Sivas Cumhuriyet University Research Information System
Not a member yet
61356 research outputs found
Sort by
Bioactive properties of Vicia canescens subsp. variegata (Willd.) P.H. Davis, Fabaceae: antioxidant, antiparkinsonian and relevance to food and agriculture use
No full textBACKGROUND: Various Vicia species belonging to the Fabaceae family are known to be used in different parts of the world both in human nutrition and as animal feed, and also have pharmacological potential in the prevention and treatment of various diseases. With this perspective, in the present study, the possible antiparkinsonian effects of extracts prepared from Vicia canescens subsp. variegata were investigated in cell culture and on 6-hydroxydopamine (6-OHDA)-induced Parkinson's model rats. The effects of the plant on the pathophysiology of Parkinson's disease were evaluated by biochemical and histopathological analyses; in addition, the structures of the compounds isolated from the active extracts were elucidated and the in vitro antioxidant and antiparkinsonian activities of these compounds were determined. RESULTS: Methanol and n-butanol extracts prepared from the aerial parts of V. canescens subsp. variegata showed significant antiparkinsonian effects both in cell culture and in a rat model. Histopathological and biochemical analyses were also parallel to in vivo experiments. As a result of the isolation studies, six flavonol glycosides were obtained from the plant, and their antioxidant capacities as well as antiparkinsonian effects were subsequently evaluated. The highest biological effect was observed in quercetin-3-O-α-l-rhamnopyranoside (quercitrin, VCB-3). CONCLUSION: In the light of the studies, the antiparkinsonian effects of V. canescens subsp. variegata was evaluated. It was seen that they prevented neurodegeneration and the oxidative stress that occurred, and the most effective compounds were determined. Two new compounds named viciacoside A and B have been added to the literature as a result of this research. © 2025 Society of Chemical Industry
LC-MS/MS Analysis, Molecular Docking, DFT Investigation, and Antioxidant Properties of Amphoricarpos praedictus
No full textThis study aimed to investigate the antioxidant activities of ethanol extracts from the flower, stem, and leaf parts of Amphoricarpos praedictus using both in silico and in vivo methods. Secondary metabolites were identified by LC-MS/MS, while total phenolic content (TPC), total flavonoid content (TFC), DPPH radical scavenging activity, FRAP, and CUPRAC reducing capacities, as well as total antioxidant status (TAS) and total oxidant status (TOS) levels, were measured spectrophotometrically. LC-MS/MS analysis identified quinic acid, protocatechuic acid, chlorogenic acid, rutin, hesperidin, and apigenin as the active secondary metabolites. Antioxidant activity showed a strong correlation with the higher phenolic and flavonoid content of the extracts. Density functional theory (DFT) calculations indicated that quinic acid is the most stable molecule, whereas rutin is the most reactive. Molecular docking revealed that fumaric acid exhibited the strongest interactions with key amino acid residues. To validate the docking results, MM-GBSA calculations were performed, demonstrating that rutin had the most negative binding free energies for both proteins (-51.324 kcal/mol for 1Q41 and -38.340 kcal/mol for 4UND). Overall, A. praedictus contains significant amounts of secondary metabolites and exhibits strong potential as a natural source of antioxidants
Investigation of microstructure, electrical and mechanical properties of Zn-Mg-Sn high-temperature lead-free solder alloy
No full textTüketicilerin Kendin Yap Motivasyonları ve İnternetten Montaja Hazır Mobilya Satın Alma Davranışları
No full textBireyler ihtiyaç duydukları çeşitli mal ve hizmetleri kendin yap faaliyetleri ile karşılayabilmektedir. Ev boyama, bahçe peyzajı ve çeşitli ev tamirat işleri kendin yap faaliyetlerine örnek olarak verilebilir. Çalışma kapsamında bireylerin kendin yap motivasyonları incelenmektedir. Bunun yanında, kendin yap faaliyetlerinden, bireylerin internetten satın aldıkları mobilyaların montajı ele alınmaktadır. Teknoloji kabul modeli yardımıyla tüketicilerin internetten montaja hazır mobilya satın alma davranışları incelenmektedir. Araştırma hipotezlerini test etmek amacıyla kesit analizi tasarımı kullanılmıştır. Online anket formu ile 331 katılımcıdan veri elde edilmiştir. Araştırma sonucunda mobilya montajı imajının bireylerin kullanışlılık algısı ile olumlu ilişkide olduğu bulunmuştur. Bunun yanında bireylerin mobilya montajından eğlence algısının kullanım kolaylığı algılarını olumlu yönde etkilediği görülmektedir. Mobilya montajından kullanım kolaylığı ve kullanışlılık algısı, bireylerin montaja hazır mobilya satın almalarına yönelik tutumlarını olumlu etkilemektedir. Bireylerin tutumlarının ise davranışları ile olumlu bir ilişkide olduğu ortaya çıkmıştır. Katılımcıların genel olarak kendin yap davranışlarında ekonomik fayda sağlama güdülerinin belirgin olduğu görülmektedir. Cinsiyetin kendin yap davranışlarında önemli olabilecek bir değişken olduğu araştırma sonucunda bulunmuştur.</p
Strategic design and mechanistic unveiling of Ni-based S-scheme heterojunctions for efficient CO2 photoreduction to C1 products: Coordination chemistry, spectroscopic evidence, and future directions
No full textTackling the rising anthropogenic CO2 level aligns directly with the United Nations Sustainable Development Goals (SDGs), exclusively SDG 7 (Affordable and Clean Energy) and SDG 13 (Climate Action). The CO2 photoreduction into C1 products, i.e., CO and CH4, provides a favorable route to reduce greenhouse gas emissions. Among various modification strategies, the S-scheme heterojunction construction has a bright shine in the material chemistry field owing to its enhanced charge carrier separation efficiency, minimized charge carrier recombination, strong redox ability, and enhanced photocatalytic performance. The review significantly explores the recent advancements in Ni-based S-scheme junctions for CO2 reduction, highlighting their interfacial charge transfer kinetics to achieve high selectivity. Firstly, the general CO2 photoreduction mechanism was introduced to provide essential background knowledge. The article then probes the development of S-scheme mechanism and various classifications of S-scheme heterojunctions based on Ni-LDH, NiO, Ni(OH)2, Ni-MOF, NiS, Ni2P, etc., integrated with suitable semiconductors. Ni-based photocatalysts are a potential component within S-scheme heterojunctions because of their strong stability, suitable band potentials, cost-effectiveness, and earth-abundant nature. The advanced spectroscopic techniques, including DFT, KPFM, and ISI-XPS, are highlighted to validate the S-scheme charge transfer route. Moreover, the CO2 reduction pathways were discussed with the primary focus on CO2 adsorption, activation, intermediate stability, and C1 product selectivity. Finally, the article outlines the respective challenges and future prospects in the field with the hope that this work offers strategic insight for developing photocatalytic CO2 reduction technologies, supporting the pursuit of global carbon neutrality goals
Short-Term Inspiratory Muscle Training Enhances Functional and Metabolic Health in Older Adults
No full textBackground: Age-related declines in respiratory muscle strength and ventilatory efficiency can impair functional capacity and metabolic health in older adults. Inspiratory muscle training (IMT) has been proposed as a practical intervention to counteract these changes, yet its systemic effects remain unclear. This study aimed to examine the effects of short-term IMT on functional capacity, diaphragm thickness, and liver tissue characteristics in healthy elderly men. Methods: Thirty community-dwelling men aged 60–80 years were randomly assigned to an IMT or control group. The IMT group performed four weeks of breathing exercises using a POWERbreathe® device at 40% of maximal inspiratory pressure, with a weekly 10% increase in pressure. Pre- and post-intervention assessments included the six-minute walk test (6MWT), diaphragm thickness and liver density via computed tomography, and quality of life (QoL; SF-12). Results: Four weeks of inspiratory muscle training significantly improved diaphragm thickness (11.7%), fatty liver density (FLD) (+16.7%), and six-minute walk performance (+5.3%), with large time × group effects favoring the IMT group. While the physical quality of life showed modest, comparable improvements, mental health outcomes demonstrated a moderate, time-dependent improvement without a significant group-by-time interaction. Conclusions: Short-term IMT improved diaphragmatic function and functional capacity in older men and was associated with favorable changes in a liver-related biomarker; however, given that only a single liver-related metric was assessed, these findings should not be interpreted as evidence of overall improvements in liver health.</p