Indian Journal of Research in Homoeopathy
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Indian Standard for Globules used in Homoeopathy
No full textThis article aims to describe and critically examine the Indian Standard (IS 18947:2024) for globules used in Homoeopathy, outlining the technical specifications, testing methods, and significance for pharmaceutical quality assurance. The implications of the standard for manufacturers, quality control laboratories, consumers and regulatory bodies engaged in the production and evaluation of homoeopathic drugs are highlighted by presenting a consolidated view of the standard\u27s scope and applications. This discussion underscores the continued importance of systematic standardization in ensuring the safety, consistency, and global credibility of homoeopathic medicinal products produced in India
Effectiveness of homoeopathic medicines in reducing the size of non-specific chronic leg ulcers - A single-arm, prospective observational study
No full textBackground: A chronic leg ulcer (CLU) is a chronic wound of the leg that does not tend to heal easily. Venous, arterial insufficiency, diabetes mellitus, or a combination of these factors may cause pain, restricted mobility, impaired social activities, and increased personal expenses, all of which can adversely affect the quality of life. Objectives: To determine the e ectiveness of homoeopathic medicines in reducing the size of non-specific chronic leg ulcers using the Leg Ulcer Measurement Tool (LUMT) and changes in the quality of life by the Euro QoL (EQ-5D-3L) score. Materials and methods: A prospective clinical study was conducted at the National Homoeopathy Research Institute in Mental Health, Kottayam, India, from February 2021 to August 2022, and was registered in CTRI/2021/02/030951. Out of 35 cases, 34 completed the treatment for six months and were analyzed by evaluating the size of the ulcer, LUMT score, and Euro QoL score at baseline, as well as at the 3rd and 6th months. Results: Of 52 screened patients, 35 were enrolled and prescribed individualized homoeopathic medicine. Statistically significant reduction was observed in the size of the ulcer, from 5.6 cm2 to 0 and in the LUMT score from 31 to 7 (pp \u3c 0.001). Lycopodium clavatum, Sulphur, Lachesis mutus, Phosphorus, Arsenicum album, Mercurius solubilis, Natrum muriaticum, and Pulsatilla nigricans were frequently indicated, and no serious adverse events were recorded during the study. Conclusion: The study determined that individualised Homoeopathy effectively reduces the size of non-specific chronic leg ulcers and improves patients’ QoL. Well-designed pragmatic trials are warranted
Acknowledgement to our reviewers (2025)
No full textThe following experts are sincerely acknowledged for their invaluable inputs, while reviewing the manuscripts for the Indian Journal of Research in Homoeopathy in 2025. Their timely inputs enabled a fair and rigorous peer-review process, and we are immensely thankful for the same
Homoeopathy in integrative management of reduced left ventricular ejection fraction: An evidence-based case report
No full textBackground: Left ventricular ejection fraction (LVEF) is the central measure of left ventricular systolic function. It is one of the most useful tools to evaluate cardiac diseases. Heart failure with a reduced ejection fraction affects more than 50% of individuals. This subject is inadequately documented in Homoeopathy. This case study intends to create evidence-based documentation and generate the hypothesis that Homoeopathy can treat these potentially fatal illnesses. Case Summary: A 33-year-old female presented with complaints of palpitation, dyspnoea on least exertion and pain in both upper and lower limbs with associated numbness extending downwards for three months. She had a low pulse rate of 44–46 beats/min. As per echocardiography report, she had severely reduced LVEF (25%). Following the principles of Homoeopathy, Kalmia latifolia was prescribed in 50-millesimal potency. The patient was advised to continue her conventional medication schedule. The subjective evaluation was done using Outcome Related to Impact on Daily Living (ORIDL) scale, which improved gradually. Her pulse rate also increased to 74 beats/min with a regular sinus rhythm. Echocardiography reports are presented as objective evidence, where 50% enhancement of LVEF was recorded. Modified Naranjo Criteria for Homeopathy (MONARCH) established (score +8) the likelihood of improvement between the given intervention and the clinical outcome of the patient. Here, in addition to conventional medicine, Kalmia latifolia in 50-millesimal potency from 0/1 to 0/12 was found to be useful and efficiently managed to show results within six months. Further documentation of this integrated approach is warranted in the future
Management of leiomyoma and ovarian cyst with homoeopathic medicine Thuja occidentalis: An evidence-based case report
No full textIntroduction: Leiomyoma (Uterine Fibroid [UF]) is the most prevalent benign solid tumour arising from the neoplastic transformation of smooth muscle cells of myometrium in the reproductive age of females. Fibroids are rare before puberty, increase in prevalence during the reproductive years, and usually reduce in size after menopause.
Case Summary: A 34-year-old woman presented with a complaint of hypogastric pain, and heavy bleeding during her menstrual periods since 3–4 months. Her menstrual cycle was irregular. She was diagnosed with an intramural UF and a right ovarian cyst on ultrasonography. Thuja occidentalis (in different potencies) was prescribed based on individualisation, repertorial totality, and miasmatic analysis. Within seven months of homoeopathic treatment, there was a complete regression in the size of the UF and ovarian cyst, with amelioration of all the associated symptoms. The VAS score also reduced from 6 to 0. The Modified Naranjo Criteria for Homeopathy was used, and a score of +9 indicated a strong causal attribution between clinical outcome and the homoeopathic intervention. The case was followed up with a symptomatic assessment reported by the patient, the Visual Analogue Scale, and laboratory investigations
Uterine fibroid and haemorrhagic ovarian cyst treated with homoeopathic medicine Sepia officinalis in LM potency: An evidence-based case report
No full textIntroduction: Uterine fibroids are the most common benign neoplasms of the female genital tract in reproductive-age women. The wide range of symptoms includes menorrhagia, metrorrhagia, continuous/post-menopausal bleeding, pain and pressure symptoms. The haemorrhagic ovarian cyst is an adnexal mass which resolves spontaneously by itself but requires surgery if it is more than 5 cm in size. Case Summary: A 46-year-old female patient came to the outpatient department with profuse uterine bleeding during menses lasting approximately 8–10 days and cutting pain in the lower abdomen extending to the back for two years. Magnetic resonance imaging studies showed a uterine fibroid along with a haemorrhagic cyst. Sepia officinalis was prescribed based on the results obtained from repertorisation of the totality of symptoms. The Modified Naranjo Criteria for Homeopathy score of +8 indicated that clinical improvement was likely attributable to the homoeopathic treatment, which aligns with imaging results obtained during and after treatment. This case report emphasises the effect of homoeopathic treatment on uterine fibroids and haemorrhagic cysts
Development and validation of Susceptibility Assessment Tool in Homoeopathy (SATH) in homoeopathic clinical practice
No full textBackground: The homoeopathic philosophy identifies susceptibility as a key concept for prescribing a similimum, i.e., the indicated remedy and its potency. No validated instrument to measure susceptibility as high, medium or low could be identified in the literature. Objective: The present study was undertaken to identify the factors governing susceptibility assessment and to develop a simple tool for physicians to assess the susceptibility of the cases they see in their clinical practice. Material and Methods: A new questionnaire was developed using standardised procedures including item development, pilot testing, and psychometric evaluation. The psychometric properties of this pilot tool were assessed by applying it on patients in routine clinical practice in different types of illnesses. Data was computerised and analysed by principal component analysis as an extraction method and orthogonal varimax as a rotation method. Results: The final 17-item questionnaire was arranged into nine domains as per rotated component matrix analysis. Overall internal consistency of the final questionnaire, as calculated by Cronbach\u27s alpha, was 0.607, and the measure of sampling adequacy was 0.729. Conclusion: A simple, homoeopathically appropriate, easy-to-use tool has been developed which can be applied by the practitioners during case taking to come up with a score, identifying low, normal or high susceptibility. This susceptibility assessment tool in Homoeopathy (SATH) can be further applied in diverse settings to enhance its validity and clinical utility
6C potency of Terminalia chebula reveals secondary metabolites and induces apoptosis in Triple-Negative Breast Cancer Cells (TNBCs)
No full textBackground: Breast cancer is a prevalent malignancy in women globally, and TNBCs, being ER-/PR-/Her2-, pose challenges in treatment options. Complementary and alternative medicines, including homoeopathic remedies, have gained popularity as potential anti-cancer agents to mitigate the side e ects of conventional drugs. Previously, the anticancer activity of homoeopathic potencies of Terminalia chebula (MT, 3X, 6C, and 30C) against breast cancer cell lines has been reported. Objectives: This study aimed to evaluate the mechanism of anticancer activity of 6C potency of T. chebula against the TNBC cell line, MDAMB231 and to understand the phytochemical composition of 6C potency. Methods: Lactate release was studied by LDH assay, and mitochondrial membrane potential was evaluated by JC- 1 assay. The mRNA expression of tumour suppressor and pro-apoptotic genes was done by qRT-PCR assay. Mother Tincture (MT) and 6C potencies were phytochemically characterised by LCMS analysis. Results: The 6C potency of TC increased lactate release in TNBCs, indicating a shift towards glycolysis and potentially inducing metabolic changes that contribute to its anticancer activity. The increased lactate release led to loss of mitochondrial membrane potential and an increase in mRNA expression of pro-apoptotic markers (caspase 3, caspase 9, and cytochrome c) and tumour suppressor proteins (p53 and pRb). LCMS analysis of 6C potency revealed phytocompounds with anticancer, anti-inflammatory, and antioxidant activities. Conclusion: The 6C potency of T. chebula induced apoptosis in TNBCs, however, further in vivo efficacy and safety studies are warranted to understand the anti-cancer mechanism of 6C in-depth