Ho Chi Minh City Open University Journal of Science
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Identification of Seed and Soil-Borne Fungal Disease Agents in Okra Plants (Abelmoschus esculentus L.) and Characterization of Biological Control Possibilities with Antagonist Bacterial Isolates
No full textUnlocking nature’s potential: anticancer potential of Helichrysum sanguineum (L.) Kostel on breast cancer cells and its chemical composition
No full textHelichrysum sanguineum (L.) Kostel (H. sanguineum), a member of the Asteraceae family, has been traditionally employed for various medicinal purposes owing to its rich phytochemical composition. This study investigates the anticancer properties of various extracts of H. sanguineum (ethanol, acetonitrile, hexane, and chloroform) against breast cancer cells, shedding light on its chemical constituents and their potential therapeutic effects. In vitro assays demonstrate the profound inhibitory effects of H. sanguineum extract on human fibroblast and breast cancer cells. Furthermore, we elucidate the underlying mechanisms of action, revealing its ability to induce apoptosis and cell cycle arrest in breast cancer cells. The cytotoxicity and apoptosis outcomes in breast cancer cells varied across different extracts, yet no adverse effects were observed on healthy cells at equivalent concentrations. Furthermore, all extracts initially promoted breast cancer cell proliferation, with the chloroform extract notably reducing cancer cell proliferation even at low concentrations. GC-MS analysis identifies the major chemical constituents of the extract, including flavonoids, terpenoids, and phenolic compounds, which likely contribute to its anticancer activity. Our findings highlight the potential of H. sanguineum extract as a natural agent for breast cancer treatment and the need for further exploration of its mechanisms and clinical applications
AKUT GASTROENTERİTLİ ÇOCUKLARDA HASTANEYE YATIŞKARARINDA NÖTROFİL-LENFOSİT ORANININ ETKİNLİĞİ
No full textInvestigation of Awareness of Proton Pump Inhibitor Therapy in Adults Using Proton Pump Inhibitors Admitted to Primary Care
No full textObjectives: Because proton pump inhibitors are effective and well tolerated, their use without an appropriate indication is increasing. This raises concerns about long-term side effects. Materials and Methods: This cross-sectional survey study was conducted among patients using proton pump inhibitors for any reason in 4 primary care centers in Hatay province. The study included 451 participants. The statistical significance level of the data obtained was interpreted with the “p” value. p<0.05 values were considered statistically significant. Results: In this study, 39.9% of patients were using proton pump inhibitors inappropriately. 38.4% of the patients had been using proton pump inhibitors for more than 2 years. There was also a significant association between use for more than 2 years and the occurrence of side effects (p=0.001). 75.4% of the patients stated that they were not informed about the side effects of the drug. In addition, in patient-physician communication, there was a significant correlation between the physician's mention of side effects and inappropriate use of proton pump inhibitors (p=0.009). Conclusion: Inappropriate proton pump inhibitors can be prevented by starting the appropriate dose of proton pump inhibitor in the patient with the necessary indication, informing the patient at the first prescription, creating a physician's plan about when to terminate proton pump inhibitors, and raising awareness of the patient about this issue
Prospective Turkish Language Teachers’ Perceptions of Summarization: Definitions, Rationales and Rules
No full textThe aim of this study was to determine prospective Turkish language teachers’ perceptions of the concept ofsummarization. The study group consisted of 139 teacher candidates enrolled in the 1st, 2nd, 3rd, and 4th grades ofthe Turkish Language Teaching department in the faculty of education of a state university in 2019. Aphenomenological design, a qualitative research pattern, was employed in the research. The data analysis wasconducted using the Nvivo 10 software. Research data was gathered through a standardized open-ended interviewform consisting of three questions. The research findings indicated that the students predominantly summarize basedon what they read (f=76), and hear (f=19), from books (f=12), and events (f=12). Regarding the definition ofsummarization, the students mostly defined it as “writing without changing the essence” (f=84), “shortening” (f=81),and “writing essential parts” (f=51). The identified rationales for summarization were primarily “providingopportunities for permanent learning” (f=65), “preventing waste of time” (f=48), and “remembering essential parts”(f=39). As for summarization rules, the students mostly paid attention “not to deviate from the main idea” (f=69),“to write essential parts” (f=64), and “to remove unessential parts” (f=57)</p
Effects of Different Treatment Modalities on Lung Injury in Experimental Pulmonary Contusion Model
No full textIntroduction: The study experimentally evaluated the efficacies of different agents in treating pulmonary contusion. Methods: In our study, 42 Wistar albino rats were divided into six groups of seven animals each. A model of lung contusion with blunt chest trauma was performed in five groups, except for the control group. One group with pulmonary contusion was considered an untreated group, and saline was administered. For other groups, prednisolone, tranexamic acid, N-acetylcysteine, and vitamin E were applied to determine their efficacy in treatment. The rats were sacrificed 24 h after trauma, and their injured lungs were collected for histopathological examination and blood samples for blood gas analysis. Histopathologically, bronchial damage, alveolar hemorrhage, emphysema, and leukocyte infiltration were assessed using the scoring system. Results: In our study, statistically significant differences were detected between the rat groups in terms of intraalveolar hemorrhage, leukocyte infiltration, and bronchial damage. In post hoc analysis, intraalveolar hemorrhage was significantly higher in the untreated group compared to the control group (P = 0.012). A near-significant difference was observed between the untreated group and the N-acetylcysteine group (P = 0.061). Regarding leukocyte infiltration, the tranexamic acid group showed significantly higher values compared to both the prednisolone and control groups (P = 0.007; P = 0.016, respectively). For bronchial damage, the levels observed in the vitamin E and tranexamic acid groups were significantly higher than those in the control group (P = 0.08 and P = 0.037, respectively). Conclusions: Many agents are used to treat pulmonary contusion, but no gold standard treatment exists. Prednisolone and N-acetylcysteine play significant roles in treatment. These two drugs contributed to the regression of the findings in pulmonary contusion treatment
