International Medical Publishing Group(IMPG), India
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Cancer Systems Biology & Epidemiology: Application in Target Identification,Combinatorial Drug Therapy & Personalized Medicine
No full textCancer-signalling networks are typically complex which involves gene regulation,signalling, cell metabolism, and the alterations in its dynamics caused by the severaldifferent types of mutations leading to malignancy. Computational model of networks makepossible to understand the complex behaviour of cancer-signalling network. Correlationbetween complexity (clustering coefficient) of cancer-signalling network pathway andCancer Epidemiological data sets (cancer incidence, death rate and lifetime risk of cancer)has been validated. Results of study support the initial assumption, that the complexity ofnetwork matrices is a direct indicator of cancer threat. Understanding the differentialbehaviour of regulatory networks during health, disease and in response to drugs play acrucial role to enhance drug development efforts, new target identification, delineation ofoff-target effects, methods of disease prediction, combinatorial drug regimens and also indevelopment of molecularly targeted personalized treatment
Anti-inflammatory Plants: An Elementary Review
Get PDFThe inflammatory action is described as a chain of events that arise in response to noxious stimuli,infection or trauma. Various botanical species and plant parts comprise a diverse array of polyphenolicnon-steroidal phytochemicals that are incorporated as floral pigments for the attraction of insects astheir pollination. Various autoimmune disorders are defined by distinct inflammation and associatedfailure of the repair process. Pro-inflammatory molecules like TNF, certain interleukins,prostaglandins and even pathogenic concentration of nitric oxide are instrumental in raising suchresponse. More interestingly, nitric oxide has been shown to have the ability to stimulate COX-2showing a potential synergism. Bryophyllum pinnatum commonly known in some parts of Africa as“good luck” or “resurrection plant”, often used as an herbal remedy for human disorders, including:hypertension, diabetes mellitus, rheumatism, joint pains, insect bites, arthritis, bruises, wounds, boils,abscesses, headaches, and body pains. The leaves are also used for inguinal lymphadenitis and eardiseases. Rue contains different active compounds, out of them rutin, a flavonoid, is known to havenitric oxide scavenging activity
Biofilm formation and effect of disinfectant onthe isolates obtained from aquatic ecosystem
Get PDFAeromonas spp. are common aquatic micro-organisms that occur in seawater, irrigation water, river water, brackish water, fresh water, ground water, spring water, industrial and domestic waste water. Aeromonas spp. is associated gastrointestinal diseases, mainly diarrhea, septicemia, wound infections and diseases of amphibians, reptiles, frog, fish etc. Every month water samples were collected from well (village pal), river (Tapti river), tap(Surat Municipal Cooperation), mineral (Aquafina), sea (brackish) and swimming pool (chlorinated) of Surat city during year 2009 to 2010 and analyzed microbiologically. Isolates like Aeromonas hydrophila, Aeromonassalmonicida, Aeromonas salmonicida sub spp. smithia, Aeromonas salmonicida sub spp. masoucida, Aeromonas schubertii, Aeromonas veronii, Aeromonas media and Aeromonas caviae were obtained from the water samples and were further tested for their Biofilm formation and effect of disinfectant was checked on the produced Biofilm. As Aeromonas species are one of the Biofilm producing organism, the Biofilm production test was carried out by using polycarbonated plastic/PVC and Glass coupons deeped in three different containers like copper, steel and clay. Weight of the polycarbonated plastic coupons and glass coupons were noted and at the interval of 15 days and 30 days, increase in weight of the plates and coupons showed Biofilm formation. In water distribution system these organisms produce the Biofilm and so to remove it disinfectant treatment is used. Disinfectant treatment using (chlorine tablets) containing sodium dichloro isocyanurate, having 10 ppm of chlorine commercially available to disinfect drinking water. Serial plate count was done using M-Aeromonas selective media to get specific number of Aeromonas species. The hanging glass coupons were removed at timeinterval of 30min, 60min, 90min (with treatment of disinfection) and 0 min (without disinfection). The coupons were stain by using fluorescent dye Acridine orange to get number of viable and non viable cells forming Biofilm. We can also conclude that the Biofilm produced by them in a water distribution system i.e. pipe lines or domestic vessels can be controlled easily by disinfectants within an hour
AVULSION FRACTURE OF THE CALCANEAL TUBEROSITY: REPORT OF TWO CASES WITH LITERATURE REVIEW
Get PDFAvulsion fractures of the calcaneal tuberosity remains rare; they usually caused by forced ankle dorsiflexion; direct trauma occur infrequently; it must be treated immediately; to avoid the skin necrosis of the posterior heel; the treatment approach is of interest in this rare injury and the operative management is based on a review of the literature. ;Non operative treatment is classically associated with bad results. Hence the surgical intervention is generally the treatment of choice. The authors report two cases of unusual avulsion fractures of the calcaneal tuberosity treated by open reduction and internal fixation with a good functional result
ROLE OF THE LABORATORY IN THE DIAGNOSIS OF PLASMA CELLLEUKEMIA, ABOUT ANOBSERVATION
No full textThe plasma cell leukemia (PCL) is an extremely uncommon malignant blood disorder with a pejorative prognosis. It isdefined by the presence of at least 20% of plasma cells in the peripheral blood or an absolute number of circulating plasmacells greater than 2 G /L. It appears under two variants: secondary PCL that complicates known multiple myeloma andprimitive PCL that is immediately leukemic. We report the case of a 56 years old male patient who presented 2 monthsbefore his hospitalization diffuse bone pains with asthenia. The CBC revealed an anemia and a leukocytosis. The bloodsmear objectified 3 G/L circulating plasma cells. The bone marrow exam noted a rich cellularity and a marrow invaded upto 60% by dystrophic plasma cells. The clinical presentation of the plasma cell leukemia, its cytological smearcharacteristics, immunophenotypical, pathophysiological, therapeutic approach and outcome will be reminded in thisarticle
TONGUE IS AN UNUSUAL SITE OF ABSCESS DEVELOPMENT- AN EXPERIENCE OF TWO CASES
Get PDFTongue abscess is a rare entity, despite exposure to large number of potential pathogen, relatively resistant to infection. Here in this article we were discussed the two cases of tongue abscess in a young females, with their clinical presentation, differential diagnoses, management and a review of literature
TREATMENT OF CLOSED TIBIAL PILON FRACTURES WITHOPEN REDUCTION, INTERNAL FIXATION AND BONE GRAFTING.A STUDY OF 22 CASES COMPARING THE OBJECTIVE ANDSUBJECTIVE EVALUATION
No full textThe cases of twenty two fractures of the ankle joint that involved the tibial plafond were reviewed. The fractures wereclassified in to five types according to the severity of the injury. Open reduction and internal fixation was performed usingone third tubular plate for fibula and recon plate for the tibia. Bone grafting was done to augment the fixation and maintainthe reduction.For each fracture treated Objective and Subjective evaluation is done. The objective and subjective scores are compared.With this method we noticed that the Type III & IV fractures also had a good or excellent resul
Estimation of Age by Eruption of Permanent Canine Tooth in Male Subjects ofSouth Karnataka, Population
Get PDFEstimation of age from eruption of permanent canine tooth is an important parameter in Anthropology, Medicolegal cases, Judicians and Biology. The present study consists of 150 male subjects among the various schools of Davangere in South Karnataka. The age groups were 08-12 years. The aim of the study is to estimate the range of age from recent eruption of permanent canine tooth by their traits in right and left upper and lower quadrants and to compare the observation of various research studies who studied the eruption of permanent canine tooth in the past. Statistical analysis like range of age, mean and standard deviation were calculated. The present study revealed that the permanent canine tooth in the lower jaw eruption earlier than the upper jaw which was not highly significant (p value-0.62) in all the age groups between 08-12 years of age and erupted permanent canine tooth in the age group of 11 years was significant. No significant asymmetry in permanent teeth emergence time has been found between right and left sides of either jaw and it was found to erupt from eleventh to twelfth year of age
Diagnosis of Breast Cancer Using Neural Network Approach
Get PDFBackground: Breast cancer is one of the fatal disorders causing death in people and second most common reason of mortality (death rate) in women. Early detection of cancer, which usually results in reducing the extent of damage, less extensive treatment and better outcomes. In this paper, we present an artificial neural network inspired from biological neural network which is used for pattern classification of benign and malignant cells Methods: A feed forward neural network model with back propagation learning algorithm for training the neural network using breast cancer database is simulated with all the variable network constraints to make it efficient, robust and fault tolerated pattern classifier. Results: The viability of this approach is demonstrated for classification with predictive success of 96.34% with 99.41% sensitivity to malignancy. Hence, it will probably enhance the decision on classifying the malignant cells. Conclusions: Despite the fact, not all general hospitals have the mammogram facilities the neural network prediction model can increase the rate of diagnosis for breast cancer. This scheme can be used as an auxiliary tool to differentiate between benign and malignant breast cancers
Role of Cyanobacteria In Biodeteriorationof Historical Monuments -A Review
Get PDFThe presence and deteriorating action of microorganisms on monuments and stone works of art have received considerable attention in the last few years. Knowledge of the microbial populations living on stone materials isthe starting point for successful conservation treatment and control. This review describes some biodegradation processes originating from activity of microorganisms in black microbial crusts growing on historic monuments. The crusts are mainly composed of gypsum, carbonaceous particles and polycyclic aromatic carbons. They are slowly dissolving gypsum from black crusts represent a continuous source of sulphur for microbial growth. The sulphate bonding capacity of the sheath of cyanobacteria causes a particularly high demand for sulphate, thusmaking sulphur nutrition a relevant aspect in their physiology. Growing concern for the preservation of cultural heritage has led to a greater interest in the biological attack on these monuments. The importance ofcyanobacteria as deteriogens is emphasized and the traditional and more modern molecular methods used to detect microorganisms are discussed