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Nahasketa bitarren Soret koefizientearen neurketa ingurune porotsuan
No full textThis paper describes the process followed for the validation of the experimental procedure known as Soret elementary cell in porous media. First, numerical simulations of the key parts of the process have been carried out; these being the temperature transmission and the separation of components. Once this phase was completed, experimental tests were carried out with samples based on hydrocarbons and aqueous mixtures; and with both positive and negative Soret coefficients.Artikulu honetan ingurune porotsuan Soreten oinarrizko zelula gisa ezagutzen den prozedura esperimentala baliozkotzeko jarraitutako prozesua deskribatzen da. Horretarako, lehenik eta behin, prozesuaren funtsezko aldagaiak aztertu dira zenbakizko simulazioen bitartez, zelularen zeharreko tenperaturaren transmisioa eta nahasketaren osagaien bereizketa, besteak beste. Horren ondoren, hidrokarburo eta ur-nahasketa ezberdinekin saiakuntza esperimentalak egin dira; baita Soret koefiziente positibo zein negatiboa duten nahasketekin ere
Bektore ez-biral lipidikoak garatzeko erabiltzen diren teknikak eta hauen garrantzia etorkizunerako
No full textIn recent years, non-viral lipid vectors have gained important recognition thanks to the new vaccines that have been developed for COVID. For this reason, in this article we wanted to refer to the two types of vectors that we work with in our research group, niosomes and lipid particles. Focusing on their production processes, we will show the importance of microfluidic and sonicator methods in the activity of these formulations. Finally, we will mention the present and future applications of these new formulations, highlighting their potential to become one of the major advances in medicine.Azken urteotan, bektore ez-biral lipidikoak oso aintzatetsiak izan dira COVID gaixotasunerako garatu diren txerto berriei esker. Hori dela eta, artikulu honetan, gure ikerketa-taldean lantzen ditugun bi bektore ez-biral motak azaltzen ditugu: niosomak eta partikula lipidikoak. Horien ekoizpenerako mikrofluidika eta sonikazio metodoak erabiltzen ditugu, eta aipatutako formulazioen aktibitatean metodo bakoitzak duen eragina erakusten dugu. Azkenik, formulazio berri horien oraingo eta etorkizuneko aplikazioak aipatzen ditugu, medikuntzaren arloan ekarri ditzaketen aurrerapenak azpimarratuz
Epe luzerako ondorioak loki-lobuluko epilepsia sagu-eredu baten garunean
No full textTemporal lobe epilepsy is the most common type of epilepsy in adults. Although available anticonvulsants reduce the excessive neuronal excitability, they are not always effective. Nowadays research focuses on the control of neuroinflammatory mechanisms switched on in epilepsy. Hence, non-neuronal brain cells and the endocannabinoid system have emerged as potential targets because the role of this system in neuroinflammation mediated by cannabinoid receptor-expressing glial cells. We show changes in glial cells and the cannabinoid 1 (CB1) receptor, the main target of endogenous and exogenous cannabinoids, throughout brain regions in a mouse model of temporal lobe epilepsy. Remarkably, these anatomical changes impact on cognition (memory) and behavioral states (anxiety).Loki-lobuluko epilepsia helduetan ematen den epilepsia mota ohikoena da. Eskuragarri dauden farmakoek neuronen gehiegizko kitzikagarritasuna murrizten duten arren, beti ez dira eraginkorrak izaten. Gaur egungo ikerketak gaitzean aktibatutako mekanismo neuroinflamatorioen kontrolean oinarritzen dira. Hartara, garuneko zelula ez neuronalak eta sistema endokannabinoidea itu terapeutiko gisa proposatu dira. Izan ere, neuroinflamazioarekin erlazionaturik dauden glia zelulek kannabinoide hartzaileak adierazten dituzte. Ikerketa honetan, glia zelula eta kannabinoide sisteman gertatutako aldaketak eta burmuinean zehar erasandako eskualdeak aztertu dira loki-lobuluko epilepsia sagu ereduan. Era ohargarrian, aldaketa anatomiko hauek kognizio (oroimenean) eta emozio-egoeretan (antsietatea) eragina dute
Ingurumen-justizia nazioartean: giza eskubideak benetan bermatzeko bitartekoa
No full textEnvironmental destruction causes serious injustices and particularly affects the most vulnerable inhabitants on the planet, who endure a disproportionate environmental sacrifice. It is therefore urgent to understand the notion of environmental justice. And that is precisely the core of the article, which highlights the tendency of legal systems to recognize environmental rights as a prerequisite for the fulfilment of human rights. This recognition is made at the international level by various means, but there is a clear tendency to do so through jurisprudence. It is therefore important to address environmental justice as a broad genre or concept with multiple perspectives, as well as to explore its jurisdictional aspect, in order to explain how environmental justice is defined and interpreted internationally.Ingurumenaren suntsiketak injustizia larriak eragiten ditu eta, bereziki, planetako biztanle ahulenei erasaten die, neurrigabeko ingurumen-sakrifizioa jasanaraziz. Horregatik, premiazkoa da ingurumen-justiziaren nozioa ulertzea. Eta hori da, hain zuzen ere, artikuluaren muina, zeinak agerian uzten duen sistema juridikoek duten joera ingurumen-eskubideak ezinbesteko baldintzatzat aitortzeko giza eskubideak bete daitezen. Aitortza hori hainbat bidetatik egiten da nazioartean, baina nabarmena da jurisprudentziaren bidez egiteko joera. Horregatik, garrantzitsua da ingurumenjustizia ikuspegi askotarikoak dituen genero edo kontzeptu zabal gisa jorratzea, baita haren alderdi jurisdikzionala aztertzea ere, nazioartean ingurumen-justizia nola definitzen eta interpretatzen den azaltzeko
Inés Medinaren sorkuntza garaikidea historiaratzeko estrategiak
No full textThe place of Inés Medina's work in Basque historiography has been associated with abstraction, based on the artist's formal plastic study. However, in recent years she has made public a different painting, based on psychoanalysis and reflecting on gender-based violence. An example of this line is the pioneering 19th series. To investigate these works, I suggest building a new framework, as the one developed around abstraction does not seem applicable. In order to do this, I use two subjects that are important to feminism, and present in Medina's work: the relationship between body and mind, and femininity. I also contextualize her work with other contemporary artists who have dealt with violence against women.Inés Medinaren lanak euskal historiografian duen tokia abstrakzioarekin lotu da, artistak burututako azterketa formal plastikoan oinarrituz. Hala ere, azken urteetan bestelako pintura plazaratu du, psikoanalisitik abiatuz eta genero indarkeriaren inguruan hausnartuz. Ildo horren adibidea dugu bide hori ireki zuen 19. seriea. Lan horiek ikertzeko, abstrakzioan garatutako markoa nahikoa ez dela iradokitzen dudan heinean, berri bat eraikitzea proposatzen dut. Horretarako, feminismoarentzat garrantzitsuak diren, eta Medinaren lanean ageri diren, bi gai aztertzen ditut bere lanari lotuta: gorputzaren eta adimenaren arteko harremana eta feminitatea. Horrez gain, emakumeenganako bortizkeriaren landu duten beste artista garaikideekin batera testuinguratzen dut bere lana
EAE mendiko erreskate taldearen sasoi fisikoa
No full textIn recent years, mountain rescues have increased, leading to a higher demand of the rescue teams. The physical performance of rescuers is considered essential for dealing with the emergency. Nowadays, research on mountain rescuers is scarce. The purpose of this investigation is to study the physical condition of mountain rescuers. As a result of the tests, it should be noted that the rescuers that took part in this study are in a good physical condition. More research is needed to increase the information about mountain rescuers.Azken urteetan mendi erreskateek gorakada izan dute, erreskate taldeen lana handituz. Erreskate taldeen prestaketa fisikoa ezinbestekoa da larrialdiei aurre egiteko. Gaur egun, mendiko erreskatatzailei buruzko ikerketak urriak dira. Horregatik ikerketa honen helburua erreskatatzaileen egoera fisikoa aztertzea da. Burututako testen emaitzen ondorioz aipatzekoa da aztertutako erreskate taldeak egoera fisiko ona daukala. Baina, ikerketa gehiago behar dira mendiko erreskatatzaileen inguruko informazioa handitzeko
Nanopartikulen sintesian zeharreko tamainaren neurketa denbora errealean
No full textParticle size and particle size distribution (PSD) are important properties of polymer latexes because they strongly affect the film formation and the rheology of the latexes. Thus, controlling them is of paramount importance during the production of waterborne polymeric dispersions. Advanced control strategies (feedback control) require online/inline measurements of the particle size to be able to track optimal trajectories. A number of technologies exist for the characterization of particles in suspension at the nanoscale. However, these techniques need highly diluted particle concentration samples. To overcome this problem, NanoPAT European Project was created, whose aim is to test the suitability of some new technologies to monitor the size of different type of particles in real time production.Partikulen tamaina eta partikulen tamainaren banaketa (PSD) latex polimerikoen ezaugarrigarrantzitsuak dira, besteak beste filmaren eraketari eta latexaren erreologiari eragiten baitiete. Beraz, euren kontrola oso garrantzitsua da ur dispertsio polimerikoak ekoiztean. Kontrol-estrategia aurreratuek (berrelikadura-kontrola) partikulen tamaina lerroan neurtzea eskatzen dute, ibilbide optimoak jarraitu ahal izateko. Hainbat teknologia daude eskala nanometrikoko partikula sakabanatuen tamainak neurtu ahal izateko, baina guztiek kontzentrazio oso baxuetan lan egitea eskatzen dute. Arazo honi aurre egiteko, NanoPAT europar proiektua sortu zen, zeinen helburua partikula mota desberdinak denbora errealean eta lerroan monitorizatzeko zenbait teknika aztertzea den
Psilozibinaren administrazio akutuaren eraginen ebaluazioa garun kortexean serotonina, noradrenalina eta dopamina mailak neurtuz: garunmikrodialisiaren bidez burututako ikerlana esna dauden saguetan
No full textPsilocybin is a natural hallucinogenic compound that has been shown to have potential antidepressant effects. However, the mechanism of action is largely unknown. Therefore, in this study, we investigated the effect of psilocybin on the frontal cortex monoamine extracellular concentrations using in vivo brain microdialysis technique.At the dose used (1 mg/kg), no significant changes in monoamine concentration were observed. This leads to the conclusion that the antidepressant mechanism of action of psilocybin, unlike current antidepressants, does not primarily involve an increase in extracellular monoamines in frontal cortex.Psilozibina eraginkortasun antidepresiboa duen haluzinatzaile naturala da. Bere ekintza mekanismoa nahiko ezezaguna da. Hori dela eta, lan honetan, psilozibinaren ekintza mekanismo akutua aztertu da monoamina maila estrazelularrak ebaluatuz, kortex frontalean egindako garun-mikrodialisia in vivo teknika erabiliz.Erabilitako dosian, 1 mg/kg hain zuzen, ez da monoaminen kontzentrazioan aldaketa esanguratsurik ikusi eta, beraz, psilozibinaren ekintza antidepresiboak, egungo antidepresiboen kasuan ez bezala, ez du erlazio zuzenik kortex frontaleko monoaminen mailen igoerarekin
Osasun-arloko entitate izendunen etiketatzea
No full textThis work has a double objective: on the one hand, it identifies named entities using language models based on transformers and, on the other hand, it links the identified clinical entities with the diseases and symptoms of the Wikidata knowledge base. To identify the entities, experiments have been performed on the MedMentions biomedical corpus with a generalpre-trained language mode˜n BERT (BERT small) and two specialised BERTs (BiomedNLP-PubMedBERT and BioBERT). When assessing whether a succession of tokens constitutes a medical entity, an F1 value of 0.819 was obtained, while assessing the specific class to which the entity belongs, an F1 value of 0.62 was obtained. In addition, a recall close to 50% has been achieved in the first attempt to associate Wikidata to known entities using the Levenhstein distance.Lan honek helburu bikoitza du: alde batetik, transformerretan oinarritutako hizkuntza-ereduak erabiliz medikuntzaren alorreko entitate izendunen identifikazioa egiten du, eta bestetik, identifikatutako entitate klinikoak Wikidata ezagutza-baseko gaixotasunekin eta sintomekin lotzen ditu. Entitateak ezagutzeko, biomedikuntzako MedMentions corpusaren gainean, aldez aurretik entrenatutako BERT hizkuntza-eredu orokor batekin (BERT small) eta bi BERT espezializaturekin (BiomedNLP-PubMedBERT eta BioBERT) egin dira esperimentuak. Token segida batek medikuntzako entitate bat osatzen ote duen ebaluatu denean, 0,819ko F1 balioa lortu da, eta entitatea zein klase zehatzetakoa den ebaluatu denean, 0,62ko F1 balioa. Gainera, Levenhstein distantzia erabiliz ezagututako entitateak Wikidatarekin lotzeko lehenengo saiakeran %50 inguruko estaldura lortu da
Tetrafluoroetileno sulfonatuan oinarritutako ionomero komertzialen saretzea protoi-trukatzaileko erregai-pilen mintzen eroankortasuna hobetzeko
No full textDespite the wide utilization of the sulfonated tetrafluoroethylene based ionomers in proton exchange membranes for fuel cells (PEMFCs) they still present certain drawbacks. Nonenvironmentally friendly solvents are used to create the ionomers and the membranes present a rapid decline of the proton conductivity and a loss of performance at high temperatures, because at such conditions they lose the adsorbed humidity. In this work, we have tried to overcome these limitations by creating a cross-linked form of Nafion® sulfonated tetrafluoroethylene ionomer.Nahiz eta tetrafluoroetileno sulfonatatuan oinarritutako ionomeroen erabilera mintz protoi-trukatzaileko erregai-piletan (PEMFC) handia izan, beren potentziala mugatzen duten eragozpen batzuk daude oraindik. Ionomero hauek sortzeko ingurumenean inpaktu negatiboa duten disolbatzaile organikoak erabiltzen dira. Horrez gain, tenperatura altuetan hezetasuna galtzen dutenez, mintzek protoi-eroankortasunean beherakada azkarra jasaten dute. Lan honetan, muga horiek gainditzen saiatu gara, Nafion® tetrafluoroetileno ionomero sulfonatuaren forma saretua sortuz