Indian Journal of Research in Homoeopathy
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Clinical trial for evaluation of a Human Immunodeficiency Virus nosode in the treatment for Human Immunodeficiency Virus-Infected individuals
No full textIntroduction: Identifying the need for strengthening of the immune system, the investigator has developed new Human Immunodeficiency Virus (HIV) nosode and evaluated its effect on HIV positive individuals through a clinical trial. Methods: Standardized and the scientific method of HIV nosode preparation has been described and documented. Thirty-seven HIV-infected persons were registered for the trial, and ten participants were dropped out from the study, so the effect of HIV nosode 30C and 50C, was concluded on 27 participants under the trial. Results: Out of 27 participants, 7 (25.93%) showed a sustained reduction in the viral load from 12 to 24 weeks. Similarly 9 participants (33.33%) showed an increase in the CD4+ count by 20% altogether in 12 th and 24 th week. Significant weight gain was observed at week 12 (P = 0.0206). 63% and 55% showed an overall increase in either appetite or weight. The viral load increased from baseline to 24 week through 12 week in which the increase was not statistically significant (P \u3e 0.05). 52% (14 of 27) participants have shown either stability or improvement in CD4% at the end of 24 weeks, of which 37% participants have shown improvement (1.54-48.35%) in CD4+ count and 15% had stable CD4+ percentage count until week 24 week. 16 out of 27 participants had a decrease (1.8-46.43%) in CD8 count. None of the adverse events led to discontinuation of study. Conclusion: The study results revealed improvement in immunological parameters, treatment satisfaction, reported by an increase in weight, relief in symptoms, and an improvement in health status, which opens up possibilities for future studies
Research highlights: Latest homoeopathic research synopsis during October - December 2014
No full textAn investigation to evaluate the analgesic and central nervous system depressant activities of Solanum nigrum (Linn.) in Homoeopathic potencies in experimental animal models
No full textBackground and Objective: In Homoeopathy, Solanum nigrum is clinically used in the treatment of ergotism, meningitis, irritation during dentition and some of the symptoms of neurological disorders but its Central Nervous System (CNS) potential has not been explored experimentally yet. Therefore, a preliminary study was conducted with an objective to evaluate the analgesic and CNS depressant effects of homoeopathic potencies of S. nigrum in experimental animal models. Materials and Methods: The study was conducted in Wistar albino rats using a hot plate, ice plate and Randall-Selitto assay for analgesic; rota-rod and open field test for CNS depressant activities. The different potencies (3X, 6X, 12X and 30C) of Solanum nigrum were administered orally (0.5 ml/rat/day) for 30 days and response was assessed after 30 minutes of drug administration on 10 th , 20 th and 30 th day. Results: The result shows that all the four potencies of Solanum nigrum has increased the latency time required to raise and lick the paws for thermal sensation on hot plate test and for cold sensation on ice plate test and also increased the degree of threshold pressure to mechanically induced pain on Randall-Selitto assay but depressed the motor coordination and locomotor activities. Conclusion: The result obtained from this preliminary study suggests that homoeopathic preparation of Solanum nigrum in different potencies possess analgesic and CNS depressant activities. Further detailed investigations are required for its possible human use
Evaluation of homoeopathic medicines as add-on to institutional management protocol in Acute Encephalitis Syndrome: An exploratory observational comparative study
No full textBackground: Acute Encephalitis Syndrome (AES) treated according to Institutional Management Protocol (IMP) has considerable mortality and morbidity. The study was undertaken to evaluate the effect of homoeopathic treatment (H) as an add-on to IMP (IMP + H) for children affected with AES. Materials and Methods: This was an exploratory observational study carried out in the IPD setting (epidemic ward) of Baba Rhaghav Das Medical College and Nehru Hospital, Uttar Pradesh (July to November 2012) using convenience sampling. Children whose guardians gave consent were treated with IMP + H and rest remained on IMP only. Glasgow outcome scale was used at discharge for the final outcome. Results: 151 children (121 in IMP + H and 30 in only IMP) diagnosed with AES (aged 6 months to 18 years) were enrolled. The results showed 12 (9.9%) death out of 121 children administered IMP + H whereas it was 13 (43%) out of 30 children on IMP alone. Proportional odds analysis with covariate adjustment showed added benefit of Homoeopathy in children with AES as compared to IMP alone (adjusted odds ratio, 0.17, 95% confidence interval 0·06-0.45, P = 0·0001). The most useful medicines are Belladonna, Stramonium, Arsenicum album, Helleborus, Bryonia alba, Sulphur, and Cuprum metallicum. Conclusion: This exploratory observational study suggests reduction of mortality and morbidity with add-on homoeopathic medicine. Further randomized controlled trial study with comparable groups is desirable. If findings are confirmed by subsequent research, add-on Homoeopathy might have relevant implication for its management
A review of Basic Research on Homoeopathy from a physicist′s point of view
No full textHomoeopathic medicine has been one of the world′s most widely practiced alternative therapies. However, that the potency of a homoeopathic medicine increases with dilution followed by succussion (together termed as potentization) has thrown challenges to the scientific community at large. A recent hypothesis, advanced by us and others, is that due to the process of potentization, the size of the constituent particles decreases and eventually reaches nanodimension. This decrease in size with increase in potency has been verified by scanning electron microscopy and dynamic light scattering studies. The increase in potency is manifested in its increased effect on membrane fluidity. The change in potency also leaves its signature on Ultraviolet-Visible spectra, Fourier transform infrared radiation spectra and Raman spectra. We have taken one step further to carry this nano-dimensional property of homoeopathic medicine and put it into several technical applications. And in so doing, we have connected the important, old, un-quantifiable effects with the latest quantifiable technology and opened up an era of applications with more possibilities
Republished: Sulphur alters NFκB-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell lung carcinoma
Get PDFAdverse side effects of chemotherapy during cancer treatment have shifted considerable focus towards therapies that are not only targeted but are also devoid of toxic side effects. We evaluated the antitumorigenic activity of sulphur, and delineated the molecular mechanisms underlying sulphurinduced apoptosis in non-small cell lung carcinoma (NSCLC) cells. A search for the underlying mechanism revealed that the choice between the two cellular processes, NFκBp65-mediated survival and p53-mediated apoptosis, was decided by the competition for a limited pool of transcriptional coactivator protein p300 in NSCLC cells. In contrast, sulphur inhibited otherwise upregulated survival signaling in NSCLC cells by perturbing the nuclear translocation of p65NFκB, its association with p300 histone acetylase, and subsequent transcription of Bcl-2. Under such anti-survival condition, induction of p53-p300 cross-talk enhanced the transcriptional activity of p53 and intrinsic mitochondrial death cascade. Overall, the findings of this preclinical study clearly delineated the molecular mechanism underlying the apoptogenic effect of the non-toxic homeopathic remedy, sulphur, in NSCLC cells
Protective effect of Zincum metallicum on rat model of Parkinson′s disease
No full textBackground: Parkinson′s Disease (PD) is one of the major neurodegenerative disorders, and oxidative stress has been implicated in playing an important role in the pathogenesis of the disease. Zincum metallicum, produces symptoms mentioned in Homoeopathic Materia Medica which are akin to PD on which basis it might be considered as one at the intermediate to treat the disease. Materials and Methods: Rats were divided into eight groups; surgery was done by stereotaxic apparatus. 6 - hydroxydopamine was used to induce parkinsonism thereafter on 16 th day of lesioning animals were assessed by the video path analyzer. Animals were sacrificed and biochemical assays (Lipid peroxidation [LPO], glutathione [GSH], glutathione peroxide [GPx], glutathione reductase [GR], glutathione-S-transferase [GST]) and level of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA), were estimated. Further dopaminergic D 2 receptor binding was also done to confirm the induced parkinsonism. Results: The behavior activities (locomotor, distance travel, stereroevent) were decreased whereas the rest time was increased in lesion group animals as compared to the sham group. The locomotor activity and the distance traveled were protected significantly with 6C whereas rest time was protected significantly with 30C and 200C of Homoeopathic medicine Zincum metallicum. On the other hand, S + 30C and S + 200C groups have shown increased locomotor activities as compared to S group. The rest time was also increased significantly in S + 6C and S + 30C group animals as compared to S group. The elevated level of LPO and DA D 2 receptor binding density in PD group was protected significantly with Zincum metallicum (6C, 30C, and 200C). The depleted level of GSH and activity of antioxidant enzymes (GPx, GR, and GST) and DA and its metabolites DOPAC and HVA were protected significantly with Zincum metallicum (6C, 30C, and 200C). Conclusion: The study indicates the Zincum metallicum may be helpful in slowing down injury in parkinsonism and could be a beneficial drug for the prevention of PD
Protective effect of Gymnema sylvestre L. against advanced glycation end-product, sorbitol accumulation and aldose reductase activity in Homoeopathic Formulation
No full textBackground: Oxidative stress ensues due to the imbalance between the production and elimination of reactive oxygen species. Chronic hyperglycemia along with oxidative stress plays major role in aggravation of chronic disorders such as diabetes and its related complications. Objective: This study was designed to evaluate the protective effect of Gymnema sylvestre L. against oxidative stress. Materials and Methods: Potencies of G. Sylvestre were procured from Dr. Willmar Schwabe India Pvt. Ltd. In vitro antioxidative potential of G. sylvestre was evaluated by employing various in vitro antioxidant methods. Results: The total phenol content was found to be 2124, 998 and 546 mg/g Gallic Acid Equivalents in Mother tincture, 6C and 30C of G. sylvestre and total antioxidant capacity was found to be 2940,802 and 559 μM/g ascorbic acid equivalents respectively. Mother tincture, 6C and 30C of G. sylvestre were found to have strong reducing power, 2,2-diphenyl-1-picrylhydrazyl radical, hydrogen peroxide, nitric oxide and superoxide radical scavenging activity. Percentage inhibition of advanced glycation end-products formation by Mother tincture, 6C and 30C of G. sylvestre (10-50 μl) was found to be 38.66 to 95.80%, 30.93 to 81.48% and 31.34 to 60.92% respectively. Mother tincture, 6C and 30C of G. sylvestre showed an inhibitory effect against sorbitol accumulation with inhibitory concentration (IC50) value 27.55 μl, 197.96 μl and 1.009 ml respectively whereas in aldose reductase inhibition assay, the IC50value of 28.10 μl, 159.71 μl and 0.82 ml respectively. Conclusion: These results suggested that Homoeopathic preparations of G. Sylvestre had potent antioxidant and antiglycation activity
Report on World Homoeopathy Summit organized by Global Homeopathy Foundation
No full textThe Global Homeopathy Foundation (GHF) organized the World Homoeopathy Summit (WHS) at Birla Matoshree Sabhaghar, Mumbai, 400020, India on 11-12 April, 2015. Ministry of AYUSH, Central Council for Research in Homoeopathy, Central Council of Homoeopathy and Homoeopathic Pharmacopeia Laboratory were the institutional collaborators. Homoeopathic Medical Association of India, Indian Homoeopathic Medical Association and the Indian Chapter of Liga Medicorum Homeopathica Internationalis supported the event. The WHS was aimed at enhancing research aptitudes of young homoeopaths, increasing clinical proficiency of practitioners, encouraging scientists from pure and applied sciences to associate in fundamental research and also inviting government as well as non government institutions to patronize research in Homoeopathy. About 800 delegates from across the country, mainly practitioners, teaching faculties, postgraduate students, Ph.D. scholars and scientists attended the summit. Scientific sessions on nature of homoeopathic medicine, Evidence and Mechanism of its action were presented by molecular biologists, engineers, physicists, immunologists, pharmacologists, chemists, nano-technologists, zoologists, homeopaths and conventional doctors from some of the premium Universities. The conference ended with panel discussion moderated by Dr. Raj K. Manchanda and Dr. Rajesh Shah. It was recommended to encourage more scientific research and better documentation in Homoeopathy and to review the existing approaches in practice
