Salud, Ciencia y Tecnología (Journal)
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Computational identification of erα antagonists derived from natural products for breast cancer treatment
Full text linkEstrogen receptor alpha-positive (ERα+) breast cancer remains the most prevalent hormone-driven malignancy in women. While current endocrine therapies target ERα, emerging drug resistance underscores the need for novel antagonists. This study computationally evaluates natural compounds from the ZINC database as potential ERα antagonists using multi-stage in silico approaches. Molecular docking (HTVS, SP, XP) identified two compounds, ZINC000085627072 and ZINC000085592636, with superior binding affinities (XP scores: -14.811 and -14.366 kcal/mol) compared to the reference antagonist H3B-9224 (-13.620 kcal/mol). MM-GBSA binding free energy calculations further corroborated their stability, yielding energies of -61.51, -88.77, and -85.38 kcal/mol for ZINC000085627072, ZINC000085592636, and H3B-9224, respectively. Pharmacokinetic profiling via ADME analysis revealed acceptable properties for both natural compounds. Molecular dynamics (MD) simulations over 100 ns demonstrated stable binding: ZINC000085592636 and H3B-9224 exhibited comparable RMSD trajectories (~3 Å), while ZINC000085627072 showed moderate fluctuations (~4 Å). Protein-ligand flexibility analysis (RMSF) revealed average ligand-RMSF values of 1.4 ±1.14 Å (ZINC000085627072), 1.2 ±0.4 Å (ZINC000085592636), and 1.4 ±1.1 Å (H3B-9224), with protein-RMSF consistently at ~3 Å, indicating minimal structural fluctuations. These results suggest ZINC000085627072 and ZINC000085592636 as promising ERα antagonists with superior predicted affinity to H3B-9224, warranting further experimental validation. This integrated computational framework highlights the potential of natural product-derived scaffolds in addressing ERα+ breast cancer drug resistance
Dewey to Digital Age: How Pragmatism Shapes EdTech Today
Full text linkIntroduction:The prevalent use of educational technologies (edtech) in classrooms has revolutionized the way educators teach and support students. This study builds on the tradition of John Dewey\u27s pragmatism to investigate how experiences, student-centered approaches, and activity-centered democratic experiences continue and evolve in tech-mediated spaces.With a qualitative narrative inquiry stance, the research collected verbal stories from five educators that included experienced and novice teachers using semi-structured interviews. The stories were analyzed through the lens of the philosophical paradigm of Dewey\u27s pragmatism and were contextualized within larger psychological and sociological frameworks.Results:The stories illustrated how teachers actively wrestled with the integration of technology while also trying to uphold Deweyan principles. Educators discussed how they wanted to successfully promote inquiry-based and reflective learning using digital tools, while also facing hindrances like access issues, bureaucratic demands, and overly standardized systems. The results indicated a persistent tension between progressive pedagogy and technocentric educational practice.Conclusions:The stories revealed how teachers purposefully grappled with using technology while working to uphold the Deweyan ideals. Teachers identified benefits such as the ability to engage in inquiry and reflective, fluid learning using digital platforms, while they also identified challenges such as inequality, mandated procedures, and over-standardized learning environments. The results displayed persistent tension in the educational landscape between progressive pedagogy and technocentric tendencies
Interdisciplinary education and skills driving sustainable innovation in applied biosciences
Full text linkIntroduction: interdisciplinary education has emerged as a strategic approach to enhance competencies in applied biosciences, fostering sustainable innovation in professional training.Objective: to analyze pedagogical, technological, and curricular strategies that promote integral learning in bioscience programs, based on recent literature.Method: An exploratory review of scientific publications from 2020 to 2025 was conducted, structured according to the PRISMA methodology, with a focus on educational approaches in biological and environmental sciences.Results: Active methodologies—such as problem-based learning, the use of information and communication technologies (ICTs), and the integration of Sustainable Development Goals (SDGs)—strengthened critical skills including analytical thinking, multidisciplinary collaboration, and socio-environmental awareness. Integrated curricula and collaborative projects proved effective in connecting theoretical knowledge with real-world problem solving, reinforcing both academic and social relevance. However, structural limitations persisted, including curricular rigidity, limited teacher training in interdisciplinary methods, and the digital divide.Conclusions: Despite these challenges, the incorporation of emerging technologies—such as artificial intelligence and virtual learning environments—offers promising pathways to transform education into more flexible, inclusive, and sustainable models. Interdisciplinary education not only drives innovation in applied biosciences but also responds to the scientific, technological, and environmental demands of the 21st century
A Decade of Local Culture Integration in Mathematics Learning: A Bibliometric Analysis of Scopus-Indexed Publications (2015-2024)
Full text linkResearch on the integration of local culture into mathematics learning has gained growing international attention because of its potential to promote contextual, meaningful, and culturally relevant learning, yet systematic mapping of its scholarly progress and thematic directions is still limited. This study aims to examine the development, research trends, and institutional collaborations in culture integrated mathematics education over the last decade. A bibliometric analysis of 129 Scopus indexed journal articles published between 2015 and 2024 was conducted using VOSviewer 1.6.20 to visualize publication patterns, keyword cooccurrence structures, and collaboration networks. The results show a substantial increase in publications, particularly after 2018, with the highest output recorded in 2024. Thematic mapping identified three dominant clusters: culturally responsive pedagogical strategies, reinforcement of mathematical understanding through indigenous and local knowledge systems, and digital innovations such as augmented reality and STEM based tools supporting cultural preservation and learning. Indonesia emerged as the most prolific contributor, followed by the United States and the United Kingdom, indicating strong regional research engagement supported by international collaboration. Overall, the findings demonstrate the growing significance of culturally grounded mathematics education and provide an empirical foundation for future studies, the development of culturally responsive curricula, and policy formulation aligned with inclusive and multicultural educational practices
Stress and burnout syndrome in healthcare personnel: diagnosis and prevention strategies
Full text linkIntroduction: burnout syndrome is a global occupational crisis that seriously affects the mental health of healthcare workers and the quality of medical care. The COVID-19 pandemic has intensified this phenomenon, highlighting the urgent need for effective diagnosis and prevention strategies.Objective: to analyse the prevalence, risk factors, diagnostic tools, and intervention strategies for burnout syndrome in healthcare personnel, based on recent scientific evidence.Method: a systematic review of the scientific literature (2019–2024) was conducted following PRISMA guidelines. International databases (PubMed, Scopus, Cochrane, SciELO) were consulted, selecting 28 studies of high methodological quality that evaluated prevalence, risks, instrument validity, and the effectiveness of preventive interventions.Results: the overall prevalence of burnout among healthcare workers was 39%, reaching up to 59.5 % among nurses during the pandemic. The main risk factors were workplace bullying (OR: 4.05–15.01), low job satisfaction (OR: 5.05) and high perceived stress (OR: 4.21). Among the diagnostic instruments, the Maslach Burnout Inventory (MBI) and the Oldenburg Burnout Inventory (OLBI) showed the best psychometric properties. Mindfulness-based and coaching interventions moderately reduced burnout (SMD: -0.44).Conclusions: burnout is a multifactorial problem where organisational causes predominate. It is recommended to implement preventive institutional policies, strengthen workplace wellbeing and standardise diagnostic tools to improve the sustainability of the healthcare system
Knowledge diffusion as a key element in smart governance
Full text linkThis study examines the critical role of knowledge diffusion in smart governance within complex and globalized contexts, emphasizing its importance in driving technological advancement and fostering an information-driven society. By integrating smart governance with knowledge diffusion, the research aims to identify strategies for building a more equitable and inclusive society. A narrative review of documents from 2015 to 2023 was conducted using Boolean operators across major databases, followed by a rigorous selection and analysis using a traceability matrix. The findings highlight the innovative culture of smart governance, showcasing successful integration of citizen participation, public value creation, open government, and interorganizational collaboration. The results demonstrate that effective knowledge diffusion is essential for establishing robust governance systems that contribute significantly to economic and social development. The study concludes that embedding knowledge diffusion within smart governance frameworks can drive substantial societal improvements, promoting greater equity and justic
The Difficult Management of Depressive Symptoms in a Patient with Myasthenia Gravis: A Case Report
Full text linkIntroduction: Depression in patients with Myasthenia Gravis (MG) can be multifactorial, involving biological, psychological, and social factors. Depressive manifestations may arise as a result of the emotional impact of a chronic and potentially disabling condition, as well as from neurobiological changes associated with the disease or immunosuppressive treatment. Method: In this article, we report a case of a 51-year-old man diagnosed with MG and concomitant depressive symptoms. Treatment was initiated with sertraline 150 mg/day and trazodone 50 mg/day. Results: The choice of psychotropics should be made with caution, opting for drugs with a lower likelihood of affecting neuromuscular function. SSRIs are the most effective drugs for treating depression in patients with MG, and it is advisable to avoid drugs with anticholinergic effects, such as tricyclics and haloperidol. Conclusion: Caution is important when prescribing psychotropic medications to patients with MG due to the risk of affecting neuromuscular transmission
Clinical experience in a 28-year-old male patient with mandibular osteosarcoma. Case Report
Full text linkIntroduction: osteosarcoma (OS) is the most common primary bone tumor in adolescents and young adults. Osteosarcoma is a malignant tumor in which cancer cells produce osteoid matrix or mineralized bone. Six percent of osteosarcomas involve the mandible, making it the fourth most common site after the femur, tibia and thigh bone. Overall, mandibular OS is a high-grade and relatively rare lesion. This suggests that osteosarcoma of the mandible behaves differently than osteosarcoma of the long bones. The location of the tumor also presents a different set of resection and reconstruction difficulties than long bone tumors. The aim of the present study is to learn about the clinical and diagnostic presentation of this pathology. Clinical Case: We present a 28-year-old male patient who reports a painful tumor in the left mandibular region, which has evolved over the last 1 year. The patient refers pain on mobilization and makes it difficult to consume food, which is the reason for his visit. Patient with a reserved prognosis, complementary examinations were performed and tumor recension of the same with a diagnosis of malignant osteosarcoma. Conclusion: osteosarcoma is a very rare malignant tumor of the oral cavity. The best prognostic results are obtained with technically feasible radical tumor resection. To achieve this, diagnosis or at least suspicion should be established as early as possible
Post-operative rehabilitation in a hospital setting for people with scoliosis: a narrative review
Full text linkIntroduction: Idiopathic scoliosis, known as a three-dimensional alteration in the shape and position of the spine, is highly prevalent in children and adolescents. It causes major motor, respiratory, social and psychological limitations. After determining the degree and location of the scoliosis, corrective surgery may be indicated in the most advanced situations.Objective: Identify rehabilitation programs to be implemented for people undergoing corrective surgery for scoliosis, in the post-operative period, in a hospital setting.Methods: A narrative review was carried out using a bibliographic search on EBSCOhost, with the words: scoliosis, hospitalization, postoperative period, rehabilitation, nursing, functionality, exercises, physical, postural and pulmonary, over the last 5 years.Results: The 9 studies included were mostly primary, focused on knowledge and instruction for people with scoliosis, the importance of respiratory and motor rehabilitation, body balance and self-care in activities of daily living. Several authors suggest building rehabilitation protocols for people with scoliosis, from pre- to post-surgery, due to the gains in functionality and quality of life that can be achieved.Conclusions: The core areas of rehabilitation intervention for people undergoing corrective surgery for scoliosis in the post-operative period are functional respiratory re-education, functional motor re-education and re-education of body balance and self-care
Bibliometric Analysis of IoT-Based Technologies for Health Monitoring: Trends, Impact, and Key Findings (2014-2024)
Full text linkIntroduction:The integration of IoT technologies into health monitoring has revolutionized healthcare delivery, enabling real-time data collection, remote patient monitoring, and improved management of chronic diseases. Objective:This study conducts a comprehensive bibliometric analysis of IoT-based health monitoring research, aiming to identify influential contributors and emerging research themes.Methods:The analysis was based on data retrieved from the Scopus database using a search query designed to capture studies focused on IoT in health monitoring. Only peer-reviewed journal articles published between 2014 and 2024 in English or Spanish were included. The study adhered to PRISMA guidelines for literature selection and employed the biblioshiny package in R for data processing and visualization.Results:The analysis revealed an increase in research activity, particularly after 2017, with notable peaks in publication volume during the COVID-19 pandemic. Journals such as Sensors and IEEE Access were identified as key publication outlets, while authors like Pasi Liljeberg and Amir M. Rahmani were the most influential contributors. Geographically, the United States, China, and India dominated scientific output. Thematic analysis indicated an evolution from early studies focused on IoT architecture to recent concerns over data privacy, cybersecurity, and interoperability.Conclusions:The growing body of research on IoT-based health monitoring highlights its transformative potential for healthcare, especially in managing chronic conditions and remote care. However, challenges such as data security and device interoperability must be addressed. Future research should focus on developing standardized protocols and ensuring the ethical use of IoT in healthcare to enhance its adoption and effectivenes