) fabricados con aleación de aluminio AA2219-T87 y soldadura por fricción-agitación (FSW). Se ha desarrollado un modelo global de elementos finitos (MEF) para capturar las distribuciones de esfuerzo bajo condiciones criogénicas, apoyado por un submodelo refinado para un análisis preciso de la propagación de grietas. Se han examinado dos enfoques: la estimación clásica de vida a fatiga
basada en la iniciación de grietas usando datos S–N y la evaluación de tolerancia al daño mediante mecánica de fractura de crecimiento de grietas a temperaturas criogénicas. Los resultados indican
una sobreestimación de la vida a fatiga durante la iniciación, principalmente debido a suposiciones y la limitada evidencia experimental, mientras que la propagación de la grieta es significativamente
más rápida y fuertemente influenciada por las condiciones ambientales y el espesor reducido de las paredes del tanque. Estos hallazgos resaltan la importancia de complementar los análisis a escala estructural con evaluaciones localizadas de fractura. El trabajo futuro se centrará en la validación experimental y técnicas avanzadas de monitorización para mejorar la seguridad y fiabilidad de los tanques de hidrógeno líquido.Hidrogenoa iristen ari da hegazkinaren deskarbonizaziorako soluzio gako bezala, kutsaduraren emisioak murrizteko alternatiba garbia eta jasangarria eskainiz, klima aldaketaren eragile nagusietako bat den sektorea. Tesi honek hidrogenozko tanke baten neke analisia aurkezten du.
AA2219-T87 aluminio aleazioko eta marruskadura-agitazioko (FSW) soldadurarekin fabrikatutako hidrogeno likidoko (LH2) biltegiratze-tanken diseinu aldaketa hasiberriak aztertuz. Elementu finitoen metodo orokor (EFM) eredua garatu da krio-tenperaturako baldintzetan tentsio banaketak
jasotzeko, eta azpisistema batekin haustura-propagazioaren azterketa zehatza egiteko lagundu da. Bi ikuspegi aztertu dira: haustura hasierako eta nekearen iraupenaren estimazio klasikoa S-N datuetatik
abiatuta, eta haustura-propagazioaren kalte-tolerantzia azterketa krio-tenperaturan. Emaitzek neke iraupenaren gehiegizko estimazioa erakusten dute, batez ere hipotesiak eta frogagintza mugatuaren
ondorioz; hausturaren propagazioa askoz azkarragoa da eta inguruneko baldintzak eta tankearen hormaren lodiera txikia direla eta eragin handia du. Aurkikuntzak egitura-mailako azterketak haustura lokalizatuarekin osatzea garrantzitsua dela azpimarratzen dute. Etorkizuneko lana izango
da frogak egiteko esperimentuak eta aurreratutako jarraipen-teknikak erabiliz hidrogeno likidoko tankeak segurtasun eta fidagarritasunez hobetzera bideratzea
Fotokatalisian oinarritutako kutsatzaile emergenteen degradazioa TiO2 erabilita
No full text[EU] Gaur egun, teknika-analitikoen aurrerapenen ondorioz, gero eta gehiago identifikatzen ari dira orain arte antzeman gabe igaro diren uretako kutsatzaile emergenteak (KE); ingurumenarekiko eta osasunerako dakartzaten arriskuagatik kezka handia sortuz. KEen artean produktu farmazeutikoak eta pestizidak nabarmendu daitezke, non jarduera industrialaren, nekazaritzaren eta herritarren etengabeko hazkundearen ondorioz gero eta presenteagoak dauden ingurumenean. Uraren saneamendurako erabiltzen diren ohiko tratamenduek kutsatzaile hauek ezabatzeko gai ez direnez, Prozesu Aurreratuen Oxidazioak (PAO) alternatiba gisa aurkezten dira. Hauen artean, fotokatalisi heterogeneoak interes berezia piztu du eguzki-argiaren aprobetxamendua dela eta. Lan honetan, titanio dioxidoa (TiO2) fotokatalisatzaile gisa aplikatu da ibuprofeno farmakoaren eta atrazina herbizidaren degradazio fotokatalitikoa ikertzeko.
Horretarako, hiru TiO2 komertzial (P25, G5 eta DT51) karakterizatu dira, fotodegradazio-prozesua ahalik eta eraginkorrena izateko. Honako teknika hauek erabili dira: X-Izpien Difrakzioa (XRD), zeta potentziala, argiaren sakabanaketa dinamikoa (DLS), fisisortzioa N2 bidez, ekorketa bidezko mikroskopia elektronikoa (SEM), Raman espektroskopia eta erreflektantzia difusozko UV-Vis espektroskopia. Emaitzek erakutsi dute hiru fotokatalizatzaileek abantailak eta desabantailak dituztela, baina P25 hautatu da degradazio-erreakzioetarako: banda-tarte txikiagatik, anatasa-rutilo konposizio bifasikoagatik eta kristaltasun handia dela eta.
Fotokatalisi saiakuntzak 4 ordu eta erdiz burutu dira, 17°C eta 23°C arteko tenperaturan, pH 4ra doituta eta 5 rpm-ko irabiatzearekin. Gainera, konposatuen kontzentrazioen jarraipena errendimendu handiko likido kromatografiaz (HPLC) egin da, diodo-arrai bidezko detekzio ultramorearekin (UV-DAD), azetonitrilo/Mili Q ur fase mugikorrarekin (70:30, v/v), eluzio isokratikoan, 221 nm-ko detekzio uhin-luzeran eta 1,2 mL/min-ko emariarekin. Baldintza horietan ikusi da ibuprofenoaren konbertsioa % 90ekoa izan dela eta atrazinaren kontzentrazioa ez dela aldatu. Beraz, fotodegradaziorako hautatutako baldintza esperimentalen eraginkortasuna mugatua izan da atrazinarentzat, ibuprofenoarentzat emaitza positiboak lortu diren bitartean.[ES] Nowadays, advances in analytical techniques have led to the increasing identification of water emerging contaminants (ECs) that have previously gone undetected, raising significant concern due to the risks they pose to both the environment and human health. Among ECs, pharmaceutical products and pesticides are particularly noteworthy, as they are becoming increasingly prevalent in the environment because of continuous industrial activity, agricultural practices and population growth. Since conventional water treatment processes are not capable of eliminating these contaminants, Advanced Oxidation Processes (AOPs) are proposed as an alternative. Among these, heterogeneous photocatalysis has attracted special interest due to its potential to harness solar energy. In this work, titanium dioxide (TiO2) has been applied as photocatalyst to investigate the photocatalytic degradation of the pharmaceutical compound ibuprofen and the herbicide atrazine.
For this purpose, three commercial TiO2 samples (P25, G5 and DT51) were characterized to optimize the efficiency of the photodegradation process. The following techniques were employed: X-ray diffraction (XRD), zeta potential, dynamic light scattering (DLS), nitrogen physisorption, scanning electron microscopy (SEM), Raman spectroscopy and diffuse reflectance UV-Vis spectroscopy. The results showed that each of the three photocatalysts has its own advantages and disadvantages; however, P25 was selected for the degradation experiments due to its narrower band gap, biphasic anatase-rutile composition and high crystallinity.
Photocatalysis experiments were conducted for four and a half hours at temperatures between 17°C-23°C, at pH 4 and stirring at 5 rpm. Additionally, the concentrations of the compounds were monitored using high-performance liquid chromatography (HPLC) with UV-DAD detection, employing an acetonitrile-milli Q water mobile phase (70:30, v/v) in isocratic elution mode, detection at a wavelength of 221 nm and a flow rate of 1,2 mL/min. Under these conditions, it was observed that the conversion of ibuprofen reached 90 % while the concentration of atrazine remained unchanged. Therefore, the effectiveness of the selected experimental conditions for photocatalytic degradation was limited for atrazine, although positive results were achieved for ibuprofen
CLARIAH-EUS. Zientzia Sozialak eta Humanitate Digitalak gaur egun
No full text142 p.CLARIAH-EUS Humanitateetan eta Gizarte Zientzietan Europako ikerketa-azpiegiturekin lankidetzan euskara eta euskarari buruzko ikerketa bultzatzeko azpiegitura da. Hain zuzen ere, Europa mailako CLARIN eta DARIAH azpiegiturek eskaintzen dituzten ikerkuntzarako baliabideak eta laguntza euskara eta euskarari buruzko ikerketa egiteko eskuragarri jarri nahi ditu CLARIAH- EUSek. Horretarako, hainbat ekintzaren artean, ikertzaileen lanen berri izateko eta elkartrukea sustatzeko CLARIAH-EUS workshopak antolatzen ditugu.
Bigarren CLARIAH-EUS workshop honetan, gure helburua euskal ikerketa-komunitatea biltzea eta ikertzaileen eta bestelako eragileen arteko elkar ezagutza sustatzea izan zen, baita ikerketaazpiegiturak eta -tresnak hobetzea eta euskal kulturaren eta hizkuntzaren ikerketa sustatzea ere. Workshopak euskal ikerketa-esparruko 50 aditu eta ikertzailetik gora batu zituen Donostiako San Telmo Museoan. Maria Cristina Marinescu (BSC-CNS) eta Gustavo Candela (Alacanteko Unibertsitatea) izan genituen hizlari gonbidatu eta 21 poster aurkeztu ziren. Arratsaldean CLARIAHEUSen lehen batzar orokorrean azpiegituraren lehen urratsei buruz hitz egin genuen. Laburbilduz, CLARIAH-EUS azpiegiturak martxan jartzeko behar zituen osagaiak batu genituen: komunitatearen indarra, adituen jakinduria eta antolakuntzaren egitura.
Hemen bildutako ikerketa-ekarpenak CLARIAH-EUS azpiegituran jaso nahi diren baliabideen isla dira. CLARIAH-EUS komunitateak asko du eskaintzeko eta handia da baliabide horietatik atera daitekeen etekina. Ondoko bilduma CLARIAH-EUS komunitatea osatzen duten ikertzaileek sortutako eta prozesu itsu bikoitz baten bidez hautatutako lanek osatzen dut
Dos nuevas aras con divinidades vascónicas en Navarra/Nafarroa
No full textThe presence of onomastics of Basque origin in Aquitaine has been proven since the end of the 19th century by a large number of personal and divine names, but only in recent decades has the Basque territory south of the Pyrenees provided onomastic material related to the Basque language. Together with personal names, such as those attested in the Lerga inscription, there is a small group of names of divinity, located in the central and western part of Navarre, which present lexical, graphic-phonetic and morphological characteristics similar to those known in Aquitaine and which can be related to the Basque language.In this article, two recently discovered votive altars (Zaldua 2022) are published. Both are dedicated to two Basque divinities which were already previously known: Larahi and Losae (in their attested forms), and come from two places in the Salado river basin not far from each other: Riezu/Errezu and Anitz, Lerate, respectively. Although the theonyms are clearly legible, the names of the dedicators have been damaged, so they have been restored taking into account the textual circumstances of the inscription as well as the onomastic parallels compatible with the preserved remains: Agustina or Augustina is proposed as the dedicator of the altar from Riezu, and either Paenius, -a, or Dafnus, -e, is proposed for the dedicator of the altar from Anitz.Unlike the majority of Basque divinities whose epigraphic documentation is limited to one place, these two divinities are the ones with the greatest geographical expansion. This leads us to reflect on the regional and not strictly local nature of their cult, now reinforced by the discovery of a new testimony of Larahe in Larunbe (Agirre-Mauleón (ed.) 2024). The graphic varieties of the theonym are analysed linguistically, with regard to the double representation of the rhotics (r/rr) and the alternation in the ending (-he /-hi). Finally, the differences in gender and social background of the dedicators, from Roman citizens to slaves, suggests a broad functionality of these divinities; Mientras que la presencia en Aquitania de una onomástica de filiación vasca está probada desde fines del s. XIX por gran cantidad de nombres de persona y de divinidad, el territorio vascón al sur de los Pirineos solo ha proporcionado material onomástico relacionable con la lengua vasca en los últimos decenios. Junto a nombres de persona, como los atestiguados en la inscripción de Lerga, destaca un pequeño conjunto de nombres de divinidad, localizado en la parte media y occidental de Navarra, que presentan características léxicas, grafico-fonéticas y morfológicas semejantes a las conocidas en Aquitania y relacionables con la lengua vasca.Se editan aquí dos aras votivas recientemente descubiertas (Zaldua 2022), dedicadas a sendas divinidades vascónicas previamente conocidas: Larahi y Losae (en sus formas de atestiguación) y proceden de dos lugares de la cuenca del río Salado –Riezu/Errezu y Anitz, Lerate, respectivamente–, no alejados entre sí. Aunque los teónimos son bien legibles, los nombres de los dedicantes han sufrido deterioros, de modo que se ha procedido a una restitución de los mismos teniendo en cuenta las circunstancias textuales de la inscripción así como los paralelos onomásticos compatibles con los restos conservados: como dedicante del ara de Riezu se propone Agustina o Augustina, y para el dedicante del ara de Anitz se propone bien Paenius, -a, bien Dafnus, -e.A diferencia de la mayoría de divinidades vasconas cuya documentación epigráfica se limita a un lugar, nuestras dos divinidades son las de mayor expansión geográfica; ello lleva a reflexionar sobre la naturaleza regional y no estrictamente local de su culto, ahora reforzado por el descubrimiento de un nuevo testimonio de Larrahe en Larunbe (Agirre-Mauleón 2024). Se analizan lingüísticamente las variedades gráficas del teónimo, en lo que respecta a la doble representación de las vibrantes (r/rr) y a la alternancia en la terminación (-he /-hi). Por último, la variedad de género y de extracción social de los dedicantes, desde ciudadanos romanos hasta siervos, sugieren una funcionalidad amplia de estas divinidades
Sustainable anti-corrosion coatings based on biomaterials for marine applications
No full text252 p.Anti-corrosion coatings based on biomaterials have been produced from epoxidized soybean (ESO) oil and tannic acid (TA), referred to as ESOTA during this document. By adjusting the ratio of these two components, various thermosetting materials were created, each with different curing conditions, mechanical properties, and rheological behaviours. Thus, opening the possibilities for adjusting the final properties to specific applications requirements. These bio based coatings were found to be as effective in corrosion protection as conventional petroleum derived coatings when applied to carbon steel. To further enhance the anti-corrosion performance, graphene oxide (GO) was incorporated into the bioepoxy matrix, forming a nacre-like layered structure that improved the barrier properties of the coatings. Additionally, multi-walled carbon nanotubes (MWCNTs) and reduced graphene oxide (rGO) were added to create multifunctional coatings with properties such as piezoresistivity, thermoresistivity, and dielectric behaviour