Texas Journal of Medical Science
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Antibodies To Insulin In Children With Diabetes Mellitus
Get PDFThe levels of antibodies to insulin analysed in 58 children with diabetes mellitus with the help of enzyme immunoassay were found to be increasing with the disease duration and insulin dependence in the patients. The concentration of antibodies was found correlating with the frequency of viral infections in the anamnestic data of the children, and with the presence of microangiopathic, lipodystrophic and immunopathologic condition
Clinical-Pharmacological Approach To Rational Use Of Antimicrobial Drugs In Children
No full textThe article discusses the clinical and pharmacological rationale for the rational use of antibacterial drugs in the treatment of infectious diseases in pediatric patients. It emphasizes the importance of individualized antibiotic therapy based on the principles of evidence-based medicine, taking into account the age-related pharmacokinetics and pharmacodynamics in children. The study highlights current challenges such as increasing antibiotic resistance, inappropriate prescribing, and lack of pediatric-specific clinical guideline
Complex Treatment Of Purulent Wounds In Experimental Rats: New Promising Approaches
No full textStudy of the effect of the new drug Reomannisol on endogenous intoxication and wound healing, taking morphological aspects into the complex treatment of experimental diabetic foot syndrom
NGAL As A Biomarker For Early Detection Of Renal Allograft Dysfunction In Living Donor Transplantation
No full textThis open-label, randomized, retrospective, comparative study investigated the prognostic value of urinary NGAL (neutrophil gelatinase-associated lipocalin) levels in predicting renal allograft dysfunction in 18 patients who underwent living related donor kidney transplantation at the Samarkand Regional Multidisciplinary Medical Center between January and September 2024. Participants were followed up for three months after transplantation. Renal graft dysfunction (DGF) was defined based on the criteria of Halloran et al. Dynamic measurements of NGAL, serum creatinine, and urea during the first week of the postoperative period showed a significant decrease in these parameters in 17 of 18 patients. Graft dysfunction was observed in one case, which was accompanied by abnormalities. The data obtained confirm that NGAL is a useful biomarker for the early diagnosis and monitoring of renal graft function. This method may improve the prediction of complications and optimize the clinical management of patients after kidney transplantation
Preventing Diseases And Treating Stomach And Duodenal Ulcers Using “Anti-Ulcer” Medication That Contains A Biologically Active Substance Against Ulcers
No full textThe article discusses about how effect Anti ulcer for stomach and duodenal ulcer and the distribution areas of the plants hypericum, plantago , as well as the unsurpassed role of leaves in promoting human health, the chemical composition and biological significance of vitamins hypericum, plantago, as well as several recommendations for the treatment of stomach and duodenal ulcerin modern medicine and medicine. traditional medicine based on the compound leaves hypericum, plantago, as well as data on the mechanism of action on the stomach and duodenal wall and their discussion
Monoclonal Antibody in Treatment of Severe Allergic Asthma: A Meta-Analysis on The Effectiveness of Omalizumab
No full textAsthma is a chronic obstructive pulmonary disease that has persistent symptoms with intermittent periods of exacerbation, representing the reduction in health status. Chronic obstructive pulmonary disease has become fourth leading cause of death in 2021, responsible for approximately 5% of total deaths[1,2,3,4]]. Frequent, recurring periods of exacerbation may reach significant severity, and advanced therapy may become necessary, including the prescription of omalizumab, the anti-IgE monoclonal antibody. This meta-analysis aims to determine and systematically review the effect of omalizumab compared with the placebo in the control of severe asthm
Prevention Of Growth And Development Retardation In Infants Born With Intrauterine Growth Restriction During The First Year Of Life
No full textThis article examines the strategies and methods for preventing growth and development retardation in infants born with intrauterine growth restriction (IUGR) during their first year of life. IUGR is a significant perinatal complication that affects a child’s physical and cognitive development, potentially leading to long-term health consequences. The research highlights the importance of early identification, monitoring, and intervention to mitigate the negative effects of restricted intrauterine growth
Dietary Control Of Early-Stage Chronic Kidney Disease
No full textEarly-stage chronic kidney disease (CKD) represents a critical opportunity for intervention aimed at delaying disease progression and reducing long-term complications. Although pharmacological treatment remains essential, increasing evidence indicates that dietary management plays a central role in modulating the pathophysiological mechanisms underlying renal decline. This study reviews and analyzes current evidence on the effects of targeted dietary interventions — including moderate protein restriction, sodium reduction, phosphorus control, and plant-forward dietary patterns — on renal outcomes in patients with CKD stages 1–3. The findings suggest that individualized nutritional strategies can slow the decline in glomerular filtration rate, reduce proteinuria, improve metabolic and inflammatory profiles, and enhance cardiovascular risk management. Integrating dietary therapy into early CKD care may therefore offer a safe, cost-effective, and sustainable approach to improving patient outcome
Cardiomyopathy
Get PDFCardiomyopathy is a group of diseases characterized by primary or secondary damage to the heart muscle, leading to impaired mechanical or electrical functions of the heart. This disease occurs in different forms: dilated, hypertrophic, restrictive, and arrhythmogenic right ventricular dysplasia. Cardiomyopathy can be accompanied by heart failure, arrhythmias and thromboembolic complications. The etiology of the disease may be related to genetic, infectious, toxic, autoimmune or metabolic factors. Clinical symptoms include shortness of breath, fatigue, palpitations, and edema. Treatment options include medications (ACE-inhibitors, beta-blockers, diuretics), invasive procedures (ICD, CRT, heart transplant), and lifestyle changes. Prevention includes heart health care, risk factor management, and regular checkups. Early detection and treatment of cardiomyopathy is important in improving the patient's quality of life and reducing complication
Clinical Pharmacological Approach To Rational Drug Treatment Of Chronic Heart Failure
Get PDFThe clinical pharmacological approach to the rational drug treatment of chronic heart failure (CHF) focuses on optimizing therapeutic strategies to improve patient outcomes. This article examines the pharmacological classes of drugs used in CHF management, including angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, diuretics, aldosterone antagonists, and novel agents. The mechanisms of action, indications, contraindications, and potential adverse effects of these drugs are analyzed. Special emphasis is placed on the importance of individualized treatment, drug interactions, and evidence-based guidelines. Advances in pharmacotherapy and personalized medicine approaches for enhancing the efficacy and safety of CHF treatment are also discussed