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Мобільний додаток “3–D HAOC” версій APP-RELEASE-V.5.0.0 і АPP-DEBUG для студентів фармацевтичних спеціальностей та його застосування в освітньому процесі
No full textАктуальні питання використання препаратів дифенілметилу в умовах війни
No full textНа сьогоднішній день фармацевтичний ринок переповнений препаратами, які зі слів фармацевтичних маркетологів, мають можливість вирішити проблеми, що пов’язані із різними когнітивними порушеннями, поліпшення пам'ять, концентрації уваги та загальний психологічний стан. В умовах військового стану дані препарати часто використовують деякі військовослужбовці для того, щоб покращити виконання військових завдань
Борис Євгенович Балковський: від асистента кафедри ВМІ до відомого українського флориста-бріолога
Get PDFУ статті йдеться про наукову та викладацьку діяльність відомого українського флориста, бріолога, викладача Вінницького медичного інституту - Бориса Євгеновича Балковського
Impact of CAKUT syndrome and UTI on pediatric BMI
No full textBackground: Several recent studies suggest that continuous low-dose antibiotics prophylaxis used in VUR may affect the growth of children. Guidos P.J. et al. (2018) found a significant increase in BMI in children who had prior antibiotic usage. CAKUT syndrome involves both the kidney and urinary tract and generally is associated with antibiotic therapy among pediatric patients and metabolism of waste products.
Aim: We aimed to evaluate the impact of congenital genitourinary defects (CAKUT syndrome) on BMI in pediatric patients compared to patients without structural pathology.
Materials and methods: We prospectively enrolled 49 pediatric patients admitted to the surgical and nephrological departments from June 1 to November 31, 2023. All patients were divided into two groups: study group (n=27) – CAKUT syndrome (VUR, PKD, horseshoe kidney, renal agenesis/hypoplasia, etc.) and prior/current episodes of CAP; control group (n=22) – UTI, without CAKUT (proved by US, VCUG or CT). All patients underwent complete work-up including clinical examination, evaluation of BMI according to WHO standards(underweight, healthy weight, overweight, obese, renal function tests (creatinine, urine, GFR), and imaging studies (US and/or VCUG/CT). Written informed consent was obtained from the parents. P<0,05 was considered significant.
Results: In the study group, 7.4% of patients were obese; 14.8% - overweight; 51.8% -healthy weight; 26% -underweight. BMI distribution in the control group: 4.5% -obese; 4.5% -overweight, 72.7% -healthy weight; 18.3% -underweight. We observed no significant risk of obesity (OR=1.68; 95% CI 0.1422 to 19.8541; P=0.06805), being overweight (OR=3.6522; 95% CI 0.3774 to 35.3435; P=0.2633) or underweight (OR=1.575; 95% CI =0.3948 to 6.2839; P=0.5199) among children with CAKUT syndrome comparing to their peers without congenital defects of urinary system.
Conclusion: CAKUT syndrome does not affect pediatric BMI. There is the same risk of being obese, overweight, or underweight among children with and without congenital defects of urinary system and UTI
Застосування біопеллет з метформіном за експериментального метаболічного синдромy
No full textThe global prevalence of metabolic syndrome in Ukraine and the world gives reason to consider it one of the most
dangerous diseases of the modern world. One of the promising directions in the pharmacotherapy of pathological conditions is the
use of the drug in the form of bioidentical implants that contain a medicinal substance. Experimental metabolic syndrome in
animals was modeled with the help of a Cafeteria diet, which imitated the problematic eating patterns of modern humans. Animal
body weight, blood glucose, lactate and insulin content, HOMA index, and lipid metabolism indicators were evaluated as markers
of metabolic syndrome and criterion signs of treatment effectiveness. Results showed that a 6-week Cafeteria diet causes a
metabolic imbalance and is accompanied by signs characteristic of metabolic syndrome. Probable signs of insulin resistance
accompanied these changes. Both the tablet and pellet form of the drug positively affected the indicators of carbohydrate
metabolism and reduced the manifestations of insulin resistance. Metformin in bioidentical implants also significantly improved
experimental animals' general condition and appearanc
Взаємозв’язки амплітудних показників реовазограми стегна з параметрами зовнішньої будови тіла у легкоатлетів-спринтерів екто-мезоморфного типу конституції
No full textDetermining the state of peripheral hemodynamic indicators is one of the modern challenges, which can be a barrier for athletes of a particular type of sport of a certain somatotype in relation to individual constitutional features and prevent achieving sports results. The aim of the work was to study the relationship between the parameters of the rheovasogram of the hip with anthropometric dimensions and components of body weight and somatotype in track and field athletes with a high level of mastery of the ecto-mesomorphic somatotype. We conducted a study of high-level sprinters using the method of P.P. Shaparenka where 50 anthropometric body sizes were determined. The component composition of body weight was carried out using the Matejko method, and the Heath-Carter method was used for score assessment of the somatotype components. It was determined that 28 track and field athletes belonged to the ecto-mesomorphic constitutional type. Rheovasographic indicators of the thigh were measured on a computer diagnostic multifunctional complex by using tetrapolar rheography. Correlation analysis was performed using Spearman’s non-parametric statistical method in the STATISTICA 5.5 program. It was established that in sprinters who belong to the ecto-mesomorphic somatotype, there are numerically reliable correlations between the amplitude parameters of the hip rheovasogram with anthropometric dimensions and somatotypological indicators. The greatest strength and number of relationships was seen between between longitudinal, girth, transverse, body dimensions, the thickness of skin and fat folds, components of somatotype and body weight and basic impedance, amplitudes of the systolic wave and rapid blood filling, where the average strength of the connections prevail. The characteristics of the relationship between the amplitude indicators of the rheovasogram of the thigh and the indicators of the external structure of the body, which we determined, confirm the conditioning of the indicators of peripheral hemodynamics by constitutional features
Topographic anatomy of kidneys and changes in the size and position of a single kidney
No full textThe article examines the influence of macroscopic and microscopic changes in the kidney on function and the development of pathological processes. Kidney volume has been shown to be the optimal parameter for predicting kidney function. It has been established that weight gain often leads to nephroptosis. The variability of the renal vessels in terms of number, sources of departure from the main vessels, method of branching, spatial relationships of the branches was noted
Medical consequences of the use of chemical weapons of irritant action during the full-scale invasion of the Russian Federation into Ukraine
No full textAbstract: The full-scale invasion of the russian federation into Ukraine actualized the problem of the use of chemical weaponsof destruction, in particular with a pronounced irritant effect. Today, there is a need to analyze cases of the use of such weapons duringmilitary operations in Ukraine and to characterize the consequences of their use, to develop tactics for preserving the lives and healthof both employees of the Armed Forces of Ukraine, employees of the security and defense sector, and the civilian population. Thepurpose of the article is to highlight the problem of using chemical weapons of irritant action in the conditions of a full-scale invasionof the russian federation into Ukraine and the social and medical consequences of its use. We used the following methods andtechniques: empirical analysis (observation, historical analogy, comparison), complex research (structural analysis and synthesis,generalization, argumentation). The basis for our research was the sources of scientometric databases Web of Science, Scopus, PubMed, Index Copernicus and our own experience. Our research makes it possible to develop a complex of medical and othermeasures aimed at preventing or as much as possible weakening the impressive and destructive effect of weapons of mass destructionin order to preserve the life, health, fighting capacity and working capacity of the personnel of the troops and the population, as well asthe preservation of military, civilian, natural objects, animals, material values and development of tactics for protection in case of itsapplication. The need for high-quality training of units of the Medical Forces of the Armed Forces of Ukraine, health care institutions,employees of the State Emergency Service and the National Police to protect personnel and the population during the use of chemicalweapons of irritant action was emphasized
Recommendations for asthma monitoring in children: A PeARL document endorsed by APAPARI, EAACI, INTERASMA, REG, and WAO
No full textMonitoring is a major component of asthma management in children. Regular monitoring allows for diagnosis confirmation, treatment optimization, and natural historyreview. Numerous factors that may affect disease activity and patient well-beingneed to be monitored: response and adherence to treatment, disease control, disease progression, comorbidities, quality of life, medication side-effects, allergen andirritant exposures, diet and more. However, the prioritization of such factors and theselection of relevant assessment tools is an unmet need. Furthermore, rapidly developing technologies promise new opportunities for closer, or even “real-time,” monitoring between visits. Following an approach that included needs assessment, evidenceappraisal, and Delphi consensus, the PeARL Think Tank, in collaboration with majorinternational professional and patient organizations, has developed a set of 24 recommendations on pediatric asthma monitoring, to support healthcare professionals indecision-making and care pathway design