International Medical Publishing Group(IMPG), India
Not a member yet
181 research outputs found
Sort by
ASSESSMENT OF HEAVY METALS CONTENT AND THEIREFFECTS ON TOXICITY OF Acmella uliginosa Sw.
Get PDFThe use of medicinal plants has increased in recent decades due to their affordability and especially because of the assumption that natural remedies are safe. Some medicinal plants are used as leafy vegetable. In Bénin, Acmella uliginosa is one of these medicinal plants used as green leafy vegetable. Unfortunately, they are contaminated by environmental and industrial waste such as heavy metals. Thus, the aim of this study was to evaluate the heavy metals (As, Pb, Cd, Hg, Cu, Mn and Zn) contents of Acmella uliginosa, harvested in Cotonou (CAU) and Pobè (PAU) and to assess and compare the oral acute toxicity of the two samples. The heavy metals content was assessed by anodic and cathodic stripping voltam-metry method. The oral acute toxicity of aqueous extracts was evaluated following the guidelines N° 423 of the Organization of Cooperation for Economic Development. The phytochemical study was assessed by thin layer chromatography (TLC) method. The heavy metal analysis revealed the presence of arsenic, lead, mercury, copper, manganese, and zinc in Cotonou sample while only zinc, manganese and copper are present in sample collected in Pobè. The heavy metals concentrations range rom 0.028 ± 0.007 to 0.108 ± 0.052. Cadmium is absent in studied samples. At a dose of 2000mg/kg body weight, no adverse effects were recorded in Pobè sample in contrary to sample collected at Cotonou. The results showed that Acmella uliginosa harvested in Pobé (PAU) does not contained toxic heavy metals while sample from Cotonou (CAU) contained various heavy metals. Aqueous extract of PAU has no toxicity effect in contrary to Cotonou sample. The toxicity of A. ulignosa collected in Cotonou could be due the presence of heavy metals
5a-dihydrotestosterone (DHT) inhibits Tumor Necrosis Factor - alpha (TNF-a) inducedJanus Kinase-1 (JNK-1) activation and apoptosis in breast cancer in p21 dependent manner
Get PDFBeside established primary reproductive functions, the male hormone androgen act as a growth andsurvival factor for most of its target tissues. Though male androgenic hormones are widely studied,still some aspects of underlying mechanisms are not completely clear. In addition to their influenceon female reproductive hormones which are considered to be crucial factor in breast carcinogenesis,several reports shows that male androgenic hormones may have direct influences on breast cancertissues. Here, we have used dihydrosterone as model of male androgen to understand its impact onsome major molecular circuitry and their by in the process of breast carcinogenesis. We observedthat DHT convincingly inhibits tumor necrosis factor-alpha (TNF-α) induced Janus Kinase-1 (JNK-1) activation and apoptosis in breast cancer cells, MCF-7 in p21 dependent manner. Inhibition byandrogen requires the transcription activity of androgen receptor (AR) and de novo protein synthesis.AndrogenAR induces expression of p21 that in turn inhibits tumor necrosis factor-α induced JNKactivation and apoptosis. Our results reveal a novel cross-talk between AR and JNK in breast cancer(MCF-7) cells, thereby providing a molecular mechanism underlying the survival function ofandrogen on its target tissues or organ
EFFECT OF SALINITY ON SOME MORPHOPHYSIOLOGICAL CHARACTERS OF SOMATIC EMBRYOGENESIS-REGENERATED PLANTS OF PINEAPPLE [Ananas comosus (L.) MERR. CV. SMOOTH CAYENNE]
Get PDFPineapple in Côte d'Ivoire is going through problems of various origins. Reviving this state imperatively requires both to clean up the plant material and to select varieties which easily adapt to the current pedoclimatic conditions of growing areas. This work assesses the impact of salinity on regenerated pineapple plants by somatic embryogenesis. The tests were carried out in polyethylene bags filled with sea sand, under semi-controlled conditions. Regenerated pineapple plants were watered with six saline solutions (2, 4, 6, 8, 10 and 14 g/L). Control plants were watered with water. The results revealed that salt stress reduces the studied morphophysiological parameters (number of leaves and roots, length of leaves and roots, chlorophyll a, chlorophyll b and total chlorophyll content, the carotenoids content and the relative water content). Pineapple tolerates low salt levels (2 and 4 g/L). However, important disturbances were observed in the metabolism of stressed plants with high levels of NaCl (6 and 10 g/L). As an adaptation strategy to maintain its metabolism from this stress, pineapple responded by accumulating proline. The highest saline content (14 g/L) was found to be lethal for pineapple plants
HISTOPATHOLOGICAL STUDY OF TUMOURS OF CERVIX
Get PDFCarcinoma of cervix is the most common cancer in Indian women and accounts for 20% of all malignant tumours in the females. Squamous cell carcinomas (SCC) account for 75-80%, adenocarcinoma 15-25%, and adenosquamous carcinomas 3-5% of cervical cancers. Objectives: To study histopathology of carcinoma of cervix and to find out the incidence rate, most common type of the carcinoma of cervix and to find out age predilection in various types of carcinoma of cervix. Material and Method: This study was undertaken in the department of pathology over a period of 2 years from May 2010 to April 2012. All Hysterectomy specimens and cervical biopsies were rocessed routinely and paraffin sections were taken and stained with Haematoxylin and Eosin (H&E) for microscopic examination. Tumours of the cervix were classified and studied according to WHO classification. Results: The most frequent condition diagnosed on cervical biopsies and hysterectomy specimens were benign cervical polyp (66.3%), followed by carcinoma (23.7%) and squamous intraepithelial lesion (0.2%). Out of all benign cervical polyps, occurrence of adenomatous polyp was highest. Incidence of squamous cell carcinoma (19.6%) was more as compared to adenocarcinoma (3.7%). The mean age of the squamous cell carcinoma, adenocarcinoma, squamous intraepithelial lesion and benign cervical polyp was 49.1 years, 43.5 years, 47.7 years and 44.6 years respectively. Conclusion: Incidence of squamous cell carcinoma was more as compared to adenocarcinoma. Occurrence of malignant lesions was earlier during 4 th decade as compared to benign cervical lesion
A HUGE MUCINOUS OVARIAN CYST DISCOVERED IN A 70-YEAR-OLD PATIENT
Get PDFThe most common ovarian tumors are stromal-epithelial tumors. Mucinous cyst is a benign tumor of the ovary containing a mucoid fluid they are often seen in women aged 20 to 50, with an average age of 42 years. We report the case of a 70-year-old patient with a huge mucinous cyst. Mucinous cysts sit in the ovary in about half of the cases, the volume of mucinous cysts is variable,. Of the mucinous tumors of the ovary: 85% are benign, 5% are borderline tumors of good prognosis, 10% are malignant tumors. The etiology of mucinous cysts is unknown, but it has occasionally been described that these cysts may be associated with other ovarian tumors. The management of benign mucinous cysts of the ovary is total cystectomy or oophorectomy (depending on the context) that are curative for mucinous cysts of the ovary. Most epithelial tumors of the cystic ovary have a benign and malignant side, but also a malignant or borderline border that is difficult to manag
PHENOTYPE FREQUENCIES OF RH AND KELL BLOOD GROUPSYSTEMS IN BLOOD TRANSFUSION DEPARTMENT OFAVICENNA MILITARY HOSPITAL, MARRAKECH, MOROCCO
Get PDFThe purpose of our study is presenting new national statistics of phenotypic prevalence Rhesus systems (Rh) and Kell usinga new sample of blood donors
A STATISTICAL STUDY ON FACTORS INFLUENCING ARTHRITISAMONG WORKING WOMEN
Get PDFThe purpose of the present study is to explore the factors that influence arthritis among working women. A sample of 200working women whose age more than 20 years is taken for the study. The data is collected through questionnaire methodusing 5-point Likert scale. The objective of this paper is also to find the most prominent type of arthritis for different agegroups, awareness, cause and medication for arthritis among working women. Exploratory Factor analysis is performedand five important factors that influence arthritis is extracted. The five factors are named as Personal stress, calciumdeficiency, obese, hereditary and age
HYPERTENSION AMONG WOMEN IN TIRAIRA MADANI, RURALSUDAN: PREVALENCE AND RISK FACTORS, 2014
Get PDFBackgroundHypertension is a major risk factor for strokes, cardiovascular and kidney diseases worldwide and it has considerablevariation in its prevalence across different geographic locations and ethnic groups.ObjectivesThis study aimed to estimate the prevalence of hypertension and to determine its major risk factors among women.MethodsA Descriptive cross-sectional community based study was conducted in Tirira Madani village –Sennar state- Sudan. A totalof 255 women aged (15 – 75) years were interviewed using a structured questionnaire. Blood pressure was measured twice.Hypertension was taken as blood pressure ≥ 140 mmHg and/or ≥ 90 mmHg for systole and diastole respectively.Descriptive cross-tabulations and bivariate analyses were used. The statistical significance was tested using chi-square test.Predictor factors to hypertension were tested by logistic regression.ResultsPrevalence of hypertension among participants was 25.9%. Factors found to be associated with hypertension were; age,illiteracy, low salt intake, family history of hypertension, Coffee intake of more than two cups daily, fish consumption, lowphysical activity, and high socio-economic status. Certain ethnic groups were at increased risk compared to others(RR=2.11, 95%CI: 1.265 – 4.588). Logistic regression model showed age, ethnicity, physical activity level, education leveland family history were predictors of hypertension (P-value <0.05).ConclusionHypertension was prevalent in rural Sudan. Age, ethnicity, socio-economic status, level of education and family history ofhypertension were the major risk factors of hypertension
Cognitive dysfunction in hypertension
Get PDFThe objectives of the study is; cognitive dysfunctions between the essential hypertensive. 50 hypertensives were taken for the study, assessed and analyzed. The samples were matched for age, sex, education and socio-economic status. The tools used were socio-demographic data and clinical proforma, SMMSE (Standardized Mini Mental Status Examination) scale and BCRS (Brief Cognitive Rating Scale). They’re very significant cognitive deficits measured by SMMSE on orientation and constructional ability and in BCRS it was in orientation only. The overall cognitive decline on both SMMSE and BCRS scores were very highly significant, thus signifying a global cognitive decline
Surgical management of Fracture Humerus
Get PDFFracture shaft of the humerus is a major injury commonly resulting from Road Traffic Accident. It is associated with multiple fractures because of high velocity trauma of R T A. Although the close reduction is ideal, the O.R. + I.F. with plating is treatment of choice in certain indications. The DCP plating has an advantage over the ASIF type of plates in securing rigid fixation and early mobilisation with out any external splintage. Full attention to the training and familiarity with the proposed procedure will yield good operative results. Poor technique of fixation often results in poor results. The complication of infection can be prevented with aseptic precautions, pre-op preparation, pre-per and post-op antibiotics and above all meticulous dissection and minimum soft tissue damage. Early mobility of the limb is responsible for excellent results and is good for fracture and joints and for the patient. Early return to the jobs thus saves the patients from economic setbacks is possible by stable fixation which result in early healing. Exploration of radial nerve in cases with radial N. palsy, for relieving compression and neurolysis has certainly helped in early recovery. One of the aim in the management of patient with multiple injuries is to achieve an upright position with painfree extremities. The early plating of humeral shaft fracture help to attain this goal and prevents "Fracture disease" by allowing early mobilisatio