Ho Chi Minh City Open University Journal of Science
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Aksaray İli Şeker Pancarı (Beta vulgaris var. saccharifera L.) Ekim Alanlarında Bulunan Yabancı Ot Türlerinin Yaygınlıkları, Yoğunlukları ve Bazı Bitki Uçucu Yağlarının Allelopatik Etkilerinin Belirlenmesi
No full textComparison of biological activities and bioactive components of fruits and leaves of six local apple cultivars (Malus domestica) from Ardahan and Erzurum Provinces, Türkiye: Part II
No full textThis study aimed to investigate the biochemical composition and biological activities of the fruits and leaves of six apple cultivars (Malus domestica) grown in the microclimatic regions of Ardahan, and Erzurum in Türkiye. Accordingly, pigment composition, total anthocyanin (TA), total soluble solids (TSS), pH, titratable acid content (TIAC), total phenolic content (TPC), total ascorbic acid (TAC), antioxidant, antimicrobial, and antimutagenic activities were analyzed. Leaf TPC values, except for the Tatlı and Dacik cultivars, were higher than those of the fruit peel. Similarly, TAC and pigment content were markedly higher in the leaves. Among the fruit extracts, the Paşa and Tatlı cultivars showed higher DPPH values, whereas the Kış cultivar exhibited the highest ABTS value. Leaf extracts displayed a markedly greater FRAP-based reducing capacity than fruit extracts. Moreover, the fruit extract of the Kış cultivar exhibited greater antibacterial activity against Staphylococcus aureus ATCC 6538 than that of the other cultivars. The antimutagenic potential of apple fruit and leaf extracts against Salmonella typhimurium TA 98 and TA 100 strains was dose-dependent and varied among cultivars. These findings highlight that not only fruit extracts but also apple leaves, represent a valuable natural source of bioactive compounds for functional, nutraceutical, and health applications
Influence of Implant Scan Body Material and Exposure on the Accuracy of Implant Positioning in Digital Scanning
No full textPurpose: The purpose of this in vitro study was to evaluate the influence of implant scan body material and its exposed portion on ti-base (titanium-based) positioning accuracy. Material and Methods: In this study, a total of 14 diagnostic casts were created using two different scan bodies in 7 subgroups, ranging from the bone level to a depth of 6 mm. The diagnostic casts were scanned using a desktop scanner (Ceramill Map 600+, Amann Girrbach, Austria) for reference. The experimental data were scanned five times with an intraoral scanner (TRIOS 5, 3Shape, Copenhagen, Denmark) in each group (n = 70). All scan data were transferred to CAD software (Exocad, DentalCAD 3.1 Rijeka, Darmstadt, Germany). The ti-base positions were determined after the scan body image matching. The ti-base position deviations were analysed in three dimensions. A two-way ANOVA test was used to compare data according to depth and material variables. Results: The depth factor (p = 0.000) and the interaction between depth and material (p = 0.006) had statistically significant effects on the accuracy of ti-base positioning, whereas the material factor did not show a significant effect (p = 0.559). Conclusions: As the exposure of the scan bodies decreased, the obtained deviation values tended to increase for both scan body materials
Effect of miR-27a, miR-29B, miR-142, miR-148a on milk quality and mammary health in cows with low and high somatic cell count
No full textThis study investigated expressions of miR-27a-3p, miR-29B-2, miR-142-5p, miR-148a in Holstein with low (LSCC) and high somatic cell counts (HSCC). Relationships between miRNAs, SCC and key milk quality parameters were examined. Milk was aseptically collected from multiparous Holsteins in mid-lactation on a dairy farm, and cows were grouped by SCC (200,000 cells/mL). miRNAs expressions were quantified by RT-qPCR, and target genes, Protein-Protein Interaction, and pathway analysis were also conducted. In HSCC, all samples were CMT positive (1.91 +/- 0.17). The overall SCC was approximately 320,000 cells/mL, with values around 60,000 cells/mL in the LSCC and 540,000 cells/mL in HSCC. Milk composition parameters were similar between groups, while electrical conductivity (EC) was higher in HSCC. miR-27a-3p and miR-29B-2 were upregulated by approximately 3-fold in HSCC, whereas miR-148a showed more than 6-fold upregulation. miR-27a-3p correlated positively with miR-29B-2, miR-148a, and EC. miR-29B-2 was positively correlated with miR-148a, SCC, fat, and EC. miR-142-5p showed negative correlation with protein, while miR-148a was positively correlated with SCC. A total of 1,020 target genes were identified, with PTEN being a common target of all four miRNAs, while SMAD3, TGFB2, OTUD4, and RPS6KA5 were regulated by three. Network analysis revealed 84 proteins engaged in 402 interactions. MCODE identified key genes related to host response, lipid metabolism, inflammation, and apoptosis. The results provide insights into the molecular mechanisms underlying mammary gland health and potential targets for improving milk quality
Quantile-based insights into the impact of public environmental protection expenditures and renewable energy on sustainability performance in the EU-27
No full textThis study examines how government environmental protection expenditures and renewable energy consumption influence environmental sustainability in the 27 European Union (EU-27) countries from 1995 to 2022. Environmental quality is assessed using the Environmental Performance Index (EPI), a comprehensive composite indicator that captures multiple dimensions of ecological sustainability. To address heterogeneity among countries with varying environmental performance, the analysis employs the Method of Moments Quantile Regression (MMQR), which allows for the evaluation of policy effectiveness across the entire conditional distribution of the EPI. The results indicate that environmental protection expenditures exert a statistically significant and positive impact on environmental quality mainly in countries in the lower quantiles of the EPI distribution, indicating that fiscal interventions are most effective where baseline environmental performance is relatively weak. This effect diminishes at higher quantiles, suggesting a saturation threshold in more environmentally advanced EU member states. In contrast, renewable energy consumption demonstrates a robust and consistently positive effect across all quantiles, underscoring its role as a effective tool for enhancing environmental sustainability within the EU-27. By replacing fossil fuel–based energy with renewables, EU-wide renewable energy expansion improves EPI by lowering air pollution, and enhancing ecosystem vitality. These findings align with Sustainable Development Goal 7 by highlighting the environmental benefits of renewable energy deployment, and with Sustainable Development Goal 13 by emphasizing the importance of targeted public expenditures in strengthening climate resilience. Overall, adaptive and differentiated policy frameworks are essential for translating quantile-specific insights into effective strategies for achieving sustainable environmental outcomes across the EU-27
Dermocosmetic Training in Dermatology Residency in Türkiye: Current Status and Changes Over Time
No full textFormulation and Characterization of Hydrogel Based on Pectin, Collagen, Alginate and Myrtus communis Essential Oil for Applications in Skin Regeneration
No full textThis paper proposes a potential solution to the current issue of developing advanced, biocompatible biomaterials with integrated therapeutic functionality, which would contribute to improving the treatment of skin defects. This study aimed to develop, characterize and evaluate hydrogels based on type I collagen, pectin, alginate and myrtle essential oil, in order to obtain biomaterials with potential in skin regeneration applications. Hydrogels incorporating alginate, pectin, type I collagen and Myrtus communis essential oil were prepared via a multistep procedure comprising homogenization, crosslinking and lyophilization. The obtained hydrogels were characterized by physicochemical and structural methods, such as FTIR spectroscopy, to identify interactions between components; micro-computed tomography, to evaluate internal morphology and porosity; antibacterial tests, for evaluating the ability of the hydrogel to prevent infections at the application site; and in vitro cellular tests, such as the XTT test or cytotoxicity tests, such as LDH, essential for evaluating the biocompatibility of the hydrogel. The highest viability value was recorded for sample J4 (99.53 ± 11.88%), indicating an exceptional compatibility with the cells used, almost identical to that of the untreated control. The samples showed encouraging results, supporting their potential for applications in wound treatment and skin regeneration
Từ chuẩn quốc tế đến khung chỉ số đánh giá phù hợp cho trường Kinh doanh Việt Nam
Full text linkThis study constructs a performance evaluation framework tailored for Vietnamese business schools within multidisciplinary universities. Using qualitative content analysis, the research synthesizes and systematizes criteria from four international evaluation systems: QS, THE, Eduniversal, and AACSB. Secondary data were collected from annual reports, official websites, and self-assessment documents of three typical business schools (FTU, NEU, and UEH) from 2019 - 2024 to identify gaps against international standards. The results show significant disparities in research productivity (the total ISI/Scopus publications of the three schools are only about 20% of a mid-tier regional institution), international student ratios (under 5% compared to 15 - 25% in Malaysia), and social impact. This study proposes a framework of 05 groups and 13 specific criteria with adjusted weightings, emphasizing core competencies and adaptability. In practice, the framework provides an effective management tool for policymakers and university leaders in self-assessment and sustainable development strategy.Nghiên cứu xây dựng một khung chỉ số đánh giá hiệu quả hoạt động phù hợp với bối cảnh các trường kinh doanh Việt Nam trong đại học đa ngành. Dựa trên phương pháp phân tích nội dung định tính, nghiên cứu tổng hợp và hệ thống hóa tiêu chí từ bốn hệ thống đánh giá quốc tế uy tín: QS, THE, Eduniversal và AACSB. Dữ liệu thứ cấp được thu thập từ báo cáo thường niên, website chính thức và tài liệu tự đánh giá của ba trường kinh doanh tiêu biểu (FTU, NEU, UEH) trong giai đoạn 2019 - 2024 để đối chiếu và xác định khoảng cách so với chuẩn quốc tế. Kết quả cho thấy một khoảng cách đáng kể về năng suất nghiên cứu (tổng số bài báo ISI/Scopus của 03 trường chỉ bằng khoảng 20% so với trường cỡ trung bình trong khu vực), tỷ lệ sinh viên quốc tế (dưới 5% so với mức 15 - 25% ở Malaysia) và tác động xã hội. Nghiên cứu đề xuất bộ chỉ số gồm 05 nhóm, 13 tiêu chí cụ thể với trọng số được điều chỉnh, nhấn mạnh vào năng lực cốt lõi và khả năng thích ứng. Về thực tiễn, khung chỉ số cung cấp một công cụ quản trị hữu hiệu cho các nhà hoạch định chính sách và lãnh đạo các trường trong việc tự đánh giá và xây dựng chiến lược phát triển bền vững
Hiệu quả của Protein tái tổ hợp FGF-7 (fibroblast growth factor 7) đối với việc kích thích tăng sinh nguyên bào sợi
No full textFibroblast growth factor (FGF7/KGF), belonging to the FGF family, has long been known for its role in wound healing, angiogenesis, and especially cell growth stimulation. Therefore, generating a large quantity of highly purified FGF7 for applications in regenerative biomedical research is a significant challenge. The mouse fibroblast cell line (L929) plays a crucial role because fibroblasts are largely involved in the entire wound healing process, particularly at the end of the healing process. In this study, FGF7 was generated using recombinant technology and its stimulation of mouse fibroblasts was evaluated. The results showed that the recombinant FGF-7 protein source achieved a concentration of 75.5 µg/ml with 96.2% purity from the Escherichia coli BL21 (DE3) expression system. The MTT assay results showed that after 24 hours of culture, fibroblast cells achieved the highest proliferation rate at a concentration of 10 µg/ml (1.76 times) compared to the control without FGF-7 supplementation at the same time.Yếu tố tăng trưởng nguyên bào sợi (FGF7/KGF) thuộc họ FGF, từ lâu đã được biết đến với vai trò chữa lành vết thương, kích thích hình thành mạch máu và đặc biệt là kích thích tăng trưởng tế bào. Do đó, việc tạo ra một lượng lớn FGF7 có độ tinh sạch cao nhằm ứng dụng các nghiên cứu trong y sinh học tái tạo là một thách thức lớn. Dòng tế bào nguyên bào sợi chuột (L929) đóng vai trò quan trọng bởi sự hiện diện của nguyên bào sợi là phần lớn trong toàn bộ quá trình phục hồi vết thương, đặc biệt là ở điểm cuối của quá trình lành vết thương. Trong nghiên cứu này, FGF7 được tạo ra bằng công nghệ tái tổ hợp và thử nghiệm đánh giá sự kích thích nguyên bào sợi chuột. Kết quả tạo ra nguồn protein tái tổ hợp FGF-7 đạt nồng độ 75.5 µg/ml với độ tinh sạch 96.2% từ hệ thống biểu hiện Escherichia coli BL21 (DE3). Kết quả xét nghiệm MTT cho thấy sau 24 giờ nuôi cấy, tế bào nguyên bào sợi đạt tỷ lệ tăng sinh cao nhất ở nồng độ 10 µg/ml (1.76 lần) so với đối chứng không bổ sung FGF-7 tại cùng thời điểm
Evaluating the Impact of Toolbox Training on Health Professionals in Radiation Environments: A Randomized Controlled Trial
No full textIn recent years, the use of radiation diagnostics, treatment services, and many areas of health services has become widespread with technological developments. The widespread use of radioactive substances and radiation-producing devices in health services has increased the need for effective radiation protection programs, and the need for training in terms of the applicability of these programs is also increasing. This randomized controlled trial was conducted to evaluate the effect of on-the-job toolbox training defined as a short, informal safety meeting led by a supervisor that focuses on specific workplace hazards or safe work practices on the knowledge, practices, and safety-related behaviors of healthcare professionals working in radiation environments. Sixty-three participants from the radiology units of a university hospital in Hatay, Türkiye, were randomly assigned to an intervention group (n=33) or a control group (n=30). The intervention group received brief, face-to-face training sessions using visual materials in their work environments. Data was collected before and after the training and at two follow-up periods. After the training, radiation protection knowledge increased significantly in the intervention group (p<0.001), while no change was observed in the control group. Observational assessments revealed that there was an improvement in practice scores in the intervention group and that the gains were largely maintained over time. Additionally, adverse event reporting, an important quality indicator, increased significantly in the intervention group, indicating increased safety awareness. These results confirm that toolbox training is an effective method for improving both knowledge and safe practices among healthcare professionals. Its brief, practical, and workplace-based format contributes to increased engagement and retention of learning. The findings support the integration of toolbox training into in-service training programs as a complement or alternative to traditional methods. Future studies should examine its long-term effectiveness and applicability in a variety of healthcare settings