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Rekreatif ve lisanslı sporcuların bilinçli farkındalık düzeylerinin bayesçi yaklaşımla incelenmesi
No full textBu çalışma, rekreatif ve lisanslı olarak spor yapan bireylerin bilinçli farkındalık düzeylerini Bayesçi istatistiksel yaklaşım ile karşılaştırma amacıyla yürütülmüştür. Çalışma grubunu Sivas Cumhuriyet Üniversitesi Spor Bilimleri Fakültesinde öğrenim gören 157 öğrenci-sporcu (65 kadın, %41.40; 92 erkek %56.60; yaş ortalaması = 21.93 ± 3.82) oluşturmuştur. Katılımcıların 67’si (%42.67) rekreatif, 90’ı (%57.33) lisanslı sporcular olup, ortalama spor yaşları 6.96 ± 4.49 yıldır. Veri toplama aracı olarak kişisel ve spor bilgi formu, sporda bilinçli farkındalık ölçeği kullanılmıştır. Verilerin analizi R (4.5.1) programı ile gerçekleştirilmiştir. Spor düzeyine (rekreatif/lisanslı) göre farkındalık (BF10 = 0.33), yargılamama (BF10 = 0.34) ve yeniden odaklanma (BF10 = 0.25) boyutlarında, rekreatif ve lisanslı sporcu grupları arasında fark olmadığı yönündeki sıfır hipotezini orta düzeyde destekleyen bulgulara ulaşılmıştır. Cinsiyet değişkenine göre, farkındalık boyutu için (BF10= 1.29) kadınlar lehine fark olduğu yönündeki alternatif hipotezi destekleyen zayıf kanıt elde edilmiştir. Yargılamama (BF10 = 0.22) ve yeniden odaklanma (BF10 = 0.21) boyutlarında ise, kadın ve erkek grupları arasında fark olmadığı yönündeki sıfır hipotezini orta düzeyde destekleyen bulgular elde edilmiştir. Sonuçlar, bilinçli farkındalık düzeyinin kadın ve erkeklerde veya rekreatif ve lisanslı sporcu gruplarına bağlı olarak değişmediğini göstermektedir.</p
Novel alpha-functionalized nickel(ii) phthalocyanines: photochemical, antioxidant, antibacterial, cytotoxicity studies and theoretical insights
No full textIn this study, novel nickel(ii) phthalocyanines (1a–4a) with functional groups containing different atoms such as fluorine, sulfur, and oxygen connected through oxygen bridges from their non-peripheral positions were synthesized and characterized. Singlet oxygen generation, antioxidant and antibacterial activities, and cytotoxicity of the phthalocyanines (1a–4a) were evaluated. The synthesized phthalocyanines (1a–4a) exhibited solvent-dependent singlet oxygen generation, demonstrating their potential as photosensitizers and providing useful insights into their photochemical behavior. Moderate antioxidant activity was found when compared to the previous studies. The synthesized phthalocyanines (1a–4a) showed antibacterial activity against S. aureus. Molecule (2a) showed the highest antibacterial activity with a 12 mm inhibition zone. The phthalocyanines (1a–4a) did not exhibit cytotoxic activity in the MTT assay against HEK 293 cells. In conclusion, Gaussian calculations were used to investigate the synthesis of target nickel(ii) phthalocyanines (1a–4a). These computations were performed at the B3LYP, HF, and M062X levels, and the basis set utilized was 6-31++G(d,p). Proteins such as zinc superoxide dismutase protein (PDB ID: 1CB4), human peroxiredoxin 5 protein (PDB ID: 1H2D), and FabH inhibitor protein (PDB ID: 4Z8D) were among those that were subjected to molecular docking calculations
The impact of TMPRSS11A rs353163 and rs977728 polymorphisms on COVID-19 severity: genotypic and clinical associations
No full textObjective: COVID-19, caused by SARS-CoV-2, represents a significant global health challenge, with genetic factors influencing the severity of the disease. Transmembrane Serine Protease 11 A (TMPRSS11A) is a serine protease, and the relationship between the rs353163 and rs977728 polymorphisms in its coding region and COVID-19 severity has not been fully elucidated. In this context, we aimed to investigate the association between the TMPRSS11A rs353163 and rs977728 polymorphisms and the severity of COVID-19. Methods: The study included 84 control participants, 80 patients with mild COVID-19 (MC-19), and 168 patients with severe COVID-19 (SC-19). Genotyping was conducted using the restriction fragment length polymorphism (RFLP) method. The genotype distributions, haplotype frequencies, and their relationships with clinical parameters were statistically analyzed. Results: This study investigated the impact of TMPRSS11A rs977728 C > T and rs353163 T > C polymorphisms on COVID-19 disease severity by examining their associations with genetic variations and clinical parameters. No homozygous mutant genotype was detected for the rs353163 T > C polymorphism. The heterozygous TC genotype was associated with a 3-fold increased risk of developing severe COVID-19 (OR = 3.300; p T polymorphism, the TT and CT genotypes were observed at significantly higher frequencies in the SC‑19 group, corresponding to 7.6-fold and 2.3-fold increased risks, respectively. Haplotype analysis revealed that the rs977728 wild-type C / rs353163 mutant C* haplotype was strongly associated with SC‑19 disease severity. All genotype combinations carrying the mutant allele (rs977728 C > T / rs353163 T > C*) were associated with poor prognosis, as indicated by clinical parameters including CRP, D-dimer, ferritin, hs‑troponin, Neu, Neu%, Lym, Lym%, and Neu/Lym. ROC curve analysis identified CRP and D-dimer levels as sensitive markers for distinguishing the SC-19 group from other groups. Notably, the TT/TC* and CT/TC* genotype combinations were particularly associated with elevated CRP and D-dimer levels within the SC-19 group. Conclusion: Carriers of the mutant alleles of TMPRSS11A rs977728 and rs353163 are thought to increase the risk of severe COVID‑19, in association with systemic inflammation, hypercoagulability, and organ damage
Glycaemic control and complications in haemodialysis patients: The TURK-HEMODIAB Study
No full textBackground The most common cause of end-stage kidney disease is diabetes mellitus (DM). The most commonly used renal replacement therapy in Turkey and in many countries around the world is haemodialysis (HD). Glycaemia control is important in these populations. In this study we aimed to screen for glycaemic control and complications in a large population of diabetic HD patients in Turkey. Methods A total of 16 043 patients were screened in 253 dialysis centres in Turkey and 5038 diabetic HD patients were included in the study. At participating centres, patients' diabetes history, complications, medications, haemoglobin A1c (HbA1c) and other laboratory data were reviewed and recorded by nephrologists. Results The average age of the patients was 64.0 ± 11.2 years and 56% were male. The mean HbA1c was 7.4 ± 1.5%. Patients were divided into three groups according to the HbA1c level (8%). As the HbA1c levels increased, the mean systolic blood pressure and diastolic blood pressure increased significantly. In addition, as the HbA1c levels increased, the number of patients with coronary artery disease, patients undergoing coronary artery bypass graft surgery and the rate of patients with diabetic retinopathy and vision loss increased. Diabetic foot disease and amputation rates were also higher in the group with poor glycaemic control. The number of patients using intensive or mixed insulin was also higher in the group with high HbA1c levels. In ordinal logistic regression analysis, age significantly decreased and higher body mass index slightly increased the risk of a higher HbA1c. Also, the need for a diabetic diet was greater in those with high HbA1c levels. Conclusion Our study highlights that the target values for diabetic HD patients in Turkey are partially compatible with the 2022 Kidney Disease: Improving Global Outcomes guidelines for diabetes management. Nevertheless, more effort and teamwork are needed to improve patient outcomes
Femvertising Yaklaşımla Femtrafik Mücadelesi Üzerine Bir İnceleme
No full textAraştırmada trafikteki kadınların güçlü imajlarının ön plana çıkarılması hedeflenmiş, femvertising desen kullanılmıştır. Otomobil imgesindeki agresif-eril erkeksi imajlar eleştirilmiş, femvertising yaklaşımla güçlü ve feminen imajlar öne çıkarılmıştır. Teorik çerçeve postmodern feminist kurama dayanmakta; örnek grubunu Porshe Taycan otomobil reklam filmi ve kadın sürücüler oluşturmaktadır. Reklam filmi görsellik, üretilen dil, mekan bağlamlarıyla kesitsel olarak incelenmiş; ardından kadın sürücülerden yarı yapılandırılmış mülakatla veri toplanmıştır. Tematik analizin yapıldığı çalışmada Braun ve Clarke ile Coutés’ın teknikleri kullanılmıştır. Bulgularda trafikteki kadına yönelik toplumsal cinsiyet yargıları eleştirilmekte; kadınların erkeklerden daha iyi araç kullandığı görülmektedir. Kadınların gündelik yaşamlarında ve medyada trafikteki erkeklerle mücadele ettikleri söylenebilir. Erkek sürücüler trafikteki kadınlara kendilerini güvensiz hissettirmekte; kendi riskli davranışlarına meşru zemin oluşturmaktalardır. Trafiğin agresif hegemonik yapısı kadınlara güvenli otomobili tercih ettiren unsurlardandır. Otomobilin kadınlar için özgürlük kapsamlı feminist değeri vardır. Trafikte kadının güçlü temsili için femtrafik kavramı öne sürülmüştür. Trafikte kadına yönelik ayrımcılığa karşı toplumsal farkındalığın geliştirilmesi, akademik ve kurumsal çalışmaların artırılması femtrafik hareket için önemlidir.</p
Coherence-driven quantum battery charging via autonomous thermal machines: Energy transfer, memory effects, and ergotropy enhancement
No full textIn this work, we study a hybrid quantum system composed of a quantum battery and a coherence-driven charger interacting with a Quantum Autonomous Thermal Machine (QATM). The QATM, made of two qubits, each coupled to Markovian bosonic thermal reservoirs at different temperatures, acts as a structured environment that mediates energy and coherence between the charger and the battery. By applying a coherent driving field on the charger, we investigate the coherence injection effect on the dynamics, including non-Markovianity, power of charging, coherence storage, and ergotropy. We show that the QATM filters the decoherence induced by the thermal baths and induces non-Markovian memory effects due to correlation backflow. Our results demonstrate that coherence driving enhances the battery's ergotropy; coherence driving raises the maximum ergotropy by approximately 40 % compared to the case without coherence driving, and the power of charging by preserving the internal energy of the charger
Novel 8-hydroxyquinoline compounds used to inhibit mild steel corrosion in the presence of hydrochloric acid 1.0 M: an experimental and theoretical electrochemical study Nouveaux composés d’hydroxyquinoléine-8 utilisés pour inhiber la corrosion de l’acier doux en présence d’acide chlorhydrique 1.0 M: une étude électrochimique expérimentale et théorique
No full textThe present study examined the corrosion inhibition property of two derivatives of 8-hydroxyquinoline, namely diethyl 1,1-(4-(4-chlorophenyl)-1-((8-hydroxyquinoline-5-yl)methyl)-2, 6-dimethyl-1, 4-dihydropyridine-3,5-diyl) diethanone (P1) and diethyl 1,1-(4-(4-bromophenyl)-1-((8-hydroxyquinoline-5-yl)methyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-diyl)diethanone (P2). against mild steel (MS) degradation in 1.0 M hydrochloric acid (HCL) solution. The study was carried out using electrochemical techniques such as dynamic potential polarisation (DPP) and impedance spectroscopy (EIS) at different temperatures (298–328 K). Inhibition efficiency (IE %) increased with inhibitor concentration, reaching 97.0% for P1 and 91.8% for P2 at 10−3 M (298 K). Impedance measurements indicated that charge transfer resistance (Rct) increased, while double-layer capacitance (Cdl) decreased with increasing concentration of P1 and P2. Analysis of the polarisation curves shows that P1 and P2 act as mixed-type inhibitors. According to the Langmuir isotherm and thermodynamic parameters, P1 and P2 are adsorbed onto the mild steel surface by chemical interactions. The SEM/EDX analysis results revealed the formation of an adsorption film on MS. DFT calculations show that free heteroatom doublets of oxygen (O) and nitrogen (N) promote electron sharing between the molecules studied and the steel surface. Data from theoretical methods (DFT) confirm the experimental results
Evidence for KISS-1 nuclear translocation and PI3K/AKT signaling in the ultrastructurally and morphometrically analyzed human endometriosis
No full text Background Endometriosis is a common estrogen-dependent disease marked by ectopic endometrial growth. Although the PI3K/AKT and kisspeptin pathways are known to regulate endometrial homeostasis, their interplay in disease progression remains unclear. This study investigated the relationship between nuclear Kisspeptin (KiSS-1) localization and PI3K/AKT pathway activity in endometriotic tissues, focusing on stage-specific cellular alterations. Methods In this prospective study, control, eutopic and ectopic endometrial biopsies were collected from 27 women (18 controls, 9 with ovarian endometriosis). Histopathological assessments were performed using JB4 embedding, immunofluorescence, and transmission electron microscopy. Morphometric analyses were used to quantify structural alterations. Results In both eutopic and ectopic endometrium from patients with endometriosis, PI3K and AKT expression levels were significantly increased, whereas KiSS-1 expression was reduced and showed nuclear localization in a subset of cells. TEM analysis revealed features consistent with cellular stress, including autophagy-related vesicles, mitochondrial structural disruption, and alterations in nuclear architecture. Morphometric evaluation demonstrated a fibrotic remodeling in ectopic tissue. Specifically, glandular volume decreased, while stromal matrix content increased (p &lt; 0.05). Conclusion These findings suggest a mechanistic link between PI3K/AKT signaling and nuclear KiSS-1 translocation as an adaptive response to chronic hypoxia and inflammation in endometrial cells. This interaction may regulate survival, proliferation, and fibrotic remodeling processes characteristic of endometriosis. This integrated ultrastructural and molecular analysis provides novel insights into the pathophysiological role of nuclear KiSS-1 and its potential as a diagnostic and therapeutic target in endometriosis. </jats:sec