Seminars in Medical Writing and Education
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Assessment of the Risk Factors for Gastrointestinal Bleeding Among Individuals with Left Ventricular Support Machines
Get PDFGastrointestinal bleeding is a known complication among individuals with left ventricular support machines, also known as left ventricular assist devices (LVADs). LVADs are mechanical pumps that are used to support the pumping function of the heart in individuals with severe heart failure. To shield patients from thromboembolic intricacies, require anticoagulation (AC) with warfarin and insect platelet treatment. AC or anti-platelet medication is frequently reduced or discontinued in these individuals to address gastrointestinal bleeding (GI), a serious side effect. The likelihood of thromboembolic (TE) events later in LVAD therapy could be affected by changes to AC that are made to control GI bleeding. Provided continuous-flow LVADs to 389 patients, including 308 men, the typical age at implant was 60 years of age. The results were looked at to see if there was a link between GI bleeding and later TEs, which were either suspected or confirmed to be hemolytic, stroke, transient ischemic attack, or pump thrombosis. Using time-dependent variables, the relationships between GI bleeding, subsequent TEs, and mortality were investigated. There were 199 GI draining occasions in 116 of 389 patients, or 0.45 GI drains each quiet year of care. 97 of the 389 patients experienced 128 TE events, or 25% of the total, for a rate of 0.31 TE events per patient-year of assistance. This suggests that a decrease in anticoagulation and anti-platelet therapy for the treatment of GI bleeds could increase this risk, despite the fact that the exact cause of this association is unknown
Exploring the Role of Genetic Testing in Personalized Oncology Treatment and Patient Prognosis
Get PDFGenetic testing is now an important part of specialized cancer care because it gives doctors useful information that can greatly improve treatment results and patients\u27 prognoses. As cancer care moves from one-size-fits-all to more personalized approaches, genetic testing is a key part of finding the exact genes and genetic changes that cause tumors to grow. This lets doctors tailor treatment plans to each person\u27s unique genetic makeup, which increases the chances of success while lowering the risk of side effects. Genetic testing is being used more and more in personalized cancer treatments to help make choices about tailored therapies, immunotherapies, and precision drugs. Oncologists can find the best drugs and treatment plans for each patient by looking at genetic markers and changes that are unique to that patient\u27s cancer. Finding flaws that can be used, like those in the EGFR or BRCA1/2 genes, makes it possible to use tailored treatments that are more exact in how they work and have a higher chance of success than standard chemotherapy. Genetic tests can also help predict how well certain treatments will work, which makes planning treatments smarter and keeps people from having to go through steps that aren\u27t necessary. Genetic testing not only helps doctors choose the best treatment, but it also tells doctors a lot about the patient\u27s outlook. Oncologists can better predict how violent the disease will be, how likely it is that the tumor will spread, and the patient\u27s total chance of life by looking at its genetic makeup. Finding genetic predispositions to cancer return or spread early on lets treatments start on time, which increases the chance of life
Current Approaches and Clinical Implications of Epigenetic Modifications in Cancer Therapy
Get PDFEpigenetic changes are very important for the growth and spread of cancer because they control gene expression without changing the DNA sequence. Some of these changes, like DNA methylation, histone modifications, and non-coding RNA control, can turn on oncogenes, turn off tumor suppressor genes, and make cancer cells more aggressive. Because epigenetic changes can be undone, they are considered potential therapeutic targets for treating cancer. This essay talks about the latest methods to epigenetic medicines and what they mean for cancer care. The main goal of epigenetic treatments is to undo the abnormal epigenetic changes that cause cancer to spread. Some of the epigenetic drugs that have been studied the most are DNA methyltransferase inhibitors (like azacytidine) and histone deacetylase inhibitors (like vorinostat). Several of these drugs are already in use or are going through clinical studies. Besides that, going after non-coding RNAs like microRNAs and long non-coding RNAs has become an interesting way to change gene expression in cancer cells. Using epigenetic medicines along with common treatments like chemotherapy, immunotherapy, and targeted therapy has been shown to have better healing benefits, sometimes leading to better patient results. Epigenetic changes have a huge range of clinical effects. Epigenetic analysis of cancers can give useful signs for figuring out prognosis and treatment reaction, which makes it possible to create individual treatment plans. Also, epigenetic treatments might be able to beat drug resistance by going after the epigenetic processes that make traditional medicines less effective. However, there are problems with using epigenetic treatments in the field, such as making sure the drugs are safe, making sure they are bioavailable, and finding good ways to give the drugs.
Diagnostic and Prognostic Value of Liquid Biopsies in Non-Invasive Cancer Monitoring
Get PDFResearchers are finding that liquid biopsies, which are samples of blood, saliva, or pee that are not solid, can be used to find biomarkers that can help diagnose and track cancer. Traditional tissue biopsies are invasive and may not always be possible. Liquid biopsies, on the other hand, can be used over and over again and in real time to find genetic changes linked to cancer, differences in tumors, and treatment reactions. This piece talks about the diagnostic and predictive worth of liquid samples in cancer care. It focuses on how they can help with early diagnosis, tracking the development of the disease, figuring out the minimal residual disease (MRD), and guessing how well treatment will work. A liquid biopsy has gotten a lot of attention as an early cancer screening method because it can find genetic changes early on, often before any signs show up. It is possible to find cancer-related changes in cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), and circulating tumor cells (CTCs) using liquid samples. This information can help with early action and specific treatment plans. Liquid biopsies also show differences between tumors and how genes change over time, which is very important for figuring out how drug resistance works. Liquid biopsy has been very helpful for figuring out how well treatment is working and finding relapses. Monitoring ctDNA levels in real time can show how much of a tumor there is, which lets doctors see how well treatment is working and make changes to treatment plans as required. The amount and prevalence of ctDNA have been linked to tumor growth, showing an early sign of recurrence even before regular imaging methods show disease that can be seen by a doctor.
Consequences of the academic evaluation stage on the habits and physical health of students in the medicine career of the University del Valle
Get PDFIntroduction: Academic evaluation is a necessary stage in the training of the medical student; It can end in negative habits and stress that can influence physical health and performance; In this way, the objective of this work is to determine this relationship that directly affects medical students. Material and methods: Cross-sectional study in 110 medical students from the Universidad Privada del Valle in Cochabamba, between 18 and 25 years old; through closed surveys, their study habits and health were evaluated during evaluation stages; The information was processed in SPSS (Statistical Package for the Social Sciences) version 24 and Microsoft Office Excel, version 2021. Results: 73 % of students reported negative effects on their habits during exams. 51 % indicated sleep problems, 31 % nutritional neglect and 19,8 % an increase in tobacco consumption; additionally, 80 % experienced weight changes, and 70 % slept less than 6 hours. Discussion: Academic stress generates negative changes in student well-being, affecting sleep, eating and tobacco consumption; these problems are common in Latin America; it is recommended to implement stress management programs and promote healthy habits in the evaluation stage
Detection of tampered data using steganography techniques
Get PDFSteganography is the practice of hiding data within other data, such as hiding a message within an image. Data tampering is the unauthorized alteration of data. To detect data tampering through steganography techniques, one can use steganalysis, which is the process of detecting the presence of hidden data. Steganalysis techniques include statistical analysis, visual detection, and signature detection. These techniques can be used to detect if an image, audio, or video file has been tampered with by analyzing its statistical properties and comparing them to known properties of original files. Additionally, digital signature can be used to ensure the integrity of the data, by comparing the signature of the original file with the signature of the file that is being verified. Therefore, staying informed about the latest developments and using a combination of different detection methods is necessary for maximum effectiveness.
Factors that influence academic performance in mathematics: essential elements for effective education
Get PDFIntroduction: The present study, of a descriptive and non-experimental nature, aims to identify the factors that influence academic performance in Mathematics in high school students in Turbo, Colombia. It seeks to analyze the difficulties and errors in mathematical learning, providing a broader vision of the problem and its impact on school performance. Methods: A mixed, qualitative and quantitative methodology was used, with data collection through questionnaires applied to students and teachers. The sample corresponds to the San Vicente del Congo Educational Institution. Data analysis was performed using frequency distribution tables and statistical tools in Excel. Results: The factors that most influence academic performance in Mathematics include study time (100%), the way of study (65%), participation in classes (45%), completion of tasks (99%), selection of materials by the teacher (50%), understanding of the exercises (77%) and motivation for learning (55%). Conclusions: The study shows that dedication to study and constant practice are essential for the development of mathematical skills. In this sense, the appropriate selection of pedagogical resources and student motivation play a key role in improving performance. The teacher\u27s role must integrate teaching strategies that promote active and participatory learning
Teaching Optional Voting from the Citizenship Education Perspective and Its Impact on High School Students in Ecuador
Get PDFThis research uses the Flipped Classroom methodology with a mixed methodological approach, integrating both qualitative and quantitative methods to provide a comprehensive understanding of the investigated issue. The main objective is to train and motivate young people between the ages of 16 and 18 in the conscious exercise of optional voting. The Flipped Classroom seeks to encourage students to take a more active role in their learning, allowing theoretical knowledge acquisition to take place outside the classroom through resources such as videos, readings, and digital materials. In a second phase, inside the classroom, students engage in practical activities, debates, and reflections guided by the teacher, which strengthens their understanding and critical thinking skills. The focus is on familiarizing students with topics related to civic participation, electoral processes, and political rights, so they develop analytical skills and critical reflection on their role as voters. Practical activities in the classroom will simulate electoral processes and analyze real cases from Ecuadorian politics. The expected outcomes include improved understanding of optional voting among young people, as well as increased involvement in the electoral process. Furthermore, it is anticipated that the Flipped Classroom methodology will foster greater autonomy and responsibility in their learning, enhancing their civic education and future participation in democratic life
Evolution of digital education in Mexico: ICT and digital literacy
Get PDFThe Information and Communication Technologies (ICT) course in Mexico has played a fundamental role in strengthening digital literacy since 2022. Its implementation sought to provide students with tools to interpret, analyse and create digital content in the educational context. In the wake of the pandemic, the government promoted digitisation strategies, although challenges such as the digital divide and lack of infrastructure in some regions persisted. It was observed that, at secondary level, students initially used ICT passively, but with the inclusion of more structured programmes, more participatory and critical learning was promoted. The use of artificial intelligence and personalised digital platforms made it possible to improve efficiency in the teaching process, facilitating the adaptation of content to individual needs. In addition, teacher training was promoted to ensure the effective integration of technology in the classroom. However, resistance to change persisted in certain communities. Despite these barriers, the incorporation of constructivist methodologies and progressive access to technology have enabled students to develop stronger digital skills, essential for their academic and professional development. The digitalisation of education in Mexico continues to evolve and will shape the future of learning
Virtual Health Classroom in the training of Health Information Systems students
Get PDFIntroduction: the use of the Virtual Health Classroom (VHC) has generated a change in the paradigm of the training of Health Information Systems students. Objective: to describe the state of the use of VHC in the training of Health Information Systems students. Method: a cross-sectional descriptive study was carried out in the Faculty of Health Technology, focused on the training of students of Health Information Systems. A population of 61 subjects taught in the career was covered, to a total of 41 students of plan E. The variables were studied: students registered in the VHC, mode of study, students enrolled in VHC courses, subjects by discipline of the career and subjects by academic year. Results: 100.0 % of the students of the day course and meeting modalities are registered in the VHC and are enrolled in the courses (subjects) corresponding to the academic year. 80.5% of the subjects of the 13 disciplines of the degree are present in the VHC, with constant interaction of students and professors. The fourth year stands out with 100.0% of the subjects in the VHC, with traceable evidence of use for teaching and learning. Conclusions: the state of the use of the VHC in the training of students of Health Information Systems was described, where considerable advances are seen in terms of the use of this virtual teaching and learning environment