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Rekreatif ve lisanslı sporcuların bilinçli farkındalık düzeylerinin bayesçi yaklaşımla incelenmesi
No full textBu çalışma, rekreatif ve lisanslı olarak spor yapan bireylerin bilinçli farkındalık düzeylerini Bayesçi istatistiksel yaklaşım ile karşılaştırma amacıyla yürütülmüştür. Çalışma grubunu Sivas Cumhuriyet Üniversitesi Spor Bilimleri Fakültesinde öğrenim gören 157 öğrenci-sporcu (65 kadın, %41.40; 92 erkek %56.60; yaş ortalaması = 21.93 ± 3.82) oluşturmuştur. Katılımcıların 67’si (%42.67) rekreatif, 90’ı (%57.33) lisanslı sporcular olup, ortalama spor yaşları 6.96 ± 4.49 yıldır. Veri toplama aracı olarak kişisel ve spor bilgi formu, sporda bilinçli farkındalık ölçeği kullanılmıştır. Verilerin analizi R (4.5.1) programı ile gerçekleştirilmiştir. Spor düzeyine (rekreatif/lisanslı) göre farkındalık (BF10 = 0.33), yargılamama (BF10 = 0.34) ve yeniden odaklanma (BF10 = 0.25) boyutlarında, rekreatif ve lisanslı sporcu grupları arasında fark olmadığı yönündeki sıfır hipotezini orta düzeyde destekleyen bulgulara ulaşılmıştır. Cinsiyet değişkenine göre, farkındalık boyutu için (BF10= 1.29) kadınlar lehine fark olduğu yönündeki alternatif hipotezi destekleyen zayıf kanıt elde edilmiştir. Yargılamama (BF10 = 0.22) ve yeniden odaklanma (BF10 = 0.21) boyutlarında ise, kadın ve erkek grupları arasında fark olmadığı yönündeki sıfır hipotezini orta düzeyde destekleyen bulgular elde edilmiştir. Sonuçlar, bilinçli farkındalık düzeyinin kadın ve erkeklerde veya rekreatif ve lisanslı sporcu gruplarına bağlı olarak değişmediğini göstermektedir.</p
Novel alpha-functionalized nickel(ii) phthalocyanines: photochemical, antioxidant, antibacterial, cytotoxicity studies and theoretical insights
No full textIn this study, novel nickel(ii) phthalocyanines (1a–4a) with functional groups containing different atoms such as fluorine, sulfur, and oxygen connected through oxygen bridges from their non-peripheral positions were synthesized and characterized. Singlet oxygen generation, antioxidant and antibacterial activities, and cytotoxicity of the phthalocyanines (1a–4a) were evaluated. The synthesized phthalocyanines (1a–4a) exhibited solvent-dependent singlet oxygen generation, demonstrating their potential as photosensitizers and providing useful insights into their photochemical behavior. Moderate antioxidant activity was found when compared to the previous studies. The synthesized phthalocyanines (1a–4a) showed antibacterial activity against S. aureus. Molecule (2a) showed the highest antibacterial activity with a 12 mm inhibition zone. The phthalocyanines (1a–4a) did not exhibit cytotoxic activity in the MTT assay against HEK 293 cells. In conclusion, Gaussian calculations were used to investigate the synthesis of target nickel(ii) phthalocyanines (1a–4a). These computations were performed at the B3LYP, HF, and M062X levels, and the basis set utilized was 6-31++G(d,p). Proteins such as zinc superoxide dismutase protein (PDB ID: 1CB4), human peroxiredoxin 5 protein (PDB ID: 1H2D), and FabH inhibitor protein (PDB ID: 4Z8D) were among those that were subjected to molecular docking calculations
The impact of TMPRSS11A rs353163 and rs977728 polymorphisms on COVID-19 severity: genotypic and clinical associations
No full textObjective: COVID-19, caused by SARS-CoV-2, represents a significant global health challenge, with genetic factors influencing the severity of the disease. Transmembrane Serine Protease 11 A (TMPRSS11A) is a serine protease, and the relationship between the rs353163 and rs977728 polymorphisms in its coding region and COVID-19 severity has not been fully elucidated. In this context, we aimed to investigate the association between the TMPRSS11A rs353163 and rs977728 polymorphisms and the severity of COVID-19. Methods: The study included 84 control participants, 80 patients with mild COVID-19 (MC-19), and 168 patients with severe COVID-19 (SC-19). Genotyping was conducted using the restriction fragment length polymorphism (RFLP) method. The genotype distributions, haplotype frequencies, and their relationships with clinical parameters were statistically analyzed. Results: This study investigated the impact of TMPRSS11A rs977728 C > T and rs353163 T > C polymorphisms on COVID-19 disease severity by examining their associations with genetic variations and clinical parameters. No homozygous mutant genotype was detected for the rs353163 T > C polymorphism. The heterozygous TC genotype was associated with a 3-fold increased risk of developing severe COVID-19 (OR = 3.300; p T polymorphism, the TT and CT genotypes were observed at significantly higher frequencies in the SC‑19 group, corresponding to 7.6-fold and 2.3-fold increased risks, respectively. Haplotype analysis revealed that the rs977728 wild-type C / rs353163 mutant C* haplotype was strongly associated with SC‑19 disease severity. All genotype combinations carrying the mutant allele (rs977728 C > T / rs353163 T > C*) were associated with poor prognosis, as indicated by clinical parameters including CRP, D-dimer, ferritin, hs‑troponin, Neu, Neu%, Lym, Lym%, and Neu/Lym. ROC curve analysis identified CRP and D-dimer levels as sensitive markers for distinguishing the SC-19 group from other groups. Notably, the TT/TC* and CT/TC* genotype combinations were particularly associated with elevated CRP and D-dimer levels within the SC-19 group. Conclusion: Carriers of the mutant alleles of TMPRSS11A rs977728 and rs353163 are thought to increase the risk of severe COVID‑19, in association with systemic inflammation, hypercoagulability, and organ damage
LC-MS/MS Analysis, Molecular Docking, DFT Investigation, and Antioxidant Properties of Amphoricarpos praedictus
No full textThis study aimed to investigate the antioxidant activities of ethanol extracts from the flower, stem, and leaf parts of Amphoricarpos praedictus using both in silico and in vivo methods. Secondary metabolites were identified by LC-MS/MS, while total phenolic content (TPC), total flavonoid content (TFC), DPPH radical scavenging activity, FRAP, and CUPRAC reducing capacities, as well as total antioxidant status (TAS) and total oxidant status (TOS) levels, were measured spectrophotometrically. LC-MS/MS analysis identified quinic acid, protocatechuic acid, chlorogenic acid, rutin, hesperidin, and apigenin as the active secondary metabolites. Antioxidant activity showed a strong correlation with the higher phenolic and flavonoid content of the extracts. Density functional theory (DFT) calculations indicated that quinic acid is the most stable molecule, whereas rutin is the most reactive. Molecular docking revealed that fumaric acid exhibited the strongest interactions with key amino acid residues. To validate the docking results, MM-GBSA calculations were performed, demonstrating that rutin had the most negative binding free energies for both proteins (-51.324 kcal/mol for 1Q41 and -38.340 kcal/mol for 4UND). Overall, A. praedictus contains significant amounts of secondary metabolites and exhibits strong potential as a natural source of antioxidants
Investigation of microstructure, electrical and mechanical properties of Zn-Mg-Sn high-temperature lead-free solder alloy
No full textTüketicilerin Kendin Yap Motivasyonları ve İnternetten Montaja Hazır Mobilya Satın Alma Davranışları
No full textBireyler ihtiyaç duydukları çeşitli mal ve hizmetleri kendin yap faaliyetleri ile karşılayabilmektedir. Ev boyama, bahçe peyzajı ve çeşitli ev tamirat işleri kendin yap faaliyetlerine örnek olarak verilebilir. Çalışma kapsamında bireylerin kendin yap motivasyonları incelenmektedir. Bunun yanında, kendin yap faaliyetlerinden, bireylerin internetten satın aldıkları mobilyaların montajı ele alınmaktadır. Teknoloji kabul modeli yardımıyla tüketicilerin internetten montaja hazır mobilya satın alma davranışları incelenmektedir. Araştırma hipotezlerini test etmek amacıyla kesit analizi tasarımı kullanılmıştır. Online anket formu ile 331 katılımcıdan veri elde edilmiştir. Araştırma sonucunda mobilya montajı imajının bireylerin kullanışlılık algısı ile olumlu ilişkide olduğu bulunmuştur. Bunun yanında bireylerin mobilya montajından eğlence algısının kullanım kolaylığı algılarını olumlu yönde etkilediği görülmektedir. Mobilya montajından kullanım kolaylığı ve kullanışlılık algısı, bireylerin montaja hazır mobilya satın almalarına yönelik tutumlarını olumlu etkilemektedir. Bireylerin tutumlarının ise davranışları ile olumlu bir ilişkide olduğu ortaya çıkmıştır. Katılımcıların genel olarak kendin yap davranışlarında ekonomik fayda sağlama güdülerinin belirgin olduğu görülmektedir. Cinsiyetin kendin yap davranışlarında önemli olabilecek bir değişken olduğu araştırma sonucunda bulunmuştur.</p
Glycaemic control and complications in haemodialysis patients: The TURK-HEMODIAB Study
No full textBackground The most common cause of end-stage kidney disease is diabetes mellitus (DM). The most commonly used renal replacement therapy in Turkey and in many countries around the world is haemodialysis (HD). Glycaemia control is important in these populations. In this study we aimed to screen for glycaemic control and complications in a large population of diabetic HD patients in Turkey. Methods A total of 16 043 patients were screened in 253 dialysis centres in Turkey and 5038 diabetic HD patients were included in the study. At participating centres, patients' diabetes history, complications, medications, haemoglobin A1c (HbA1c) and other laboratory data were reviewed and recorded by nephrologists. Results The average age of the patients was 64.0 ± 11.2 years and 56% were male. The mean HbA1c was 7.4 ± 1.5%. Patients were divided into three groups according to the HbA1c level (8%). As the HbA1c levels increased, the mean systolic blood pressure and diastolic blood pressure increased significantly. In addition, as the HbA1c levels increased, the number of patients with coronary artery disease, patients undergoing coronary artery bypass graft surgery and the rate of patients with diabetic retinopathy and vision loss increased. Diabetic foot disease and amputation rates were also higher in the group with poor glycaemic control. The number of patients using intensive or mixed insulin was also higher in the group with high HbA1c levels. In ordinal logistic regression analysis, age significantly decreased and higher body mass index slightly increased the risk of a higher HbA1c. Also, the need for a diabetic diet was greater in those with high HbA1c levels. Conclusion Our study highlights that the target values for diabetic HD patients in Turkey are partially compatible with the 2022 Kidney Disease: Improving Global Outcomes guidelines for diabetes management. Nevertheless, more effort and teamwork are needed to improve patient outcomes