Ho Chi Minh City Open University Journal of Science
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Dual seropositive nonerosive lupus arthritis: rhupus or not?
No full textBackground: There is no consensus on the classification of lupus arthritis (LA). In this study, we aimed to investigate patients with LA who were clinically and serologically very similar to those patients with rheumatoid arthritis (RA).Methods: The electronic medical files of systemic lupus erythematosus (SLE) patients from a single tertiary rheumatology department between 2017 and 2022 were reviewed. The inclusion criteria were being age >= 18 years, having nonerosive peripheral arthritis lasting longer than six months, and having dual seropositive (rheumatoid factor (RF) and anti-citrullinated protein antibody (anti-CCP)) serology. A nonerosive course of arthritis was demonstrated by both conventional radiography and joint ultrasound. Images were assessed by two blinded rheumatologists. Patients with drug-induced lupus and those with other rheumatologic diseases were excluded.Results: The cases of 528 patients were reviewed, and eight patients were included in the study. All patients were female, and the median age was 48.5 years. The median SLE and arthritis durations were 12 and seven years, respectively. The most common SLE symptom was photosensitivity (n = 8). Only one patient had life-threatening involvement (LTI), which was a seizure and autoimmune haemolytic anaemia. All patients had arthritis affecting the wrist and hand. Anti-dsDNA was the most common anti-ENA antibody (n = 7), followed by anti-SSA (n = 5). The median RF and anti-CCP titres were 82.5 IU/ml and 81.5 U/ml, respectively. Five patients had high titres of autoantibodies, and only one patient had slight hypocomplementemia. Three patients needed biologic agents, and remission was achieved after treatment with rituximab.Conclusion: Despite a long arthritis duration and dual seropositive serology with high titres of RF and anti-CCP, our patients had SLE rather than rhupus syndrome. The low frequency of LTIs, such as lupus nephritis, was a remarkable feature of our patients. Lupus arthritis may be clinically and serologically indistinguishable from RA. Prospective studies are needed to better define LA.</p
EMERGING, CONTEMPORARY AND FUTURE VISIONS IN FOOD INDUSTRY
No full textFood fraud represents a persistent phenomenon, originating in ancient times, prevailing in the present, and likely to continue in the future. It is characterized by the deliberate deception of consumers concerning the quality and/or composition of food products, typically conducted to secure an unfair economic advantage for food sellers.A 2016 study on food fraud in Canada revealed that more than 75% of participants reported they would be willing to pay 1–5% more for products certified as free from food fraud, while 24% perceived food fraud as a significant health risk (Statista, 2020). Economically motivated food adulteration and food fraud can pose a serious threat to food safety: the melamine scandal in milk led to the illness of more than 300,000 individuals (BBC, 2010). Similarly, the toxic oil syndrome caused by aniline-contaminated olive oil resulted in the deaths of approximately 300 people shortly after the onset of the outbreak and left many others with chronic illnesses.</p
Associations Between the Difference in subjective Objective Walking Distance and Disease severity and Fatigue in Multiple sclerosis
No full textÇelik, Yasemin (2025). Tarihsel Metinlerde Eklerin İmlası Üzerine: 1818 ve 1830 Tarihli Cönk Metinleri Örnekleminde
No full textParenting in the Neonatal Intensive Care Unit: A Qualitative Study
No full textBackgroundThis qualitative study is aimed at describing parental feelings, their readiness during discharge, and their needs while their infant is in the neonatal intensive care unit.MethodsThe study was conducted with the parents of infants being monitored in a neonatal intensive care unit. A total of 30 in-depth interviews were conducted with 15 parents. This qualitative study was carried out using the Gadamerian-based research method. After parents were informed about the study, written and verbal consent was obtained from them.ResultsThe content analysis of the interview data resulted in six themes: 'sense of trust and cocoon effect, anxiety and conflicting emotions, parent-infant bonding and breastfeeding, fear of providing care, readiness/unreadiness and support needs and recommendations'.ConclusionParents often feel anxious and fearful about harming their vulnerable infants, with added stress surrounding their ability to provide care and the discharge process
Pharmacokinetics of Carprofen Administered Intravenously at Different Doses in Goats
No full textThis investigation focuses on understanding the pharmacokinetic behavior of intravenously administered carprofen at doses of 0.7, 1.4, and 4 mg/kg in goats. Eighteen animals were randomly assigned into three groups, with six goats per group, and blood samples were collected at 22 time points post-administration. Plasma concentrations were analyzed using a validated HPLC-UV method, and key pharmacokinetic parameters were derived using non-compartmental analysis. Results show that, at 0.7 mg/kg, carprofen exhibited the total clearance (ClT) of 2.19 mL/h/kg, volume of distribution at steady state (Vdss) of 126.56 mL/kg, area under the curve (AUC0-last) of 321.00 h*mu g/mL, and elimination half-life (t1/2 lambda z) of 44.32 h. When comparing doses, an increase in ClT was observed at 4 mg/kg, and the volume of distribution increased at both 1.4 and 4 mg/kg dosages. Additionally, a reduction in dose-normalized AUC0-last was evident at the highest dose. Data showed that the effect of the drug may be prolonged as the dose increases. These differences between dose groups may be clinically insignificant after the single administration of all doses. Carprofen can be used at all three dose levels in goats; however, vigilance regarding the potential side effects and drug residues is essential, especially during repeated treatments
Makarnalık buğday çeşitlerinde farklı dönemlerde uygulanan üst gübre formlarının verim ve bazı verim öğelerine etkisi
No full textBu araştırma, 2019-2021 yılları arasında GAP Uluslararası Tarımsal Araştırma ve Eğitim Merkezi Müdürlüğü (GAPUATEM) deneme alanlarında bazı makarnalık buğday çeşitlerinin üst gübrelenmesinde kullanılan azotlu gübre formları ile uygulama zamanlarının verim ve bazı verim parametreleri üzerine etkisinin belirlenmesi amacı ile yürütülmüştür. Çalışma, Burgos, Eyyubi ve Hasanbey makarnalık buğday çeşitlerinde üç azotlu gübre formu (üre (%46 N), amonyum sülfat (%21 N) ve kalsiyum amonyum nitrat (%26 N)) kullanılarak altı farklı uygulama zamanının etkisi tesadüf bloklarında bölünen bölünmüş parseller deneme desenine göre üç tekrarlamalı olarak yürütülmüştür. Çalışma sonucunda; buğday çeşitlerinin tane verimine etkisi denemenin birinci yılında önemli, ikinci yılında ise önemsiz bulunmuştur. Gübre çeşitlerinin her iki üretim sezonunda incelenen özelliklere etkisi önemsiz olmasına rağmen tane verimi açısından üre gübresinin diğer gübre formlarına göre etkisinin daha iyi olduğu belirlenmiştir. Sonuç olarak, tane verimi açısından iklimsel şartlar dikkate alındığında Ocak-Mart ayları arasında yağışın yeterli olduğu durumlarda dördüncü uygulama zamanında yavaş salınımlı gübreler (Üre %46) kullanılması, aynı dönemler için yağış miktarının yetersiz olduğu durumlarda ise üçüncü uygulama zamanında hızlı etkili gübrelerin (amonyum nitrat) tercih edilmesi önerilebilir.This research was conducted to determine the effects of nitrogen fertilizer forms and application times used in the top dressing of some durum wheat varieties on yield and some yield parameters in GAP International Agricultural Research and Training Center Directorate (GAPUATEM) test fields between 2019-2021. In the study, the effect of six different application times using three nitrogen fertilizer forms (Urea (U 46% N), ammonium sulfate (AS 21% N) and calcium ammonium nitrate (CAN 26% N)) in Burgos, Eyyubi and Hasanbey durum wheat cultivars were treated according to the split-split plots in randomized complete block design. As a result of the study; the effect of wheat varieties on grain yield was found to be important in the first year of the experiment and insignificant in the second year. Although the effect of fertilizer varieties on the characteristics examined in both production seasons is insignificant, it has been observed that the effect of urea fertilizer is better than other fertilizer forms in terms of grain yield. As a result, when considering the climate conditions, in cases where precipitation is sufficient between January and March at the fourth application period, it can be recommended to use slow-release fertilizers (Urea 46%). If the amount of precipitation is insufficient in the same periods, it can be recommended to prefer fast-acting fertilizers (ammonium nitrate) at the third application time
